CN207164073U - automated diagnostic analyzer - Google Patents

Abstract

The application is related to a kind of automated diagnostic analyzer.Analyzer be automated and from preanalysis system receive carrying sample shuttle.Analyzer has robot, and shuttle is transferred in analyzer by it from preanalysis system.Shuttle is then placed on shuttle and kept in component, and system automatically extracts aliquot sample from the sample cell being placed in shuttle there.When sample is obtained aliquot sample from sample cell, shuttle keeps component that sample cell is maintained in shuttle.Automatic analyzer includes inventory machine people, and it includes inventory scan device and end effector, and end effector is configured as handling a variety of consumptive materials, including shuttle shuttle, amplification box, liquid reagent plate, dry agent plate and sample treatment plate.Amplification box, liquid reagent plate and dry agent plate can be transported to position by the end effector that inventory machine people has from the position in automatic system.

Description

Automated diagnostic analyzer

Cross-reference to related applications

The rights and interests for the U.S. Provisional Application No. 62/326,259 submitted this application claims on April 22nd, 2016, above patent The disclosure of application is incorporated herein by reference.

Background technology

The diagnostic test of biological sample contributes to quickly and to effectively to diagnose and treat disease in health care industry.It is real The clinical labororatory for applying such diagnostic test has received thousands of individual samples up to a hundred daily, and demand is continuously increased.Processing The challenge of such huge number of sample has obtained the help of sample analysis automation.Sample analysis is automated generally by automating Analyzer performs, and Automatic analyzer is typically independent system, multi-step processing can be performed to biological sample to be diagnosed As a result.

At present it is several automation clinical analysers provide a user can be performed on the sample provided it is a series of from Dynamicization is tested or experiment.However, when sample reaches laboratory, they are often not ready for analyzing.In order to prepare sample Product are used for the test of automatic analyzer, the primary appearance that laboratory technicians generally receive the sample of aliquot from laboratory Device is transferred in the secondary containers of suitable analyzer.In addition, technical staff generally has to know what test implemented to sample, So technical staff can select the test particular agent or diluent with sample match.This is probably time-consuming, and may Cause operator's mistake and exposed to communicable disease.

Preanalysis system is intended to help to prepare the sample for analysis, and further receives sample and analyzer from laboratory Test result between workflow in delete the operator still having.However, many such systems still need greatly The technical staff of amount participates in, for example, in preanalysis system before load sample；And sample is prepared by preanalysis system After good；And after analyzer has completed analysis.

For example, the sample of aliquot automatically can be transferred to the second appearance by some preanalysis systems from the first container Device.However, such system is frequently necessary to technical staff by the identification code manual pairings of the first and second containers, then by them It is loaded into the system, this may be time-consuming and easily malfunctioned.

In addition, many such systems can not integrate with one or more analyzers, also, conversely, the analysis Instrument can not be with such system integration.At this point, it is necessary to technical staff be present and manually turn sample from preanalysis system Analyzer is moved on to, and storage location is transferred to from analyzer at the end of analysis.It is insignificant that this will carry out technical staff Work, and may interfere, because technical staff must often pay attention to sample entering in preanalysis system and analyzer Exhibition so that technical staff shifts sample when being ready to minimize downtime.

Moreover, current preanalysis system generally prepares sample to assess the speed of the sample different from analyzer, therefore This is further such that integrated complex between preanalysis system and analyzer.At this point, it may be necessary to which technical staff is continuous The sample that is prepared by preanalysis system is paid attention on ground, until have accumulated by the gross sample to be transferred to analyzer manually.Alternately, Part batch can be transferred to analyzer by technical staff, and this can reduce the productivity ratio of analyzer.

Therefore, although current automation preanalysis system and analyzer is beneficial to clinical labororatory, for The integrated and automation of different system still has further improved space.

The content of the invention

The present disclosure describes the devices, systems, and methods for sample treatment and analysis.Especially, describing one kind includes Analyzer in high throughput system.In one embodiment, the high throughput system can also include the second analyzer And the preanalysis system integrated with the first and second analyzers.These parts (i.e. analyzer and preanalysis system) are modularizations And can be integrated to adapt to the diagnostic requirements of special laboratory with several different configurations.

Particular analysis instrument described herein generally has the stage construction (deck) or layer (level) being vertically arranged.One layer Face can store the consumptive material for different tests, and can accommodate consumptive material discarded object, and it includes waste liquid.In one embodiment In, enough consumptive materials can be stored in allow it to operate continuously 24 hours in analyzer, without reloading system.Should Aspect can also include being used for the detector for testing and analyzing thing (such as DNA target mark).

Another aspect can include the multiple processing modules being arranged side by side.Each in these processing modules can be There is similar configuration in terms of its 26S Proteasome Structure and Function.In one embodiment, each processing module can be implemented widely to test, Each processing module is allowd to run the experiment different from the experiment run in other processing modules.On this point, depend on In the processing needs in particular point in time, each processing module automatically can be specified and reassigned to implement any quantity Experiment.For example, each processing module can implement any one of the first experiment, the second experiment or the 3rd experiment, but first Processing module can be designated to implement the first experiment, and Second processing module specifies the second experiment, and the 3rd module specifies the 3rd examination Test, wherein each experiment is different.However, when those experiments are completed, any one in processing module can be by automatically Reassign and implement different analyses so that such as first, second, and third processing module runs identical experiment simultaneously.Such as This, analyzer is flexibly adapted to need in real time, as long as being used for the sufficient consumptive material of particular analysis in its housing memory storage.

Each processing module can have multi-pipeline pipettor, and it carries the multiple liquid relief pipelines being associated.In addition, Analyzer can have inventory machine people, and it is periodically carried out Stock Check to determine whether that enough consumptive materials can use, will Consumptive material moves back and forth in stock between processing aspect, and shuttle is moved back between preanalysis system and analyzer It is dynamic.More particularly, inventory machine people includes inventory scan device and is configured as handling the end effector of a large amount of consumptive materials, including sample Product container shuttle, amplification box (amplification cartridge), liquid reagent plate, do agent plate and sample treatment plate.

Brief Description Of Drawings

Feature, aspect and benefit of the present utility model will become more preferable by following explanation, appended claims and accompanying drawing Understand, wherein：

Fig. 1 is the front perspective view according to the high-throughput diagnostic system of one embodiment of the disclosure.

Fig. 2 be according to the forward part transparent view of the first analyzer of Fig. 1 of one embodiment of disclosure system, and And eliminate its external shell and some parts therein.

Fig. 3 is the front perspective view of Fig. 2 analyzer.

Fig. 4 A are the perspective views according to first pipette tip of one embodiment of the disclosure.

Fig. 4 B are the perspective views according to second pipette tip of one embodiment of the disclosure.

Fig. 5 is the perspective view according to the shuttle shuttle of one embodiment of the disclosure.

Fig. 6 is the perspective view according to the process plate of one embodiment of the disclosure.

Fig. 7 is the perspective view according to the dry agent plate of one embodiment of the disclosure.

Fig. 8 is the perspective view according to the liquid reagent plate of one embodiment of the disclosure.

Fig. 9 is the top view according to the amplification box of one embodiment of the disclosure.

Figure 10 A are the rear views according to the consumptive material storage of one embodiment of the disclosure.

Figure 10 B are the rear views according to the discarded object storage of one embodiment of the disclosure.

Figure 10 C are the front perspective views according to the pipette tip drawer of one embodiment of the disclosure.

Figure 11 A are the top views according to the processing aspect of one embodiment of the disclosure.

Figure 11 B are the top views according to the first processing module of Figure 11 A of one embodiment of disclosure processing aspect.

Figure 11 C are the schematic diagrames of the shuttle engaged by the shuttle holding component of Figure 11 A processing aspect.

Figure 12 A are the front perspective views of the extractor of the processing module of Figure 11 B in accordance with an embodiment of the present disclosure.

Figure 12 B are the top views of Figure 12 A extractor.

Figure 12 C are the perspective views of the alternate embodiment of extractor and process plate.

Figure 12 D are Figure 12 C extractor and the side view of process plate.

Figure 12 E are the fragmentary perspective views of the processing aspect of Fig. 1 systems for the extractor and process plate for including Figure 12 C.

Figure 13 A are the front perspective views according to the inventory machine people of one embodiment of the disclosure.

Figure 13 B are the end effectors according to Figure 13 A of one embodiment of disclosure robot.

Figure 13 C are the amplification box engagement members of Figure 13 B end effector.

Figure 13 D are the side views of Figure 13 C engaged with amplification box engagement member.

Figure 14 A are the front views according to the liquid handling component of one embodiment of the disclosure.

Figure 14 B are the front perspective views of the multi-pipeline pipettor of Figure 14 A liquid handling component.

Figure 15 is the block diagram of the example arrangement of the computing system of the analyzer comprising Fig. 2, and wherein analyzer includes being applicable In the example components for performing disclosed method.

Figure 16 is the flow chart according to the application method of Fig. 2 of one embodiment of disclosure analyzer.

Figure 17 A are the front views according to the analyzer of another embodiment of the disclosure.

Figure 17 B are the front perspective views of Figure 17 A analyzer.

Figure 17 C are the side views of Figure 17 A analyzer.

Figure 18 A are the front perspective views of the analyzer for Figure 17 A for including shell but being the absence of front door.

Figure 18 B are the partial front perspective views of the analyzer for Figure 18 A for including single front door.

Figure 18 C are the perspective views of removable consumptive material stock.

Illustrate

As used herein, word " about ", " usual " and " substantially " it is intended to mean that the slight deviations bag with absolute value Include in the range of the term so modified.And when referring to specific direction, it is such as left, right, front and rear, upper and lower, with In lower discussion, it is understood that on describing these sides towards the angle of the user of following systems during exemplary operation To.

Fig. 1 depicts high throughput system 00, and it includes the first analyzer 2000, the second analyzer 4000 and preanalysis System 10, such as the preanalysis system described in U.S. Provisional Application 62/296,349 (" described ' 349 application ' "), its disclosure Content is fully incorporated herein by quoting.Analyzer 2000,4000 and preanalysis system 10 are modular and they can be with Physically it is connected and disconnected from each other, and can also be electronically connected and disconnect each other.Although the first analyzer 2000 and second Analyzer 4000 is different in terms of the operation and experiment that they implement, it should be understood that the second analyzer 4000 can be first The copy (duplicate) of analyzer 2000 so that preanalysis system 10 is coupled at least two identical analyzers.Should also It should be appreciated that the modularization of preanalysis system 10 allows it to be coupled to any analyzer being configured so that.As shown, first The analyzer 4000 of analyzer 2000 and second is with the opposite side arranged in a straight line for being arranged on preanalysis system 10.Although preanalysis system System 10 and analyzer 2000,4000 be configured as the physical arrangement, it is contemplated that be that preanalysis system 10 can be configured as Adapt to more than two analyzer and preanalysis system 10 and analyzer 2000,4000 can be adapted so that they can be in Other existing physical arrangements, such as L-shaped.

The analyzer relevant with preanalysis system

As shown in Fig. 2 the first analyzer can be coupled to the either side of preanalysis system 10.On this point, analyzing In the case that instrument 2000 is located at the right side of system 10, the shuttle shuttle of preanalysis system 10 transports component 300a directions point The left side extension of analyzer 2000, or in the case where analyzer 2000 is located at the left side of system 10, the sample of preanalysis system 10 Container shuttle is transported component 300b and extended towards the right side of analyzer 2000.Such component 300a-b can neighbouring analysis The entrance of instrument terminates, as shown in the figure.However, in certain embodiments, such component 300a-b can extend through analyzer Entrance and enter analyzer 2000.Inventory machine people 2300, as described further below, can be from such component 300a-b obtains shuttle shuttle 2030, and the which side of analyzer 2000 is transported to but regardless of shuttle shuttle 2030.

Structural framing

As Fig. 2 and Fig. 3 are further described, analyzer 2000 includes structural framing 2011, and it is by several support members Composition, such as metal section, support member are configured to support and limit the every aspect or layer for sample treatment and analysis. Such aspect can be included at detection/analysis level 2012, stock's aspect 2014, processing aspect 2016 and liquid robot Reason aspect 2018.However, it is possible to provide more or less aspects are to reduce the horizontal length of analyzer 2000 or vertical height. Analyzer 2000 also includes the as shown in Figure 1 shell or housing 2010 that wrap its internal part.

Aspect relation

Detection/analysis level 2012 is set close to the bottom of analyzer 2000, and is positioned in stock's aspect 2014 Lower section.Stock's aspect 2014 is arranged between processing aspect 2016 and detection/analysis level 2012.Processing aspect 2016 is set Put between stock's aspect 2016 and liquid handling robot aspect 2018.Liquid handling robot aspect 2018 is set close to The top of analyzer 2000.Detection/analysis level 2012, stock's aspect 2014 and processing aspect 2016 are each positioned in analysis Instrument 2000 front portion and reach analyzer back before terminate, cross over analyzer 2000 in the lateral direction to provide Length and also along analyzer 2000 height extend space so that with detection/analysis level 2012, stock's aspect 2014 and processing aspect 2016 it is intersecting.Inventory machine people 2300 is arranged in so provided space, before this allows it to access Each for these three aspects that face is mentioned.

Consumptive material

Fig. 4 A-8 show different consumptive materials, and it, which can be automated, is handled and using with to the extensive menu of a few class samples progress Interior experiment, the sample include blood, mucus, sputum, urine, excrement, liquid based cytology sample etc..Such menu includes It is related to detection chlamydia trachomatis, Diplococcus gonorrhoeae, trichomonas vaginalis, B races streptococcus, enteric bacteria (such as campylobacter Category, Salmonella, Shigella, Escherichia coli, shigella dysenteriae) and Enterozoa (for example, giardia lamblia stiles, hidden spore Sub- worm, Entamoeba histolytica) experiment and be related to measure blood viral charge (such as HIV, HCV and HBV) experiment.It is real The ability for applying this menu extensively obtains the part support of consumptive material design.Such consumptive material include pipette tip, shuttle, Shuttle shuttle, process plate, dry agent plate, liquid reagent plate and amplification box.

Pipette tip

Pipette tip 2020 includes the first pipette tip 2020a (Fig. 4 A) and the second pipette tip 2020b (figures 4B).First pipette tip 2020a is bigger than the second pipette tip 2020b.For example, the first pipette tip 2020a can be 1mL tips, and the second liquid relief tip 2020b can be 175 μ L tips.Appoint however, analyzer 2000 can be applicable as needed The pipette tip of what size.

Sample shuttle and shuttle

Shuttle shuttle 2030 (Fig. 5) and ' 349 applications ' shuttle 284 it is similar, and including receiver 2032, Each receiver is configured as receiving shuttle 03.Described specific shuttle 2030 includes 6 receivers of two rows 2032,12 receivers altogether.However, it is possible to provide any amount of receiver 2032.For example, shuttle 2030 can include 12 receivers 2032 of two rows, altogether 24 receivers.In described particular analysis instrument 2000, a collection of sample can include 24 samples altogether, it should be equal to 24 shuttles altogether.However, analyzer 2000 can implement binary channels experiment, or Other multichannels are tested, and wherein simple sample is processed and analyzed two or more times in an operation.Therefore, altogether 24 Some batches of sample may only 12 shuttles be counted needs with obtaining the gross sample altogether.So so that each to shuttle The intact sample batch that device 2030 accommodates half is supplied to analyzer to effectively adapt to binary channels experiment or the examination of other multichannels The flexibility tested.

Shuttle 2030 also include be used for inventory machine people 2300 engage the first transverse opening 2034 and with it is corresponding Receiver 2032 is intersecting to allow shuttle to keep component (discussed below) close to the of the container 03 placed wherein Two transverse openings 2036.Shuttle 03 and ' 349 application ' in third category vessel 03 it is identical.On this point, shuttle 03 Including with the lid that can puncture sealing 09.

Process plate

Process plate 2040 (Fig. 6) includes plate main body 2041.Engagement member 2049 extends from the upper surface of plate main body 2041.So Engagement member 2049 include engagement recesses 2042.Therefore, recess 2042 be arranged on the top of plate main body 2041 and relative to The side of plate main body 2041 is inside.This allows end effector 2360 as described further below, above plate main body 2041 Clamp process plate 2040.However, in some embodiments of plate 2040, recess 2042 can extend into the side of main body 2041 Surface, it allows peripheral joining process plate 2400 of the inventory machine people 2300 from main body 2041.

Plate main body 2041 at least partially defines multiple extraction tubes 2044, mix aperture 2046 and pipette tip holding station (station)2047.There is each extraction tube 2044 corresponding mix aperture 2046 aligned with it and pipette tip to keep Stand 2047.Extraction tube 2044 is positioned as the center line closer to main body 2041 compared to mix aperture 2046, and the quilt of mix aperture 2046 It is positioned as the center line closer to main body 2041 compared to pipette tip holding station 2047.Extraction tube 2044 has to be limited by main body 2041 Fixed is open and with the pipe main body 2045 extended from the lower surface 2043 of main body 2041.Pipe main body 2045 defines rotation The outer surface turned, such as the conical surface of rotation.Pipette tip holding station 2047 also have the opening that is limited by main body 2041 and from The sleeve pipe 2048 that lower surface 2043 extends.When pipette tip is arranged in the sleeve pipe, though process plate in movement, should Sleeve pipe 2048 keeps the stabilization of pipette tip 2020.Two row extraction tubes 2044, mix aperture 2046 and pipette tip retainer 2047 are provided and are aligned to parallel to each other.In described specific embodiment, process plate 2040 includes six of two rows 2044, six mix apertures 2046 of extraction tube and six pipette tip holding station 2047, it allows to handle 12 samples wherein. However, it is possible to consider more or less quantity.For example, process plate 2040 can include two rows 12 extraction tubes 2044, 12 mix apertures 2046 and 12 pipette tip holding station 2047 or even a line are such to be set.Process plate 2040 The identifier (such as bar code) being included in its side or other surfaces, it contributes to analyzer 2000 to identify the plate.

Dry agent plate

Dry agent plate 2050 (Fig. 7) includes plate main body 2051.Engagement recesses 2052 extend into the side surface of main body 2051 2053, it allows inventory machine people 2300 to do agent plate 2050 with respect to side engagement from its any two.Plate main body 2051 defines Multiple dry agent compartments 2054.Film (not shown) can be punctured and be placed on each top of these compartments 2054, and sealed To plate main body 2051 so that if film is punctured with close to a compartment, remaining compartment keeps sealing.This allows plate 2050 It is stored up to needs and is used for another a batch of sample.As shown, one shares 96 agent compartments 2054, and it allows agent plate 2050 are used for 4 isolated operations of the batch comprising 24 samples.However, the sum can change.Dry agent plate 2050 Including the identifier (such as bar code) on its side 2053 or other surfaces, it is described that it contributes to analyzer 2000 to identify Plate.

In one embodiment, do agent plate 2050 and be used for each experiment：First dry agent plate or extracts reagent plate The dry agent plates of 2050a and second or amplifing reagent plate 2050b (see Figure 10 C).On this point, extracts reagent plate 2050a is loaded Lysis buffer and extraction microballon, and amplifing reagent plate 2050b has been loaded main mix reagent.

Each agent compartment 2054 in same plate 2050 has been loaded identical reagent, so as to which agent plate is that experiment is special Property.Therefore, when analyzer 2000 implements more than one analysis, the specific reagent for the experiment is carried using each Single agent plate.Therefore, for the analysis implemented by analyzer 2000, at least two dry agent plates 2050 have been used (for example, an extracts reagent plate 2050a and amplifing reagent plate 2050b).Similarly, two are implemented not in analyzer 2000 During with experiment, at least four dry agent plates 2050 (such as two extracts reagent plate 2050a and two amplifing reagent plates have been used 2050b).Although extraction and the dry agent plate 2050a-b of amplification are described as separation, it may be considered that they can be combined into One single agent plate.

Liquid reagent plate

Liquid reagent plate 2060 (Fig. 8) is included by upper and lower surface and the side surface 2062 extended in-between The plate main body 2061 of restriction.Engagement recesses 2064 are extended into the side surface 2062 of main body 2061, and it allows inventory machine people 2300 carry out engaging liquid reagent plate 2060 from the relative side of its any two.Liquid reagent plate 2060 is included with four Manage multiple agent compartments 2066 of the tissue line of row 2066.Each in these rows 2066 includes four compartment 2066a-d, its In each compartment accommodate reagent for sample handling procedure.For example, each processing row 2066 includes being used to restore buffer solution First compartment 2066a, for the second compartment 2066b of lavation buffer solution, for the 3rd compartment 2066c of elution buffer, and The 4th compartment 2066d for neutralization buffer.These compartments 2066a-d is ranked up with they using order.However, it Can carry out other arrangements.In addition, each compartment 2066 accommodates carries out whole batch (such as batch of 24 samples altogether enough It is secondary) processing reagent.Film (not shown) can be punctured and be placed on each top of these compartments 2066, and be sealed to plate Main body 2061 so that if film is punctured with close to a compartment, remaining compartment keeps sealing.This allows liquid reagent plate 2060 are stored up to and are required for another a batch of sample.Liquid reagent plate 2060 also include positioned at its side 2062 or its Identifier (such as bar code) on his surface, it contributes to analyzer 2000 to identify the plate.

Expand box

Box 2070 (Fig. 9) is expanded to be similar to and BD MAX^TMThe related BD MAX of system^TMPCR boxes (Becton Dickinson, Franklin lake, New Jersey), and U.S. Patent number 7,332,130,7,998,708,8 is described in, In 105,783,8,440,149,8,709,787,8,765,976, the disclosure of which is fully incorporated herein by quoting.Expand box 2070 include ingress port 2073, microfluidic pipeline (not shown), wax valve 2074, amplification chamber 2075 and passage 2076.Quilt The sample of processing is inserted in box 2070 by ingress port 2073, and it enters amplification chamber 2075 along microfluidic pipeline.When Sample along pipeline advance when, passage 2076 allow air escape.The sealed chamber 2075 in fusing of wax valve 2074 causes sample The amplification of product can occur inside it.Partly the transparent or semitransparent window of limit chamber 2075 allows detector to detect The presence of analyte therein or target.

Amplification box 2070 also includes engagement recesses 2072, and it extends into the side surface of box 2070.These recesses 2072 exist The opposite side of box 2070 extends into box 2070, and is inwardly tapered towards the center line of box.In addition, recess 2072 is positioned proximate to At the side of the side for including ingress port 2073 and passage 2076 of box.This is prevented, recess 2072 interferes these structures.It is recessed Mouth 2072 allows inventory machine people 2300 to engage amplification box 2070 so as to which box 2070 can be carried by robot 2300.But In some embodiments, amplification box 2070 can not have such recess 2072 and can use to enter with robot gripper Other features of row engagement.The lower surface 2079 of the box 2070 intersected with recess 2072 be chamfered or otherwise shape with The profile of bond post 2365 with robot, shown in as further discussed below and Figure 13 D, it encloses in lower surface 2079 Recess or depression 2077 are formed around recess 2072, to further help in robot engagement.Expanding box is also included positioned at its top Or the identifier (such as bar code) of lower surface 2078,2079, indications contribute to analyzer 2000 to identify the box.

Consumptive material framework (staging)

Figure 10 A-10C describe the different aspect of the consumptive material framework of stock's aspect 2014 and processing aspect 2016.Stock's layer Face 2014 includes at least one consumptive material storage, such as consumptive material storage 2110 (Figure 10 A).Stock's aspect 2014 is also included at least One discarded object storage, such as discarded object storage 2130 (Figure 10 B).Processing aspect 2016 also includes multiple pipette tips Drawer appliance 2140 (Figure 10 C).Consumptive material storage 2110, discarded object storage 2130 and pipette tip drawer 2140 are each Can be approached from the front of analyzer 2000 by user so that user can be analyzed with load or unload instrument 2000 use it is more Kind consumptive material.

Consumptive material storage

As shown in Figure 10 A, consumptive material storage 2110 includes supporting construction or beam 2114, and it is horizontal-extending from post 2118, post 2118 extend vertically from pedestal 2119.Supporting construction 2114 limits the compartment for single consumptive material project so that consumptive material project It can be loaded into compartment from the first side of cylinder 2118, and be carried from the second side dumping of cylinder 2118.For example, such as Figure 10 A institutes Show, supporting construction 2114 slidably can receive and support dry agent plate 2050 or liquid reagent plate 2060.Such plate 2050 Can slip into their own compartment from the front side of post 2118 by user with 2060 so that identifier (such as bar code) towards Inside system 2000.As described further below, inventory machine people 2300 can scan identifier as needed to identify Specific plate and the rear side of suitable plate 2050,2060 from post 2118 is removed.On this point, consumptive material project, such as plate 2050 and 2060, it can be loaded in any order by user, because system 2000 can manage stock simultaneously by robot 2300 And automatically determine the order that user loads consumptive material.In addition, plate 2050,2060 is maintained at its lower end by supporting construction 2114 so that Its opening 2052,2064 is exposed, and thus allows robot 2300 to be engaged with option board to be removed from their own compartment. Also as shown, amplification box 2070 can be stacked on the corresponding box storage compartments positioned at the top of consumptive material storage 2110 In 2116.Box 2070 can be stacked in storage compartments 2116 by user from the front side of system 2000, and passes through robot 2300 Walked from preceding sidesway.

In one embodiment, consumptive material storage 2100 can be attached to one group of track, and this allows the picture of storage 2100 Drawer is equally drawn out, for resupplying.Pneumatic plunger (not shown) can be assisted to open storage 2110 and can also carried It is too fast and by consumptive material release location to prevent storage 2110 from closing for damping.In other embodiments, storage 2110 can To be hinged so as to which door 2112 can show storage to resupply towards user's Unscrew.

Discarded object storage

Discarded object storage 2130 (Figure 10 B) includes door 2132, and it is approached by user in the front of analyzer 2000.It is discarded Thing compartment 2134, it has the opening 2136 parallel to door 2132, is attached to the rear side of door 2132.Storage 2130 Including the shelf 2138 extended from discarded object compartment 2134.The shelf 2138 allows used process plate 2040 by stock's machine Device people is stacked on thereon, as shown.Storage 2130 can also be included in the liquid container in opening 2136, and the opening can To be connected (see Figure 11 B) with one or more liquid debris receivers 2260 in processing aspect 2016.Discarded object stores up Hiding device 2130 can be attached on one group of track, and this allows storage 2130 to be drawn out as drawer, for emptying.Pneumatically Plunger (not shown) can assist to open storage 2130 and can also provide damping to prevent that it is too fast that storage 2130 from opening And it is pushed against process plate 2040.Alternately, storage 2130 can be hinged so as to be emptied towards user's Unscrew.

Pipette tip drawer

Hydraulic tube tip drawer appliance 2140 (Figure 10 C) includes sophisticated drawer 2142, and it is typically the structure of similar box, its Including side wall 2144 and transverse wall 2145, transverse wall includes one or more and is open for receiving the multiple pipette tips of carrying Pipette tip frame.In the embodiment shown, have in the transverse wall 2145 of sophisticated drawer 2142 for receiving two liquid reliefs Two openings of tip end-rack (not shown).First can include the first pipette tip, and the second frame can include second Pipette tip.Pipette tip drawer 2142 is attached on one or more tracks 2148, its allow drawer 2142 from point Analyzer 2000 is partially pulled out to remove the sophisticated frame of sky and feed new sophisticated frame again.Door (not shown) can be attached To one end of drawer 2142, so as to which when drawer 2142 is closed, door forms a part for the shell of analyzer.Pneumatic plunger 2149 can assist to open drawer 2142 and can also provide damping to prevent drawer 2142 from opening or closing too fast.

Processing module

Processing module/passage

Figure 11 A show processing aspect 2016, and it includes the multiple processing modules 2200 being arranged side by side.As shown, place Reason aspect 2016 includes three processing modules：First processing module 2200a, Second processing module 2200b, and the 3rd processing mould Block 2200c.However, analyzer 2000 can include more or less processing modules 2200 to adapt to the production of special laboratory Amount needs and space requirement.Processing module 2200a-c is similarly configured in their physical layout, and their difference is They keep the position of component 2210 relative to shuttle, and shuttle keeps component to be shared by neighbouring module.Example Such as, the first and second processing module 2200a-b can keep component 2210ab therefore to keep sample using the first shuttle Product container 03, and second and the 3rd processing module 2200b-c all can keep component 2210bc using the second shuttle Therefore to keep shuttle 03.

Although each processing module 2200 is similarly configured, each processing module 2200 can be implemented widely to try Test so that each processing module 2200 can run with another processing module while experiment that the experiment that runs is different.Close In this point, depending on the process demand in particular point in time, each processing module 2200 can automatically be designated and refer to again Determine to implement any amount of test type.Tested for example, first processing module 2200a can be designated implementation first, second Processing module 2200b implements the second experiment, and the 3rd processing module 2200c implements the 3rd experiment, wherein each experiment is not With.However, when those experiments are completed, any one of processing module 2200a-c can be reassigned automatically to implement Different experiment so that each operation identical experiment in such as first, second, and third processing module 2200a-c.Such as This, analyzer 2200 is flexibly adapted to need in real time, as long as being applied to the enough of special test in its memory storage of housing 2010 Consumptive material.

The example of processing module

Figure 11 B show first processing module 2200a, and are the examples of other processing modules.First processing module 2200a generally includes the first shuttle and keeps component 2210ab (it is shared by Second processing module 2200b), does reagent stations 2220, liquid reagent station 2230, extractor 2240, expand box station 2250, pipette drawer 2140 and discarded object receiver 2260. These parts can be arranged with any configuration.However, in an illustrated embodiment, do reagent stations 2220 and liquid reagent station 2230 are located in the rear end of processing aspect 2016, and are configured to located adjacent one another.First and second extractor 2240a-b quilts Positioning is adjacent to reagent stations 2220 and 2230 and between amplification box station 2250 and reagent stations 2220,2230.This allows liquid Effective transfer therebetween.Pipette tip drawer 2140 is located in the front of processing aspect 2016, and this allows user easy Ground close to it.Processing module 2200a preferably includes three pipette tip drawers 2140, and each receiving carries the first shifting Liquid pipe tip 2020a the first pipette tip frame 2022a and the second liquid relief tip that carry the second pipette tip 2020b End-rack 2022b.The amount of the pipette tip 2020 allow processing module 2200a implement about 12 test runs without from Resupplies.Shuttle keeps component 2210ab to be set to the side of extractor 2240a-b and reagent screen station 2220,2230 simultaneously And between the first and second processing module 2200a-b.Discarded object receiver 2260 is also between the first and second processing modules Between 2200a-b.Discarded object receiver allows used pipette tip to be abandoned from above-mentioned processing aspect 2016 to discarded In thing storage 2130.Discarded object receiver 2260 can also include liquid debris entrance (not shown), and it allows liquid Discarded object is set into the bottle in discarded object storage 2130 or some other containers.

Shuttle keeps component

Shuttle keep component 2210ab with ' 349 application ' shuttle keep component 1100 it is similar, wherein it bag Include clamp assemblies 2212, it is closed towards the shuttle 2030 that is arranged in clamp assemblies, with keep shuttle 2030 and Container 03 is maintained in shuttle 2030 when aliquot sample suctions out out of container 03.At this point, clamp assemblies 2212 include Engagement member 2214, it is configured as, when clamp assemblies 2212 are turned off to the skirt section of the bottom end of joined sample container 03 (skirt) 07 when, engagement member 2214 projects through the second transverse opening 2036 of shuttle 2030, as Figure 11 C are fully aobvious Show.These engagement members 2214 puncture/bitten the skirt section 07 of cell therefor 03 to prevent that container 03 is not by aspiration procedure Carefully removed from shuttle 2030.However, from keeping unlike component 1100, keep component 2210ab to have and fix Platform 2216, shuttle 2030 is parked in thereon, and keeps component 1100 using mobile conveyer 1116.Therefore, instead of For shuttle 2030 to be transported to the conveyer of the position in clamp assemblies 2210ab, inventory machine people 2300 is by shuttle 2030 are placed on the position in clamp assemblies 2212.

Reagent screen station

Dry reagent screen station 2220 and liquid reagent screen station 2230 can be each included by extending from the surface of aspect 2016 The receiver that is limited of supporting construction (not shown) (such as a pair of guide rails).Such receiver can receive corresponding reagent Plate is to assist in ensuring that each plate is placed on accurate position.As shown, processing module 2200a includes a dry reagent screen station 2220 and a liquid reagent screen station 2230.Because analyzer 2000 generally uses two dry reagents to each experiment of implementation Plate 2050a-b, so dry agent plate 2050a-b is changed during operation.However, it is possible to consider in processing module 2200a Interior another dry reagent screen station of merging, to allow being each once positioned in processing aspect 2016 in agent plate 2050a-b. Processing module 2200a can also include recess supports structure, and it allows amplification box 2070 accurately to be put by inventory machine people 2300 Put.

Extractor

As shown in Figures 12 A and 12 B, extraction device assembly includes two extractors：First extractor 2240a and the second extractor 2240b.Each extractor 2240a-b includes shell 2242, printed circuit board (PCB) 2247 (" PCB "), motor 2244, drive mechanism 2246th, permanent magnet 2241 and heating element heater 2248.Other exemplary extraction device assemblies include BD MAX^TMThe extractor of system (Becton Dickinson, Franklin lake, New Jersey) and described by U.S. Patent number 8,133,671, in its disclosure Appearance is fully incorporated herein by reference.Permanent magnet 2241 is installed to drive mechanism 2246 and is arranged in shell 2242. Permanent magnet 2241 is aligned to six magnet of two rows, so as to form six couples of neighbouring magnet 2241a-b.It is it has been found that this Be arranged into magnet 2241a-b relative to single magnet enhancing process plate 2040 in magnetic bead magnetic attracting force.Magnet 2241 Row be removably couplable to drive mechanism 2246, and can be by drive mechanism 2246 via the top of shell 2242 opening Shell 2242 is movable into and out, wherein drive mechanism 2246 is operated by motor 2244.

PCBs 2247 and heating element heater 2248 are connected to the opposite side of shell 2242.Heating element heater 2248 is arranged to two Row six and the extension above shell 2242.Each heating element heater 2242 limits the recess 2249 for forming cup-like structure, and it has There is the geometry of the rotating exterior surface for the extraction tube 2045 for meeting process plate.This allows heating element heater 2248 directly to contact so Surface of revolution to transfer heat in extraction tube 2045, and allow process plate 2040 to be extracted device 2240 in a stable manner Support.In addition, extractor 2040a-b width is such that when process plate is kept by it, pipette tip 2020 Pipette tip clamping can be placed into stand and extend through process plate 2040, without by any dry of extractor 2240 Relate to.When motor 2244 is run, the row of permanent magnet 2241 can be moved upwardly into the space 2243 between heating element heater 2248 Interior and neighbouring drawing holes 2045, to attract the magnetic bead that can be placed in drawing holes.

Figure 12 C and 12D describe the extractor 2240 ' and process plate 2040 according to the further embodiment of the disclosure.Such as Preceding described, process plate can include the engagement recesses 2042 in the opposite side of plate main body 2041.However, instead of being positioned in Engagement recesses 2042 on the side of plate main body 2041, process plate 2040 preferably include engagement member 2049, and it is from plate main body 2041 upper surface extension.Such engagement member 2049 includes engagement recesses 2042.Therefore, process plate 2040 is by recess 2042 It is positioned above plate main body 2041 and inside relative to the side of plate main body 2041.This allows end effector 2360 from plate master The top of body 2041 clamping process plate 2040, rather than clamped in its side, this allows end effector 2360 between very little Operated in the space of gap, as described in more detail below.

Extractor 2240 ' is similar with extractor 2240, and difference is that extractor 2240 ' includes drain pan 2280.As institute Show, drain pan 2280 includes the groove component 2281a-b connected by intermediate member 2088.Intermediate member 2088 is in extractor 2240 ' Opposite side between extend, and the opening including being extended through for extraction tube 2045 and mix aperture 2046, to carry Pipe 2045 is taken to engage the heating element heater 2248 of extractor 2240 ', as Figure 12 D are fully shown.In addition, because intermediate member 2088 generally have flat upper surface, it is allowed to which process plate main body 2041 is parked in thereon, so intermediate member 2088 helps to prop up Support process plate 2040.Each groove component 2281a-b includes outer shield 2082, interior shield 2084 and lower shield 2086.Interior shield 2084 are connected to intermediate member 2088 and are extended downwardly from intermediate member so that when process plate 2040 is installed to extractor When 2240 ', interior shield 2084 is located between heating element heater 2248 and a line liquid relief pipe-in-pipe 2048, such as the abundant institutes of Figure 12 D Show.Lower shield 2086 is connected to outer shield and extended between outer shield 2082 and interior shield 2084.Outer shield 2082 is under Shield 2082 upwardly extends.The configuration forms groove, when such liquid relief tip 2020 is placed on corresponding liquid relief pipe-in-pipe When in 2048, it is sized to receive a line pipette tip 2020.On this point, groove component 2281a-b forms system 2000 Interior barrier, it helps to prevent the pollution from pipette tip 2020, and pipette tip 2020 can be stored in liquid relief To reuse in pipe-in-pipe 2048.

Figure 12 E describe the 3rd processing module 2210c, and it includes extractor 2240 '.Process plate 2040 is installed to described Extractor 2240 '.Extractor 2240 ' and process plate 2040 are arranged on dry agent plate 2050, liquid reagent plate 2060 and liquid relief Between tip end chute 2135, amplification card station 2070.However, as shown, process plate 2040 is generally than those peripheral parts positions In position lower on processing platform 2016.However, in order to help to protect the overall dimensions of system 2000, these parts and processing Sideshake between plate 2040 is minimized.Therefore, there are enough gaps for end effector 2360 with by process plate 2040 are placed on extractor 2240 ' and may is that difficulty from the pickup processing of extractor 2240 ' plate 2040.On this point, place Manage plate 2040 and engagement member 2049 is provided, engagement member is that end effector 2360 provides enough gaps for picking up and placing Process plate 2040.Moreover, as shown, elongated open 2017 extends through processing aspect surface 2016, and it allows to be installed to Reusable pipette tip 2020 in process plate 2040 extends through processing aspect surface.The groove component of drain pan 2281a-b aligns with such opening 2017, to prevent locking system 2000 by from the described dropping liquid of pipette tip 2020 pollution.

Detector

Each processing module 2200a-c has related detector 2270, and it is each in the embodiment described by Figure 10 A Detector is located in detection/analysis level 2012 of the bottom of analyzer 2000.For example, first processing module 2200a and first Detector 2270a is related, and Second processing module 2200b is related to the second detector 2270b, and the 3rd processing module 2200c It is related to the 3rd detector 2270c.Detector 2270a-c, which is located under processing aspect 2016, to be contributed to detector 2270a-c Isolate with possible pollution.Exemplary detectors are BD MAX^TMSystem (Becton Dickinson, Franklin lake, New Jersey State) detector and by U.S. Patent number 8,133,671 describe, the disclosure of which by quote be fully incorporated herein.Each Detector 2270a-c includes reader head 2271 and thermo cycler 2275.Reader head 2271 includes optical transmitting set and detector (not shown), the detector are configured to detect the presence of fluorescence probe in the chamber 2075 of amplification box 2070.Thermo cycler 2275 include moveable platform 2276, and it has the recess 2277 for being configured to receive amplification box 2070.Thermo cycler 2275 has Heating element heater (not shown), it periodically heats the content of amplification box 2070, such as the DNA of purifying, to predetermined temperature, with The amplification of content as assistance.Reader head 2271 is hung from the structure of analyzer 2000 so that its reader refers to To downwardly direction.Thermo cycler 2275 is arranged on the lower section of reader head 2271 and including motor 2278 and drive screw, The drive screw causes platform 2276 to expand box 2070 with vertical direction movement to be pressed against reader head 2271.Thermo cycler Between 2275 and reader head 2271 existing space it is sufficiently wide with allow inventory machine people 2300 by expand box 2070 be placed into On thermo cycler 2275.

Consumptive material processing

Figure 13 A-13D describe the inventory machine people 2300 according to one embodiment of the disclosure.Inventory machine people 2300 Help all consumptive material stocks in all consumptive materials in analyzer 2000, and also in Treatment Analysis instrument 2000.In addition, stock Robot 2300 can be reached outside analyzer 2000 to enter preanalysis system 10 so that by the shuttle with shuttle 03 Device moves back and forth between analyzer 2000 and preanalysis system 10.On this point, the shell of analyzer 2000 can be included in The side opening of its left or right side, its size allow robot 2300 to be reached through it.Inventory machine people 2300 includes track structure Part 2300, main body/post 2320, shoulder 2330, the first arm member 2340, the second arm member 2350 and end effector or hand 2360。

Robots arm

Track component 2310 extends to opposite side from the side of analyzer 2000 in left-right direction and is oriented to than upper The aspect 2012,2014 and 2016 for being positioned at front stated is closer to the behind end of analyzer 2000.Main body 2320 is slideably Track component 2310 is attached to, and is orthogonally extended from it.Main body 2320 is coupled to track component 2310 by bracket 2322. Bracket 2322 and track component 2310 form linear electric machine, and it allows single axle of the main body 2320 along left and right directions to translate.Can It is Festo linear electromechanical actuators (" FLMA ") (Festo AG＆ to implement the embodiment of the linear electric machine in analyzer 2000 Co.KG Esslingens, Nei Kahe, Germany).However, other drive mechanisms, such as belt and belt pulley machinery, it is contemplated that it is used for Main body 2320 is driven along track component 2310.

Shoulder 2330 is attached slidably to the vertical axes quilt that main body 2320 allows shoulder 2330 along main body 2320 Driving, the motion can also be realized by linear electric machine or some other drive mechanisms.Shoulder 2330 is in the first arm member 2340 An end be attached to the first arm member 2340 so that the first arm member 2340 can surround the arm of shoulder 2330 and first The shared vertical axis rotation of part 2340.Second arm member 2350 is connected to the other end of the first arm member 2340 so that the Two arm members 2350 can surround the shared vertical axis rotation of two arm members 2340 and 2350.The quilt of end effector 2360 It is connected to end of second arm member 2350 away from the first arm member 2340 and surrounds the arm structure of end effector 2360 and second The shared vertical axis rotation of part 2350.

End effector

End effector 2360 includes main body 2362 and is coupled to a pair of removable finger 2363a-b of main body 2362. Removable finger 2363a-b is exercisable so that they move close to or away from grasping or releasing, such as schemed together Shown in 13A.On this point, the usual keeping parallelisms during operation of finger 2363a-b are may move.Main body 2360 is included in main body One or more identifier readers 2366 on 2362 surface, such as bar code scanner, it is generally faced away from finger 2363a-b direction.Main body 2362 can rotate about 180 degree relative to the second arm member 2350, with mark as permission Reader 2366 is accorded with towards the front of analyzer 2000 and scans the consumptive material positioned at stock's aspect 2014 or other positions.Main body 2362 are additionally may included in the identifier reader in its lower surface so that such reader can read upwardly facing Identifier, such as those be likely located at amplification box 2070 on identifier.

Finger 2363a-b is particularly configured to engage many different consumptive materials.On this point, finger 2363a-b bags Include the first engagement features 2361 and the second engagement features 2364.As shown, the first engagement features 2361 are from one The lug or projection that finger 2363 extends internally towards another finger 2363.The size quilt of first engagement features 2361 Design respectively to adapt to the engagement recesses 2042,2052,2062 of plate 2040,2050,2060, and adaptation shuttle 2030 the first transverse opening 2034.In operation, when closing finger 2362a-b for consumptive material article, the first engagement is special Sign part 2361 is extended in recess or the opening of corresponding consumptive material article, prevents that consumptive material article from dropping while finger 2363a-b Itself it is clamped on the side of consumptive material article further to control and keep the article.As shown, each finger 2363a- B preferably includes two engagement features 2361, and it helps to prevent that consumptive material article is neglectful during finger grasps Rotate.

Second engagement features 2364 are levied is usually located at finger 2362a-b's compared with the first engagement features 2361 Opposite side, and the post including extending downwardly or dovetail 2365.Post 2365 is from the usual flat bottom of engagement features 2364 Surface 2366 extend and from its outwards it is tapered to form conical butt surface of revolution, as Figure 13 C are fully shown.These posts The corresponding recess 2072 of 2365 engagement amplification boxes 2070.As discussed above, expanding box 2070 includes surrounding each recess 2072 beveled surface or contour surface, it forms depression 2077.In operation, when post 2365 slips into corresponding recess 2072, post 2365 finally reaches the depression 2077.When it reaches depression 2077, post 2365 is received in a manner of matching In depression 2077, as illustrated in figure 13d.When depression 2077 matches with the surface of revolution of post, this contributes to as around analyzer The box 2070 of 2000 movements provides firm platform.In addition, the expansion or taper of post 2365 help to prevent box 2070 from dropping.

As shown in Figure 13 B, each finger 2363a-b includes three engagement features 2364.Although however, it is contemplated that More or less engagement features 2364, but preferably each finger 2363a-b includes single second engagement features 2364.This allows finger 2363 fully to engage amplification box 2070, and it absent-mindedly may rotate around vertical axis causes Its side is not parallel with finger 2363a.This with the finger 2363a-b more than single engagement features 2364 for coming Say to be probably significantly more difficult task, because if box 2070 is absent-mindedly rotated, at least some features 2364 are not It can be properly aligned with expanding recess 2072 corresponding to box 2070.

And each finger 2363a-b can be flexible, enabling downwards or be bent up around horizontal axis Song, while be sufficiently resilient, in order to avoid surrender is easy to that can not contact.Such flexibility can be along whole close to finger The length of not-go-end is endowed each finger 2363a-b, and the finger includes the second engagement features 2364.This allows finger-like Part 2363a-b automatically regulates expands box 2070 to engage, and the amplification box 2070, which may surround horizontal axis and tilt, causes box 2070 is parallel with finger 2363a-b.

Liquid handling

Figure 14 A and 14B describe the liquid handling robot 2400 according to one embodiment of the disclosure.Liquid handler Device people 2400 is suspended in liquid handling robot aspect 2018, and above processing aspect 2016.Liquid handling robot 2400 include track component 2405, and it extends to opposite side from the side of analyzer 2000 in left-right direction.Multiple multi-pipelines move Liquid device 2440 is connected to track component 2405 by bracket 2420 and transverse arm 2430.Arm 2430 is connected to bracket 2420, And bracket 2420 is slidably attached to track component 2405 so that arm 2430 is in the transverse direction relative to track component 2405 Side upwardly extends.Bracket 2420 and track component 2405 form linear electric machine, and it allows multi-pipeline pipettor 2440 and arm 2430 Driven along track component 2405 with left and right directions.The example of such linear electric machine is Festo linear electromechanical actuators (" FLMA ") (Festo AG＆Co.KG Esslingens, Nei Kahe, Germany).As shown, each processing module 2200 has one Multi-pipeline pipettor 2440.Therefore, in this particular example, there are three pipette assemblies：First multi-pipeline pipettor 2440a, the second multi-pipeline pipettor 2440b, and the 3rd multi-pipeline pipettor 2440c.First multi-pipeline pipettor 2440a is corresponding In first processing module 2200a, the second multi-pipeline pipettor 2440b corresponds to Second processing module 2200b, and the 3rd multitube Road pipettor 2440c corresponds to the 3rd processing module 2200c.However, more or less multi-pipeline pipettors 2440 are possible , and be the quantity based on processing module 2200.

Multi-pipeline pipettor

Figure 14 B describe multi-pipeline pipettor 2442 in accordance with an embodiment of the present disclosure, and it is multi-pipeline pipettor 2440a-c example.Multi-pipeline pipettor 2442 includes back panel connector 2450 and is connected to the multiple of back panel connector 2450 Liquid handling component 2442.In the embodiments described, there are three liquid handling components 2442：First liquid handling component 2442a, second liquid processing component 2442b, and the 3rd liquid handling component 2442c.However, it is possible to consider more or less Liquid handling component.Each liquid handling component 2442 includes mainboard assembly 2460 and pipette assembly 2470.Liquid handling group Part 2442a-c is connected to back panel connector 2450 in close proximity to each otherly.

Each mainboard assembly 2460 helps to provide data, electric power and positive/negative air pressure to corresponding pipette assembly 240. In the embodiment shown, there are three pipette assemblies：First pipette assembly 2460a, the second pipette assembly 2460b, and 3rd pipette assembly 2460c.These components 2460a-c corresponds to corresponding liquid handling component 2442a-c.Each mainboard group Part 2460 is similar in ' 349 applications ' Figure 27 A and 27B be described and the mainboard assembly 1401 of display.On this point, each Shell 2462 of the mainboard assembly 2460 including being internally provided with various parts, such as PCB, malleation and negative pressure input, valve, and with The liquid/gas conduit that input connects with valve.Mainboard assembly 2460a-c also includes z- drive mechanisms, and it includes being located at shell The upright guide rail 2462 and motor 2466 and drive shaft (not shown) of 2462 sides.Drive shaft is arranged in shell 2462.

Each pipette assembly 2470 is similar to ' 349 applications ' Figure 27 A and 27B pipette assembly 1402 and figure 17A-17D pipette assembly 502, except each pipette assembly 2470 is not to be hingedly attached to its corresponding mainboard group Part 2460, and multiple hinge positions will not be rotated into.Each pipette assembly 2470 is rotated by limitation and passes through motor 2466 move in the z-direction along upright guide rail 2464.Therefore, first, second, and third pipette assembly 2470a-c can Independently moved on vertical or z- directions.In addition, pipette assembly 2470 is configured to be similar to the He of pipette assembly 502 1402, especially with regard to its pipette conduit assembly (not shown) and pipette tip injector assembly 2472.

Back panel connector 2450 be similar to ' 349 application ' Figure 29 A and 29B back panel connector 1600, except backboard connect Connect device 2450 and be configured with the multiple liquid handling components 2442 being mounted thereto, such as shown first, second and Three component 2442a-c.On this point, back panel connector 2450 is connected to the mainboard assembly of each liquid handling component 2442 2470a-c and including for providing the several of necessary electric power, pressure and data-signal to liquid handling component 2442a-c Connector (not shown), such as the input of Ethernet, multicore connector, malleation and negative pressure input connector.This contribute to reduce or The external cable of management may be stumbled and be likely difficult to by eliminating, and plurality of liquid handling component 2442 is closely leaned on such Nearly mode connects.

Automation

Figure 15 describes the general structure of the computing system of analyzer 2000.Computing system 2510 can be ' 349 applications ' Figure 26 system 1300 in subsystem, which depict the computing system schematic diagram of high throughput system 00.On this point, across Instrument bus 2504 and workflow computing device 2540 and ' 349 applications ' Figure 26 described in bus 1320 and calculating fill It is identical to put 1330.In addition, computing device 2510 and computing device 1360 are similar, and herein to it in analyzer 2000 Interior input and output is described in more detail.

Computer Control Unit 2510 can be any general computer and can include processor 2512, memory 2514 and the miscellaneous part that is typically found in all-purpose computer control device.And Computer Control Unit 2510 can include To perform the dedicated hardware components of specific calculating process.Processor 2512 can be any traditional processor, such as business CPU obtained by industry.Alternatively, processor 2512 can be special-purpose member, such as special-purpose integrated circuit (" ASIC ") Or other hardware based processors.

Memory 2514 can be stored by 2512 addressable information of processor, including can be performed by processor 2512 Instruction 2516.Memory 2514 can also include data 2518, and it can be retrieved, operate or be stored by processor 2512.Deposit Reservoir 2514 can be any nonvolatile type that can store the information that can be accessed by processor 2512, such as hard drive Device, storage card, ROM, RAM, DVD, CD-ROM, writable memory and read-only storage.

Instruction 2516 can be any instruction set that can be directly performed by processor 2512, such as machine code, or non-straight Connect the instruction set of execution, such as shell script.On this point, word " instruction ", " application program ", " process " and " program " can be with It is used alternatingly herein.Instruction 2516 can be stored as object code format so that processor 2512 is directly handled, or by Save as any other computing device language, including shell script or the independent source code mould being explained or compiled in advance on demand The set of block.

In one embodiment of analyzer 2000, computing system 2510 can include several instruction set.Such as each treat The experiment of implementation can have a several instruction set related to it, the instruction set can include operation inventory machine people 2300 with Implement Stock Check and obtain the instruction of the suitable reagent and other consumptive materials for the experiment.In another embodiment, instruction Collection can determine the sequence of operation implemented by specific multi-pipeline pipettor 2440, with the analysis of assist process sample.

Data 2518 are transfused to and checked that the graphic user interface can be shown by graphic user interface (" GUI ") Show on the display interface 2500 especially relevant with analyzer 2000, or be displayed on associated with whole high throughput system 00 ' 349 application ' Fig. 1 and Figure 26 display interface 1332 on.Data 2518 can input from scanner, such as inventory machine The scanner in scanner 2366 or preanalysis system 10 on the end effector 2360 of people 2300.Data can also pass through Sensor obtains, such as optical sensor, temperature sensor etc., to obtain on some conditions occurred in analyzer and work Dynamic information, such as the position of specific consumptive material and air quality.

The data 2518 can implement at the scene or relational database in be digitally labeled as specific identification code (example Such as, bar code sequence number), it can also be stored in memory 2514.This helps analyzer 2000 to keep to analyzer Different consumptive materials in 3000 are tracked and help to provide certain to processor 2512 during processor instruction 2516 performs A little information, inputted without user.For example, liquid reagent plate 2060 can have can be with the bar code on its outer surface Related identification code, the identification code can be in databases with some data storages (such as type for the reagent being stored therein Used with which reagent) mark.This allows analyzer to check its stock to determine when that reagent and other consumptive materials are transported Row deficiency is not enough to perform extra experiment.In another embodiment, shuttle 2030 can have identification code, the identification code It can be labeled with some data storages in database, such as data include the shuttle 03 that is carried by shuttle 2030, Such as patient's name, experiment, processing parameter etc. to be performed.In further example, when testing completion, the knot of experiment Fruit can associate with the specific sample in database so that when such result can be communicated to workflow by device 2510 During journey computing device 2540, user can easily obtain result by accessing workflow computing device 2540.

Although Figure 15 is functionally by other yuan of processor 2512, memory 2514 and Computer Control Unit 2510 Part is shown as in same, but Computer Control Unit 2510, processor 2512, and/or memory 2514 can wrap respectively Include the multiprocessor that may or may not be stored in identical physical enclosure, Computer Control Unit and memory composition.Example Such as, memory 2514 can be hard disk drive or in shell different from Computer Control Unit 2510 position in its His storage medium.Therefore, reference processor 2512, Computer Control Unit 2510 and memory 2514 should be understood that bag Include to may or may not the processor of parallel work-flow, Computer Control Unit and memory set reference.

Display interface

Display interface 2520 can be especially associated with analyzer 2000 and can only shown on analyzer 2000 Information and can also be integrated into the structure of analyzer 2000.However, display interface 2520 is optionally (in Figure 15 In show by a dotted line) also, in the embodiment shown in fig. 1, it is not included, but use overall system display interface 1332.However, during including display interface 2520, interface 2520 can be coupled to the front panel of shell 2010 or be positioned to remote Monitor, LCD panels from analyzer 2000 etc..Display interface can show GUI, user's prompting, user instruction and possibility The other information related to user.

Inputting interface

User's control/inputting interface 2530 allows user to manipulate GUI, and again, can be provided for The part of overall system inputting interface separation, the overall system inputting interface are provided by Fig. 1 display interface 1332.But carry During for user's control/inputting interface 2530, such interface may, for example, be touch pad, keyboard or mouse.In addition, inputting interface 2530 can be integrated into display interface 2520 so that the same apparatus of display reminding etc. is to allow prompting described in user response Same apparatus.

As shown in figure 15, Computer Control Unit 2510 may be connected to workflow computing device 2540, its quilt For all parts of high throughput system 00 to be integrated, such as the second analyzer 4000 and preanalysis system 10, and with spy The laboratory information system (" LIS ") for determining laboratory is integrated.Therefore it is relevant with analyzer 2000 from preanalysis system 10 Information can be communicated by workflow computing device 2540 and arrive analyzer 2000.Similarly, from analyzer 2000 with it is pre- The relevant information of analysis system 10 can be communicated by Computer Control Unit 2500 and arrive workflow computing device 2540, and it will The information communicates to preanalysis system 10.Such information can also be obtained by workflow computing device 2540 with from LIS Information supplement, such as patient information etc..

Computer Control Unit is also coupled to multiple parts in analyzer 3000, with sharing information to and fro, such as Instruction and data.Some parts connected with Computer Control Unit by internal bus include processing module 2200a-c, stock Each in robot 2300, detector 2270a-c and liquid handling robot 2400.With Computer Control Unit 2510 This connection allow Computer Control Unit 2510 to provide information to such part and obtain information from such part. For example, inventory machine people 2300 can receive instruction to obtain some consumptive materials and be put into them from Computer Control Unit 2510 Ad-hoc location, and inventory information can be communicated and arrive Computer Control Unit 2510.Therefore when analyzer 2000 is fully automated During change, the result by the operation that the internal part of analyzer 2000 is implemented usually as the instruction provided by processor 2512.

Method

Step 1：Receive order

In the method (Figure 16) of Operations Analyst instrument 2000, the order on experiment can be analyzed instrument 2000 from work Received at workflow management device 2540.When a collection of sample is pre-processed by preanalysis system 10 and is ready to analyzed, the life Order can be communicated to workflow computing device 2540 from preanalysis system 10 first.On this point, preanalysis system 10 can So that shuttle 2030 is loaded with whole batch, it includes two shuttles 2030, each shuttle 2030 in this embodiment With 12 shuttles 03.Such shuttle 2030 be parked in ' 349 application ' Figure 12 A Docking station 260 at.

Step 2：Stock

Once the analyzed instrument 2000 of order receives, it is enough to determine no to have that inventory machine people 2300 interrogates and examines 2604 consumptive materials Consumptive material is used to implement the experiment specified.Such interrogate and examine can be implemented by inventory machine people 2300.On this point, when receiving During order, inventory machine people 2300 moves end effector 2360 towards stock's aspect 2014 of the lower section of processing aspect 2016. End effector 2360 is rotated about 180 degree and causes identifier reader 2366 towards stock's aspect 2014.Inventory machine people 2300 are scanned sequentially for the consumptive material of position in the inner to determine which consumptive material is loaded into analyzer 2000.Analyzer 2000 next determine whether enough consumptive materials be used for implement order experiment.It is contemplated that for monitor consumptive material stock other Automation equipment.Other automatic modes for following the trail of consumptive material stock are known in those skilled in the art and not existed Discuss herein.

Inventory machine people 2300 can need not scan consumptive material when receiving order every time.Instead, analyzer 2000 Keep being tracked the consumptive material for being input to analyzer 2000 by user.For example, when user loads consumptive material, inventory machine people 2300 scan consumptive materials and they are registered in the database in memory 2514.Analyzer 2000 is kept to when using consumption The tracking of material.Therefore, analyzer 2000 can be in response to scanning the database in its memory 2514 (by processor 2512) Instruction consumptive material is interrogated and examined, be not used with determining which consumptive material has been previously used with which consumptive material to have obtained Whole record.

In one embodiment, for identifying that the existing experimental order of special test target (such as Chlamydia) is analyzed Instrument 2000 receives.Analyzer 2000 knows which reagent must implement the experiment inside analyzer 2000.In addition, analyzer 2000 know which other consumptive material must be used, such as pipette tip 2020, process plate 2040 and amplification box 2070.This The information of sample can be pre-programmed in its memory 2514.Analyzer 2000 scans the database in its memory 2514 Or the use of inventory machine people 2300 with consumptive material necessary to checking is available.

If available consumptive material not enough implements the experiment of order, user is notified 2620, and the form of notice can be display The sending out notice or mail of warning, mobile device on display 1332 or 2520.If other samples that different tests need Product get out analyzed instrument 2000 and handled, and have enough consumptive materials to implement the experiment, and analyzer 2000 can receive those Container 03, to avoid downtime, the consumptive material loading analysis instrument 2000 necessary to user uses.

When user loads consumptive material and the analyzed reception of instrument 2,000 2622 of such consumptive material, such as the beginning in work shift When or in response to the inadequate warning of consumptive material, user passes through the anterior loading consumptive material of analyzer 2000.Therefore, user can be by liquid relief Tip end 2020 is loaded into pipette drawer 2142, and agent plate 2050 and 2060, amplification box 2070 and/or process plate 2040 are added It is downloaded in consumptive material storage 2110.Enough consumptive materials can be loaded to allow analyzer 2000 continuously to run 24 hours uninterruptedly.

When such consumptive material is loaded by user, analyzer 2000 for example identifies stock's aspect 2014 by door sensor It has been approached.Inventory machine people 2300 can then automatically carry out inventory scan and is loaded into identifying in analyzer 2000 Any new consumptive material.Positioned at consumptive material (such as agent plate 2050,2060, process plate 2040, tip frame 2022 and amplification box 2070) identifier on be used for determining be what consumptive material and they what is accommodated, such as in agent plate 2050 and 2060 In the case of accommodate reagent.

Step 3：Obtain shuttle

Once analyzer 2000 determines have enough consumptive materials can quilt for implementing one of the experiment and processing module 2200 Use, analyzer 2000 sends its SBR to workflow computing device 2540.Workflow computing device 2540 connects Notice preanalysis system 10, the shuttle 2030 comprising shuttle 03 is responsively loaded into shuttle by preanalysis system Transport on component 300 and send it to analyzer 2000.Shuttle 2030 can reach entering for analyzer 2000 at it just Stopped before mouthful.But in certain embodiments, shuttle 2030 can be directly transferred in analyzer 2000.

Inventory machine people 2300 then moves and reached inside 2606 preanalysis systems 10 towards preanalysis system 10. End effector 2360 clamps shuttle 2030 and first engagement features 2361 is received in the second transverse opening 2036. Shuttle 2030 is then transported in analyzer 2000 and reaches the holding of the shuttle near the processing module 2200 specified Component 2210, and shuttle 2030 is put into fixed platform 2216.Clamp assemblies 2212, which then close, causes engagement features 2214 extend through the second transverse opening 2034 and are pierced into the skirt section 07 of cell therefor 03, so as to which container 03 be maintained at The position aspirated for multi-pipeline pipettor 2440.

Step 4：(stage) consumptive material and aliquot sample are provided

As shuttle 03 is fully kept, there is provided give processing module 2200 suitable consumptive material.On this point, stock Robot 2300 obtains one plate of placement on two process plates 2040 and each extractor 2240a-b and causes each plate 2040 Extraction tube 2044 is received by corresponding extractor 2240a-b heating element heater 2248.Inventory machine people 2300 also obtains first Do agent plate 2050a and liquid reagent plate 2060 and they are individually positioned in dry reagent stations 2220 and liquid reagent station 2230.Normally, liquid reagent plate 2060 and dry agent plate 2050 provide the examination of the sample size carried more than shuttle 2030 Agent.Such analyzer 2000 may not necessarily provide agent plate when each shuttle 2030 is put into analyzer instrument.Additionally, Inventory machine people 2300 from stock's aspect 2014 by the engagement recesses 2072 of the second engagement features 2364 by obtaining amplification box 2070.Amplification box 2070 is placed in amplification box station 2250 so that entrance opening 2073 is located at neighbouring extractor 2240a.

Afterwards, multi-pipeline pipettor 2440 is obtained in the first pipette tip 2020a, three pipette assembly 2470a-c Each have a tip.The sealing that punctures that shuttle is punctured by using pipette tip 2,020 09 and is aspirated therein Sample, 2607 aliquot samples are obtained from each shuttle 03.Aliquot sample is drawn into the corresponding of process plate 2040 Extraction tube 2044.After each mixing tube 2044 is divided sample inoculation, multi-pipeline pipettor 2440 is by pipette tip 2020a is inserted after neighbouring sophisticated holding station 2047 is used for and used.Implement the process until extracting decile from each container 03 Sample.In the case where failure be present and prevent aliquot sample from being obtained, such as because sealing is not punctured, analyzer 2000 retain the information in its memory 2514, and such information can be communicated to preanalysis system 10, preanalysis system Defective sample will suitably be organized, as ' 349 application ' discussed.

Step 5：Return to shuttle shuttle and obtain another shuttle shuttle

Once each shuttle 03 out of shuttle 2030 obtains aliquot sample, analyzer 2000 communicates to work Workflow management device 2540, shuttle 2030 is returned to 2608 and arrives preanalysis system 10.Workflow computing device 2540 will The communication, which is pass on, moves another shuttle 2030 of the other half comprising the batch to preanalysis system 10, preanalysis system Move shuttle and transport component 300.In analyzer 2000, clamp assemblies 2212 discharge shuttle 2030, and inventory machine People 2300 by shuttle 2030 be put into shuttle transport component 300 backward channel, used container 03 will be included Shuttle 2030 returns to preanalysis system 10.Inventory machine people 2300 then engages and moves second of 2610 batches Shuttle 2030, and it is transported to shuttle and keeps component 2210, it is kept and residue of the batch etc. there Sample is divided to be extracted.Once aliquot sample is transferred in the remaining extraction tube 2044 of process plate 2040, shuttle 2030 passes through Inventory machine people 2300 is again returned to preanalysis system 10.

In certain embodiments, binary channels experiment can be implemented by analyzer 2000, wherein from each shuttle 03 aliquot sample is drawn into two extraction tubes 2044, rather than one.In such embodiments, there are 12 samples The single shuttle 2030 of container 03 will fill two process plates 2040, and each process plate has 12 extraction tubes 2044.Therefore, In this embodiment, inventory machine people 2300 for test only obtain a shuttle 2030, and will not obtain it is any in addition Shuttle 2030.

Step 6：Handle sample

As process plate 2040 is divided sample inoculation, analyzer 2000 handles 2612 samples.The program is typically Identical, and it is unrelated with experiment.There is no many differences in terms of method, difference is reagent used.Therefore, processing module 2200 can implement widely to test.Processing generally includes extracting and developing and the amplification of analyte (such as DNA target mark).

Extraction includes rebuilding dry decomposition agent, and it can include the magnetic bead for being configured as being combined with DNA.On this point, Pipette tip holding station 2047 of the multi-pipeline pipettor 2440 out of process plate 2040 picks up previous used pipette tip 2020a.Although multi-pipeline pipettor 2440 generally includes multiple pipette assembly 2470a-c, single liquid relief component 2470 Driven independently of other pipette assemblies 2470 along corresponding z- guide rails 2464, it is previously used to be obtained from process plate 2040 Pipette tip 2020a.Once sophisticated 2020a is obtained, pipette assembly 2470 punctures rebuilds in liquid reagent plate 2060 The sealing of buffer solution, the buffer solution of decile is obtained, and it is transferred to dry agent plate 2050a, it punctures compartment there The sealing of one of 2044 tops, and compartment 2054 is inoculated with aquation decomposition agent again with buffer solution.The decomposition agent of reconstruction is connect And aspirate and be transferred to extraction tube 2044.The process is repeated until all extraction tubes 2044 are cleaved agent and magnetic bead inoculation.

Then, extractor 2240a-c by the heating extraction pipe 2044 of heating element heater 2248 that is contacted with extraction tube 2044 and Content therein.When mixture is inoculated with, inventory machine people 2300 moves the first dry agent plate 2050 from processing module 2200 Walk and obtain the second dry agent plate 2050b from stock's aspect 2014 and it is put into dry reagent screen station 2220.

When being inoculated with completion, permanent magnet 2241 is moved out their own shell by extractor 2240a-b motor 2244 2242 and neighbouring extraction tube 2044 place permanent magnet, magnetic bead and be attached to the extraction DNA of magnetic bead there and be attracted to pipe 2044 side.Then, multi-pipeline pipettor 2440 obtains the cleaning buffer solution of decile from agent plate 2060 and rinses test tube Mixture.Magnet 2241 is moved back in their shell 2242 and supernatant is removed from mixing tube and by with The liquid debris entrance of the liquid debris bottle connection of stock's aspect 2014 is abandoned.Neutralization buffer is by from liquid reagent plate 2060 are transferred to the mix aperture 2046 of neighbouring extraction tube 2044 in process plate 2040.Then, pipettor 2440 is from liquid reagent plate 2040 obtain elution buffers and elution buffer distribution are entered into extraction tube 2044 so that magnetic bead to be separated with isolation DNA. Magnet 2241 is moved back in situ and eluent and is extracted and is transferred in mix aperture 2046, there it and neutralization buffer Liquid mixes.Then the sample of neutralization is used for the main mixture rebuild in the second dry agent plate 2050b.Then, multi-pipeline is passed through Mixture is loaded into amplification box 2070 by the pipette tip 2020b of pipettor 2440 and second, the second pipette tip 2020b Box 2070 is inoculated with by being drawn to mixture in the entrance opening 2073 of box 2070.Amplification box 2070 can connect Receive whole batch.

Step 7：Amplification/analysis/detection

Afterwards, the end effector 2360 of inventory machine people 2300 engages box 2070 and is carried to it and processing module At 2200 associated detectors 2270.Box 2070 is put on the platform 2276 of thermo cycler 2275 by inventory machine people 2300, Without significantly tilting box 2070.This is at least possible, because box 2070 is hung or carried so that it is positioned ground Less than the finger 2363a-b of end effector 2360.If finger 2363a-b is positioned less than box 2070, box 2070 May be under the pendant of end effector 2360.Motor 2278 then raises thermo cycler 2275 and pressed with abutting against reader 2271 Box 2070.Box 2070 then carries out thermal cycle and to expand test objective.Reader 2271 detects 2614 boxes 2070 Experiment target target in chamber 2075 is present.

Step 8：Abandon and repeat

Once detection terminates, workflow computing device 2540 is as a result sent to.Used amplification box 2070 passes through storehouse Robot 2300 is deposited by mobile 2616 to amplification box discarded object, it can be in discarded object storage 2130 or analyzer 2000 Elsewhere.Inventory machine people 2300 is also by the way that process plate 2040 is stacked on the shelf 2138 of discarded object storage 2130 So that used process plate 2040 to be abandoned.Dry agent plate 2050 and liquid reagent plate 2060 are put back into consumptive material storage 2110 In case another experiment uses in their own compartment.Dry agent plate 2050 and liquid reagent plate 2060 may be generally used for 4 test runs.The holding of computing device 2510 following the trail of plate 2050 or 2060 has used how many times and analyzer 2000 is at them Final operation after by the way that plate 2050,2060 is put into discarded object storage 2130 automatically to abandon these plates.Once consumption Material is abandoned, and processing module 2200 can implement 2618 another experiment.

Once multiple experiments

If appropriate consumptive material is taken inventory in its shell 2010, at any given time, each processing module 2200 can implement any analysis on test sheet.This allows analyzer 2000 neatly to respond to optimize output.For example, the One processing module 2200a can implement several operations to the first experiment.If however, the second examination in preanalysis system 10 be present The overstocked sample of (it is different from the first experiment) needs is tested, first processing module 2200a can be used for by implementing the second examination Test, with sample as assist process and analysis.The process can be automatically performed by analyzer 2000, without the association of user Help, because analyzer 2000 and preanalysis system 10 keep lasting communication.

On the basis of without departing from the utility model, can apply features discussed above a variety of additional, modifications and Combination.Such as Figure 17 A-17C describe the analyzer 3000 according to another embodiment of the disclosure.Analyzer 3000 and analysis Instrument 2000 is similar, because it includes the processing aspect 3016 with multiple processing module 3200a-c, with gripping ends actuator 3360 inventory machine people 3300 including multiple multi-pipeline pipettor 3440a-c liquid handling robot, consumptive material storage region 3014 and for testing and analyzing the detector 3270a-c of thing.In addition, the application of analyzer 3000 consumes with the identical of analyzer 2000 Material, such as foregoing pipette tip 2020, shuttle 2030, process plate 2040, liquid reagent plate 2060, dry agent plate 2050 and amplification box 2070.However, the different consumptive materials for being analyzer 3000 store 3014 and detector 3270a-c and certain The arrangement of a little consumptive material storages.

Especially, analyzer 2000 includes detection/analysis level 2012, and it is located at the lower section of stock's aspect 2014.But point These aspects are flatly separated rather than vertically separated by analyzer 3000.Therefore, analyzer 3000 includes inventory component 3014 With detection/analysis part 3012.In described specific embodiment, inventory component 3014 is located at the left side of analyzer 3000 simultaneously And detection/analysis part is located at the right side of analyzer 3000.

Inventory component 3014 includes the first consumptive material storage 3110, the second consumptive material storage 3120 and discarded object storage 3130.First storage 3110 is similar with storage 2110, and they receive and stored consumptive material project, such as agent plate 2050, 2060 and box 2070.Second storage 31130 is between the first storage 3110 and discarded object storage 3130.

Second storage 3120, as Figure 18 C are fully shown, there is vertical compartment, it is by wall 3122 and is arranged on wall The vertical bar on 3122 opposites/post limits.The stacking for being dimensioned to reception processing plate 2040 of these compartments.Bar 3124 has Help prevent the stacking of process plate 2040 from falling, while allow process plate 2040 by the fully exposed robot 2300 that enables Plate 2040 is obtained from corresponding stack.

Discarded object storage 3130 is identical generally with discarded object storage 2130.Discarded object storage 3130 defines The lateral boundaries of the inventory component 3140 of analyzer 300 and contribute to original consumptive material and detection/analysis part 3012 Separate, this can help to completely cut off any potential pollution sources with any region.

Detection/analysis part 3012 includes discarded object storage 3130 (in one embodiment, discarded object is amplification box), Liquid debris storage 3170, and multiple detectors 3270.Discarded object storage 3160 has discarded for receiving and accommodating The opening of thing (such as used amplification box 2070), until user empties storage 3160.Expanding discarded object storage 3160 can To be attached slidably to pass in and out the motion of analyzer 3000 with control on one or more guide rails.Liquid debris storage 3170 are connected to processing aspect 3016 by flexible pipe or some other plumbing installation (not shown) so that liquid debris can be with Disposed from processing aspect 3016.Detector 3270a-c is identical with detector 2270a-c, and each includes thermo cycler 3275 and reader head 3271.Detector 3270a-c is positioned as being vertically arranged so as to which the second detector 3270b is located in Directly over 3rd detector 3270c, and the first detector is located in directly over the second detector 3270b.Detector 3270a-c is opened in identical direction, for being approached by the binding clasp 3360 of inventory machine people 3300.In certain embodiments, At least one detector 3270 can be positioned at on another detector identical horizontal plane, and can be relative to it into just Hand over arrangement.

Figure 18 A-18C describe the analyzer 3000 ' according to another embodiment of the present disclosure.Analyzer 3000 ' and analysis Instrument 3000 is similar, and difference is that one or more consumptive material storages are transportable in order to close.For example, as schemed Shown in 18B, the second consumptive material storage 3120 can be drawer-like may move so that user person can approach it is each vertically every Between with supplement process plate 2040.In another embodiment shown in Figure 18 C, the first discarded object storage 3110 and the second discarded object Storage 3120 can be located on movable base 3144 so that form removable consumptive material stock 3142.On this point, pedestal 3144 can be slided on guide rail (not shown) allow the first consumptive material storage 3110 and the second consumptive material storage 3120 by The position being moved to outside system 3000 ' is to supplement consumptive material.In a further embodiment, rotating disk consumptive material stock (not shown) can So that including multiple compartments, it can surround vertical axis and rotate.Such rotating disk stock can be rotated to its compartment is sudden and violent Reveal to user to be supplemented, while also allow the consumptive material that positioning is stored therein to be approached by robot 3300.

Analyzer 3000 ' also includes shell 3010, and it is included in the hole 3012 in before it so that various storages can To be moved or removed, such as the first storage 3110 and the second storage 3120, solid waste storage 3130, liquid give up Gurry storage 3170 and amplification discarded object storage 3160, as shown in Figure 18 A.Door 3140, it can be hingedly connected to Shell 3010, and can open to allow user close to such storage

Although this paper utility model is described by reference to specific embodiment, it should be appreciated that these embodiments Only principle of the present utility model and the explanation of application.Therefore it will be appreciated that without departing substantially from of the present utility model such as appended Illustrative examples can be carried out with a variety of modifications on the premise of the spirit and scope that claim is limited and can be designed Other arrangements.

Claims (25)

1. A kind of 1. Automatic analyzer, it is characterised in that including：

   Shell；

   Robots arm, it includes end effector, and the end effector includes：

   The main body being rotatably connected on articulated jib；With

   It is coupled in the main body and moveable first finger and the second finger relative to each other in a first direction, Each of the finger has an engagement features, and the engagement features are from first finger and second finger-like Each of part is inwardly and towards another raised, described engagement features in first finger and second finger Part is configured as the recess of jointed article, wherein the recess is configured as receiving the engagement features so that connect when described Close feature by it is such engaged with the product when, the robots arm can be carried from first finger and the second finger-like The product of part suspension；

   At least one shuttle platform, it is used for the shuttle for receiving carrying shuttle, carries the container of sample by institute State analyzer assessment；And

   The shuttle platform includes the jaw component that closed position is automatically moved to from open position, the jaw component bag Engagement member is included, the engagement member will not contact what is carried by the shuttle when the jaw component is in an open position The bottom of the shuttle, and the bottom when the jaw component is in the closed position with the shuttle connects Close.
2. 2. Automatic analyzer according to claim 1, it is characterised in that further comprise aspirating sample from the shuttle The automatic pipettor of product, and wherein when automatic pipettor aspirated specimens from the shuttle, the shuttle The jaw component of platform is closed.
3. 3. Automatic analyzer according to claim 2, it is characterised in that wherein when the jaw group of the shuttle platform When part is in an open position, the shuttle is placed on the shuttle platform by the robots arm.
4. 4. Automatic analyzer according to claim 3, it is characterised in that further comprise magnetic extractor.
5. 5. Automatic analyzer according to claim 4, it is characterised in that wherein described magnetic extractor further comprises：

   Limit the shell of cavity；

   Adjacent permanent magnet row, it is shiftably disposed in the cavity of the shell；

   Drive mechanism, its be connected to the permanent magnet row and be configured as the permanent magnet row being moved in the cavity or Removed from the cavity；With

   Multiple heating element heaters, its row along the opposite side for being arranged on the cavity extend from the shell；

   The permanent magnet row is wherein moved to the second place from first position the permanent magnet row is set directly at described add Between the row of thermal element so that each permanent magnet is directed at corresponding heating element heater；With

   The draining board of groove is limited, the groove both is set to neighbouring with the corresponding line of heating element heater.
6. 6. Automatic analyzer according to claim 5, it is characterised in that wherein described magnetic extractor is suitable in receiving area thereon Plate is managed, each defines recess to the heating element heater, and the recess is configured as receiving and remains set at the magnetic extraction The extraction tube of the process plate above device, the heating element heater are connected to the power supply for heating the heating element heater so that work as institute When stating process plate and being placed on above the heating element heater, the drop is extended into by the pipette tip that the process plate is kept In the groove of water plate.
7. 7. Automatic analyzer according to claim 6, it is characterised in that wherein described process plate is placed by the robots arm On the magnetic extractor.
8. 8. Automatic analyzer according to claim 7, it is characterised in that wherein by by described in the robot finger Engagement features are engaged with the engagement member upwardly extended from the process plate, and the robots arm transports the process plate It is sent on the magnetic extractor, wherein the engagement member upwardly extended has opening, when the robot finger is in During the first bonding station, the opening receives the engagement features, wherein the robot finger is in the described first engagement It is close together in position than in the second position, the distance pair at the second place between the robot finger It is spaced too far apart so that the engagement member can not be engaged in the engagement features.
9. 9. Automatic analyzer according to claim 1, it is characterised in that wherein described robot finger has from the machine The second engagement features that device people's finger extends downwardly.
10. 10. Automatic analyzer according to claim 9, it is characterised in that the spy wherein extended downwardly from the robots arm Sign part includes post, and the post has the frusto-conical protrusion of falling from its extension.
11. 11. Automatic analyzer according to claim 10, it is characterised in that the wherein described part of falling frustoconical feature engagement The corresponding recess of consumptive material product, the consumptive material product are transported to second in the Automatic analyzer from first position Put.
12. 12. Automatic analyzer according to claim 1, it is characterised in that further comprise being used to receive in the automation The consumptive material storage of the consumptive material project used in analyzer.
13. 13. Automatic analyzer according to claim 12, it is characterised in that wherein described consumptive material project be selected from by process plate, The group of dry agent plate, liquid reagent plate and amplification box composition.
14. 14. Automatic analyzer according to claim 13, it is characterised in that wherein described robots arm further comprises scanning Device, wherein the robots arm reads the code on the consumptive material by using scanner is stored in the consumptive material storage to obtain Consumptive material in device.
15. 15. Automatic analyzer according to claim 13, it is characterised in that wherein described consumptive material storage is received from the first side joint Consumptive material, and wherein robots arm obtains consumptive material from the second side draw of the consumptive material storage.
16. 16. Automatic analyzer according to claim 1, it is characterised in that the processing wherein in the Automatic analyzer Module includes the shuttle platform and magnetic extractor.
17. 17. Automatic analyzer according to claim 1, it is characterised in that neighbouring including multiple processing modules, two of which Processing module uses a shuttle platform.
18. 18. Automatic analyzer according to claim 16, it is characterised in that wherein processing module further comprises neighbouring described The dry reagent stations of magnetic extractor and liquid reagent station, wherein the magnetic extractor is suitable in reception processing plate thereon and wherein institute Process plate is stated relative to the dry agent plate and liquid reagent plate being placed at corresponding dry reagent stations and liquid reagent station to be located at The lower of the processing module.
19. A kind of 19. process plate for automated diagnostic system, it is characterised in that including：

    Plate main body, which defines multiple extraction tubes, mix aperture and pipette tip holding station, the extraction tube, mix aperture and shifting Each of liquid pipe tip holding station defines the opening for the upper surface for extending through the plate main body；With

    Engagement member, it extends upwardly vertically from the upper table of the plate main body, and in the vertical portion of the engagement member Dividing has opening, wherein the opening surface, to the periphery of plate main body, the opening is configured as receiving automation conveyer Engagement features.
20. 20. process plate according to claim 19, it is characterised in that wherein described plate main body includes upper surface, lower surface and side Edge, the edge extend between the upper and lower surface, and limit the periphery of the plate main body.
21. A kind of 21. process plate for automated diagnostic system, it is characterised in that including：

    Plate main body, it has upper surface, lower surface and edge, and the edge prolongs between the upper surface and the lower surface Stretch, and limit the periphery of the plate main body；

    In the upper surface of the plate main body and multigroup opening of the upper surface is extended through, wherein the opening exists Closed end terminates and further wherein each group includes following each one：

    Extraction tube, it has extends and defines the pipe main body for the tube opening for extending through the upper surface from lower surface；

    Hole；With

    Pipette station, it is configured to receive and keep pipette tip,

    Each of which group extraction tube, hole and pipette station are aligned to a line, wherein the pipette station be oriented near The edge at least on side of the plate main body, wherein the extraction tube and the hole are further away from the process plate The periphery.
22. 22. process plate according to claim 21, it is characterised in that further comprise engagement member, it is from the plate main body The upper table extends upwardly vertically, and has opening in the vertical portion of the engagement member, wherein the opening surface is to institute The periphery of plate main body is stated, this opening is configured as receiving the engagement features of automation conveyer.
23. A kind of 23. inventory machine people, it is characterised in that including the robots arm with the end effector for carrying product, The end effector includes：

    It is rotatably connected to the main body of articulated jib；With

    It is coupled to the main body and from least two fingers of main body extension, one at least two finger Relative at least two finger another is removable, each of wherein at least two finger is included with first Another extends described in direction towards described two fingers first is raised, to engage the corresponding recess of the product, Wherein corresponding recess is configured as receiving one of described projection, wherein each of at least two finger includes It is raised with downward direction extend second relative to the first direction, wherein second projection is used for the top of jointed article Recess in portion, wherein the recess is configured as receiving second projection.
24. A kind of 24. Automatic analyzer, it is characterised in that including：

    Robots arm with the end effector for carrying product, the end effector include：

    It is rotatably connected to the main body of articulated jib；With

    First finger and the second finger, first finger and the second finger assembly are coupled to the main body and with One direction extends from the main body and may move relative to each other in the second direction transverse to first direction, the finger-like Each of part has the first engagement features for extending along the second direction from it and from first finger and second The second engagement features that finger extends downwardly, second engagement features are configured as the top that engagement is arranged on product Interior recess, wherein the recess is configured as receiving second engagement features so that when the robots arm is by described in When product is carried to the second place from first position, the product is hung from first finger and the second finger.
25. A kind of 25. Automatic analyzer, it is characterised in that including：

    Inventory machine people, it includes robots arm, has end effector on the robots arm, the end effector includes It is rotatably connected to the main body of articulated jib；

    The multiple clamp fingers extended from the first side of the main body from the main body, wherein the main body is on vertical axis It is rotatable；

    Scanner on the end effector, it is taken near product by the inventory machine people, wherein the storehouse Deposit robot and be configured as identification information of the scan setting on product, and the scanner is located on the end effector Opening position in addition to the position of clamp finger extension；With

    Magnetic extractor, it includes：

    Limit the shell of cavity；

    Adjacent permanent magnet row, it is shiftably disposed in the cavity of the shell；

    Drive mechanism, it is connected to the permanent magnet row and is configured as the permanent magnet row being moved in the cavity Or removed from the cavity；With

    Multiple heating element heaters, it extends with embarking on journey from the shell, and the row is arranged on the opposite side of the cavity, each The heating element heater limits recess, the process plate that the recess is configured as receiving and remained set above the magnetic extractor Extraction tube, the heating element heater is connected to the power supply for heating the heating element heater；

    The magnet wherein is moved into the second place from first position includes the magnet of the row being set directly at described add Between the row of thermal element so that each permanent magnet is directed at corresponding heating element heater；

    From multiple heating element heaters of shell extension；

    The draining board of groove is defined, the groove both is set to neighbouring with the corresponding line of heating element heater；With

    Suitable for receiving the consumptive material storage of consumptive material process plate, the process plate is included in machine-readable tag thereon, wherein institute State process plate and the machine-readable tag in the consumptive material storage and on the consumptive material is placed into from the first side by institute Inventory machine people scanner is stated to read from the second side of the consumptive material storage；

    Wherein described inventory machine people is moved to the consumptive material storage and stored with obtaining process plate and scanning the consumptive material The label on product in device, when it is identified wait the consumptive material obtained, the consumptive material is removed from the consumptive material storage And the consumptive material is placed on the magnetic extractor so that the pipette tip kept by the process plate extend into it is described In the groove of draining board.