CN110045133A - A kind of consumptive material monitoring device and monitoring method - Google Patents
A kind of consumptive material monitoring device and monitoring method Download PDFInfo
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- CN110045133A CN110045133A CN201910365231.5A CN201910365231A CN110045133A CN 110045133 A CN110045133 A CN 110045133A CN 201910365231 A CN201910365231 A CN 201910365231A CN 110045133 A CN110045133 A CN 110045133A
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- 239000000463 material Substances 0.000 title claims abstract description 161
- 238000012806 monitoring device Methods 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000012544 monitoring process Methods 0.000 title claims abstract description 9
- 238000003745 diagnosis Methods 0.000 claims abstract description 19
- 238000000605 extraction Methods 0.000 claims abstract description 14
- 238000013178 mathematical model Methods 0.000 claims description 4
- 239000013589 supplement Substances 0.000 claims description 3
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000012840 feeding operation Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003793 prenatal diagnosis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
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- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Manipulator (AREA)
Abstract
The invention discloses a kind of consumptive material monitoring device and monitoring methods, are used for molecular diagnosis extraction/purifier apparatus, and Y-direction sliding rail connect with X-axis component slippage and can move in the X direction；Y-direction sliding block is slidably connected with Y-direction sliding rail and can move in the Y direction；Y-direction driving portion is connected with Y-direction sliding block, for driving Y-direction sliding block to move in the Y direction.Photo module is set on Y-direction sliding block, for shooting molecular diagnosis extraction/purifier apparatus consumptive material region.Liftable manipulator is set on Y-direction sliding block, and liftable manipulator can extend and shrink in z-direction, for from external consumptive material library feeding and being added to corresponding consumptive material region.X-axis component, Y-direction sliding rail, Y-direction sliding block, Y-direction driving portion and liftable manipulator are electrically connected with the controller.Controller is electrically connected with photo module, and for receiving the image information of photo module output and handling image information, the instruction for whether supplementing consumptive material issued to liftable manipulator according to the information of processing.
Description
Technical field
The invention belongs to molecular diagnosises to examine apparatus field more particularly to a kind of consumptive material monitoring device and monitoring method.
Background technique
Molecular diagnosis refers to the structure or expression of applied molecular biology method detection patient's body inhereditary material
Change and make the technology of diagnosis.Molecular diagnosis is the main method of predictive diagnosis, can both carry out the diagnosis of individual inheritance disease,
It can also carry out pre-natal diagnosis.Molecular diagnosis be primarily referred to as relevant to the disease various structural proteins of coding, enzyme, antigen-antibody,
The detection of immunological molecule gene.
Molecular diagnosis detection, is related to automation extraction/purification process of sample, extraction/purifying method of sample is more
Kind multiplicity, can be related to the various methods such as biology, chemistry, physics, these methods are completed by the step of various complexity, each
It is required to consumptive material in extraction/purification step, in automation extraction/purifier apparatus, preset consumptive material is in equipment running process
It gradually decreases, is usually refilled by by artificial observation and after estimating, this mode will increase human cost and error, need to grasp
Make personnel constantly to observe, also be easy to cause and be finished equipment break-off because estimating inaccurate consumptive material, or be refilled by number and excessively make
Pollution risk caused by equipment closing door is opened excessively increases and equipment operation suspension efficiency reduces.
Summary of the invention
It is automatic to improve equipment the technical problem to be solved in the present invention is to provide a kind of consumptive material monitoring device and monitoring method
Change service efficiency and reduces cost of labor.
To solve the above problems, the technical solution of the present invention is as follows:
A kind of consumptive material monitoring device of the invention is used for molecular diagnosis extraction/purifier apparatus, including X-axis component, Y-direction are slided
Rail, Y-direction sliding block, Y-direction driving portion, photo module, liftable manipulator, controller；
The Y-direction sliding rail connect with the X-axis component slippage and can move in the X direction；
The Y-direction sliding block is slidably connected with the Y-direction sliding rail and can move in the Y direction；
The Y-direction driving portion is connected with the Y-direction sliding block, for driving the Y-direction sliding block to move in the Y direction；
The photo module is set on the Y-direction sliding block, for shooting the consumptive material of the molecular diagnosis extraction/purifier apparatus
Region；
The liftable manipulator is set on the Y-direction sliding block, and the liftable manipulator can be gone up and down in z-direction, is used
In from external consumptive material library feeding and being added to corresponding consumptive material region；
The X-axis component, the Y-direction sliding rail, the Y-direction sliding block, the Y-direction driving portion and the liftable manipulator are equal
It is electrically connected with the controller；
The controller is electrically connected with the photo module, for receiving the image information of photo module output and right
Described image information is handled, according to the information of processing to the X-axis component, Y-direction driving portion and the liftable manipulator
Issue the instruction whether moved and whether supplement consumptive material.
Consumptive material monitoring device of the invention, the X-axis component include X to sliding rail, X to sliding block and X to driving portion；The X
It is slidably connected to sliding block with the X to sliding rail；The X is connected with the X to sliding block to driving portion, and drives the X to sliding block
It moves in the X direction.
Consumptive material monitoring device of the invention, the liftable manipulator include Z-direction sliding rail, Z-direction sliding block, Z-direction driving portion；Institute
Z-direction sliding rail is stated to be connected with the Y-direction sliding block；The Z-direction sliding block is slidably connected with the Z-direction sliding rail；The Z-direction driving portion and institute
It states Z-direction sliding block to be connected, and the Z-direction sliding block is driven to move in z-direction.
Consumptive material monitoring device of the invention, the photo module include CCD camera assembly and data line；The data
The first end of transmission line is electrically connected with the CCD camera assembly, and the second end of the data line is electrically connected with the controller
It connects.
Consumptive material monitoring device of the invention, the controller are STM32F101 single-chip microcontroller.
A kind of consumptive material monitoring method of the invention, for above-mentioned consumptive material monitoring device, steps are as follows:
S1: being based on image processing techniques, according to no material consumption image and has consumptive material image founding mathematical models；
S2: mobile photo module to the first consumptive material area；
S3: shooting image and be transmitted to controller and to image carry out processing analysed whether consumptive material；
S4: the liftable manipulator is moved if no material consumption, consumptive material is supplemented；
S5: mobile photo module to next consumptive material area；
S6: step S3 is repeated to step S5.
The present invention due to using the technology described above, makes it have the following advantages that and actively imitate compared with prior art
Fruit:
One embodiment of the invention by setting X-axis component, Y-direction sliding rail, Y-direction sliding block, photo module, liftable manipulator,
Consumptive material region, controller, X-axis component are set to molecular diagnosis extraction/purifier apparatus consumptive material overlying regions, Y-direction sliding rail and X-axis group
Part is slidably connected, and Y-direction sliding block is slidably connected with Y-direction sliding rail, and photo module is set on Y-direction sliding block, for shooting the consumptive material area
Domain；Image Acquisition is carried out to consumptive material region by photo module and is transmitted to processing and analysis that controller carries out image, judgement
Whether there are also consumptive materials in consumptive material region, and liftable manipulator is controlled if no material consumption and extracts consumptive material from external consumptive material library and is added to
In corresponding region, by this automation control based on image procossing, equipment automatization service efficiency and drop are improved
Low cost of labor.
Detailed description of the invention
Fig. 1 is the schematic diagram of consumptive material monitoring device of the invention；
Fig. 2 is the consumptive material area schematic of consumptive material monitoring device of the invention；
Fig. 3 is the photo module schematic diagram of consumptive material monitoring device of the invention；
Fig. 4 is the first consumptive material area schematic diagram of consumptive material monitoring device of the invention；
Fig. 5 is another schematic diagram of consumptive material monitoring device of the invention；
Fig. 6 is the work flow diagram of consumptive material monitoring device of the invention.
Description of symbols: 1: photo module；2:Y is to sliding block；3:Y is to sliding rail；4: liftable manipulator；5: consumptive material area
Domain；501: the first consumptive material areas；502: the second consumptive material areas；503: third consumptive material area；504: the four consumptive material areas；505: the five consumptive materials
Area；6:X is to sliding block；7:X is to sliding rail；8:X is to driving portion；9:Z is to sliding block；10:Z is to sliding rail；11:Z is to driving portion.
Specific embodiment
Below in conjunction with the drawings and specific embodiments to a kind of consumptive material monitoring device proposed by the present invention and monitoring method make into
One step is described in detail.According to following explanation and claims, advantages and features of the invention will be become apparent from.
Embodiment 1
Referring to Fig. 1, Fig. 3 and Fig. 4, in one embodiment, a kind of consumptive material monitoring device, for molecular diagnosis extract/it is pure
Change equipment, including X-axis component, Y-direction sliding rail 3, Y-direction sliding block 2, Y-direction driving portion, photo module 1, liftable manipulator 4, consumptive material area
Domain 5, controller.Y-direction sliding rail 3 connect with X-axis component slippage and can move in the X direction；Y-direction sliding block 2 and Y-direction sliding rail 3 slide
It connects and can move in the Y direction；Y-direction driving portion is connected with Y-direction sliding block 2, for driving Y-direction sliding block 2 to move in the Y direction.
Photo module 1 is set on Y-direction sliding block 2, for shooting molecular diagnosis extraction/purifier apparatus consumptive material region.Liftable manipulator 4
On Y-direction sliding block 2, liftable manipulator 4 can extend and shrink in z-direction, for from external consumptive material library feeding and adding
To corresponding consumptive material region.X-axis component, Y-direction sliding rail 3, Y-direction sliding block 2, Y-direction driving portion and liftable manipulator 4 are and controller
Electrical connection.Controller is electrically connected with photo module 1, for receive photo module 1 output image information and to image information into
Row processing, the instruction for whether supplementing consumptive material is issued according to the information of processing to liftable manipulator 1.By the way that X-axis component, Y is arranged
To sliding rail 3, Y-direction sliding block 2, Y-direction driving portion, photo module 1, liftable manipulator 4, consumptive material region 5, controller, X-axis component is set
In molecular diagnosis extraction/purifier apparatus consumptive material overlying regions, Y-direction sliding rail 3 is connect with X-axis component slippage, Y-direction sliding block 2 and Y-direction
Sliding rail 3 is slidably connected, and photo module 1 is set on Y-direction sliding block 2, for shooting consumptive material region；By photo module 1 to consumptive material area
Domain 5 carries out Image Acquisition and is transmitted to processing and analysis that controller carries out image, judges whether there are also consume in consumptive material region 5
Material controls liftable manipulator 4 if no material consumption and extracts consumptive material from external consumptive material library and be added in corresponding region, passes through this
Automation control of the kind based on image procossing, improves equipment automatization service efficiency and reduces cost of labor.
Further, X-axis component includes X to sliding rail 7, X to sliding block 6 and X to driving portion 8.X is set to X to sliding rail to sliding block 6
On 7.X is connected with X to sliding block 6 to driving portion 8, and X is driven to move in the X direction to sliding block 6.From X to sliding rail 7, X to sliding block 6,
The plane moving area that Y-direction sliding rail and Y-direction sliding block are constituted makes photo module that can cover entire consumptive material region.
Preferably, liftable manipulator 4 includes Z-direction sliding rail 10, Z-direction sliding block 9, Z-direction driving portion 11.Z-direction sliding rail 10 and Y-direction
Sliding block 2 is connected.Z-direction sliding block 9 is set on Z-direction sliding rail 10.Z-direction driving portion 11 is connected with Z-direction sliding block 9, and drives Z-direction sliding block 9 in Z
It is moved on direction.
Liftable manipulator 4 further includes suction nozzle, for drawing required consumptive material.
Further, photo module 1 includes CCD camera assembly and data line.The X of data line is to end and images
Head assembly electrical connection, the Y-direction end of data line is electrically connected with the controller.
Further, referring to Fig. 2 and Fig. 4, consumptive material region 5 includes the first consumptive material area 501, the second consumptive material area 502, third consumption
Material area 503, the 4th consumptive material area 504, the 5th consumptive material area 505.First consumptive material area 501, the second consumptive material area 502, third consumptive material area
503, the 4th consumptive material area 504, the 5th consumptive material area 505 are set on consumptive material region 5, are respectively used to place required consumptive material.It takes pictures
Module 1 takes pictures to consumptive material region 5 in angular field of view, because angular field of view is limited and consumptive material specification and 5 size of consumptive material region not
Together, so consumptive material is distinguished into several shooting areas according to angular field of view and consumptive material specification, guarantee each region in visual angle model
It encloses.The size in consumptive material region 5 is related with equipment instrument, test sample amount, and consumptive material places shape area and instrument space utilizes
Rate is related to service efficiency, and different device structures can have the different shape in consumptive material region 5.Each done project purification of sample
The same specification consumptive material quantity needed is fixed.
Further, by taking the first consumptive material area 501 as an example, by the image mesh segmentation of each consumptive material, each dotted line is indicated
Grid in only one consumptive material, judge whether to have in grid consumptive material and cumulative have the grid number of consumptive material that can calculate consumptive material
Number.
Further, controller is STM32F101 single-chip microcontroller.
The operating process of the consumptive material monitoring device of the present embodiment is said with a specific consumptive material adding procedure below.It is first
First controller control X is moved to opposite with the first consumptive material area in the X direction to the driving X of driving portion 8 to the drive Y-direction sliding rail 3 of sliding block 6
The position answered, controller control Y-direction driving portion driving Y-direction sliding block 2 again and photo module 1 are driven to be moved in the first consumptive material area 501
Side.After the completion of movement, controller control photo module 1 is taken pictures, and image information is reached controller and carries out gray proces and divides
Whether analysis has consumptive material, and photo module 1 is controlled if having consumptive material to next consumptive material area；If no material consumption, Y-direction driver drives are controlled
Y-direction sliding block 2 and liftable manipulator 4 thereon are moved to position corresponding with external consumptive material library, and controller controls X to drive again
Dynamic portion 8 drives X to sliding block 6, is moved to liftable manipulator 4 above external consumptive material library, and after the completion of mobile, controller controls Z
Drive Z-direction sliding block 9 mobile to driving portion 11, after carrying out feeding operation, controller controls Z-direction driving portion 11 and Y-direction driving portion is former
Road returns, and after reaching original position, controller controls Z-direction driving portion 11 and drives Z-direction sliding block 9 mobile, carries out filler operation.Above-mentioned behaviour
After the completion of work, controller controls photo module 1 to next consumptive material area and repeats aforesaid operations.
Embodiment 2
Referring to Fig. 6, a kind of consumptive material monitoring method, for being used for molecular diagnosis extraction/purifier apparatus consumption in embodiment 1
Material monitoring device, steps are as follows:
S1: being based on image processing techniques, according to no material consumption image and has consumptive material image founding mathematical models.Shoot consumptive material point
Image when benchmark image, that is, no material consumption of cloth regional scope is as standard reference data, after arranging consumptive material, because of consumptive material point
Visible change has occurred in cloth hole location, and shooting gained image can also change, and computer is handled by the comparison to image grayscale
Whether can not only there be consumptive material with interpretation, but also can identify how many quantity calculated by subregion, and pass through each sample institute
The consumable quantity for making project needs calculates the sample number that can satisfy.It is lossless by what is taken first using image processing techniques
Material image and have consumptive material image distinguish founding mathematical models, divide the image into it is latticed, each grid include a consumptive material, root
Information is extracted according to the grey scale change of grid, picture material is compared and is identified, whether interpretation has consumptive material.It further can be with
A series of iconic model for constructing known consumptive materials, the object to be identified and each iconic model matched and compared with, judge
Whether this region has consumptive material.
S2: mobile 1 to the first consumptive material area 501 of photo module.
S3: shooting image is simultaneously transmitted to controller and carries out processing analysis and 501 no material consumption base of the first consumptive material area to image
Quasi- image, which compares grey scale change multilevel iudge, no material consumption, then the grey scale change compared with having consumptive material benchmark image, if changing
Overall intensity is adjusted, whether multilevel iudge has consumptive material again after keeping periphery gray scale consistent with benchmark gray scale, counts if having consumptive material.
S4: if no material consumption without counting, and mobile liftable manipulator 4 supplements consumptive material.Same size consumptive material meter
Number is cumulative, and different size consumptive material counts respectively, can calculate the respective quantity of different size consumptive material, each sample items institute in this way
Whether it is fixed for needing different size consumptive material quantity, therefore can calculate consumptive material number according to preset sample number and consumptive material number and can
Enough meet sample number.
S5: mobile photo module 1 to next consumptive material area.
S6: step S3 is repeated to step S5.
Embodiments of the present invention are explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned implementations
Mode.Even if to the present invention, various changes can be made, if these variations belong to the model of the claims in the present invention and its equivalent technologies
Within enclosing, then still fall within the protection scope of the present invention.
Claims (6)
1. a kind of consumptive material monitoring device is used for molecular diagnosis extraction/purifier apparatus, which is characterized in that sliding including X-axis component, Y-direction
Rail, Y-direction sliding block, Y-direction driving portion, photo module, liftable manipulator, controller；
The Y-direction sliding rail connect with the X-axis component slippage and can move in the X direction；
The Y-direction sliding block is slidably connected with the Y-direction sliding rail and can move in the Y direction；
The Y-direction driving portion is connected with the Y-direction sliding block, for driving the Y-direction sliding block to move in the Y direction；
The photo module is set on the Y-direction sliding block, for shooting the consumptive material area of the molecular diagnosis extraction/purifier apparatus
Domain；
The liftable manipulator be set to the Y-direction sliding block on, the liftable manipulator can be gone up and down in z-direction, for from
External consumptive material library feeding is simultaneously added to corresponding consumptive material region；
The X-axis component, the Y-direction sliding rail, the Y-direction sliding block, the Y-direction driving portion and the liftable manipulator are and institute
State controller electrical connection；
The controller is electrically connected with the photo module, for receiving the image information of the photo module output and to described
Image information is handled, and is issued according to the information of processing to the X-axis component, Y-direction driving portion and the liftable manipulator
Whether move and whether supplement the instruction of consumptive material.
2. consumptive material monitoring device described in accordance with the claim 1, which is characterized in that the X-axis component includes X to sliding rail, X to cunning
Block and X are to driving portion；The X is slidably connected with the X to sliding rail to sliding block；The X is to driving portion and the X to sliding block phase
Even, and the X is driven to move in the X direction to sliding block.
3. consumptive material monitoring device described in accordance with the claim 1, which is characterized in that the liftable manipulator include Z-direction sliding rail,
Z-direction sliding block, Z-direction driving portion；The Z-direction sliding rail is connected with the Y-direction sliding block；The Z-direction sliding block and Z-direction sliding rail sliding connect
It connects；The Z-direction driving portion is connected with the Z-direction sliding block, and the Z-direction sliding block is driven to move in z-direction.
4. consumptive material monitoring device described in accordance with the claim 1, which is characterized in that the photo module include CCD camera assembly and
Data line；The first end of the data line is electrically connected with the CCD camera assembly, and the second of the data line
End is electrically connected with the controller.
5. consumptive material monitoring device described in accordance with the claim 1, which is characterized in that the controller is STM32F101 single-chip microcontroller.
6. a kind of consumptive material monitoring method, the consumptive material monitoring device for claim 1 to 5 any one, which is characterized in that step
It is as follows:
S1: being based on image processing techniques, according to no material consumption image and has consumptive material image founding mathematical models；
S2: mobile photo module to the first consumptive material area；
S3: shooting image and be transmitted to controller and to image carry out processing analysed whether consumptive material；
S4: the liftable manipulator is moved if no material consumption, consumptive material is supplemented；
S5: mobile photo module to next consumptive material area；
S6: step S3 is repeated to step S5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910365231.5A CN110045133A (en) | 2019-04-30 | 2019-04-30 | A kind of consumptive material monitoring device and monitoring method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910365231.5A CN110045133A (en) | 2019-04-30 | 2019-04-30 | A kind of consumptive material monitoring device and monitoring method |
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| CN110045133A true CN110045133A (en) | 2019-07-23 |
Family
ID=67280606
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| CN111951248A (en) * | 2020-08-12 | 2020-11-17 | 上海仁度生物科技有限公司 | Positioning calibration device and method for automatic nucleic acid extraction equipment |
| CN115841199A (en) * | 2022-11-29 | 2023-03-24 | 深圳市国赛生物技术有限公司 | Automatic consumable management system |
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