CN102046085A - Optical sensor apparatus and method of using same - Google Patents
Optical sensor apparatus and method of using same Download PDFInfo
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- CN102046085A CN102046085A CN2009801203104A CN200980120310A CN102046085A CN 102046085 A CN102046085 A CN 102046085A CN 2009801203104 A CN2009801203104 A CN 2009801203104A CN 200980120310 A CN200980120310 A CN 200980120310A CN 102046085 A CN102046085 A CN 102046085A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
- A61B5/489—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/04—Measuring blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4494—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
Abstract
An apparatus for, and method of, sensing characteristics of a vessel and a fluid conveyed therein.
Description
Require priority
The application required all in the 12/119th of being entitled as of submitting on May 12nd, 2008 " OPTICAL SENSOR APPARATUS AND METHOD OF USING SAME (optical sensor arrangement and use the method for optical sensor arrangement) ", No. 315 U.S. Patent applications, be entitled as " DOPPLER MOTION SENSOR APPARATUS AND METHOD OF USING SAME (Doppler motion sensor device and use the method for Doppler motion sensor device) " the 12/119th, No. 339 U.S. Patent applications, be entitled as " INTEGRATED HEART MONITORING DEVICE AND METHOD OF USING SAME (integrated cardiac monitoring equipment and use the method for integrated cardiac monitoring equipment) " the 12/119th, No. 325 U.S. Patent applications, be entitled as " METHOD AND SYSTEM FOR MONITORING A HEALTH CONDITION (being used to monitor the method and system of health status) " the 12/119th, No. 462 U.S. Patent applications and in the 12/206th of JIUYUE in 2008 being entitled as of submitting in 9th " DOPPLER MOTION SENSOR APPARATUS AND METHOD OF SUING SAME (Doppler motion sensor device and use the method for Doppler motion sensor device) ", the priority of No. 885 U.S. Patent applications, all applications are submitted to by identical therewith inventor, and the full content of all applications merges to herein by reference.
Technical field
The present invention relates to sensor device and, more specifically, relate to and be used for sensor device that target is positioned and/or measures.
Background technology
For medical reasons, need in a period of time, monitor by the body intrinsic parameter to the patient.Cardiac arrhythmia is the variation that causes heart normal sequence of the electric pulse of pump blood between health.May need continuous monitoring to detect arrhythmia, may only occur contingently because unusual cardiac pulses changes.The healthcare givers utilizes the continuous monitoring can the characterization heart and set up suitable therapeutic process.
A kind of prior art equipment of measuring the rhythm of the heart is " Reveal " monitor in Medtronic (Medtronic) (U.S., the Minnesota State, Minneapolis city).This equipment comprises the implantable cardiac monitor, is used for for example determining whether patient faint (fainting) be relevant with the cardiac rhythm problem.The Reveal monitor is continuously monitored the speed of heart and the length that the rhythm and pace of moving things reaches 14 months.After from the experience of fainting, waking up, the patient with recording equipment be placed on the skin outside, above the Reveal monitor of implanting, and touch the button data be sent to recording equipment from monitor.Recording equipment is offered the doctor, thereby the doctor has determined whether to record unusual cardiac rhythm to the information analysis that is stored in the recording equipment.The use of recording equipment neither automatically neither be autonomous so the needs patient is conscious or another person's intervention is sent to recording equipment with information from monitor.
The implantable monitoring equipment of another known type is the equipment of transponder types, wherein transponder is implanted among the patient also with the mode of hand-held electromagnetism reader with non-intrusion type it to be conducted interviews subsequently.The 5th, 833, the device examples of a back type has been described in No. 603 United States Patent (USP)s
Summary of the invention
Herein disclosed is sensor device and the method for obtaining signal and calculating measurement result according to an embodiment of the invention.Sensor device comprises sensor cluster and computing equipment.Sensor cluster comprises a plurality of emitters and is used to generate a plurality of detectors of a plurality of signals.Emitter and detector are towards a side of conduit.Computing equipment is to a plurality of emitters and a plurality of detector is operated and a plurality of signals are handled obtain measured value.Sensor cluster and computing equipment are enclosed in the shell.
Comprise the steps: to provide for example such sensor device of sensor device described in above paragraph according to one embodiment of the method for the invention, operate a plurality of emitters and detector and obtain a plurality of signals, signal handled obtaining measured value, and measured value analysis is obtained to represent at least one the parameter value of characteristic in conduit and the fluid.
Disclose according to another embodiment of the invention and be used for blood vessel and flow through the equipment that at least one characteristic of the blood of blood vessel is carried out optical measurement.This equipment comprises shell, sensor cluster and computing equipment.Sensor cluster is mounted to shell and comprises a plurality of emitters and a plurality of detector, and a plurality of emitters are used to pass the first side ballistic phonon of shell, and a plurality of detectors are used to receive at least a portion of the photon of first side emission of passing shell.Each emitter in the operation with the pairing of different detector and be oriented such that from the emitter emission, impinge upon with the sensor cluster adjacent blood vessel on photon beam will partly reflect to paired detector, each detector is configured to produce the signal of the photon of the emission that expression receives by detector.Computing equipment is configured to a plurality of emitters be activated and the signal that comes self-detector is carried out decipher determine characteristic.
In conjunction with the drawings with reference to the following description of embodiments of the invention, feature of the present invention and the mode that realizes them will become and understand more and the present invention self will better understand.
Description of drawings
Figure 1A is the schematic side view of sensor device according to an embodiment of the invention;
Figure 1B is that the outer surface of the sensor device of Fig. 1 is schemed towards (outwardly-facing);
Fig. 1 C is the perspective view of the sensor device of Fig. 1;
Fig. 2 is the schematic side view of sensor device and the blood vessel of Fig. 1;
Fig. 3 is the perspective illustration of sensor cluster according to an embodiment of the invention and blood vessel;
Fig. 4 is the diagrammatic side view of sensor cluster according to an embodiment of the invention, blood vessel, emission light beam and folded light beam;
Fig. 5 A, 5B and 5C are the diagrammatic side view of sensor cluster according to an embodiment of the invention, trunk, little blood vessel, emission light beam and folded light beam;
Fig. 6 A and Fig. 6 B are respectively the schematic front view and the diagrammatic side view of the system that is applicable to that the sensor device with Fig. 1 communicates;
Fig. 7 is the flow chart of the method according to this invention.
Run through several figure, the corresponding part that corresponding Reference numeral is represented.Though accompanying drawing is represented embodiments of the invention, for description and interpretation the present invention better, accompanying drawing is not must be proportional and can amplify some feature.Herein the example that is proposed with several formal specifications embodiments of the invention and such example will can not be interpreted as by any way scope of the present invention being limited.
The specific embodiment
That embodiment discussed below does not plan limit or the present invention is limited to disclosed precise forms in the following detailed description.More properly, embodiment is selected and description so that others skilled in the art can Application Example teaching.
Figure 1A illustrates sensor device 1 according to an embodiment of the invention.Sensor device 1 generally includes a plurality of parts, and parts comprise sensor cluster 2, computing equipment 20, communication equipment 30 and energy storage device 40, and each parts all is installed on the plate 80 and with computing equipment 20 and carries out electronic communication.Parts are enclosed in the shell 90.Sensor cluster 2 comprises the transmitter array 100 with a plurality of emitters and has the detector array 200 of a plurality of detectors.
In according to one embodiment of present invention, sensor device 1 is applied to determine patient's physiological situation." patient " is meant the human or animal that the sensed equipment of physiological situation 1 is measured.Though invention disclosed herein is to be described under medical ground, teaching disclosed herein can be applicable to need under other background that small-sized data acquisition assembly measures along with the time equally.For example, sensor cluster according to the present invention in not having entry or unapproachable application in, under dangerous environment, have in the application of weight and size restrictions, enquiry-based activity is medium at the scene can be ideal.
In according to one embodiment of present invention, sensor device 1 is implanted in patient's body by subcutaneous.Yet, should be appreciated that and can use various implanted prosthetics that sensor device 1 is implanted in different positions.For example, can be implanted in sensor device 1 in the thoracic cavity, under the rib exterior feature (rib cage).Shell 90 can form with the shape of circular discs or oblong-shaped disc, and its size is roughly identical with two 25 cents of dollar coins that pile up.Certainly, depend on application, shell 90 can be configured to multiple other shape.Can comprise four outwards outstanding rings 92, shown in Figure 1B and Fig. 1 C, thereby being used to accept to sew up in patient's body fixes assembly hypodermically.The shape that depends on shell 90 can be provided with more or less ring 92.When by so fixedly the time, sensor cluster 2 quilt covers are upcountry located, and the energy coupler of following detailed description towards outside.
In another embodiment, sensor device 1 is positioned at the outside of patient body.Be provided with supporting member and support sensor device 1 at the outside sensing of health.Supporting member for good and all or provisionally can be coupled to sensor device 1.In one embodiment, supporting member comprises adhesive layer, is used for supporting member adhesively is coupled to patient body.In another embodiment, supporting member comprises it can being elastic belt, is used for respect to the fixing sensor device 1 of patient's body.
Can be by means of outside map (mapping) system of for example Ultrasound Instrument with sensor device 1 subcutaneous implantation or be positioned on the patient.Suitable placement guarantees that the blood vessel of paying close attention to is positioned at the sensing range of sensor device 1.At the blood vessel of paying close attention to is under the aortal situation, sensor device 1 can be positioned at patient's chest or certain position at back, this position make by the result who obtains to measure in mode described herein, reduce to some extent by the caused interference of rib.
In according to one embodiment of present invention, sensor device 1 have that COM1 is used for being connected with miscellaneous equipment and with the miscellaneous equipment exchange message.Show adapter 85.Adapter 85 links to each other with other parts of sensor device 1 by plate 80, below with reference to Fig. 6 A and 6B the operation of adapter 85 is further done in more detail and is described.
1. blood vessel detector
In according to one embodiment of present invention, the parameter of blood 1 couple of patient of sensor device, that transmit in the blood vessel of for example vein or tremulous pulse is carried out sensing.In the exemplary embodiment, sensor device 1 is transmitted in the interior electromagnetic energy beam of infrared ray (IR) scope of electromagnetic spectrum, and the IR signal that blood circulation reflected from blood vessel is detected.Yet, should be appreciated that, can as one man adopt the electromagnetic energy of other type with teaching of the present invention.Sensor device 1 can be launched the IR light beam on one or more frequencies, these frequencies are because disturbed by health or absorb minimum and pass the ability of patient body or because from the ability of specific blood constituent reflection and selected, and wherein specific blood constituent is selected because of the ability that the blood parameters value of wanting to obtain is transmitted.In the exemplary embodiment, sensor device 1 emission is selected to from the infrared beam of hemoglobin reflection, and hemoglobin is the iron content oxygen transport metal albumen in the erythrocyte.
Can utilize photovoltaic element (photocell) array to launch and detect the IR light beam.As following in detail disclosed, each array is shown as to have and is arranged as 16 photoelectricity list ponds that every row has the grid of four unitary four lines.Under certain operating condition described below, all photovoltaic elements in the transmitter array 100 are launched light beam simultaneously; And under other operating condition, each photovoltaic element obtains information specific and/or preservation energy at selected moment emission light beam.In yet another embodiment, photovoltaic element is dispersed in the surface of sensor device by any way, comprises emitter and detector scatters in the alternative row and column of emitter and detector and/or the mode of dispersive layout.
The relation that Fig. 2 illustrates blood vessel 3 and a pair of photovoltaic element that the blood 4 with the hemoglobin in the erythrocyte 5 is transmitted between---emitter 101 and detector 201 or sensor cluster 2---.Can from the 8572 serial optical pickocffs of making by Motorola Inc. (Motorola), select optical module 2.Emitter 101 emission comprise photon 101 ' the photon light beam.As following with reference to Fig. 3 and in further detail, a part of photon in the light beam passes blood vessel 3 and a part is reflected as folded light beam, comprise in this example photon 101 '.Receptor 201 receives folded light beam.Computing equipment 20 direct emitted devices 101 emission light beams are also measured the unit required time of 201 detection of reflected light beams.Light beam passes tissue with known constant speed.Can be from emission and the propagation time between detecting and the geometrical relationship between photovoltaic element 101 and 201 calculate distance from mid point between photovoltaic element 101 and 201, on the centrage 8 to blood vessel 3, as shown in arrow 9.
In one embodiment, can comprise that one or more lens come at least in part being focused on by emitter 101 emitted light beams so that on the propagation distance of light beam, keep constant within the little percentage rate of cross sectional dimensions in the light beam original size of light beam.Can comprise that collimator comes the light beam that is generated by each emitter is focused on.Emitter beam then can with by the interrelated additional information that provides about blood vessel of the signal that detector produced.
Fig. 3 and Fig. 4 illustrate an embodiment of sensor cluster 2, and sensor cluster 2 comprises transmitter and the receptor that is positioned respectively in transmitter array 100 and the detector array 200.Transmitter array 100 comprises 16 emitter 101-116 being arranged to matrix and 16 light beams of emission that can be guided according to computing equipment 20.For simply, in Fig. 3, only illustrate from emitter 104 emitted light beams 10.From blood vessel 3 antireflection part light beams 10 as folded light beam 11.A part of light beam 10 that numeral 7 expressions are not reflected by hemoglobin.Detector array 200 comprises 16 detector 201-216 that are arranged to matrix.The photon that detector array 200 receives in the folded light beam 11.More specifically, detector 204 receives photon in the folded light beams 11 in this example.
Comprise four unitary four lines of every row though exemplary square matrix is shown, depend on the certainty of measurement and the more or less unit of layout in sensor cluster 2 of the distance between sensor cluster 2 and the target blood of unitary size, expectation.Must launch the folded light beam that enough photons provide the intended purposes that is suitable for it.In another embodiment, each array comprises 25 unit.In yet another embodiment, each array comprises 12 unit.Number of unit in transmitter array and the detector array and each unitary size need not be equal.As being described further below, can increase the resolution that other detector increases vessels to detector array.In one embodiment, the detector in the detector array 200 is foursquare and the length on every limit is 1mm.In another embodiment, the length on every limit is 2.5mm.The width of emission light beam can be widened slightly along with distance.For example, when impinging light beam was to the blood vessel that is positioned at the 10cm distance, the 2.5mm light beam can be widened to about 3.5mm.
Fig. 4 illustrates the side view that illustrates of sensor cluster 2 depicted in figure 3.Should be appreciated that each emitter of transmitter array 100 and the pairing of the respective detection device of detector array 200.More specifically, emitter 101 and detector 201 pairings, emitter 105 and detector 205 pairings, emitter 109 and detector 209 pairings, and emitter 113 and detector 213 pairings.Other emitter and detector (not shown) match in a similar fashion.In embodiments of the invention, the angle between emitter and its paired detector is identical for every pair.As illustrated, emission light beam 113E point to blood vessel 3 and, if its bump blood vessel 3, then folded light beam 113R is received by detector 213.For each sensor cluster 2, the angle that is formed by emission light beam 113E and folded light beam 113R is with identical with the formed angle of folded light beam by the right emission light beam of other transmitter unit/detector cell.This angle refers to common angle herein.
Yet should be appreciated that, various sensor cluster 2 can be constructed with different at them emitter separately and detector between common angle.For example, the common angle between the unit of the unit of the transmitter array 100 of Fig. 4 and paired detector array 200 can be 45 degree.Be configured to penetrate more deeply in another sensor cluster 2 of patient's body, between common angle can be 30 the degree.Can determine the right sensors assembly 2 that will use to patient's concrete analysis.For example, when implanting sensor device 1 among the very thin or very little patient hypodermically, therefore distance between the blood vessel 3 of sensor cluster 2 and concern is compared with the respective distance among very heavy or the very large patient can be little, the sensor cluster 2 that has big common angle between emitter and paired detector will be suitable for thin patient, and the sensor cluster 2 with less common angle will be suitable for heavy patient.
Be also to be understood that in certain embodiments, can be with transmitter array 100 and detector array 200 relative to each other to be installed in the sensor device 1 certain angle.Transmitter array 100 and detector array 200 are coplanar (promptly relative to each other zero degree) in Fig. 4.Because dimension constraint or the transmitter array 100 of expectation and the installation site of detector array 200, array can tilt as being shown in dotted line among the figure towards each other.
Fig. 5 A-C is that the sensor cluster 2 described among Fig. 4 adds and the illustrating of the little blood vessel 12 of blood vessel 3 vertical orientations.In Fig. 5 A, only illustrate along the outer peripheral unit of transmitter array 100 and detector array 200.Each transmitter unit 101,105,109,113 is launched IR light beam 101E, 105E, 109E, 113E respectively.Blood vessel 12 is illustrated with phantom because it in the drawings at a distance and be not launched on any one bump among light beam 101E, 105E, 109E, the 113E.As shown, emission light beam 101E fully misses two blood vessels 3 and blood vessel 12.Therefore, detector 201 does not detect folded light beam.The part of emission light beam 105E impinges upon on the blood vessel 3.Impinging upon a part of photon on the blood vessel 3 is reflected and is detected at detector 205 places as folded light beam 105R.All emission light beam 109E impinge upon on the blood vessel 3.Emission light beam 109R, be detected at detector 209 places as folded light beam 109R by a part of photon that hemoglobin reflected in the blood vessel 3.101E is similar to the emission light beam, thereby a part of only launching light beam 113E impinges upon on the blood vessel 3 at detector 213 places generation folded light beam 113R.
With respect to Fig. 5 A, Fig. 5 B is the figure that the planar page or leaf of secondary series emitter 102,106,110,114 and secondary series detector 202,206,210,214 is passed in farther entering into basically.In the figure, blood vessel 12 is shown, because it is arranged in the zone of shining by from emitter 102,106,110 and 114 emitted light beams with solid line.When emitter 102 was activated, the light beam 102E of blood vessel 3 was missed in emitter 102 emissions fully.Yet the part of emission light beam 102E impinges upon on the blood vessel 12 and part bump photon is reflected as folded light beam 102R '.In this example, because blood vessel 12 residing positions, so folded light beam 102R ' is not detected by detector 202.The situation of the emission light beam 105E of image pattern 5A is such, the part bump blood vessel 3 of emission light beam 106E.Yet launch another part bump blood vessel 12 before arriving blood vessel 3 of light beam 106E here.The photon of some bump blood vessels 12 is reflected as not by detector 206 detected folded light beam 106R '.Therefore, because the interference of blood vessel 12, the part of the bump blood vessel 3 of emission light beam 106E is littler than the part of the bump blood vessel 3 of emission light beam 105E.Similarly, at the detected folded light beam 106R in detector 206 places than having littler intensity at the detected folded light beam 105R in detector 205 places.Similarly, the interference of blood vessel 12 causes folded light beam 110R ' and folded light beam 114R ' respectively, and folded light beam 110R ' and folded light beam 114R ' make the number of the photon in detector 210 and detected folded light beam 110R in 214 places and 114R reduce to some extent respectively.
Fig. 5 C is the figure that the planar page or leaf of the 3rd row emitter 103,107,111,115 and the 3rd row detector 203,207,211,213 is passed in farther entering into basically.In Fig. 5 C, once more the form of blood vessel 12 with phantom illustrated, because not occupying, it is not launched the zone that light beam 103E, 107E, 111E, 115E are shone.Blood vessel 12 does not disturb the position of emission light beam and blood vessel 3 identical with shown in Fig. 5 A, and the characteristic of launching the propagation path of light beam 103E, 107E, 111E, 115E and the folded light beam 107R that causes, 111R, 115R is with identical about the described corresponding light beam of Fig. 5 A.
According to one embodiment of present invention, computing equipment 20 is by carrying out filtering, calibration (scale) and regulate the signal that receives from detector array 200 is handled to signal, thus to the light beam that received by detector array 200, calculate corresponding to the measured value of intensity or power.In one embodiment, computing equipment 20 analog signal digital that will be generated by detector array 200.In following table 1 and table 2, the general power of value 1 expression 100%.In other words, if corresponding transmitter unit emission meets with the ripple of the maximum interference (and the blood vessel of therefore being paid close attention to 3 reflects) to the blood vessel of paying close attention to 3, value 1 equals to expect by the received power of detector cell.In an interchangeable embodiment, the electronic circuit (not shown) is used to the signal that receives from detector array 200 is carried out filtering, calibration and adjusting, and the output of electronic circuit is offered computing equipment 20 is used for handling.In another step, further describe as following, thereby 20 pairs of measured values of computing equipment calculate and the position and the diameter of the definite blood vessel 3 of map.
In according to one embodiment of present invention, full power signal is scaled for the vasculature part with 0.7 cm width and equates.The part of flat-out each partial linear ground expression 0.7 cm width.Decide as the case may be, calculate the width or the diameter of blood vessel by the measured value in the row or column of detector cell being carried out the phase Calais.When two row or more the measured value in the multirow differ less than 10% the time, perhaps when the measured value addition in the row then be two row or more the measured value in the multiple row differ less than 10% the time, determine the diameter of blood vessel.In another embodiment, when two row or more in the multirow or two row or more the measured value in the multiple row differ less than 5% the time, determine the diameter of blood vessel.
Table 1 illustrates the representation of concept of describing corresponding measured value with the blood vessel 3 shown in Fig. 4.Value representation does not have photon to be reflected from 101 to 104 emitted light beams of emitter and is detected by 201 to 204 of the paired detectors in the array 200 subsequently.Detect more photon by the unit in second row (detector 205-08) and the fourth line (detector 213-16), and detect even more photon by the unit in the third line (detector 209-12).As tangible in the table 1, detected signal is identical in each row detector.The embodiment that equals 0.7 centimetre according to above disclosed total power signal, signal times that can be by each detector in will being listed as is with 0.7 centimetre of width or diameter that then the whole phases of resulting product Calais is calculated blood vessel 3.More specifically, the diameter of the blood vessel 3 in this example is 0.0*0.7+0.8*0.7+1.0*0.7+0.8*0.7, perhaps 1.82 centimetres.
Table 1
That table 2 illustrates is similar to table 1, but describe the representation of concept of corresponding processing costs with blood vessel 3 shown in Fig. 5 A-C and blood vessel 12.The value representation of minimizing in the 2nd row, corresponding with detector 206,210 and 214 as describing among Fig. 5 B by blood vessel 12 caused interference.1st, the value in 3 and 4 row differs less than 5% (in fact, they are identical as illustrating).Therefore, computing equipment 20 can ignore in the 2nd row signal and according to mode described above, use signal in any string in the 1st, 3 and 4 row to calculate the diameter of blood vessel 2.
Table 1
In according to one embodiment of present invention, the expression of the blood vessel that blood vessel measured value deletion that exist, that have the diameter littler than predetermined size or filtering obtain more clearly to pay close attention to will be represented.In one embodiment, will with than the corresponding measured value deletion of 1 centimetre of little blood vessel diameter.In such embodiments, the blood vessel of concern is to have the known approximate diameter large artery trunks of (depending on the patient's body characteristic), and this diameter is all bigger than near almost any other blood vessel the installation site of sensor device 1 basically.
Should be appreciated that when its position of the diameter of determining blood vessel in the above described manner and map, each emitter 101-116 is activated separately by adjoining land fast.When several emission light beam is shown simultaneously, once only launch a light beam to avoid light beam and overlap and to generate the signal of not upset by such overlapping in various figure.By launching a light beam and receiving folded light beam at paired detector place, each signal provides the information about the not multilated of blood vessel.Each signal indication is by interference and diffusion that single light beam experienced.In one embodiment of the invention, launch light beam separately, from emitter 101, then unceasingly till emitter 116 is activated in the mode of lining by line scan.What follow in other embodiments, is other order.
In the time of the detector in the scanning array, interference and the diffusion experienced by each light beam of signal indication that each detector generated.Total is got up, and scanning provides and has been used for the information that position and diameter to blood vessel carry out map.If the blood in the blood vessel is by oxidized fully, blood will comprise more ferrum and detector and will generate and represent flat-out signal so.If the blood in the blood vessel is not by oxidation fully, detector will generate the signal that expression is lacked than total power so.Yet, because scanning takes place apace, thus oxidation level in each scan period be constant and, therefore, can not consider oxidation level and will be used for the position and the diameter of map blood vessel by the difference power of the light beam that each detector received.
Near large artery trunks Pulmonic diameter is similar to aortic diameter.Thereby in order to discern and measure aortic diameter, sensor device 1 must be distinguished pulmonary artery and large artery trunks, because the two all will have the diameter that surpasses predetermined diameter threshold.Sensor device 1 by measuring each blood vessel oxygen saturation and the blood vessel of selecting to have the highest oxygen saturation distinguish two blood vessels, the blood vessel with the highest oxygen saturation always trunk because pulmonary artery is transported to lung with deoxidation blood from heart.
When carrying out oxygen saturation measurements, sensor device 1 activates all emitter 101-116 of transmitter array 100 simultaneously.At first, sensor device 1 is according to the position and the diameter of the blood vessel of the concern of scan method calculated example of having described such as trunk.Based on size, transmitter array and the detector array of blood vessel and the geometric position between the blood vessel and for example transmitter array of the layout of width, emitter and the transmitter of size, the emitter beam of array and the physical characteristic of detector array, sensor device 1 calculates the maximum possible oxygen saturation value according to known photon diffusion formula.Because each patient's physiological property difference, so sensor device 1 can use the reference value in the memorizer that is stored in computing equipment 20 to calibrate the maximum possible value for each patient.Sensor device 1 is then side by side from transmitter array emission light beam, at detector array place detection of reflected light beam, and folded light beam is converted to power signal.In one embodiment, sensor device 1 will be from adding up to the signal that detector produced that is received by the photon of vasoreflex and obtain the saturation ratio with aggregate value divided by the maximum possible value, the percent saturation of this ratio representative in the blood of blood vessel of flowing through.In another embodiment, sensor device 1 only will expect that producing the emitter will impinge upon the light beam on the blood vessel activates and do not activate the emitter that its light beam will not impinge upon on the blood vessel and save energy.In another embodiment, sensor device 1 only produces the emitter will impinge upon on the blood vessel and will not impinge upon the light beam on other blood vessel to expection and activates and save energy and simplify the photon diffusion and calculate.In yet another embodiment, sensor device 1 is in order to save energy and can optionally to activate paired emitter and receptor minimizing activated paired quantity.
Under normal operating condition, sensor device can be carried out oxygen saturation measurements once or twice 1 every day.Under detecting unusual condition or ought be as described below like that as in the pulse wave detector, sensor device 1 can be carried out repeatedly oxygen saturation measurements in very short a period of time.Though consumed actual electric power when carrying out very frequent measurement, the data that obtained may be important for patient's health.
In one embodiment, sensor device 1 also calculates heart pulse rate.As discussing before, detector produces the power signal of representing the iron content in the blood.Along with the blood of heart by large artery trunks suction oxidation, power signal also fluctuates.Adjoining land obtains a plurality of power signals and catches the power measurement fluctuation fast.More specifically, by carrying out repeatedly oxygen saturation measurements (for example per second is ten times), through after a while (for example 15 seconds), oxygen saturation measurements will present pattern or the cycle of representing heartbeat.Computing equipment 20 can determine that curve comes the match saturation to measure, for example direct and corresponding sine curve of cardiac cycle of curve.Computing equipment 20 can determine that the frequency of the peak value of curve determines the cycle of curve.Each cycle is represented cardiac cycle.By multiply by the number of the cardiac cycle of (for example 15 seconds) in the same period with suitable factor, computing equipment 20 can be determined pulse velocity with the form of the cardiac cycle number of per minute.In one embodiment, computing equipment 20 storage heart pulse rate values detect unusual or irregular cardiac rhythm as normal reference value and by the heart pulse rate value is compared with reference value.
In another embodiment of sensor device 1 according to the present invention, the further feature and the implantable cardiac equipment of sensor cluster 2 and sensor device 1 are integrated, and implantable cardiac equipment for example pacemaker, cardiac resynchronization therapy (CRT) equipment, implanted heart rate changes multiple defibrillator (1CD) etc.
2. computing equipment
Program representation instructs the computer instruction of processor execution in response to the task of data.Program is present in the memorizer.The data that comprise reference data and measurement data also are present in the memorizer.Reference data can be stored among the ROM, it can be stored in perhaps among the RAM that make can be along with the time makes amendment in response to the outside input or in response to the characteristic of the measurement data of gathering along with the time.The agreement that measured value is responded can also be set.Agreement can be stored in the permanent memory or it can be stored in the volatile memory of RAM for example.
Fig. 6 A discloses the system 300 that is used for sensor device 1 exchange message.System 300 comprises the sensor device 1 with communication equipment 30, and has adapter 85 alternatively.System 300 can also comprise computer 302, operationally be coupled to Docking station (docking station) 304, the phone 306 of computer 302 via cable 303.In one embodiment of the invention, system 300 is based on being come by computing equipment 20 performed processing wirelessly to sensor device 1 transmission signal of communication 312 and from sensor device 1 receiving communication signal 312.
In according to still another embodiment of the invention, can be by adapter 85 with other pick off and devices, coupled to sensor device 1.Other pick off and equipment can unrestrictedly comprise other sensor cluster 2, temperature sensor, pressure transducer and accelerometer.Other equipment can comprise or can not comprise computing equipment.Other equipment can also be combined in shell 90 with sensor device 1.Integrated sensor device is disclosed in the relevant U.S. utility patent application of cited above being entitled as " INTEGRATED HEART MONITORING DEVICE AND METHOD OF USING SAME (integrated cardiac monitoring equipment and the method for using integrated cardiac monitoring equipment) ".By being applicable to that other pick off and program equipment, that revised of operation downloads in the memorizer of computing equipment 20, the operation of sensor device 1 goes for other pick off and equipment are operated.Download can occur in when computing equipment 20 is docked at Docking station.Replacedly, new procedures wirelessly can be downloaded by computing equipment 40.
Fig. 7 is the flow chart that a routine of the program of being carried out by computing equipment 20 is shown according to one embodiment of present invention.At step 400 place, computing equipment 20 comes activated sensors assembly 2 based on the measurement of carrying out so that all emitter 101-116 emission light beam or emitter are sequentially launched independent light beam as above description.Step 400 also is illustrated in the process that detector 201-216 place generates the signal of expression folded light beam.
At step 402 place, 20 pairs of signals of computing equipment are handled and are obtained measured value.Processing can relate to and removes the intrinsic signal noise, the signal from analog formal transformation is digital form, is digital form, calibration or detection signal regulated from the light formal transformation.Replacedly, can carry out some processing capacities by the circuit of for example A/D converter.After handling, measured value can be stored in the memorizer or can determine whether and store this value measured value analysis.Thereby repeating step 400 and 402 obtains the parameter that enough measured values come calculation expectation according to the above disclosure that provides as required.Can while execution in step 400 and 402.
At step 404 place, 20 pairs of measured values of computing equipment are analyzed.Analysis can comprise the calculating and/or the diagnosis of supplemental characteristic.Supplemental characteristic refers to for example value of calculation of blood vessel diameter and position, oxygen saturation, cardiac rhythm etc.Diagnosis refers to parameter value and reference value is compared the unusual condition that detects the patient.Reference value is corresponding to patient's normal condition.If detect unusual condition, computing equipment 20 can transmit alarm rather than when collecting measured value, transmit measured value (consuming unnecessary power) or wait for up to memorizer full or just send when reaching predetermined transmission time measured value (wait the time interim the patient is exposed to unnecessary danger).
Reference value can comprise desired value and acceptable excursion or restriction.Parameter value can be indicated unusually when parameter value exceeds reference target value or scope.In certain embodiments, parameter value can produce the statistic as moving average for example, and will detect unusual when parametric statistics amount and reference statistical amount differ above anticipated number.
If supplemental characteristic and reference value differ above anticipated number, computing equipment 20 is being tested to supplemental characteristic to starting before making diagnosis unusually new measuring period so.In one embodiment, when measured value and desired value differ when surpassing 10%, computing equipment 20 is aortic position of map and diameter again.In another embodiment, differ when surpassing 5% computing equipment 20 aortic position of map and diameter again when measured value and desired value.
A unusual medical condition is low oxygen saturation.Computing equipment 20 can be configured to carry out the analysis of measured value is determined for example whether oxygen saturation value is low excessively.Though " normally " oxygen saturation value has nothing in common with each other between patient and patient and depends on patient's situation, be usually less than 90% oxygen saturation measurements and be considered to low.Another unusual medical condition is can be according to the detected irregular cardiac rhythm of mode described above.
Use the outside value that obtains or can other unusual medical condition be detected from the value of other pick off.The other pick off that can be included in the sensor device 1 is disclosed in the relevant U.S. utility patent application of cited above being entitled as " DOPPLER MOTION SENSOR APPARATUS AND METHOD OF USING SAME; (method of Doppler motion sensor device and use Doppler motion sensor device) " and " INTEGRATED HEART MONITORING DEVICE AND METHOD OF USING SAME; (method of integrated cardiac monitoring equipment and the integrated cardiac monitoring equipment of use) ".
In the embodiment of the sensor device 1 that comprises doppler sensor, blood vessel diameter and position can be used for the speed and the aspiration rate (pumping rate) of Fluid Computation.When blood vessel is aortic situation, these parameters can be used for the unusual condition relevant with diagnosis with cardiac output to calculating.The large artery trunks parameter can be calculated heart contraction blood pressure and diastole blood pressure with combining with heart contraction blood rate value that doppler sensor obtained and diastole blood rate value.Other pick off can comprise ECG pick off and temperature sensor.
At step 406 place, if detect unusual condition, agreement according to the rules determines that situation is serious situation or dangerous situation especially, and then computing equipment 20 sends alarm.Alarm can be used for starting siren or warn the patient to adopt remedial measures.Remedial measure can be to stop or the minimizing physical exertion.Alarm can also provide global location (GPS) information to emergency service.With reference to Fig. 6 A,, it can be presented on the computer 302 and/or send it to the caregiver via communication equipment 30 (for example Nokia's modem KNL 1147-V) when the existence of the situation of noting abnormalities.Alarm can comprise text message or with the corresponding code of situation.Computing equipment 20 can also start new measuring period and measure in response to the unusual condition that detects continuously.
At step 408 place, computing equipment 20 can start treatment.Sensor device 1 can receive external command by communication equipment 30 and carry out treatment in response to alarm.Alternatively, based on agreement, thereby also can use unusual condition to come to provide this treatment to being applicable to that the equipment that treatment is provided instructs.Treatment can comprise for example shocks by electricity or medicine is provided.
At step 410 place, parameter value or other information are passed to external equipment.Can be with above any step execution in step 410 side by side.Parameter value can be stored in the memorizer and and wirelessly send with communication equipment 30.Signal of communication from communication equipment 30 can be activated under following situation periodically, situation comprises: the order that receives in response to abnormal conditions, in response to the outside, as long as long as memorizer uses and surpasses predetermined quantity or when determining that energy storage levels is low, set up that latter two situation prevents because memorizer overflows or energy loss and the loss of data that causes.Be also to be understood that sensor device 1 can also comprise a plurality of communication equipments except communication equipment 30.For example, when communication equipment 30 is situations of cellular modem, sensor device 1 can also comprise standby Bluetooth communication equipment or radio frequency communication devices.Such stand-by equipment can not send under the situation of information (for example because available horsepower is low, honeycomb or the bad reception of other signal of communication, the bad network coverage etc.) at cellular modem may be the ideal interchangeable means of communication that provides.Under these circumstances, computing equipment 20 can activate standby communication equipment to interchangeable outside receiving equipment and send information or alarm.
For example in case detected unusual condition with regard to execution in step 410 so that upgrade to the caregiver in real time basically.Step 410 is carried out at regular intervals, for example once a day, weekly, one month one inferior.Replacedly or except these transmission, thereby can programme by making communication equipment 30 send requested data or representing that the information of requested data comes the requests for data (for example from medical personnel) that is received by communication equipment 30 is responded to computing equipment 20.
Signal of communication can be received by near the equipment the patient warns the patient that situation is arranged, and perhaps remotely (for example passes through network) by medical personnel, relative or other predetermined recipient and receives.
3. communication equipment
Referring again to Fig. 6 B, wherein show system according to an embodiment of the invention, as to be applicable to transmission and receiving communication signal.Communication equipment 30 is for example via the bi-directional communication device of mobile telephone system and/or gps satellite system.Communication equipment 30 comprises the antenna 32 that is used to send with receiving communication signal.A signal of communication propagation of in a plurality of optional external communication devices wirelessly and a propagation from a plurality of optional external communication devices by numeral 312 signs.
External communication device can be computer 302 or any electronic equipment that can the wireless receiving signal of communication, for example is exemplified as the phone 306 of mobile phone herein.Phone 306 can also be emergency service switchboard or hospital or medical centre switchboard.Signal of communication is meant the signal of the feature collection with one or more signals or is changed the information in the signal is carried out encoded signals.For instance, and be not restriction, signal of communication comprises sound, radio frequency (RF), infrared ray, other wireless media, and above any combination.External communication device can also be to be positioned at the patient's body outside, for example to clip to the TU Trunk Unit of patient's belt.TU Trunk Unit can comprise the receptor that is used to receive from the transmission of communication equipment 30, and the emitter that is used for transmitting to another external communication device signal of communication.TU Trunk Unit can also be fixed and be hard-wired, is used for being connected with the Internet or directly being connected with medical personnel's computer.Similarly, TU Trunk Unit can receive from medical personnel's signal of communication and with signal and send to communication equipment 30.
Signal of communication from communication equipment 30 can comprise voice message, text message and/or measurement data.The communication that is received by communication equipment 30 can comprise order or data, for example the reference data of Geng Xining.Order for example can comprise the instruction of giving computing equipment 20, for example is used for carrying out patient's treatment, collection and sends other data or upgrade the task of reference data.Additional embodiments according to the method for the communication information of the present invention is disclosed in the relevant U.S. utility patent application of cited above being entitled as " METHOD AND SYSTEM FOR MONITORING A HEALTH CONDITION (being used for monitoring the method and system of health status) ".
4. energy storage device
Referring again to Figure 1B, 1C and 6, in according to one embodiment of present invention, can be provided for the system that energy storage device is recharged.The energy that computing equipment 20 receives from energy storage device 40.Energy storage device 40 comprises for example energy storage member of battery.Alternatively, sensor device 1 can also comprise that the energy that is used to receive from external source comes the energy coupler that energy storage device 40 is charged.
An example of energy coupler is an electromagnetic equipment, and for example sensing coil 308, is used to receive external electromagnetic signal 310 and is to be used for electric energy that energy storage member is recharged with such conversion of signals.External electromagnetic equipment 308 generates electromagnetic signals 310, by energy storage device 40 receiving electromagnetic signals 310 and be converted into electric energy.Energy storage device 40 can provide charge signal to computing equipment 20.Computing equipment 20 can compare charge signal and reference charge signal and start the low electric charge signal of communication that is used to warn patient and/or medical personnel.Replacedly, the detector of for example voltage sensor can be used for monitoring the electric charge of energy storage device 40 and signal is provided for computing equipment 20 following the time when electric charge is reduced to threshold value.Come energy storage device 40 is charged near electromagnetic equipment 308 can being placed on sensor device 1.
Can alternatively or additionally provide energy with the form of ultrasonic vibration.For example, in sensor device 1, can comprise piezoelectric transducer.Ultrasonic vibration can be arranged on the outside.Transducer generates when transducer is driven by ultrasonic vibration.
Though the present invention has been described as having exemplary designs, can in the spirit and scope of present disclosure, have revised further to the present invention.Therefore the application is intended to contain any variation, use or the adaptability revision that the present invention is carried out that uses universal principle of the present invention.In addition, the application be intended to contain fall in the technical field of the invention known or customary practice, with the departing from of present disclosure.
Claims (39)
1. a sensor device is used to obtain signal and calculates measurement result, and described sensor device comprises:
Sensor cluster, described sensor cluster comprise a plurality of emitters and are used to generate a plurality of detectors of a plurality of signals that described emitter and described detector are towards a side of conduit;
Computing equipment is to described a plurality of emitters with described a plurality of detector is operated and described a plurality of signals are handled obtain measured value; And
Shell surrounds described sensor cluster and described computing equipment.
2. sensor device according to claim 1, wherein said computing equipment comprises the algorithm that is used for the calculating parameter value.
3. sensor device according to claim 2, wherein said parameter value comprise the distance from described sensor cluster to conduit and the diameter of described conduit.
4. sensor device according to claim 2, wherein said parameter value comprise the fluidic parameter of being carried by described conduit.
5. sensor device according to claim 4, wherein said fluid is a blood.
6. sensor device according to claim 2, wherein said parameter value comprise at least one in large artery trunks position, large artery trunks diameter, oxygen saturation and the cardiac rhythm.
7. sensor device according to claim 1, wherein said shell is configured to be used for subcutaneous implantation.
8. sensor device according to claim 1, wherein said a plurality of emitters are aligned to matrix.
9. sensor device according to claim 8, wherein said a plurality of detectors are aligned to matrix.
10. sensor device according to claim 9, wherein said emitter matrix comprise the four lines of four emitters of every row and the four lines that described detector matrix comprises four detectors of every row.
11. sensor device according to claim 1, wherein each detector operationally with the pairing of different emitter.
12. the number of the detector in the sensor device according to claim 1, the number of the emitter in wherein said a plurality of emitters and described a plurality of detectors is different.
13. sensor device according to claim 1, the size of wherein said sensor device is approximately identical with two 25 cent coins that pile up.
14. sensor device according to claim 1, wherein said sensor cluster and described computing equipment are integrated in the single part.
15. sensor device according to claim 1 also comprises one or more communication equipments, is used for sending and receiving communication signal.
16. sensor device according to claim 15, wherein said communication equipment send and receive wireless communication signals.
17. sensor device according to claim 15, wherein said communication equipment comprises adapter, and described adapter is applicable to and operationally is coupled to one or more in the Docking station and second sensor device.
18. sensor device according to claim 16, wherein said sensor cluster, described computing equipment and described one or more communication equipment are integrated in the single part.
19. sensor device according to claim 1 also comprises energy storage device, is used for stored energy and described computing equipment and described pick off are powered.
20. sensor device according to claim 19, wherein said energy storage device comprises energy coupler, is used for received energy and comes described energy storage device is recharged.
21. one kind is used to the method obtaining signal and calculate measurement result, comprises:
Sensor device is provided, and described sensor device comprises
A plurality of photon emitters and detector, described emitter emission light beam, described detector detect light beam and generate a plurality of signals corresponding to detected light beam, and described emitter and described detector towards a side of conduit and
Computing equipment is used to operate described a plurality of emitter and detector;
Operate described a plurality of emitter and detector and obtain a plurality of signals;
Handle described a plurality of signal and obtain measured value; And
Analyze described measured value and obtain parameter value, described parameter value is represented at least one the characteristic in described conduit and the fluid.
22. method according to claim 21, wherein said sensor device also comprises communication equipment, and described method is further comprising the steps of: use in the described parameter value at least one to come the function that described diagnosis algorithm is responded is diagnosed and carried out to situation.
23. method according to claim 22, wherein said situation is a unusual condition.
24. method according to claim 23, wherein said function are to transmit alarm.
25. method according to claim 23, wherein said function are to start treatment.
26. method according to claim 25, wherein said treatment are electric shocks.
27. method according to claim 25, wherein said treatment provides medicine.
28. method according to claim 22, wherein said function are the information of transmitting periodically.
29. method according to claim 21, wherein said operating procedure comprise that paired emitter of operation and receptor obtain measured value.
30. method according to claim 29, wherein adjoining land operation issue device and detector are right.
31. method according to claim 29, wherein side by side operation issue device and detector are right.
32. method according to claim 29, wherein operating procedure comprises the steps
Adjoining land is operated described emitter and detector to obtaining first group of a plurality of signal corresponding to first parameter value;
Obtain described first parameter value;
Select a plurality of emitters and detector right based on described first parameter value;
And
Operate selected emitter and detector simultaneously to obtaining second group of a plurality of signal corresponding to second parameter value.
33. method according to claim 32, wherein said second parameter value is an oxygen saturation value.
34. one kind is used for blood vessel and flows through the equipment that at least one characteristic of the blood of described blood vessel is carried out optical measurement, described equipment comprises:
Shell has first side and second side;
Sensor cluster, be mounted to described shell and comprise a plurality of emitters and a plurality of detector, described a plurality of emitter is used to pass the described first side ballistic phonon of described shell, described a plurality of detector is used to receive at least a portion of the photon of described first side emission of passing described shell, each emitter in operation with the pairing of different detector and be oriented such that from described emitter emission, impinge upon with described sensor cluster adjacent blood vessel on photon beam will partly reflect to paired detector, each detector is configured to produce the signal of the photon of the emission that expression receives by described detector;
Computing equipment is configured to described a plurality of emitters be activated and the described signal from described detector is carried out decipher determine described characteristic.
35. equipment according to claim 34, wherein said characteristic are the diameters of described blood vessel.
36. equipment according to claim 34, wherein said characteristic are the oxygen saturations of described blood.
37. equipment according to claim 34, wherein the every pair of emitter and detector relative to each other position at a certain angle, described angle for all emitters and detector to being identical.
38. equipment according to claim 34, wherein said computing equipment individually order activate described a plurality of emitters each determine the described diameter of described blood vessel.
39. equipment according to claim 34, wherein said computing equipment activate the described oxygen saturation that all described a plurality of emitters are determined described blood simultaneously.
Applications Claiming Priority (11)
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| US12/119,325 US8298148B2 (en) | 2005-12-08 | 2008-05-12 | Integrated heart monitoring device and method of using same |
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| US12/119,339 US20080287800A1 (en) | 2006-12-10 | 2008-05-12 | Doppler motion sensor apparatus and method of using same |
| US12/119,315 US8442606B2 (en) | 2006-12-10 | 2008-05-12 | Optical sensor apparatus and method of using same |
| US12/119,462 US9037208B2 (en) | 2005-12-08 | 2008-05-12 | Method and system for monitoring a health condition |
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| US12/206,885 US20090048518A1 (en) | 2006-12-10 | 2008-09-09 | Doppler motion sensor apparatus and method of using same |
| PCT/IB2009/006078 WO2009138880A2 (en) | 2008-05-12 | 2009-05-12 | Optical sensor apparatus and method of using same |
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| CN2009801203104A Expired - Fee Related CN102046085B (en) | 2008-05-12 | 2009-05-12 | Optical sensor apparatus and method of using same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385703A (en) * | 2012-05-08 | 2013-11-13 | 精工爱普生株式会社 | Cardiac output monitoring system and cardiac output measurement method |
| CN103561636A (en) * | 2011-05-26 | 2014-02-05 | 皇家飞利浦有限公司 | Fever detection apparatus |
| CN104013389A (en) * | 2014-06-18 | 2014-09-03 | 香港应用科技研究院有限公司 | Method and device for searching for position of artery |
| CN104470422A (en) * | 2012-07-05 | 2015-03-25 | 微创医学科技有限公司 | Direct deployment system and method |
| CN105891136A (en) * | 2015-02-13 | 2016-08-24 | 台医光电科技股份有限公司 | MULTI-point measurement accessory, device and system |
| CN108332780A (en) * | 2017-01-10 | 2018-07-27 | 派克汉尼芬公司 | The sensor calibration data memory module of optics power supply |
| CN110013240A (en) * | 2013-01-28 | 2019-07-16 | 瓦伦赛尔公司 | Physiological monitoring device with the sensing element disengaged with body kinematics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102958448B (en) * | 2010-08-06 | 2015-01-21 | 株式会社日立医疗器械 | Medical image diagnostic device and cardiac measurement value display method |
| CN102755152A (en) * | 2011-04-27 | 2012-10-31 | 深圳市迈迪加科技发展有限公司 | Cardiac function monitoring instrument |
| CN102755151A (en) * | 2011-04-27 | 2012-10-31 | 深圳市迈迪加科技发展有限公司 | Heart function monitoring method |
| CN102293643B (en) * | 2011-05-23 | 2014-07-02 | 陕西鸿远科技有限公司 | Implanted physiological data measurement device |
| EP2768390A4 (en) * | 2011-10-21 | 2015-09-23 | Incube Labs Llc | Implantable oximetric measurement apparatus and method of use |
| CN102564857B (en) * | 2012-01-18 | 2015-07-29 | 复旦大学 | Device for measuring nonlinear mechanical property of blood vessel |
| WO2013161074A1 (en) * | 2012-04-27 | 2013-10-31 | パイオニア株式会社 | Physical condition monitoring device and method |
| JP5946904B2 (en) * | 2012-04-27 | 2016-07-06 | パイオニア株式会社 | Physical condition monitoring apparatus and method |
| JP2015533523A (en) * | 2012-08-13 | 2015-11-26 | モア リサーチ アプリケ−ションズ リミテッド | Radial artery device |
| MX364347B (en) * | 2012-09-17 | 2019-04-23 | A Rhodes Donald | Technique for determining optimum treatment parameters. |
| JP6115629B2 (en) | 2013-03-12 | 2017-04-19 | 富士通株式会社 | Wireless communication system, wireless communication method, transmission apparatus, control method, and control program |
| US9636070B2 (en) * | 2013-03-14 | 2017-05-02 | DePuy Synthes Products, Inc. | Methods, systems, and devices for monitoring and displaying medical parameters for a patient |
| CN103932737A (en) * | 2014-04-28 | 2014-07-23 | 刘树英 | Cardiovascular blood flow velocity sensor |
| JP6580863B2 (en) * | 2014-05-22 | 2019-09-25 | 株式会社半導体エネルギー研究所 | Semiconductor devices, health management systems |
| CN106999064B (en) * | 2014-11-13 | 2020-10-27 | 范德堡大学 | Device and method for hemorrhage detection and guided resuscitation and application thereof |
| WO2016131020A1 (en) * | 2015-02-12 | 2016-08-18 | Foundry Innovation & Research 1, Ltd. | Implantable devices and related methods for heart failure monitoring |
| US20160317050A1 (en) | 2015-04-28 | 2016-11-03 | Federico Perego Costa | Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient |
| US20180092626A1 (en) * | 2015-06-10 | 2018-04-05 | Koninklijke Philips N.V. | Ultrasound imaging apparatus |
| KR101653502B1 (en) * | 2015-06-12 | 2016-09-09 | 한국 한의학 연구원 | Computing apparatus and method for providing classifying of mibyoug |
| JP2018519047A (en) | 2015-06-19 | 2018-07-19 | ニューラル アナリティクス、インコーポレイテッド | Intracranial Doppler probe |
| WO2017115361A1 (en) * | 2015-12-31 | 2017-07-06 | Wear2B Ltd | Device, system and method for non-invasive monitoring of physiological measurements |
| US11589836B2 (en) | 2016-01-05 | 2023-02-28 | Novasignal Corp. | Systems and methods for detecting neurological conditions |
| WO2017120388A1 (en) * | 2016-01-05 | 2017-07-13 | Neural Analytics, Inc. | Systems and methods for determining clinical indications |
| WO2017120361A1 (en) | 2016-01-05 | 2017-07-13 | Neural Analytics, Inc. | Integrated probe structure |
| EP3422929B1 (en) * | 2016-03-04 | 2019-09-11 | Koninklijke Philips N.V. | Apparatus for vessel characterization |
| CN106073754A (en) * | 2016-05-16 | 2016-11-09 | 天津工业大学 | A kind of portable cardiac monitoring device of low-power consumption |
| CN106037643A (en) * | 2016-05-19 | 2016-10-26 | 上海应特宠企业管理有限公司 | Implanted chip and system for continuously detecting mammal signs |
| CN105994004A (en) * | 2016-05-19 | 2016-10-12 | 上海应特宠企业管理有限公司 | Pet real-time monitor system |
| JP7103644B2 (en) * | 2016-05-31 | 2022-07-20 | 国立大学法人九州大学 | Flow measuring device, flow measuring method, pressure measuring device, and pressure measuring method |
| US10182729B2 (en) * | 2016-08-31 | 2019-01-22 | Medtronics, Inc. | Systems and methods for monitoring hemodynamic status |
| AU2019251467A1 (en) | 2018-04-10 | 2020-11-26 | Cerenetex, Inc. | Systems and methods for the identification of medical conditions, and determination of appropriate therapies, by passively detecting acoustic signals generated from cerebral vasculature |
| WO2020041800A1 (en) * | 2018-08-24 | 2020-02-27 | Marcelo Malini Lamego | Monitoring device and system |
| CN109431485A (en) * | 2018-11-06 | 2019-03-08 | 天津大学 | A kind of velocity of blood flow detection device applied in foley's tube |
| CN113939222A (en) * | 2018-11-20 | 2022-01-14 | 维瑞思健康公司 | Vascular access device for monitoring patient health |
| US11464440B2 (en) | 2019-04-10 | 2022-10-11 | Autem Medical, Llc | System for prognosticating patient outcomes and methods of using the same |
| CN110339427B (en) * | 2019-05-30 | 2021-12-14 | 努比亚技术有限公司 | Infusion monitoring method, wearable device and computer-readable storage medium |
| CN110495864B (en) * | 2019-08-02 | 2022-04-05 | 深圳市德胜医疗科技有限公司 | Method and device for measuring human blood vessel blood flow contraction force and relaxation force |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4770177A (en) * | 1986-02-18 | 1988-09-13 | Telectronics N.V. | Apparatus and method for adjusting heart/pacer relative to changes in venous diameter during exercise to obtain a required cardiac output. |
| US5115133A (en) * | 1990-04-19 | 1992-05-19 | Inomet, Inc. | Testing of body fluid constituents through measuring light reflected from tympanic membrane |
| US5218962A (en) * | 1991-04-15 | 1993-06-15 | Nellcor Incorporated | Multiple region pulse oximetry probe and oximeter |
| CA2103166C (en) * | 1991-05-16 | 2003-10-28 | Britton Chance | Lateralization spectrophotometer |
| US5370114A (en) * | 1992-03-12 | 1994-12-06 | Wong; Jacob Y. | Non-invasive blood chemistry measurement by stimulated infrared relaxation emission |
| US5544649A (en) * | 1992-03-25 | 1996-08-13 | Cardiomedix, Inc. | Ambulatory patient health monitoring techniques utilizing interactive visual communication |
| US5558092A (en) * | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
| US5995860A (en) * | 1995-07-06 | 1999-11-30 | Thomas Jefferson University | Implantable sensor and system for measurement and control of blood constituent levels |
| US5606972A (en) * | 1995-08-10 | 1997-03-04 | Advanced Technology Laboratories, Inc. | Ultrasonic doppler measurement of blood flow velocities by array transducers |
| US5833603A (en) | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
| US6511426B1 (en) * | 1998-06-02 | 2003-01-28 | Acuson Corporation | Medical diagnostic ultrasound system and method for versatile processing |
| WO2001019239A1 (en) * | 1999-09-17 | 2001-03-22 | Endoluminal Therapeutics, Inc. | Sensing, interrogating, storing, telemetering and responding medical implants |
| JP2001087249A (en) * | 1999-09-27 | 2001-04-03 | Sanyo Electric Co Ltd | Blood component measuring device |
| JP4607308B2 (en) * | 2000-10-03 | 2011-01-05 | シスメックス株式会社 | Noninvasive living body measurement apparatus and method |
| US20060100530A1 (en) * | 2000-11-28 | 2006-05-11 | Allez Physionix Limited | Systems and methods for non-invasive detection and monitoring of cardiac and blood parameters |
| JP2002172095A (en) * | 2000-12-06 | 2002-06-18 | K & S:Kk | Pulse measurement device |
| EP1317902B1 (en) * | 2001-12-10 | 2005-11-09 | Kabushiki Gaisha K-and-S | Biological data observation apparatus |
| US6985771B2 (en) * | 2002-01-22 | 2006-01-10 | Angel Medical Systems, Inc. | Rapid response system for the detection and treatment of cardiac events |
| JP2003218805A (en) * | 2002-01-25 | 2003-07-31 | Tama Tlo Kk | Power and signal transmission device using ultrasonic waves |
| US6609023B1 (en) * | 2002-09-20 | 2003-08-19 | Angel Medical Systems, Inc. | System for the detection of cardiac events |
| AU2003279842A1 (en) * | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
| US7010337B2 (en) * | 2002-10-24 | 2006-03-07 | Furnary Anthony P | Method and apparatus for monitoring blood condition and cardiopulmonary function |
| JP2004148070A (en) * | 2002-10-29 | 2004-05-27 | Tse:Kk | Detector of a pluralty of components in blood |
| US6931328B2 (en) * | 2002-11-08 | 2005-08-16 | Optiscan Biomedical Corp. | Analyte detection system with software download capabilities |
| US7035684B2 (en) * | 2003-02-26 | 2006-04-25 | Medtronic, Inc. | Method and apparatus for monitoring heart function in a subcutaneously implanted device |
| US6944488B2 (en) * | 2003-04-30 | 2005-09-13 | Medtronic, Inc. | Normalization method for a chronically implanted optical sensor |
| US7303530B2 (en) * | 2003-05-22 | 2007-12-04 | Siemens Medical Solutions Usa, Inc. | Transducer arrays with an integrated sensor and methods of use |
| JP4272024B2 (en) * | 2003-09-16 | 2009-06-03 | 浜松ホトニクス株式会社 | Optical biological measurement device |
| JP4412644B2 (en) * | 2003-10-29 | 2010-02-10 | セイコーインスツル株式会社 | Cardiodynamic measurement device |
| JP4460316B2 (en) * | 2004-01-27 | 2010-05-12 | 日本電信電話株式会社 | Biological information measuring device and health management system |
| US7637871B2 (en) * | 2004-02-26 | 2009-12-29 | Siemens Medical Solutions Usa, Inc. | Steered continuous wave doppler methods and systems for two-dimensional ultrasound transducer arrays |
| JP2006026394A (en) * | 2004-06-15 | 2006-02-02 | Sysmex Corp | Noninvasive organism measuring apparatus |
| US20060129038A1 (en) * | 2004-12-14 | 2006-06-15 | Zelenchuk Alex R | Optical determination of in vivo properties |
| JP4641809B2 (en) * | 2005-01-26 | 2011-03-02 | セイコーインスツル株式会社 | Biological information measuring device |
| JP4767551B2 (en) * | 2005-02-14 | 2011-09-07 | セイコーインスツル株式会社 | Blood rheology measurement device and blood rheology measurement method |
| US7747301B2 (en) * | 2005-03-30 | 2010-06-29 | Skyline Biomedical, Inc. | Apparatus and method for non-invasive and minimally-invasive sensing of parameters relating to blood |
| WO2006123282A1 (en) * | 2005-05-18 | 2006-11-23 | Koninklijke Philips Electronics N.V. | Cannula inserting system |
| JP2006325766A (en) * | 2005-05-24 | 2006-12-07 | Sharp Corp | Biological signal measuring instrument |
| JP2007020735A (en) * | 2005-07-13 | 2007-02-01 | Toshiba Corp | Biological light measuring device |
| CN100445488C (en) * | 2005-08-01 | 2008-12-24 | 邱则有 | Hollow member for cast-in-situ concrete moulding |
| US20070088214A1 (en) * | 2005-10-14 | 2007-04-19 | Cardiac Pacemakers Inc. | Implantable physiologic monitoring system |
| US20090221882A1 (en) * | 2005-12-08 | 2009-09-03 | Dan Gur Furman | Implantable Biosensor Assembly and Health Monitoring system and Method including same |
| US20070142727A1 (en) * | 2005-12-15 | 2007-06-21 | Cardiac Pacemakers, Inc. | System and method for analyzing cardiovascular pressure measurements made within a human body |
| US8078278B2 (en) * | 2006-01-10 | 2011-12-13 | Remon Medical Technologies Ltd. | Body attachable unit in wireless communication with implantable devices |
| GB0607270D0 (en) * | 2006-04-11 | 2006-05-17 | Univ Nottingham | The pulsing blood supply |
| US7559899B2 (en) * | 2006-04-12 | 2009-07-14 | Salutron, Inc. | Power saving techniques for continuous heart rate monitoring |
| US7539532B2 (en) * | 2006-05-12 | 2009-05-26 | Bao Tran | Cuffless blood pressure monitoring appliance |
| TW200744529A (en) * | 2006-06-09 | 2007-12-16 | Avita Corp | Medical measuring device with long distant transmission function |
-
2009
- 2009-05-12 JP JP2011509039A patent/JP5497008B2/en not_active Expired - Fee Related
- 2009-05-12 CN CN200980122318.4A patent/CN102065773B/en not_active Expired - Fee Related
- 2009-05-12 WO PCT/IB2009/006081 patent/WO2009138881A2/en active Application Filing
- 2009-05-12 CA CA2722659A patent/CA2722659A1/en not_active Abandoned
- 2009-05-12 WO PCT/IB2009/006088 patent/WO2009138883A2/en active Application Filing
- 2009-05-12 EP EP09746177A patent/EP2285288A4/en not_active Withdrawn
- 2009-05-12 CN CN2009801223131A patent/CN102202568A/en active Pending
- 2009-05-12 JP JP2011509040A patent/JP5650104B2/en not_active Expired - Fee Related
- 2009-05-12 CN CN2009801203104A patent/CN102046085B/en not_active Expired - Fee Related
- 2009-05-12 EP EP09746176A patent/EP2282667A4/en not_active Withdrawn
- 2009-05-12 CA CA2722593A patent/CA2722593A1/en not_active Abandoned
- 2009-05-12 CN CN2009801189249A patent/CN102046069A/en active Pending
- 2009-05-12 JP JP2011509042A patent/JP5591794B2/en not_active Expired - Fee Related
- 2009-05-12 EP EP09746178A patent/EP2282671A4/en not_active Withdrawn
- 2009-05-12 CA CA2722616A patent/CA2722616A1/en not_active Abandoned
- 2009-05-12 WO PCT/IB2009/006082 patent/WO2009138882A2/en active Application Filing
- 2009-05-12 EP EP09746175A patent/EP2282673A2/en not_active Withdrawn
- 2009-05-12 WO PCT/IB2009/006078 patent/WO2009138880A2/en active Application Filing
- 2009-05-12 JP JP2011509041A patent/JP5405564B2/en not_active Expired - Fee Related
- 2009-05-12 CA CA2722662A patent/CA2722662A1/en not_active Abandoned
-
2010
- 2010-11-09 IL IL209212A patent/IL209212A/en not_active IP Right Cessation
- 2010-11-09 IL IL209213A patent/IL209213A/en not_active IP Right Cessation
- 2010-11-09 IL IL209210A patent/IL209210A/en not_active IP Right Cessation
- 2010-11-09 IL IL209211A patent/IL209211A/en not_active IP Right Cessation
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103561636A (en) * | 2011-05-26 | 2014-02-05 | 皇家飞利浦有限公司 | Fever detection apparatus |
| US9924879B2 (en) | 2011-05-26 | 2018-03-27 | Koninklijke Philips N.V. | Fever detection apparatus |
| CN103385703A (en) * | 2012-05-08 | 2013-11-13 | 精工爱普生株式会社 | Cardiac output monitoring system and cardiac output measurement method |
| CN104470422A (en) * | 2012-07-05 | 2015-03-25 | 微创医学科技有限公司 | Direct deployment system and method |
| CN110013240A (en) * | 2013-01-28 | 2019-07-16 | 瓦伦赛尔公司 | Physiological monitoring device with the sensing element disengaged with body kinematics |
| US11266319B2 (en) | 2013-01-28 | 2022-03-08 | Valencell, Inc. | Physiological monitoring devices having sensing elements decoupled from body motion |
| US11684278B2 (en) | 2013-01-28 | 2023-06-27 | Yukka Magic Llc | Physiological monitoring devices having sensing elements decoupled from body motion |
| CN104013389B (en) * | 2014-06-18 | 2016-01-20 | 香港应用科技研究院有限公司 | For searching for the method and apparatus of artery position |
| CN104013389A (en) * | 2014-06-18 | 2014-09-03 | 香港应用科技研究院有限公司 | Method and device for searching for position of artery |
| CN105891136A (en) * | 2015-02-13 | 2016-08-24 | 台医光电科技股份有限公司 | MULTI-point measurement accessory, device and system |
| US10132677B2 (en) | 2015-02-13 | 2018-11-20 | Taiwan Biophotonic Corporation | Multi-site sensing accessory, multi-site sensing device, and multi-site sensing system |
| CN105891136B (en) * | 2015-02-13 | 2019-11-19 | 台医光电科技股份有限公司 | Multimetering accessory, Multi point measuring apparatus and multi-point measurement system |
| CN108332780A (en) * | 2017-01-10 | 2018-07-27 | 派克汉尼芬公司 | The sensor calibration data memory module of optics power supply |
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