ZA99369B - N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl)-acetoxyl]-L-aspartic acid aldehyde as an in vivo inhibitor of interleukin-1-beta converting enzyme (ICE). - Google Patents
N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl)-acetoxyl]-L-aspartic acid aldehyde as an in vivo inhibitor of interleukin-1-beta converting enzyme (ICE).Info
- Publication number
- ZA99369B ZA99369B ZA9900369A ZA99369A ZA99369B ZA 99369 B ZA99369 B ZA 99369B ZA 9900369 A ZA9900369 A ZA 9900369A ZA 99369 A ZA99369 A ZA 99369A ZA 99369 B ZA99369 B ZA 99369B
- Authority
- ZA
- South Africa
- Prior art keywords
- interleukin
- converting enzyme
- acetoxyl
- benzyloxycarbonyl
- pyrimidinyl
- Prior art date
Links
- 108090000426 Caspase-1 Proteins 0.000 title 2
- 102100035904 Caspase-1 Human genes 0.000 title 1
- 229960005261 aspartic acid Drugs 0.000 title 1
- 229960003328 benzoyl peroxide Drugs 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000004429 Bacillary Dysentery Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 229940082909 Interleukin 1beta converting enzyme inhibitor Drugs 0.000 abstract 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 206010040550 Shigella infections Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 108010027775 interleukin-1beta-converting enzyme inhibitor Proteins 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 201000005113 shigellosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7191898P | 1998-01-20 | 1998-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA99369B true ZA99369B (en) | 1999-07-20 |
Family
ID=22104428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9900369A ZA99369B (en) | 1998-01-20 | 1999-01-19 | N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl)-acetoxyl]-L-aspartic acid aldehyde as an in vivo inhibitor of interleukin-1-beta converting enzyme (ICE). |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1049703B1 (enExample) |
| JP (1) | JP2002509153A (enExample) |
| AT (1) | ATE232536T1 (enExample) |
| AU (1) | AU1466399A (enExample) |
| CA (1) | CA2309546A1 (enExample) |
| DE (1) | DE69811404T2 (enExample) |
| DK (1) | DK1049703T3 (enExample) |
| ES (1) | ES2193589T3 (enExample) |
| PT (1) | PT1049703E (enExample) |
| WO (1) | WO1999036426A1 (enExample) |
| ZA (1) | ZA99369B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| AU2001243598A1 (en) | 2000-03-13 | 2001-09-24 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| JP2004505014A (ja) | 2000-04-05 | 2004-02-19 | ファルマシア・コーポレーション | 凝血カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換された４−ピロン類 |
| US6693121B2 (en) | 2000-04-05 | 2004-02-17 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| US6686484B2 (en) | 2000-04-17 | 2004-02-03 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| AU2001222501A1 (en) * | 2000-05-18 | 2001-11-26 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| AU2001280590A1 (en) * | 2000-07-18 | 2002-01-30 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| WO2002042272A2 (en) | 2000-11-20 | 2002-05-30 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| ES2675735T3 (es) | 2001-06-26 | 2018-07-12 | Amgen Inc. | Anticuerpos para OPGL |
| EP1432687A2 (en) | 2001-10-03 | 2004-06-30 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| US6969715B2 (en) | 2001-10-03 | 2005-11-29 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| NZ605429A (en) | 2002-09-06 | 2014-08-29 | Amgen Inc | Therapeutic human anti-il-1r1 monoclonal antibody |
| KR101135765B1 (ko) | 2004-03-12 | 2012-04-23 | 버텍스 파마슈티칼스 인코포레이티드 | 아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체 |
| US20060128696A1 (en) | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| JP2008500374A (ja) | 2004-05-27 | 2008-01-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 自己炎症性疾患の処置のためのｉｃｅインヒビター |
| CA2616337A1 (en) | 2005-07-28 | 2007-02-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| EP2635907A4 (en) | 2010-11-05 | 2014-04-16 | Univ Brandeis | ICE-COLDED ALPHA SYNNUCLEINE A BIOMARKERS |
| US12403181B2 (en) | 2018-08-13 | 2025-09-02 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| US20250283174A1 (en) | 2022-05-16 | 2025-09-11 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| NZ283876A (en) * | 1994-03-31 | 2001-03-30 | Vertex Pharma | Pyrimidinyl derivatives as interleukin inhibitors |
-
1998
- 1998-11-20 EP EP98958672A patent/EP1049703B1/en not_active Expired - Lifetime
- 1998-11-20 JP JP2000540142A patent/JP2002509153A/ja not_active Abandoned
- 1998-11-20 PT PT98958672T patent/PT1049703E/pt unknown
- 1998-11-20 DK DK98958672T patent/DK1049703T3/da active
- 1998-11-20 DE DE69811404T patent/DE69811404T2/de not_active Expired - Fee Related
- 1998-11-20 ES ES98958672T patent/ES2193589T3/es not_active Expired - Lifetime
- 1998-11-20 AT AT98958672T patent/ATE232536T1/de not_active IP Right Cessation
- 1998-11-20 AU AU14663/99A patent/AU1466399A/en not_active Abandoned
- 1998-11-20 WO PCT/US1998/024848 patent/WO1999036426A1/en not_active Ceased
- 1998-11-20 CA CA002309546A patent/CA2309546A1/en not_active Abandoned
-
1999
- 1999-01-19 ZA ZA9900369A patent/ZA99369B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1049703A1 (en) | 2000-11-08 |
| WO1999036426A1 (en) | 1999-07-22 |
| CA2309546A1 (en) | 1999-07-22 |
| ES2193589T3 (es) | 2003-11-01 |
| DE69811404T2 (de) | 2003-12-04 |
| AU1466399A (en) | 1999-08-02 |
| DK1049703T3 (da) | 2003-06-02 |
| PT1049703E (pt) | 2003-06-30 |
| ATE232536T1 (de) | 2003-02-15 |
| EP1049703B1 (en) | 2003-02-12 |
| JP2002509153A (ja) | 2002-03-26 |
| DE69811404D1 (de) | 2003-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA99369B (en) | N-[2-(5-benzyloxycarbonyl-amino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl)-acetoxyl]-L-aspartic acid aldehyde as an in vivo inhibitor of interleukin-1-beta converting enzyme (ICE). | |
| NO991674D0 (no) | Interleukin-1<Beta>omdannelsesenzym-inhibitor-sulfonamider | |
| CA2338220A1 (en) | Substituted imidazoles having cytokine inhibitory activity | |
| DK1240165T3 (da) | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamid-inhibitorer af cyclinafhængige kinaser | |
| LU91145I2 (fr) | FIROCOXIB facultativement sous forme d'un sel pharmaceutiquement acceptable (PREVICOX). | |
| EP1034164A4 (en) | BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS | |
| HU9602664D0 (en) | Pyrimidinyl derivatives as interleukin inhibitors | |
| BR9709514A (pt) | Processo e composições úteis para a inibição de angiogénese mediada por alfa beta | |
| MY129635A (en) | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases | |
| AP2000001992A0 (en) | Succinamide inhibitors of inteleukin-1B converting enzyme. | |
| IL129124A0 (en) | Sulfonamide substituted aspartic acid interleukin -1beta converting enzyme inhibitors | |
| NO20010490L (no) | Inhibisjon av ''graft-versus-host''-sykdom | |
| CA2099867A1 (en) | 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents | |
| LT2003001A (en) | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases | |
| EP0637961A4 (en) | METHOD FOR TREATING INFLAMMABLE INTESTINAL DISEASES WITH LEUKOTRIA SYNTHESIS INHIBITORS. | |
| MA24831A1 (fr) | Procede pour la preparation d'acides hydroxamiques | |
| WO1999021005A3 (en) | Pharmaceutical grade st. john's wort | |
| ATE220665T1 (de) | Azetidincarboxamidderivate zur behandlung von zns-erkrankungen |