ZA988162B - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. - Google Patents
Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.Info
- Publication number
- ZA988162B ZA988162B ZA9808162A ZA988162A ZA988162B ZA 988162 B ZA988162 B ZA 988162B ZA 9808162 A ZA9808162 A ZA 9808162A ZA 988162 A ZA988162 A ZA 988162A ZA 988162 B ZA988162 B ZA 988162B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- neutrophil elastase
- pyrrolopyrrolone
- derivatives
- pyrrolopyrrolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9719187.8A GB9719187D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA988162B true ZA988162B (en) | 2000-03-22 |
Family
ID=10818820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9808162A ZA988162B (en) | 1997-09-09 | 1998-09-07 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6228853B1 (id) |
| EP (1) | EP1019406A1 (id) |
| JP (1) | JP2001515902A (id) |
| KR (1) | KR20010023830A (id) |
| CN (1) | CN1278821A (id) |
| AP (1) | AP2000001760A0 (id) |
| AU (1) | AU9536098A (id) |
| BR (1) | BR9811651A (id) |
| CA (1) | CA2303249A1 (id) |
| EA (1) | EA200000205A1 (id) |
| EE (1) | EE200000137A (id) |
| GB (1) | GB9719187D0 (id) |
| HR (1) | HRP20000136A2 (id) |
| HU (1) | HUP0003475A3 (id) |
| ID (1) | ID24364A (id) |
| IL (1) | IL134935A0 (id) |
| IS (1) | IS5394A (id) |
| MA (1) | MA26544A1 (id) |
| NO (1) | NO20001200L (id) |
| PL (1) | PL339186A1 (id) |
| SK (1) | SK3242000A3 (id) |
| TR (1) | TR200001026T2 (id) |
| WO (1) | WO1999012931A1 (id) |
| ZA (1) | ZA988162B (id) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
| US7745226B2 (en) * | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| CN102812356B (zh) | 2009-12-11 | 2017-08-08 | 奎斯特诊断投资公司 | 多重样品中的甾族化合物的质谱法 |
| CA2783797C (en) | 2009-12-11 | 2021-06-08 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
| JP2023500182A (ja) | 2019-09-17 | 2023-01-05 | メレオ バイオファーマ ４ リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
| EP4106757B1 (en) | 2020-04-16 | 2023-08-23 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
| TW202325294A (zh) | 2021-10-20 | 2023-07-01 | 英商梅瑞奧生物製藥４有限公司 | 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983245A (en) * | 1975-02-06 | 1976-09-28 | Smithkline Corporation | Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes |
| GB8512230D0 (en) | 1985-05-14 | 1985-06-19 | Shell Internationale Researche | Preparation of carboxylic acid salt |
| GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| GB9402680D0 (en) | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
| TR199801282T2 (xx) | 1996-01-03 | 1998-12-21 | Smithkline Beecham P.L.C. | Mutilin'in karbamoiloksi t�revleri ve antibakteriyel olarak kullan�m�. |
| SK132498A3 (en) * | 1996-03-28 | 1999-08-06 | Glaxo Group Ltd | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
-
1997
- 1997-09-09 GB GBGB9719187.8A patent/GB9719187D0/en not_active Ceased
-
1998
- 1998-09-07 IL IL13493598A patent/IL134935A0/xx unknown
- 1998-09-07 TR TR2000/01026T patent/TR200001026T2/xx unknown
- 1998-09-07 MA MA25244A patent/MA26544A1/fr unknown
- 1998-09-07 HU HU0003475A patent/HUP0003475A3/hu unknown
- 1998-09-07 ZA ZA9808162A patent/ZA988162B/xx unknown
- 1998-09-07 EP EP98948905A patent/EP1019406A1/en not_active Withdrawn
- 1998-09-07 PL PL98339186A patent/PL339186A1/xx not_active Application Discontinuation
- 1998-09-07 EE EEP200000137A patent/EE200000137A/xx unknown
- 1998-09-07 BR BR9811651-7A patent/BR9811651A/pt not_active Application Discontinuation
- 1998-09-07 CA CA002303249A patent/CA2303249A1/en not_active Abandoned
- 1998-09-07 WO PCT/EP1998/005604 patent/WO1999012931A1/en not_active Application Discontinuation
- 1998-09-07 ID IDW20000665A patent/ID24364A/id unknown
- 1998-09-07 SK SK324-2000A patent/SK3242000A3/sk unknown
- 1998-09-07 EA EA200000205A patent/EA200000205A1/ru unknown
- 1998-09-07 CN CN98810967A patent/CN1278821A/zh active Pending
- 1998-09-07 JP JP2000510738A patent/JP2001515902A/ja active Pending
- 1998-09-07 US US09/508,326 patent/US6228853B1/en not_active Expired - Fee Related
- 1998-09-07 KR KR1020007002505A patent/KR20010023830A/ko not_active Application Discontinuation
- 1998-09-07 AU AU95360/98A patent/AU9536098A/en not_active Abandoned
- 1998-09-07 AP APAP/P/2000/001760A patent/AP2000001760A0/en unknown
-
2000
- 2000-03-03 IS IS5394A patent/IS5394A/is unknown
- 2000-03-08 NO NO20001200A patent/NO20001200L/no not_active Application Discontinuation
- 2000-03-09 HR HR20000136A patent/HRP20000136A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU9536098A (en) | 1999-03-29 |
| ID24364A (id) | 2000-07-13 |
| HRP20000136A2 (en) | 2000-08-31 |
| HUP0003475A3 (en) | 2002-01-28 |
| EP1019406A1 (en) | 2000-07-19 |
| PL339186A1 (en) | 2000-12-04 |
| CN1278821A (zh) | 2001-01-03 |
| HUP0003475A2 (hu) | 2001-09-28 |
| US6228853B1 (en) | 2001-05-08 |
| IS5394A (is) | 2000-03-03 |
| AP2000001760A0 (en) | 2000-03-31 |
| NO20001200L (no) | 2000-05-08 |
| NO20001200D0 (no) | 2000-03-08 |
| MA26544A1 (fr) | 2004-12-20 |
| WO1999012931A1 (en) | 1999-03-18 |
| EE200000137A (et) | 2001-02-15 |
| BR9811651A (pt) | 2000-08-08 |
| GB9719187D0 (en) | 1997-11-12 |
| SK3242000A3 (en) | 2001-03-12 |
| EA200000205A1 (ru) | 2000-10-30 |
| IL134935A0 (en) | 2001-05-20 |
| KR20010023830A (ko) | 2001-03-26 |
| CA2303249A1 (en) | 1999-03-18 |
| TR200001026T2 (tr) | 2000-09-21 |
| JP2001515902A (ja) | 2001-09-25 |
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