ZA987539B - 5,5-disubstituted-1,5-dihydro-4,1-benzoxapin-2(3H)-ones useful as HIV reverse transcriptase inhibitors. - Google Patents

5,5-disubstituted-1,5-dihydro-4,1-benzoxapin-2(3H)-ones useful as HIV reverse transcriptase inhibitors.

Info

Publication number
ZA987539B
ZA987539B ZA9807539A ZA987539A ZA987539B ZA 987539 B ZA987539 B ZA 987539B ZA 9807539 A ZA9807539 A ZA 9807539A ZA 987539 A ZA987539 A ZA 987539A ZA 987539 B ZA987539 B ZA 987539B
Authority
ZA
South Africa
Prior art keywords
benzoxapin
disubstituted
dihydro
reverse transcriptase
transcriptase inhibitors
Prior art date
Application number
ZA9807539A
Other languages
English (en)
Inventor
Anthony Joseph Cocuzza
James David Rodgers
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of ZA987539B publication Critical patent/ZA987539B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9807539A 1997-09-02 1998-08-20 5,5-disubstituted-1,5-dihydro-4,1-benzoxapin-2(3H)-ones useful as HIV reverse transcriptase inhibitors. ZA987539B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5743197P 1997-09-02 1997-09-02

Publications (1)

Publication Number Publication Date
ZA987539B true ZA987539B (en) 2000-02-21

Family

ID=22010528

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9807539A ZA987539B (en) 1997-09-02 1998-08-20 5,5-disubstituted-1,5-dihydro-4,1-benzoxapin-2(3H)-ones useful as HIV reverse transcriptase inhibitors.

Country Status (12)

Country Link
US (2) US6140320A (pt)
EP (1) EP1009742A1 (pt)
JP (1) JP2001514256A (pt)
CN (1) CN1268944A (pt)
AR (1) AR015163A1 (pt)
AU (1) AU9023998A (pt)
BR (1) BR9814933A (pt)
CA (1) CA2303295A1 (pt)
HR (1) HRP980482A2 (pt)
TW (1) TW564248B (pt)
WO (1) WO1999011635A1 (pt)
ZA (1) ZA987539B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943097B2 (en) * 2003-08-19 2005-09-13 International Business Machines Corporation Atomic layer deposition of metallic contacts, gates and diffusion barriers
US20070054940A1 (en) * 2003-09-19 2007-03-08 Eisai Co., Ltd. Remedy for down's syndrome
US20070037894A1 (en) * 2003-09-19 2007-02-15 Hahnfeld Jerry L Multifunctional menomers and polyarylene compsotions therefrom
US7323455B2 (en) 2004-03-24 2008-01-29 Wyeth 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法
WO2023192430A1 (en) * 2022-03-30 2023-10-05 University Of Florida Research Foundation, Incorported Compounds for treating psychostimulant misuse

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374842A (en) * 1980-04-18 1983-02-22 Shionogi & Co., Ltd. 4,1-Benzoxazepines and compositions
DE3471101D1 (en) * 1983-11-17 1988-06-16 Upjohn Co N-substituted-5-phenyl-4,1-benzoxazepin-2(3h)-ones having therapeutic utility
EP0417534A1 (en) * 1989-08-29 1991-03-20 Boehringer Ingelheim Pharmaceuticals Inc. Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS
DE69332792T2 (de) * 1992-04-20 2004-01-15 Takeda Chemical Industries Ltd 4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
JPH08259447A (ja) * 1995-03-24 1996-10-08 Takeda Chem Ind Ltd コレシストキニン拮抗剤
CA2268953A1 (en) * 1996-10-02 1998-04-09 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same

Also Published As

Publication number Publication date
HRP980482A2 (en) 1999-10-31
AR015163A1 (es) 2001-04-18
TW564248B (en) 2003-12-01
CA2303295A1 (en) 1999-03-11
BR9814933A (pt) 2001-01-30
CN1268944A (zh) 2000-10-04
US6489320B1 (en) 2002-12-03
JP2001514256A (ja) 2001-09-11
AU9023998A (en) 1999-03-22
EP1009742A1 (en) 2000-06-21
WO1999011635A1 (en) 1999-03-11
US6140320A (en) 2000-10-31

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