ZA986517B - Production of human mutated proteins in human cells by means of homologous recombination. - Google Patents

Production of human mutated proteins in human cells by means of homologous recombination.

Info

Publication number
ZA986517B
ZA986517B ZA9806517A ZA986517A ZA986517B ZA 986517 B ZA986517 B ZA 986517B ZA 9806517 A ZA9806517 A ZA 9806517A ZA 986517 A ZA986517 A ZA 986517A ZA 986517 B ZA986517 B ZA 986517B
Authority
ZA
South Africa
Prior art keywords
human
production
homologous recombination
mutated proteins
human cells
Prior art date
Application number
ZA9806517A
Other languages
English (en)
Inventor
Anne Stern
Konrad Honold
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA986517(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of ZA986517B publication Critical patent/ZA986517B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA9806517A 1997-07-23 1998-07-22 Production of human mutated proteins in human cells by means of homologous recombination. ZA986517B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97112639 1997-07-23

Publications (1)

Publication Number Publication Date
ZA986517B true ZA986517B (en) 2000-01-24

Family

ID=8227102

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9806517A ZA986517B (en) 1997-07-23 1998-07-22 Production of human mutated proteins in human cells by means of homologous recombination.

Country Status (17)

Country Link
US (2) US6444441B1 (pt)
EP (1) EP1000167B2 (pt)
JP (1) JP2001511341A (pt)
KR (1) KR100512018B1 (pt)
CN (2) CN1265152A (pt)
AR (2) AR013251A1 (pt)
AT (1) ATE313643T1 (pt)
AU (1) AU729489B2 (pt)
BR (1) BR9811531A (pt)
CA (1) CA2297660C (pt)
DE (1) DE59813296D1 (pt)
DK (1) DK1000167T4 (pt)
ES (1) ES2255177T5 (pt)
PT (1) PT1000167E (pt)
TR (1) TR200000172T2 (pt)
WO (1) WO1999005264A2 (pt)
ZA (1) ZA986517B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017118726A1 (en) * 2016-01-06 2017-07-13 Lonza Ltd Inhibition of protein degradation for improved production

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234686A (en) * 1985-04-03 1993-08-10 Beecham Group P.L.C. Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
DE3907679A1 (de) * 1989-03-09 1990-09-13 Max Planck Gesellschaft Verfahren zur gezielten veraenderung eines gens
JPH0576361A (ja) * 1990-05-10 1993-03-30 Takeda Chem Ind Ltd 組織プラスミノーゲンアクチベータームテイン
ATE352612T1 (de) * 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
AU664847B2 (en) 1991-05-15 1995-12-07 Cell Genesys, Inc. Genomic modifications with homologous DNA targeting
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
AU4115693A (en) * 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
EP0656747A4 (en) * 1992-08-21 1997-05-07 Univ California COMPOSITION AND METHOD FOR CHANGING DNA SEQUENCES BY HOMOLOGOUS RECOMBINATION.
TW402639B (en) * 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
CN1256986C (zh) * 1993-12-02 2006-05-24 转移染色体治疗公司 蛋白质的生产和蛋白质的输送
WO1996040271A1 (en) * 1995-06-07 1996-12-19 Yale University Treatment of hemoglobinopathies
US6087129A (en) * 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines

Also Published As

Publication number Publication date
CN1265152A (zh) 2000-08-30
EP1000167B1 (de) 2005-12-21
US20020068318A1 (en) 2002-06-06
TR200000172T2 (tr) 2000-12-21
ES2255177T3 (es) 2006-06-16
CN101348789A (zh) 2009-01-21
CN101348789B (zh) 2016-08-17
BR9811531A (pt) 2000-08-22
AR068104A2 (es) 2009-11-04
DE59813296D1 (de) 2006-01-26
EP1000167A2 (de) 2000-05-17
PT1000167E (pt) 2006-05-31
KR100512018B1 (ko) 2005-09-02
JP2001511341A (ja) 2001-08-14
KR20010022127A (ko) 2001-03-15
CA2297660C (en) 2010-04-27
AU729489B2 (en) 2001-02-01
ES2255177T5 (es) 2011-07-12
US6444441B1 (en) 2002-09-03
DK1000167T3 (da) 2006-04-24
WO1999005264A3 (de) 1999-04-22
CA2297660A1 (en) 1999-02-04
WO1999005264A2 (de) 1999-02-04
EP1000167B2 (de) 2011-04-20
ATE313643T1 (de) 2006-01-15
AU9067398A (en) 1999-02-16
DK1000167T4 (da) 2011-08-08
AR013251A1 (es) 2000-12-13
US20020177195A1 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
GB2323700B (en) Electrochemical cells
EP1012590A4 (en) IMPROVED ELECTROCHEMICAL CELL
AU4095999A (en) Cell cycle genes, proteins and uses thereof
ZA9810506B (en) Solid electrolyte ionic conductor with adjustable steam-to-oxygen production
EP0977771A4 (en) SEQUENCE CHANGE BY HOMOLOGOUS RECOMBINATION
IL133494A0 (en) Isolated dendritic cell membrane protein genes
AU1618500A (en) Human cell surface receptor proteins
IL125566A0 (en) Improved chlor-alkali electrolysis cell
ZA986517B (en) Production of human mutated proteins in human cells by means of homologous recombination.
GB9502830D0 (en) Regulation of polypeptide production in cells
AU3478599A (en) Cell cycle regulatory proteins
HK1025125A1 (en) The neurotrophic factor nnt-1.
AU8848998A (en) Insect sequences for improving the efficiency of secretion of non-secreted proteins in eukaryotic cells
AU5483799A (en) Homologous recombination in plants
AU2822999A (en) Protein expression in floral cells
GB9605515D0 (en) Improvements in or relating to cell stimulation
AU2612000A (en) Methods for producing polypeptides in cyclohexadepsipeptide-deficient cells
IL145056A0 (en) Expression of human alpha-fetoprotein in mammalian cells
AU2591199A (en) Cell cycle related proteins
AU4414397A (en) Novel human cell division cycle proteins
AU4955499A (en) Cell cycle regulation proteins
AU2438097A (en) Human natural killer cell activating factor ii
GB9702802D0 (en) Yeast artificial chromosomes
AU3368399A (en) Human rad17 cell cycle checkpoint
ZA200007678B (en) Method of making proteins in transformed yeast cells.