ZA985207B - Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds - Google Patents

Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Info

Publication number
ZA985207B
ZA985207B ZA985207A ZA985207A ZA985207B ZA 985207 B ZA985207 B ZA 985207B ZA 985207 A ZA985207 A ZA 985207A ZA 985207 A ZA985207 A ZA 985207A ZA 985207 B ZA985207 B ZA 985207B
Authority
ZA
South Africa
Prior art keywords
synthesis
intermediates useful
tricyclic compounds
substituted tricyclic
preparing bromo
Prior art date
Application number
ZA985207A
Other languages
English (en)
Inventor
Xing Chen
Marc Poirier
Yee-Shing Wong
Guang-Zhong Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA985207B publication Critical patent/ZA985207B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA985207A 1997-06-16 1998-06-15 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds ZA985207B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/882,753 US5760232A (en) 1997-06-16 1997-06-16 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Publications (1)

Publication Number Publication Date
ZA985207B true ZA985207B (en) 1999-04-07

Family

ID=25381267

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA985207A ZA985207B (en) 1997-06-16 1998-06-15 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Country Status (15)

Country Link
US (1) US5760232A (es)
EP (1) EP0991640B1 (es)
JP (1) JP3210023B2 (es)
AR (1) AR015886A1 (es)
AT (1) ATE214062T1 (es)
AU (1) AU8056898A (es)
CA (1) CA2293709C (es)
DE (1) DE69804100T2 (es)
DK (1) DK0991640T3 (es)
ES (1) ES2169917T3 (es)
IN (1) IN187755B (es)
MY (1) MY133531A (es)
PT (1) PT991640E (es)
WO (1) WO1998057958A1 (es)
ZA (1) ZA985207B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
CN100404510C (zh) 2002-10-03 2008-07-23 先灵公司 三环化合物的对映选择性烷基化
EP2797597B1 (en) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
SG11201403645VA (en) 2011-12-28 2014-07-30 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
AU2014237340C1 (en) 2013-03-15 2018-11-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA033555B1 (ru) 2013-03-15 2019-10-31 Global Blood Therapeutics Inc Фармацевтические композиции для лечения серповидно-клеточного нарушения
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CA2902711C (en) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
WO2017096230A1 (en) 2015-12-04 2017-06-08 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI825524B (zh) 2016-05-12 2023-12-11 美商全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
ES2966707T3 (es) 2018-10-01 2024-04-23 Global Blood Therapeutics Inc Moduladores de la hemoglobina para el tratamiento de la drepanocitosis
CN112341433A (zh) * 2020-11-16 2021-02-09 成都大学 一种氯雷他定的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
WO1997023478A1 (en) * 1995-12-22 1997-07-03 Schering Corporation Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
JP3210023B2 (ja) 2001-09-17
PT991640E (pt) 2002-07-31
EP0991640B1 (en) 2002-03-06
EP0991640A1 (en) 2000-04-12
JP2000513032A (ja) 2000-10-03
WO1998057958A1 (en) 1998-12-23
ATE214062T1 (de) 2002-03-15
IN187755B (es) 2002-06-15
CA2293709C (en) 2004-02-10
DE69804100T2 (de) 2002-10-31
US5760232A (en) 1998-06-02
CA2293709A1 (en) 1998-12-23
DE69804100D1 (de) 2002-04-11
AR015886A1 (es) 2001-05-30
AU8056898A (en) 1999-01-04
MY133531A (en) 2007-11-30
ES2169917T3 (es) 2002-07-16
DK0991640T3 (da) 2002-05-27

Similar Documents

Publication Publication Date Title
ZA985207B (en) Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
ZA9811314B (en) Novel compounds and methods for synthesis and therapy
AU8589698A (en) Selective synthesis of organodiphosphite compounds
IL136489A0 (en) Synthesis of cc-1065/duocarmycin analogs
ZA979264B (en) Synthesis of large crystal zeolites
IL126272A0 (en) Synthesis of indolylmaleimides
PL335443A1 (en) Method of obtaining intermediate compounds for use in synthesis of pesticides
IL128376A0 (en) Synthesis of bisindolylmalimides
IL125637A0 (en) Synthesis of carboxyalkylthiosuccinic acids
GB9621522D0 (en) Synthesis of phosphorus compounds
ZA982453B (en) Synthesis of intermediates useful in preparing tricyclic compounds
NZ298241A (en) Preparation of intermediates in the synthesis of cephalosporins
HU9700667D0 (en) Process for producing intermediates for the synthesis of iodinated kontrast materials
HK1027807A1 (en) Process for the synthesis of chloropurine intermediates
HK1038698A1 (zh) 合成有效製備三環化合物的中間體
GB9727123D0 (en) Synthesis of diamines
EP0923519A4 (en) PRODUCTION OF HALOALKYNOLS
IL122213A0 (en) Synthesis of deoxypyridinoline
IL137918A0 (en) Solid support synthesis of 2-oxopiperazines
IL118238A0 (en) Synthesis of benzoquinolinones
GB2393957B (en) Synthesis of hexaazaisowurtzitane derivatives
EP0885231A4 (en) TITANOCENSYNTHESIS
IL137917A0 (en) Solid phase synthesis of 1-aminohydantoins
LT99070A (en) Asymmetric synthesis of benzoxazones
PL336261A1 (en) Dissymmetrical synthesis of benzoxazinones through novel intermediate compounds