ZA983553B - Adenovirus-mediated intratumoral delivery of an angio-genesis antagonist inhibits tumor growth and metastasis by targeting angiogenesis - Google Patents

Adenovirus-mediated intratumoral delivery of an angio-genesis antagonist inhibits tumor growth and metastasis by targeting angiogenesis

Info

Publication number
ZA983553B
ZA983553B ZA983553A ZA983553A ZA983553B ZA 983553 B ZA983553 B ZA 983553B ZA 983553 A ZA983553 A ZA 983553A ZA 983553 A ZA983553 A ZA 983553A ZA 983553 B ZA983553 B ZA 983553B
Authority
ZA
South Africa
Prior art keywords
angio
genesis
adenovirus
metastasis
tumor growth
Prior art date
Application number
ZA983553A
Other languages
English (en)
Inventor
Hong Li
Yves Legrand
He Lu
Jeannette Soria
Franc Griscelli
Christelle Mabilat
Paule Opolon
Michel Perricaudet
Claudine Soria
Patrice Yeh
Thierry Ragot
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA983553B publication Critical patent/ZA983553B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
ZA983553A 1997-04-28 1998-04-28 Adenovirus-mediated intratumoral delivery of an angio-genesis antagonist inhibits tumor growth and metastasis by targeting angiogenesis ZA983553B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4498097P 1997-04-28 1997-04-28

Publications (1)

Publication Number Publication Date
ZA983553B true ZA983553B (en) 1999-02-04

Family

ID=21935358

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983553A ZA983553B (en) 1997-04-28 1998-04-28 Adenovirus-mediated intratumoral delivery of an angio-genesis antagonist inhibits tumor growth and metastasis by targeting angiogenesis

Country Status (14)

Country Link
US (2) US6638502B1 (fr)
EP (1) EP0979290A2 (fr)
JP (1) JP2001523103A (fr)
KR (1) KR20010020342A (fr)
CN (1) CN1177934C (fr)
AU (1) AU753781B2 (fr)
BR (1) BR9808697A (fr)
CA (1) CA2288306A1 (fr)
HU (1) HUP0002922A3 (fr)
IL (1) IL132323A0 (fr)
NO (1) NO995242L (fr)
PL (1) PL336523A1 (fr)
WO (1) WO1998049321A2 (fr)
ZA (1) ZA983553B (fr)

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CN1958075A (zh) * 2006-11-27 2007-05-09 林李家宓 含腺伴随病毒介导的抗血管生成因子的组合物及其应用
AU2008244523B2 (en) 2007-04-23 2012-02-16 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
EP2240155B1 (fr) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Dispositifs, formulations et méthodes d administration de plusieurs agents bénéfiques
SI2462246T1 (en) 2009-09-28 2018-01-31 Intarcia Therapeutics, Inc. Fast-setting and / or cessation of substantially unchanged delivery of the product
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Also Published As

Publication number Publication date
WO1998049321A3 (fr) 1999-02-25
HUP0002922A3 (en) 2003-03-28
CN1254378A (zh) 2000-05-24
WO1998049321A8 (fr) 1999-04-08
EP0979290A2 (fr) 2000-02-16
CA2288306A1 (fr) 1998-11-05
HUP0002922A2 (hu) 2000-12-28
NO995242L (no) 1999-12-27
US6638502B1 (en) 2003-10-28
CN1177934C (zh) 2004-12-01
AU7909698A (en) 1998-11-24
PL336523A1 (en) 2000-07-03
KR20010020342A (ko) 2001-03-15
BR9808697A (pt) 2000-07-11
US20040265273A1 (en) 2004-12-30
WO1998049321A2 (fr) 1998-11-05
IL132323A0 (en) 2001-03-19
AU753781B2 (en) 2002-10-31
JP2001523103A (ja) 2001-11-20
NO995242D0 (no) 1999-10-27

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