ZA967706B - 2-[2-[/2-hydroxethyl)amino]ethyl]-5-[[2-methylamino)-ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as anti-tumor agent - Google Patents

2-[2-[/2-hydroxethyl)amino]ethyl]-5-[[2-methylamino)-ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as anti-tumor agent

Info

Publication number
ZA967706B
ZA967706B ZA967706A ZA967706A ZA967706B ZA 967706 B ZA967706 B ZA 967706B ZA 967706 A ZA967706 A ZA 967706A ZA 967706 A ZA967706 A ZA 967706A ZA 967706 B ZA967706 B ZA 967706B
Authority
ZA
South Africa
Prior art keywords
ethyl
amino
indazolo
hydroxethyl
isoquinolin
Prior art date
Application number
ZA967706A
Other languages
English (en)
Inventor
Ernesto Menta
Ambrogio Oliva
Silvano Spinelli
Paul Krapcho
Original Assignee
Boehringer Mannheim Italia
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia, Univ Vermont filed Critical Boehringer Mannheim Italia
Publication of ZA967706B publication Critical patent/ZA967706B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA967706A 1995-09-13 1996-09-12 2-[2-[/2-hydroxethyl)amino]ethyl]-5-[[2-methylamino)-ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as anti-tumor agent ZA967706B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale

Publications (1)

Publication Number Publication Date
ZA967706B true ZA967706B (en) 1997-03-25

Family

ID=11372237

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA967706A ZA967706B (en) 1995-09-13 1996-09-12 2-[2-[/2-hydroxethyl)amino]ethyl]-5-[[2-methylamino)-ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as anti-tumor agent

Country Status (15)

Country Link
US (1) US6034092A (es)
EP (1) EP0876369A1 (es)
JP (1) JPH11512409A (es)
KR (1) KR19990044614A (es)
CN (1) CN1196055A (es)
AR (1) AR003997A1 (es)
AU (1) AU6988296A (es)
BR (1) BR9610601A (es)
CZ (1) CZ286654B6 (es)
HU (1) HUP9901348A3 (es)
IL (1) IL123619A0 (es)
IT (1) IT1277576B1 (es)
NO (1) NO981093D0 (es)
WO (1) WO1997010245A1 (es)
ZA (1) ZA967706B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747039B2 (en) * 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CA2596144A1 (en) * 2005-01-28 2006-08-03 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory and demyelinating diseases
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69211A (en) * 1982-07-23 1987-01-30 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
CZ288366B6 (en) * 1992-09-08 2001-06-13 Univ Vermont 2-Aminoalkyl-5-aminoalkylamino substituted isoquinoindazol-6-(2H)-ones exhibiting antitumor activity, their use, pharmaceutical preparation in which they are comprised and process of their preparation
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles

Also Published As

Publication number Publication date
CZ75098A3 (cs) 1998-07-15
IT1277576B1 (it) 1997-11-11
ITMI951904A0 (it) 1995-09-13
HUP9901348A3 (en) 2000-03-28
NO981093L (no) 1998-03-12
AR003997A1 (es) 1998-09-30
JPH11512409A (ja) 1999-10-26
HUP9901348A2 (hu) 1999-08-30
NO981093D0 (no) 1998-03-12
IL123619A0 (en) 1998-10-30
EP0876369A1 (en) 1998-11-11
CN1196055A (zh) 1998-10-14
BR9610601A (pt) 1999-12-21
WO1997010245A1 (en) 1997-03-20
ITMI951904A1 (it) 1997-03-13
CZ286654B6 (cs) 2000-05-17
US6034092A (en) 2000-03-07
KR19990044614A (ko) 1999-06-25
AU6988296A (en) 1997-04-01

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