ZA956636B - Human interleukin 6 inhibitor - Google Patents

Human interleukin 6 inhibitor

Info

Publication number
ZA956636B
ZA956636B ZA956636A ZA956636A ZA956636B ZA 956636 B ZA956636 B ZA 956636B ZA 956636 A ZA956636 A ZA 956636A ZA 956636 A ZA956636 A ZA 956636A ZA 956636 B ZA956636 B ZA 956636B
Authority
ZA
South Africa
Prior art keywords
inhibitor
supernatant
activity
protein
cell line
Prior art date
Application number
ZA956636A
Other languages
English (en)
Inventor
Delia E Penza
Susan K Faris
Kenneth J Lembach
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA956636B publication Critical patent/ZA956636B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA956636A 1994-08-10 1995-08-08 Human interleukin 6 inhibitor ZA956636B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/288,516 US5527546A (en) 1994-08-10 1994-08-10 Human interleukin 6 inhibitor

Publications (1)

Publication Number Publication Date
ZA956636B true ZA956636B (en) 1996-03-19

Family

ID=23107451

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA956636A ZA956636B (en) 1994-08-10 1995-08-08 Human interleukin 6 inhibitor

Country Status (13)

Country Link
US (1) US5527546A (xx)
EP (1) EP0696594B1 (xx)
JP (1) JPH08169840A (xx)
KR (1) KR100424553B1 (xx)
CN (1) CN1157407C (xx)
AT (1) ATE224914T1 (xx)
AU (1) AU684968B2 (xx)
CA (1) CA2155629A1 (xx)
DE (1) DE69528325T2 (xx)
ES (1) ES2183846T3 (xx)
IL (1) IL114876A (xx)
TW (1) TW438808B (xx)
ZA (1) ZA956636B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0515494A1 (en) * 1990-02-15 1992-12-02 Chiron Corporation Use of inhibitor of cytokine activity
US5527546A (en) * 1994-08-10 1996-06-18 Bayer Corporation Human interleukin 6 inhibitor
WO1996040966A1 (en) * 1995-06-07 1996-12-19 Private Biologicals Corporation Compositions and methods of treating il-6 associated diseases
US20030232813A1 (en) * 2002-04-10 2003-12-18 Orchid Chemicals & Pharmaceuticals Limited Novel amino substituted pyrimidinone derivatives
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7087576B2 (en) * 2003-10-07 2006-08-08 Bexel Pharmaceuticals, Inc. Dipeptide phenyl ethers
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
JP2008533122A (ja) * 2005-03-18 2008-08-21 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド 新規なチロシン誘導体
US20080267888A1 (en) * 2005-05-26 2008-10-30 Pandey Surendrakumar Satyanara Heterocyclic Derivatives
WO2007000655A2 (en) * 2005-06-28 2007-01-04 Orchid Research Laboratories Limited Novel pyrazolopyrimidinone derivatives
US7863446B2 (en) * 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
WO2007083182A2 (en) * 2006-01-19 2007-07-26 Orchid Research Laboratories Limited Novel heterocycles
US20080221103A1 (en) * 2007-03-09 2008-09-11 Orchid Research Laboratories Ltd. New heterocyclic compounds
JP5704924B2 (ja) 2008-02-01 2015-04-22 オーキッド リサーチ ラボラトリーズ リミティド 新規複素環化合物
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
JP6889458B2 (ja) * 2016-08-05 2021-06-18 学校法人中部大学 細胞増殖抑制剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910955A1 (en) * 1990-03-23 1991-09-25 Yamanouchi Europ Bv Il-6 inhibiting compositions
US5527546A (en) * 1994-08-10 1996-06-18 Bayer Corporation Human interleukin 6 inhibitor

Also Published As

Publication number Publication date
TW438808B (en) 2001-06-07
KR960006937A (ko) 1996-03-22
IL114876A0 (en) 1995-12-08
ATE224914T1 (de) 2002-10-15
KR100424553B1 (ko) 2004-07-01
CN1136043A (zh) 1996-11-20
ES2183846T3 (es) 2003-04-01
AU684968B2 (en) 1998-01-08
AU2838995A (en) 1996-02-22
US5527546A (en) 1996-06-18
JPH08169840A (ja) 1996-07-02
EP0696594A1 (en) 1996-02-14
CA2155629A1 (en) 1996-02-11
CN1157407C (zh) 2004-07-14
DE69528325D1 (de) 2002-10-31
EP0696594B1 (en) 2002-09-25
IL114876A (en) 2000-06-01
DE69528325T2 (de) 2003-01-23

Similar Documents

Publication Publication Date Title
IL114876A0 (en) Interleukin 6 inhibitor
WO1999012968A3 (en) Chemokine peptides, variants, derivatives and analogs, their use in methods to inhibit or augment an inflammatory response
IL79957A (en) Purification and activation of proteins from insoluble inclusion bodies
FR2640685B1 (fr) Vanne de decharge de compresseur de turboreacteur
AU3228789A (en) Biologically active proteins
CA2190373A1 (en) Yeast strains
AU5267986A (en) Variable capacity wobble-plate compressor
EP0218531A3 (en) Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies
AU1139992A (en) Natural and synthetic proteins with inhibitory activity towards pathogenic microorganisms
AU4218389A (en) Peptide compounds
DE3569112D1 (en) 4,5-dihydro-4-oxo-2- û(2-trans-phenylcyclopropyl)amino¨-3-furancarboxylic acids and derivatives thereof
AU576942B2 (en) Pulsation reduction in compressor
AU577446B2 (en) Compressor valve plate
AU576059B2 (en) Pulsation reduction in compressor
AU3320989A (en) Expression of human interleukin-2 in methylotrophic yeasts
EP0723016A3 (en) Leukocyte activation factor
ATE146526T1 (de) Neues thrombininhibitorisches protein aus zecken
AU8585791A (en) Human ifn-beta 2/il-6, its purification and use
AU2696395A (en) A purified 80 kda protein implicated in abdominal aortic aneurysms, antibodies directed thereto, and uses thereof
AU7095796A (en) Neutrophil chemotactic lymphokine, and drug and kit for the diagnosis of drug hypersensitive granulocytopenia containing the same
AU5939994A (en) Linear peptides and uses thereof
PL272501A1 (en) Membrane valve
PL270142A1 (en) Membrane valve
BR6700725U (pt) Disposicao construtiva em valvula de descarga
AU6033690A (en) Monocyte chemotactic proteins and related peptides