IL114876A - Purified interleukin 6 inhibitor and a method for its preparation - Google Patents

Purified interleukin 6 inhibitor and a method for its preparation

Info

Publication number
IL114876A
IL114876A IL11487695A IL11487695A IL114876A IL 114876 A IL114876 A IL 114876A IL 11487695 A IL11487695 A IL 11487695A IL 11487695 A IL11487695 A IL 11487695A IL 114876 A IL114876 A IL 114876A
Authority
IL
Israel
Prior art keywords
inhibitor
supernatant
activity
protein
cell line
Prior art date
Application number
IL11487695A
Other languages
English (en)
Other versions
IL114876A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL114876A0 publication Critical patent/IL114876A0/xx
Publication of IL114876A publication Critical patent/IL114876A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL11487695A 1994-08-10 1995-08-09 Purified interleukin 6 inhibitor and a method for its preparation IL114876A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/288,516 US5527546A (en) 1994-08-10 1994-08-10 Human interleukin 6 inhibitor

Publications (2)

Publication Number Publication Date
IL114876A0 IL114876A0 (en) 1995-12-08
IL114876A true IL114876A (en) 2000-06-01

Family

ID=23107451

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11487695A IL114876A (en) 1994-08-10 1995-08-09 Purified interleukin 6 inhibitor and a method for its preparation

Country Status (13)

Country Link
US (1) US5527546A (xx)
EP (1) EP0696594B1 (xx)
JP (1) JPH08169840A (xx)
KR (1) KR100424553B1 (xx)
CN (1) CN1157407C (xx)
AT (1) ATE224914T1 (xx)
AU (1) AU684968B2 (xx)
CA (1) CA2155629A1 (xx)
DE (1) DE69528325T2 (xx)
ES (1) ES2183846T3 (xx)
IL (1) IL114876A (xx)
TW (1) TW438808B (xx)
ZA (1) ZA956636B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012334A1 (en) * 1990-02-15 1991-08-22 Cetus Corporation Inhibitor of cytokine activity and applications thereof
US5527546A (en) * 1994-08-10 1996-06-18 Bayer Corporation Human interleukin 6 inhibitor
WO1996040966A1 (en) * 1995-06-07 1996-12-19 Private Biologicals Corporation Compositions and methods of treating il-6 associated diseases
AU2003216591A1 (en) * 2002-04-10 2003-10-20 Orichid Chemicals And Pharmaceuticals Limited Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
US7087576B2 (en) * 2003-10-07 2006-08-08 Bexel Pharmaceuticals, Inc. Dipeptide phenyl ethers
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
US20080319031A1 (en) * 2005-03-18 2008-12-25 Orchid Chemicals & Pharmaceuticals Limited Novel Tyrosine Derivatives
WO2006126074A2 (en) * 2005-05-26 2006-11-30 Orchid Research Laboratories Limited Heterocyclic derivatives
WO2007000655A2 (en) * 2005-06-28 2007-01-04 Orchid Research Laboratories Limited Novel pyrazolopyrimidinone derivatives
BRPI0621226A2 (pt) * 2006-01-19 2012-07-10 Orchid Reseach Lab Ltd compostos heterociclos
US7863446B2 (en) * 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
US20080221103A1 (en) * 2007-03-09 2008-09-11 Orchid Research Laboratories Ltd. New heterocyclic compounds
BRPI0912029A2 (pt) 2008-02-01 2020-06-30 Orchid Research Laboratories Limited novos heterociclos
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
JP6889458B2 (ja) * 2016-08-05 2021-06-18 学校法人中部大学 細胞増殖抑制剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910955A1 (en) * 1990-03-23 1991-09-25 Yamanouchi Europ Bv Il-6 inhibiting compositions
US5527546A (en) * 1994-08-10 1996-06-18 Bayer Corporation Human interleukin 6 inhibitor

Also Published As

Publication number Publication date
KR960006937A (ko) 1996-03-22
TW438808B (en) 2001-06-07
CN1136043A (zh) 1996-11-20
KR100424553B1 (ko) 2004-07-01
DE69528325T2 (de) 2003-01-23
AU2838995A (en) 1996-02-22
AU684968B2 (en) 1998-01-08
DE69528325D1 (de) 2002-10-31
CN1157407C (zh) 2004-07-14
ZA956636B (en) 1996-03-19
US5527546A (en) 1996-06-18
ES2183846T3 (es) 2003-04-01
JPH08169840A (ja) 1996-07-02
ATE224914T1 (de) 2002-10-15
CA2155629A1 (en) 1996-02-11
EP0696594A1 (en) 1996-02-14
EP0696594B1 (en) 2002-09-25
IL114876A0 (en) 1995-12-08

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees