ZA954430B - Novel elastase inhibitors - Google Patents

Novel elastase inhibitors

Info

Publication number
ZA954430B
ZA954430B ZA954430A ZA954430A ZA954430B ZA 954430 B ZA954430 B ZA 954430B ZA 954430 A ZA954430 A ZA 954430A ZA 954430 A ZA954430 A ZA 954430A ZA 954430 B ZA954430 B ZA 954430B
Authority
ZA
South Africa
Prior art keywords
inhibitors
elastase inhibitors
elastase
compounds
novel elastase
Prior art date
Application number
ZA954430A
Other languages
English (en)
Inventor
William Arthur Metz Jr
Steven Lee Gallion
Joseph Paul Burkhart
Michael Richard Angelastro
Norton Paul Peet
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Publication of ZA954430B publication Critical patent/ZA954430B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA954430A 1994-06-02 1995-05-30 Novel elastase inhibitors ZA954430B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25279994A 1994-06-02 1994-06-02

Publications (1)

Publication Number Publication Date
ZA954430B true ZA954430B (en) 1996-02-13

Family

ID=22957608

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954430A ZA954430B (en) 1994-06-02 1995-05-30 Novel elastase inhibitors

Country Status (20)

Country Link
EP (1) EP0804465B1 (fr)
JP (1) JP3623799B2 (fr)
KR (1) KR100347285B1 (fr)
CN (1) CN1149877A (fr)
AT (1) ATE246708T1 (fr)
AU (1) AU689589B2 (fr)
CA (1) CA2189527C (fr)
DE (1) DE69531459T2 (fr)
DK (1) DK0804465T3 (fr)
ES (1) ES2199992T3 (fr)
FI (1) FI964781A (fr)
HU (1) HU221197B1 (fr)
IL (1) IL113940A (fr)
NO (1) NO965097L (fr)
NZ (1) NZ285565A (fr)
PT (1) PT804465E (fr)
SI (1) SI0804465T1 (fr)
TW (1) TW403762B (fr)
WO (1) WO1995033763A1 (fr)
ZA (1) ZA954430B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9606034A (es) * 1994-06-02 1998-05-31 Merrell Pharma Inc Derivados enolicos acilados como profarmacos de inhibidores de elastasa.
ATE186305T1 (de) * 1994-06-02 1999-11-15 Merrell Pharma Inc Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6767991B1 (en) 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
DK1654261T3 (da) 2003-05-21 2008-01-14 Boehringer Ingelheim Int Hepatitis C-inhibitorforbindelser
ATE512971T1 (de) 2004-07-20 2011-07-15 Boehringer Ingelheim Int Peptidanaloga als hepatitis c-hemmer
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
BRPI0712021A2 (pt) 2006-05-23 2012-01-03 Irm Llc composto e composiÇÕes como inibidores da protease ativadora de canal
EP2117537A1 (fr) * 2007-02-09 2009-11-18 Irm Llc Composés et compositions servant d'inhibiteurs de protéase d'activation de canaux
KR20220079527A (ko) 2019-09-17 2022-06-13 메레오 바이오파마 4 리미티드 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
CA3234399A1 (fr) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Inhibiteurs de l'elastase neutrophile utilises dans le traitement de la fibrose

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
ATE71934T1 (de) * 1985-06-07 1992-02-15 Ici America Inc Selektionierte difluorverbindungen.
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
CA2098702A1 (fr) * 1990-12-28 1992-06-29 James C. Powers Cetoamides, cetoacides et cetoesters de nature peptidique
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.

Also Published As

Publication number Publication date
KR100347285B1 (ko) 2003-01-15
IL113940A (en) 1999-12-31
ATE246708T1 (de) 2003-08-15
PT804465E (pt) 2003-12-31
SI0804465T1 (en) 2003-12-31
JP3623799B2 (ja) 2005-02-23
FI964781A (fi) 1997-01-29
CN1149877A (zh) 1997-05-14
NO965097L (no) 1997-01-31
AU2470995A (en) 1996-01-04
WO1995033763A1 (fr) 1995-12-14
JPH10500992A (ja) 1998-01-27
DE69531459T2 (de) 2004-06-24
HU221197B1 (en) 2002-08-28
DK0804465T3 (da) 2003-11-24
CA2189527C (fr) 2000-12-19
HU9603312D0 (en) 1997-01-28
MX9606030A (es) 1998-05-31
EP0804465B1 (fr) 2003-08-06
ES2199992T3 (es) 2004-03-01
TW403762B (en) 2000-09-01
AU689589B2 (en) 1998-04-02
NO965097D0 (no) 1996-11-29
HUT76926A (hu) 1998-01-28
NZ285565A (en) 1998-08-26
EP0804465A1 (fr) 1997-11-05
CA2189527A1 (fr) 1995-12-14
FI964781A0 (fi) 1996-11-29
IL113940A0 (en) 1995-08-31
DE69531459D1 (de) 2003-09-11

Similar Documents

Publication Publication Date Title
BG105784A (en) Triazole compounds with dopamine-d3-receptor affinity
MX9706069A (es) Nuevos inhibidores de la trombina.
BG101112A (en) The use of heterocyclic compounds
PT695758E (pt) Amidas e esteres de pentapeptidos inibidores de cancro humano
GR3034208T3 (en) Human neutrophil elastase inhibitors
CA2189526A1 (fr) Inhibiteurs d'elastase au perfluoroalkyle cetone et procedes de production associes
IL138665A0 (en) Peptide factor
YU60900A (sh) Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja
ZA954430B (en) Novel elastase inhibitors
AP2000001761A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
GR3018304T3 (en) Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones.
PT971922E (pt) Compostos de tetra-hidropirido
NZ330944A (en) Peptide derivatives
DE69726743D1 (de) Peptid analoge, die einen siebengliedrigen lactamring enthalten
MX9704796A (es) Peptidos novedosos, su preparacion y uso.
PE61999A1 (es) Compuestos de tetrahidropiridina