IL113940A - Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors - Google Patents

Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors

Info

Publication number
IL113940A
IL113940A IL11394095A IL11394095A IL113940A IL 113940 A IL113940 A IL 113940A IL 11394095 A IL11394095 A IL 11394095A IL 11394095 A IL11394095 A IL 11394095A IL 113940 A IL113940 A IL 113940A
Authority
IL
Israel
Prior art keywords
inhibitors
treatment
inflammatory disease
synthetic peptides
elastase
Prior art date
Application number
IL11394095A
Other languages
English (en)
Other versions
IL113940A0 (en
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Publication of IL113940A0 publication Critical patent/IL113940A0/xx
Publication of IL113940A publication Critical patent/IL113940A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11394095A 1994-06-02 1995-05-31 Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors IL113940A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25279994A 1994-06-02 1994-06-02

Publications (2)

Publication Number Publication Date
IL113940A0 IL113940A0 (en) 1995-08-31
IL113940A true IL113940A (en) 1999-12-31

Family

ID=22957608

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11394095A IL113940A (en) 1994-06-02 1995-05-31 Synthetic peptides which are elastase inhibitors and pharmaceutical compositions for the treatment of neutrophil associated inflammatory disease containing said inhibitors

Country Status (20)

Country Link
EP (1) EP0804465B1 (fr)
JP (1) JP3623799B2 (fr)
KR (1) KR100347285B1 (fr)
CN (1) CN1149877A (fr)
AT (1) ATE246708T1 (fr)
AU (1) AU689589B2 (fr)
CA (1) CA2189527C (fr)
DE (1) DE69531459T2 (fr)
DK (1) DK0804465T3 (fr)
ES (1) ES2199992T3 (fr)
FI (1) FI964781A (fr)
HU (1) HU221197B1 (fr)
IL (1) IL113940A (fr)
NO (1) NO965097L (fr)
NZ (1) NZ285565A (fr)
PT (1) PT804465E (fr)
SI (1) SI0804465T1 (fr)
TW (1) TW403762B (fr)
WO (1) WO1995033763A1 (fr)
ZA (1) ZA954430B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
CA2189526C (fr) * 1994-06-02 2001-02-27 William A. Metz, Jr. Inhibiteurs d'elastase au perfluoroalkyle cetone et procedes de production associes
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6767991B1 (en) 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
BRPI0410456B8 (pt) 2003-05-21 2021-05-25 Boehringer Ingelheim Int compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação
CA2573346C (fr) 2004-07-20 2011-09-20 Boehringer Ingelheim International Gmbh Analogues peptidiques inhibiteurs de l'hepatite c
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
RU2419626C2 (ru) 2006-05-23 2011-05-27 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
EA016327B1 (ru) * 2007-02-09 2012-04-30 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
EP4031138A1 (fr) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvélestat destiné à être utilisé dans le traitement du rejet de greffe, du syndrome de bronchiolite oblitérante et de la maladie du greffon contre l'hôte
MX2022012942A (es) 2020-04-16 2023-01-11 Mereo Biopharma 4 Ltd Metodos que involucran el inhibidor de la elastasa de neutrofilo alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina.
IL312002A (en) 2021-10-20 2024-06-01 Mereo Biopharma 4 Ltd Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0204571B1 (fr) * 1985-06-07 1992-01-22 Ici Americas Inc. Dérivés difluoro choisis
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
EP0564561A4 (en) * 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
ZA926185B (en) * 1991-08-22 1993-03-01 Merrell Dow Pharma Novel orally-active elastase inhibitors.

Also Published As

Publication number Publication date
EP0804465B1 (fr) 2003-08-06
AU689589B2 (en) 1998-04-02
DE69531459D1 (de) 2003-09-11
CA2189527A1 (fr) 1995-12-14
AU2470995A (en) 1996-01-04
NO965097L (no) 1997-01-31
FI964781A (fi) 1997-01-29
NZ285565A (en) 1998-08-26
WO1995033763A1 (fr) 1995-12-14
EP0804465A1 (fr) 1997-11-05
FI964781A0 (fi) 1996-11-29
KR100347285B1 (ko) 2003-01-15
DE69531459T2 (de) 2004-06-24
ATE246708T1 (de) 2003-08-15
CN1149877A (zh) 1997-05-14
JPH10500992A (ja) 1998-01-27
SI0804465T1 (en) 2003-12-31
HU221197B1 (en) 2002-08-28
DK0804465T3 (da) 2003-11-24
HU9603312D0 (en) 1997-01-28
PT804465E (pt) 2003-12-31
CA2189527C (fr) 2000-12-19
MX9606030A (es) 1998-05-31
TW403762B (en) 2000-09-01
JP3623799B2 (ja) 2005-02-23
ZA954430B (en) 1996-02-13
ES2199992T3 (es) 2004-03-01
HUT76926A (hu) 1998-01-28
IL113940A0 (en) 1995-08-31
NO965097D0 (no) 1996-11-29

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees