ZA954306B - Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1h-indole-3-carboxylic acid - Google Patents

Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1h-indole-3-carboxylic acid

Info

Publication number
ZA954306B
ZA954306B ZA954306A ZA954306A ZA954306B ZA 954306 B ZA954306 B ZA 954306B ZA 954306 A ZA954306 A ZA 954306A ZA 954306 A ZA954306 A ZA 954306A ZA 954306 B ZA954306 B ZA 954306B
Authority
ZA
South Africa
Prior art keywords
tetrazol
ylmethyl
indole
biphenyl
butyl
Prior art date
Application number
ZA954306A
Other languages
English (en)
Inventor
Robin Douglas Clark
Lee Allen Flippin
Stephen Russell Stabler
Lawrence Emerson Fisher
Michael Grant Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA954306B publication Critical patent/ZA954306B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
ZA954306A 1994-05-27 1995-05-26 Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1h-indole-3-carboxylic acid ZA954306B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/250,397 US5412102A (en) 1994-05-27 1994-05-27 Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid

Publications (1)

Publication Number Publication Date
ZA954306B true ZA954306B (en) 1996-11-26

Family

ID=22947567

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954306A ZA954306B (en) 1994-05-27 1995-05-26 Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1h-indole-3-carboxylic acid

Country Status (10)

Country Link
US (3) US5412102A (pt)
EP (1) EP0760815A1 (pt)
JP (1) JPH10501230A (pt)
CN (1) CN1070193C (pt)
AU (1) AU2643995A (pt)
BR (1) BR9507771A (pt)
CA (1) CA2191576A1 (pt)
IL (1) IL113876A (pt)
WO (1) WO1995032962A1 (pt)
ZA (1) ZA954306B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007234598B2 (en) * 2002-09-23 2010-03-04 Novartis Ag Process for the manufacture of Valsartan
GB0222056D0 (en) * 2002-09-23 2002-10-30 Novartis Ag Process for the manufacture of organic compounds
ITMI20032338A1 (it) * 2003-11-28 2005-05-29 Dinamite Dipharma S P A In Forma A Bbreviata Diph Composti feniltetrazolici.
CA2720312A1 (en) * 2004-01-30 2005-08-18 Euro-Celtique S.A. Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
JP4511550B2 (ja) 2004-09-02 2010-07-28 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの調製法
JP2007525504A (ja) * 2004-12-30 2007-09-06 テバ ファーマシューティカル インダストリーズ リミティド ２．５よりも高いｐＨでオルメサルタンメドキソミルを調製するための方法
KR20090108739A (ko) 2005-01-03 2009-10-16 테바 파마슈티컬 인더스트리즈 리미티드 불순물의 양이 감소된 올메사탄 메독소밀
AR070176A1 (es) 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
JP5705984B2 (ja) 2010-08-23 2015-04-22 ノバルティス アーゲー Ｎｅｐ阻害剤を製造するための中間体の調製方法
CN102432558B (zh) * 2011-11-10 2014-04-09 浙江天宇药业股份有限公司 一种合成厄贝沙坦及其中间体的方法
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
CN103554048A (zh) * 2013-10-23 2014-02-05 安徽省郎溪县联科实业有限公司 一种2-异丙苯基-5-苯基四氮唑的制备方法
EP3393470B1 (en) 2015-12-22 2021-01-20 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
LT3393655T (lt) 2015-12-22 2021-03-25 Zogenix International Limited Fenfluramino kompozicijos ir jų paruošimo būdai
US20180055789A1 (en) 2016-08-24 2018-03-01 Zogenix International Limited Formulation for inhibiting formation of 5-ht2b agonists and methods of using same
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
WO2019216919A1 (en) 2018-05-11 2019-11-14 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5093346A (en) * 1988-01-07 1992-03-03 E. I. Du Pont De Nemours And Company Substituted 1,2,4-triazole angiotensin II antagonists
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5053329A (en) * 1990-07-05 1991-10-01 Merck & Co., Inc. Process for preparation of novel angiotensin II antagonists
US5124335A (en) * 1991-01-30 1992-06-23 Merck & Co., Inc. Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists
AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5212195A (en) * 1992-05-13 1993-05-18 Syntex (U.S.A.) Inc. Substituted indole antagonists derivatives which are angiotensin II

Also Published As

Publication number Publication date
IL113876A (en) 2001-08-26
AU2643995A (en) 1995-12-21
BR9507771A (pt) 1997-08-19
CN1070193C (zh) 2001-08-29
CN1149293A (zh) 1997-05-07
US5527918A (en) 1996-06-18
CA2191576A1 (en) 1995-12-07
JPH10501230A (ja) 1998-02-03
US5412102A (en) 1995-05-02
US5446121A (en) 1995-08-29
IL113876A0 (en) 1995-08-31
EP0760815A1 (en) 1997-03-12
WO1995032962A1 (en) 1995-12-07

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