ZA952986B - Preparation process of ginkgolide B from ginkgolide C - Google Patents
Preparation process of ginkgolide B from ginkgolide CInfo
- Publication number
- ZA952986B ZA952986B ZA952986A ZA952986A ZA952986B ZA 952986 B ZA952986 B ZA 952986B ZA 952986 A ZA952986 A ZA 952986A ZA 952986 A ZA952986 A ZA 952986A ZA 952986 B ZA952986 B ZA 952986B
- Authority
- ZA
- South Africa
- Prior art keywords
- ginkgolide
- preparation process
- reacting
- sulphonyloxyginkgolide
- prepn
- Prior art date
Links
- SQOJOAFXDQDRGF-MMQTXUMRSA-N ginkgolide-b Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]21O SQOJOAFXDQDRGF-MMQTXUMRSA-N 0.000 title abstract 3
- SQOJOAFXDQDRGF-WJHVHIKBSA-N ginkgolide B Natural products O=C1[C@@H](C)[C@@]2(O)[C@@H]([C@H](O)[C@]34[C@@H]5OC(=O)[C@]23O[C@H]2OC(=O)[C@H](O)[C@@]42[C@H](C(C)(C)C)C5)O1 SQOJOAFXDQDRGF-WJHVHIKBSA-N 0.000 title abstract 2
- AMOGMTLMADGEOQ-FNZROXQESA-N Ginkgolide C Chemical compound O([C@H]1O2)C(=O)[C@H](O)C31[C@]14[C@@H](O)[C@@H]5OC(=O)[C@@H](C)[C@]5(O)[C@@]12C(=O)O[C@@H]4[C@@H](O)[C@H]3C(C)(C)C AMOGMTLMADGEOQ-FNZROXQESA-N 0.000 title 1
- AMOGMTLMADGEOQ-DPFZUGDXSA-N ginkgolide C Natural products O=C1[C@@H](C)[C@]2(O)[C@H]([C@H](O)[C@@]34[C@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]63[C@H](O)C(=O)O[C@H]6O[C@@]24C(=O)O5)O1 AMOGMTLMADGEOQ-DPFZUGDXSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 229930184727 ginkgolide Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9408044A GB9408044D0 (en) | 1994-04-22 | 1994-04-22 | Conversion of ginkgolide c to ginkgolide b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA952986B true ZA952986B (en) | 1995-12-21 |
Family
ID=10753985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA952986A ZA952986B (en) | 1994-04-22 | 1995-04-11 | Preparation process of ginkgolide B from ginkgolide C |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5599950A (de) |
| EP (1) | EP0680968B1 (de) |
| JP (1) | JP2992575B2 (de) |
| KR (1) | KR950032203A (de) |
| AT (1) | ATE189817T1 (de) |
| AU (1) | AU684338B2 (de) |
| CA (1) | CA2147423C (de) |
| DE (1) | DE69515077T2 (de) |
| DK (1) | DK0680968T3 (de) |
| DZ (1) | DZ1874A1 (de) |
| ES (1) | ES2144585T3 (de) |
| FI (1) | FI109907B (de) |
| FR (1) | FR2719046B1 (de) |
| GB (2) | GB9408044D0 (de) |
| IE (1) | IE80950B1 (de) |
| MY (1) | MY113056A (de) |
| NO (1) | NO310557B1 (de) |
| NZ (1) | NZ270925A (de) |
| OA (1) | OA10145A (de) |
| RU (1) | RU2145326C1 (de) |
| TN (1) | TNSN95041A1 (de) |
| TW (1) | TW300897B (de) |
| ZA (1) | ZA952986B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981902A (en) * | 1994-12-15 | 1999-11-09 | Mitsubishi Chemical Corporation | Texturing apparatus for magnetic recording medium and magnetic recording medium process thereby |
| WO1998016531A1 (en) * | 1996-10-16 | 1998-04-23 | Merck & Co., Inc. | Triterpene derivatives with immunosupressant activity |
| AU4822597A (en) * | 1996-10-16 | 1998-05-11 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
| US6100293A (en) * | 1997-10-17 | 2000-08-08 | Merck & Co., Inc. | Tetracyclic triterpene derivatives with immunosuppressant activity |
| US6083980A (en) * | 1997-10-17 | 2000-07-04 | Merck & Co., Inc. | Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity |
| US6022890A (en) * | 1997-11-14 | 2000-02-08 | Merck & Co., Inc. | Immunosuppressant tetracyclic triterpenes |
| US6030621A (en) | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| US6051590A (en) * | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
| US6946283B2 (en) * | 2001-01-05 | 2005-09-20 | William Marsh Rice University | Ginkgo biloba levopimaradiene synthase |
| US7238514B2 (en) * | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
| FR2823116B1 (fr) * | 2001-04-10 | 2004-11-19 | Sod Conseils Rech Applic | Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| AU2003243158A1 (en) * | 2002-03-29 | 2003-10-13 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof |
| US6693091B2 (en) | 2002-03-29 | 2004-02-17 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies |
| US7429670B2 (en) * | 2003-08-27 | 2008-09-30 | The Trustees Of Columbia University In The City Of New York | Synthesis of derivatives of ginkgolide C |
| WO2005046829A2 (en) | 2003-11-12 | 2005-05-26 | The Trustees Of Columbia University In The City Of New York | Separation of ginkgolides and bilobalide from g. biloba |
| WO2005092324A1 (en) * | 2004-03-19 | 2005-10-06 | The Trustees Of Columbia University In The City Of New York | Ginkgolide compounds, compositions, extracts, and uses thereof |
| WO2006083366A2 (en) * | 2004-11-23 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Preparation of ginkgolide and f-seco-ginkgolide lactols |
| US20090221019A1 (en) * | 2005-06-22 | 2009-09-03 | Koji Nakanishi | Core-Modified Terpene Trilactones From Ginkgo Biloba Extract and Biological Evaluation Thereof |
| CN102382121A (zh) * | 2010-09-02 | 2012-03-21 | 秦引林 | 银杏内酯衍生物及其在制药中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8418424D0 (en) * | 1984-07-19 | 1984-08-22 | Scras | Inhibition of platelets aggregation |
| ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
| GB8725871D0 (en) * | 1987-11-04 | 1987-12-09 | Scras | Ginkgolide derivatives |
| KR940002795B1 (ko) * | 1989-06-16 | 1994-04-02 | 주식회사 선경인더스트리 | 은행잎에서 징코라이드를 분리 및 정제하는 방법 |
| GB9107425D0 (en) * | 1991-04-09 | 1991-05-22 | Scras | Preparation of ginkgolide b |
-
1994
- 1994-04-22 GB GB9408044A patent/GB9408044D0/en active Pending
- 1994-08-04 US US08/287,632 patent/US5599950A/en not_active Expired - Lifetime
-
1995
- 1995-04-10 IE IE950265A patent/IE80950B1/en not_active IP Right Cessation
- 1995-04-10 TW TW084103406A patent/TW300897B/zh active
- 1995-04-11 ZA ZA952986A patent/ZA952986B/xx unknown
- 1995-04-12 NZ NZ270925A patent/NZ270925A/en not_active IP Right Cessation
- 1995-04-18 GB GB9507801A patent/GB2288599B/en not_active Expired - Fee Related
- 1995-04-19 DZ DZ950042A patent/DZ1874A1/fr active
- 1995-04-20 EP EP95400876A patent/EP0680968B1/de not_active Expired - Lifetime
- 1995-04-20 DK DK95400876T patent/DK0680968T3/da active
- 1995-04-20 AT AT95400876T patent/ATE189817T1/de active
- 1995-04-20 AU AU16566/95A patent/AU684338B2/en not_active Ceased
- 1995-04-20 ES ES95400876T patent/ES2144585T3/es not_active Expired - Lifetime
- 1995-04-20 CA CA002147423A patent/CA2147423C/en not_active Expired - Fee Related
- 1995-04-20 MY MYPI95001032A patent/MY113056A/en unknown
- 1995-04-20 FR FR9504709A patent/FR2719046B1/fr not_active Expired - Fee Related
- 1995-04-20 DE DE69515077T patent/DE69515077T2/de not_active Expired - Lifetime
- 1995-04-21 OA OA60645A patent/OA10145A/fr unknown
- 1995-04-21 KR KR1019950009403A patent/KR950032203A/ko not_active Ceased
- 1995-04-21 TN TNTNSN95041A patent/TNSN95041A1/fr unknown
- 1995-04-21 RU RU95106678A patent/RU2145326C1/ru not_active IP Right Cessation
- 1995-04-21 FI FI951903A patent/FI109907B/fi not_active IP Right Cessation
- 1995-04-21 JP JP7096757A patent/JP2992575B2/ja not_active Expired - Fee Related
- 1995-04-21 NO NO19951524A patent/NO310557B1/no unknown
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