ZA946074B - Urea-substituted benzoylguanidines process for their preparation their use as pharmaceutical or diagnostic and pharmaceutical containing them - Google Patents
Urea-substituted benzoylguanidines process for their preparation their use as pharmaceutical or diagnostic and pharmaceutical containing themInfo
- Publication number
- ZA946074B ZA946074B ZA946074A ZA946074A ZA946074B ZA 946074 B ZA946074 B ZA 946074B ZA 946074 A ZA946074 A ZA 946074A ZA 946074 A ZA946074 A ZA 946074A ZA 946074 B ZA946074 B ZA 946074B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical
- alk
- formula
- urea
- diagnostic
- Prior art date
Links
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 206010061216 Infarction Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000007574 infarction Effects 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003293 cardioprotective effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000035778 pathophysiological process Effects 0.000 abstract 1
- -1 perfluoro Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4327244A DE4327244A1 (de) | 1993-08-13 | 1993-08-13 | Harnstoffsubstituierte Benzoylguandine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA946074B true ZA946074B (en) | 1995-03-20 |
Family
ID=6495131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA946074A ZA946074B (en) | 1993-08-13 | 1994-08-12 | Urea-substituted benzoylguanidines process for their preparation their use as pharmaceutical or diagnostic and pharmaceutical containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5559153A (da) |
| EP (1) | EP0638548B1 (da) |
| JP (1) | JP3647901B2 (da) |
| CN (1) | CN1060763C (da) |
| AT (1) | ATE165342T1 (da) |
| AU (1) | AU683273B2 (da) |
| CA (1) | CA2130031C (da) |
| DE (2) | DE4327244A1 (da) |
| DK (1) | DK0638548T3 (da) |
| ES (1) | ES2115115T3 (da) |
| FI (1) | FI943716A (da) |
| HU (1) | HU217628B (da) |
| IL (1) | IL110625A (da) |
| NO (1) | NO300680B1 (da) |
| NZ (1) | NZ264216A (da) |
| ZA (1) | ZA946074B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| IL114670A0 (en) * | 1994-08-05 | 1995-11-27 | Fujisawa Pharmaceutical Co | Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5994336A (en) * | 1995-06-07 | 1999-11-30 | Magainin Pharmaceuticals Inc. | Method of inhibiting proliferation of cells by administering an aminosterol compound |
| US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| WO1997027183A1 (en) * | 1996-01-26 | 1997-07-31 | Fujisawa Pharmaceutical Co., Ltd. | Guanidine derivatives |
| DE19603425A1 (de) * | 1996-01-31 | 1997-08-07 | Hoechst Ag | Substituierte Diaryldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6820824B1 (en) | 1998-01-14 | 2004-11-23 | 3M Innovative Properties Company | Apparatus for spraying liquids, disposable containers and liners suitable for use therewith |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
| GB1311432A (en) * | 1971-01-07 | 1973-03-28 | Ici Ltd | Guanidine derivatives their preparation and antiviral compositions containing them |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| US5276907A (en) * | 1991-01-07 | 1994-01-04 | Motorola Inc. | Method and apparatus for dynamic distribution of a communication channel load in a cellular radio communication system |
| DK0556674T3 (da) * | 1992-02-15 | 1996-10-14 | Hoechst Ag | 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation |
-
1993
- 1993-08-13 DE DE4327244A patent/DE4327244A1/de not_active Withdrawn
-
1994
- 1994-08-08 ES ES94112383T patent/ES2115115T3/es not_active Expired - Lifetime
- 1994-08-08 AT AT94112383T patent/ATE165342T1/de not_active IP Right Cessation
- 1994-08-08 DE DE59405764T patent/DE59405764D1/de not_active Expired - Lifetime
- 1994-08-08 EP EP94112383A patent/EP0638548B1/de not_active Expired - Lifetime
- 1994-08-08 DK DK94112383T patent/DK0638548T3/da active
- 1994-08-11 CN CN94109503A patent/CN1060763C/zh not_active Expired - Fee Related
- 1994-08-11 IL IL11062594A patent/IL110625A/en not_active IP Right Cessation
- 1994-08-11 US US08/289,674 patent/US5559153A/en not_active Expired - Lifetime
- 1994-08-11 AU AU70223/94A patent/AU683273B2/en not_active Ceased
- 1994-08-11 NZ NZ264216A patent/NZ264216A/en unknown
- 1994-08-11 FI FI943716A patent/FI943716A/fi unknown
- 1994-08-12 JP JP18972594A patent/JP3647901B2/ja not_active Expired - Fee Related
- 1994-08-12 HU HU9402346A patent/HU217628B/hu not_active IP Right Cessation
- 1994-08-12 NO NO942985A patent/NO300680B1/no unknown
- 1994-08-12 ZA ZA946074A patent/ZA946074B/xx unknown
- 1994-08-12 CA CA002130031A patent/CA2130031C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HU217628B (hu) | 2000-03-28 |
| JP3647901B2 (ja) | 2005-05-18 |
| EP0638548B1 (de) | 1998-04-22 |
| IL110625A0 (en) | 1994-11-11 |
| HUT71816A (en) | 1996-02-28 |
| NO300680B1 (no) | 1997-07-07 |
| CA2130031A1 (en) | 1995-02-14 |
| AU7022394A (en) | 1995-02-23 |
| US5559153A (en) | 1996-09-24 |
| NO942985D0 (no) | 1994-08-12 |
| EP0638548A1 (de) | 1995-02-15 |
| CN1060763C (zh) | 2001-01-17 |
| IL110625A (en) | 1999-03-12 |
| HU9402346D0 (en) | 1994-10-28 |
| DE59405764D1 (de) | 1998-05-28 |
| FI943716A (fi) | 1995-02-14 |
| CA2130031C (en) | 2005-11-15 |
| NO942985L (no) | 1995-02-14 |
| CN1111618A (zh) | 1995-11-15 |
| DE4327244A1 (de) | 1995-02-16 |
| DK0638548T3 (da) | 1998-11-23 |
| ES2115115T3 (es) | 1998-06-16 |
| JPH0776566A (ja) | 1995-03-20 |
| ATE165342T1 (de) | 1998-05-15 |
| AU683273B2 (en) | 1997-11-06 |
| NZ264216A (en) | 1995-10-26 |
| FI943716A0 (fi) | 1994-08-11 |
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| ZA946074B (en) | Urea-substituted benzoylguanidines process for their preparation their use as pharmaceutical or diagnostic and pharmaceutical containing them | |
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| IL106157A0 (en) | 3,4,5-substituted benzoylguanidines,process for their preparation,their use as a medicament or diagnostic and medicaments containing them | |
| NO942837L (no) | Substituerte benzoylguanidiner, fremgangsmåte for fremstilling, deres anvendelse som medikament eller diagnostikum såvel som legemidler inneholdende dem | |
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