ZA945336B - Benzospiroalkene compounds process for preparing them and pharmaceutical compositions containing them - Google Patents

Benzospiroalkene compounds process for preparing them and pharmaceutical compositions containing them

Info

Publication number
ZA945336B
ZA945336B ZA945336A ZA945336A ZA945336B ZA 945336 B ZA945336 B ZA 945336B ZA 945336 A ZA945336 A ZA 945336A ZA 945336 A ZA945336 A ZA 945336A ZA 945336 B ZA945336 B ZA 945336B
Authority
ZA
South Africa
Prior art keywords
branched
linear
group
unsubstituted
substituted
Prior art date
Application number
ZA945336A
Other languages
English (en)
Inventor
Alex Cordi
Jean Michel Lacoste
Michel Laubie
Tony Verbeuren
Jean-Jacques Descombes
Mark Millan
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of ZA945336B publication Critical patent/ZA945336B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA945336A 1993-07-20 1994-07-20 Benzospiroalkene compounds process for preparing them and pharmaceutical compositions containing them ZA945336B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9308859A FR2707981B1 (fr) 1993-07-20 1993-07-20 Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ZA945336B true ZA945336B (en) 1995-02-28

Family

ID=9449385

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA945336A ZA945336B (en) 1993-07-20 1994-07-20 Benzospiroalkene compounds process for preparing them and pharmaceutical compositions containing them

Country Status (12)

Country Link
US (2) US5486532A (xx)
EP (1) EP0635495B1 (xx)
JP (1) JP3103271B2 (xx)
AT (1) ATE171166T1 (xx)
AU (1) AU673438B2 (xx)
CA (1) CA2128119C (xx)
DE (1) DE69413333T2 (xx)
DK (1) DK0635495T3 (xx)
ES (1) ES2124379T3 (xx)
FR (1) FR2707981B1 (xx)
NZ (1) NZ264037A (xx)
ZA (1) ZA945336B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04174725A (ja) * 1990-10-30 1992-06-22 Kanebo Ltd 紡績装置におけるドラフト装置
FR2787450B1 (fr) * 1998-12-18 2001-01-26 Adir Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2323734A1 (en) * 2008-08-04 2011-05-25 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
WO2010042473A1 (en) 2008-10-07 2010-04-15 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
AR073630A1 (es) * 2008-10-07 2010-11-17 Schering Corp Analogos de espiroaminooxazolina como moduladores de los receptores adrenergicos alfa2c
WO2011041181A1 (en) * 2009-10-01 2011-04-07 Schering Corporation Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
CN110393714B (zh) * 2019-08-02 2022-09-02 上海市肿瘤研究所 一种抗肿瘤药物、合成方法及应用
CN116120232B (zh) * 2023-02-24 2024-09-03 上海市肿瘤研究所 一种dna-螺烯纳米药物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429892A (en) * 1967-03-14 1969-02-25 Smithkline Corp Spiro(naphthalene-2,2'-oxazolidine) compounds
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4226875A (en) * 1979-04-02 1980-10-07 Pfizer Inc. Novel spiro-oxazolidinediones
ZA832679B (en) * 1982-05-07 1983-12-28 Ici Plc Indoline derivatives
FR2709306B1 (fr) * 1993-07-20 1995-10-20 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2707982B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
CA2128119A1 (fr) 1995-01-21
AU673438B2 (en) 1996-11-07
JPH07165728A (ja) 1995-06-27
ATE171166T1 (de) 1998-10-15
US5648374A (en) 1997-07-15
CA2128119C (fr) 2002-02-26
AU6754894A (en) 1995-02-02
DK0635495T3 (da) 1999-06-14
EP0635495A2 (fr) 1995-01-25
EP0635495A3 (fr) 1995-02-22
FR2707981A1 (fr) 1995-01-27
FR2707981B1 (fr) 1995-09-01
NZ264037A (en) 1995-04-27
US5486532A (en) 1996-01-23
EP0635495B1 (fr) 1998-09-16
ES2124379T3 (es) 1999-02-01
DE69413333T2 (de) 1999-05-12
DE69413333D1 (de) 1998-10-22
JP3103271B2 (ja) 2000-10-30

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