ZA944345B - Amino acids useful in making GnRH analogs - Google Patents
Amino acids useful in making GnRH analogsInfo
- Publication number
- ZA944345B ZA944345B ZA944345A ZA944345A ZA944345B ZA 944345 B ZA944345 B ZA 944345B ZA 944345 A ZA944345 A ZA 944345A ZA 944345 A ZA944345 A ZA 944345A ZA 944345 B ZA944345 B ZA 944345B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino acids
- making
- unnatural amino
- peptides
- acids useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/18—Sulfenamides
- C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C313/30—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/078,965 US5352796A (en) | 1989-10-30 | 1993-06-17 | Amino acids useful in making GnRH analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA944345B true ZA944345B (en) | 1995-04-03 |
Family
ID=22147289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA944345A ZA944345B (en) | 1993-06-17 | 1994-06-17 | Amino acids useful in making GnRH analogs |
Country Status (13)
Country | Link |
---|---|
US (3) | US5352796A (xx) |
EP (1) | EP0703900B1 (xx) |
JP (1) | JPH09500110A (xx) |
KR (1) | KR100308361B1 (xx) |
AT (1) | ATE176904T1 (xx) |
AU (1) | AU682702B2 (xx) |
CA (1) | CA2165469A1 (xx) |
DE (1) | DE69416676T2 (xx) |
IL (1) | IL110032A (xx) |
NZ (1) | NZ267921A (xx) |
PH (1) | PH31215A (xx) |
WO (1) | WO1995000474A1 (xx) |
ZA (1) | ZA944345B (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
US6469158B1 (en) * | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
AU7471796A (en) * | 1995-10-27 | 1997-05-15 | Merck & Co., Inc. | Gnrh/reduced pseudomonas exotoxin conjugates |
US5912872A (en) * | 1996-09-27 | 1999-06-15 | Digital Optics Corporation | Integrated optical apparatus providing separated beams on a detector and associated methods |
US5928727A (en) * | 1997-06-02 | 1999-07-27 | Lacks Industries, Inc. | Method for electroplating elastomer-modified polyphthalamide articles |
US5977302A (en) * | 1997-11-20 | 1999-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of GnRH peptides |
US6218426B1 (en) | 1998-03-05 | 2001-04-17 | Agouron Pharmaceuticals, Inc. | Non-peptide GnRH agents |
US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
CA2413418A1 (en) | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
HUP0303197A3 (en) | 2000-07-14 | 2008-03-28 | Allergan Inc | Compositions containing alpha-2 adrenergic agonist components |
US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US8858961B2 (en) * | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
DK2153819T3 (da) * | 2000-07-14 | 2012-12-03 | Allergan Inc | Anvendelse af en opløselighedsforbedrende bestanddel i en vandig sammensætning omfattende brimonidintartrat |
US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US6598784B2 (en) * | 2000-12-20 | 2003-07-29 | Meadwestvaco Packaging Syatens, Llc | Beverage carton with strap type carrying handle |
EP1828109B1 (en) * | 2004-11-12 | 2013-06-05 | UCL Business PLC | Guanidine derivatives as inhibitors of ddah |
CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
SG11201506885UA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of cyclic imide containing peptide products |
AU2014234400B2 (en) | 2013-03-21 | 2017-11-16 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK558181A (da) * | 1981-01-30 | 1982-07-31 | Smithkline Corp | Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler |
EP0079522B1 (en) * | 1981-11-09 | 1986-05-07 | Merck & Co. Inc. | N-carboxymethyl(amidino)lysyl-proline antihypertensive agents |
US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
-
1993
- 1993-06-17 US US08/078,965 patent/US5352796A/en not_active Expired - Fee Related
-
1994
- 1994-06-13 AU AU70611/94A patent/AU682702B2/en not_active Ceased
- 1994-06-13 KR KR1019950705738A patent/KR100308361B1/ko not_active IP Right Cessation
- 1994-06-13 EP EP94919491A patent/EP0703900B1/en not_active Expired - Lifetime
- 1994-06-13 CA CA002165469A patent/CA2165469A1/en not_active Abandoned
- 1994-06-13 JP JP7502914A patent/JPH09500110A/ja not_active Ceased
- 1994-06-13 WO PCT/US1994/006726 patent/WO1995000474A1/en active IP Right Grant
- 1994-06-13 DE DE69416676T patent/DE69416676T2/de not_active Expired - Fee Related
- 1994-06-13 NZ NZ267921A patent/NZ267921A/en unknown
- 1994-06-13 AT AT94919491T patent/ATE176904T1/de not_active IP Right Cessation
- 1994-06-16 IL IL11003294A patent/IL110032A/xx not_active IP Right Cessation
- 1994-06-17 PH PH48477A patent/PH31215A/en unknown
- 1994-06-17 ZA ZA944345A patent/ZA944345B/xx unknown
- 1994-08-11 US US08/289,103 patent/US5565574A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/465,854 patent/US5710249A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL110032A (en) | 1999-09-22 |
DE69416676D1 (de) | 1999-04-01 |
ATE176904T1 (de) | 1999-03-15 |
AU682702B2 (en) | 1997-10-16 |
PH31215A (en) | 1998-05-05 |
US5565574A (en) | 1996-10-15 |
EP0703900B1 (en) | 1999-02-24 |
WO1995000474A1 (en) | 1995-01-05 |
CA2165469A1 (en) | 1995-01-05 |
DE69416676T2 (de) | 1999-09-16 |
IL110032A0 (en) | 1994-10-07 |
KR960703110A (ko) | 1996-06-19 |
NZ267921A (en) | 1997-12-19 |
AU7061194A (en) | 1995-01-17 |
EP0703900A1 (en) | 1996-04-03 |
US5710249A (en) | 1998-01-20 |
JPH09500110A (ja) | 1997-01-07 |
US5352796A (en) | 1994-10-04 |
KR100308361B1 (ko) | 2001-11-30 |
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