DE69416676D1 - Verfahren zur herstellung von phenylalanin-derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptiden - Google Patents
Verfahren zur herstellung von phenylalanin-derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptidenInfo
- Publication number
- DE69416676D1 DE69416676D1 DE69416676T DE69416676T DE69416676D1 DE 69416676 D1 DE69416676 D1 DE 69416676D1 DE 69416676 T DE69416676 T DE 69416676T DE 69416676 T DE69416676 T DE 69416676T DE 69416676 D1 DE69416676 D1 DE 69416676D1
- Authority
- DE
- Germany
- Prior art keywords
- producing
- guanidine
- gnrh
- active peptides
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/18—Sulfenamides
- C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C313/30—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/078,965 US5352796A (en) | 1989-10-30 | 1993-06-17 | Amino acids useful in making GnRH analogs |
PCT/US1994/006726 WO1995000474A1 (en) | 1993-06-17 | 1994-06-13 | PROCESS FOR THE PREPARATION OF PHENYLALANINE DERIVATIVES OR HOMOLOGUES CONTAINING A GUANIDINO OR MODIFIED GUANIDINO GROUP USEFUL FOR THE PREPARATION GnRH OF ANTAGONISTIC PEPTIDES |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69416676D1 true DE69416676D1 (de) | 1999-04-01 |
DE69416676T2 DE69416676T2 (de) | 1999-09-16 |
Family
ID=22147289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69416676T Expired - Fee Related DE69416676T2 (de) | 1993-06-17 | 1994-06-13 | Verfahren zur herstellung von phenylalanin-derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptiden |
Country Status (13)
Country | Link |
---|---|
US (3) | US5352796A (de) |
EP (1) | EP0703900B1 (de) |
JP (1) | JPH09500110A (de) |
KR (1) | KR100308361B1 (de) |
AT (1) | ATE176904T1 (de) |
AU (1) | AU682702B2 (de) |
CA (1) | CA2165469A1 (de) |
DE (1) | DE69416676T2 (de) |
IL (1) | IL110032A (de) |
NZ (1) | NZ267921A (de) |
PH (1) | PH31215A (de) |
WO (1) | WO1995000474A1 (de) |
ZA (1) | ZA944345B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
US6469158B1 (en) * | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
WO1997015317A1 (en) * | 1995-10-27 | 1997-05-01 | Merck & Co., Inc. | GnRH/REDUCED PSEUDOMONAS EXOTOXIN CONJUGATES |
US5912872A (en) * | 1996-09-27 | 1999-06-15 | Digital Optics Corporation | Integrated optical apparatus providing separated beams on a detector and associated methods |
US5928727A (en) * | 1997-06-02 | 1999-07-27 | Lacks Industries, Inc. | Method for electroplating elastomer-modified polyphthalamide articles |
US5977302A (en) * | 1997-11-20 | 1999-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of GnRH peptides |
CA2322444A1 (en) | 1998-03-05 | 1999-09-10 | Agouron Pharmaceuticals, Inc. | Non-peptide gnrh agents |
US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
AU2001268607A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Company | Piperidine amides as modulators of chemokine receptor activity |
US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US8858961B2 (en) * | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
MXPA02012206A (es) * | 2000-07-14 | 2003-06-04 | Allergan Inc | Composiciones que contienen componentes terapeuticamente activos que tienen solubilidad mejorada. |
AU7326901A (en) * | 2000-07-14 | 2002-01-30 | Allergan Sales Inc | Compositions containing alpha-2-adrenergic agonist components |
US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US6598784B2 (en) * | 2000-12-20 | 2003-07-29 | Meadwestvaco Packaging Syatens, Llc | Beverage carton with strap type carrying handle |
JP5274838B2 (ja) * | 2004-11-12 | 2013-08-28 | ユーシーエル ビジネス ピーエルシー | 化合物 |
CA2939778C (en) | 2007-01-31 | 2019-01-29 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
BRPI0809366B8 (pt) | 2007-03-28 | 2021-05-25 | Harvard College | polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica |
CN103282510A (zh) | 2010-08-13 | 2013-09-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
BR112014009418A2 (pt) | 2011-10-18 | 2017-04-18 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
EP2822572B1 (de) | 2012-02-15 | 2020-06-10 | Aileron Therapeutics, Inc. | Peptidomimetische makrozyklen |
CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
ES2624961T3 (es) | 2013-03-21 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos de péptido que contienen imida cíclica |
AU2014234400B2 (en) | 2013-03-21 | 2017-11-16 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
CA2961258A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK558181A (da) * | 1981-01-30 | 1982-07-31 | Smithkline Corp | Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler |
DE3271043D1 (en) * | 1981-11-09 | 1986-06-12 | Merck & Co Inc | N-carboxymethyl(amidino)lysyl-proline antihypertensive agents |
US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
-
1993
- 1993-06-17 US US08/078,965 patent/US5352796A/en not_active Expired - Fee Related
-
1994
- 1994-06-13 WO PCT/US1994/006726 patent/WO1995000474A1/en active IP Right Grant
- 1994-06-13 EP EP94919491A patent/EP0703900B1/de not_active Expired - Lifetime
- 1994-06-13 KR KR1019950705738A patent/KR100308361B1/ko not_active IP Right Cessation
- 1994-06-13 AT AT94919491T patent/ATE176904T1/de not_active IP Right Cessation
- 1994-06-13 JP JP7502914A patent/JPH09500110A/ja not_active Ceased
- 1994-06-13 AU AU70611/94A patent/AU682702B2/en not_active Ceased
- 1994-06-13 CA CA002165469A patent/CA2165469A1/en not_active Abandoned
- 1994-06-13 DE DE69416676T patent/DE69416676T2/de not_active Expired - Fee Related
- 1994-06-13 NZ NZ267921A patent/NZ267921A/en unknown
- 1994-06-16 IL IL11003294A patent/IL110032A/xx not_active IP Right Cessation
- 1994-06-17 ZA ZA944345A patent/ZA944345B/xx unknown
- 1994-06-17 PH PH48477A patent/PH31215A/en unknown
- 1994-08-11 US US08/289,103 patent/US5565574A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/465,854 patent/US5710249A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR960703110A (ko) | 1996-06-19 |
KR100308361B1 (ko) | 2001-11-30 |
IL110032A0 (en) | 1994-10-07 |
US5565574A (en) | 1996-10-15 |
AU682702B2 (en) | 1997-10-16 |
ZA944345B (en) | 1995-04-03 |
IL110032A (en) | 1999-09-22 |
ATE176904T1 (de) | 1999-03-15 |
CA2165469A1 (en) | 1995-01-05 |
JPH09500110A (ja) | 1997-01-07 |
EP0703900A1 (de) | 1996-04-03 |
US5710249A (en) | 1998-01-20 |
NZ267921A (en) | 1997-12-19 |
US5352796A (en) | 1994-10-04 |
WO1995000474A1 (en) | 1995-01-05 |
DE69416676T2 (de) | 1999-09-16 |
AU7061194A (en) | 1995-01-17 |
PH31215A (en) | 1998-05-05 |
EP0703900B1 (de) | 1999-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |