ZA941644B - Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof - Google Patents
Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereofInfo
- Publication number
- ZA941644B ZA941644B ZA941644A ZA941644A ZA941644B ZA 941644 B ZA941644 B ZA 941644B ZA 941644 A ZA941644 A ZA 941644A ZA 941644 A ZA941644 A ZA 941644A ZA 941644 B ZA941644 B ZA 941644B
- Authority
- ZA
- South Africa
- Prior art keywords
- nucleic acid
- acid molecules
- tumor rejection
- isolated nucleic
- rejection antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title abstract 2
- 108010035452 HLA-A1 Antigen Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Casings For Electric Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/037,230 US6235525B1 (en) | 1991-05-23 | 1993-03-26 | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA941644B true ZA941644B (en) | 1994-10-12 |
Family
ID=21893179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA941644A ZA941644B (en) | 1993-03-26 | 1994-03-09 | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
Country Status (15)
Country | Link |
---|---|
US (6) | US6235525B1 (zh) |
EP (1) | EP0690915B1 (zh) |
JP (1) | JP3594307B2 (zh) |
KR (1) | KR100288749B1 (zh) |
CN (1) | CN1110556C (zh) |
AT (1) | ATE229072T1 (zh) |
AU (1) | AU685790B2 (zh) |
CA (1) | CA2159098C (zh) |
DE (1) | DE69431834T2 (zh) |
FI (1) | FI954536A0 (zh) |
NO (1) | NO953699L (zh) |
NZ (1) | NZ263693A (zh) |
TW (1) | TW432111B (zh) |
WO (1) | WO1994023031A1 (zh) |
ZA (1) | ZA941644B (zh) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5925729A (en) * | 1991-05-23 | 1999-07-20 | Ludwig Institute For Cancer Research | Tumor rejection antigen precursors, tumor rejection antigens and uses thereof |
USRE40089E1 (en) * | 1991-05-23 | 2008-02-19 | Ludwig Institute For Cancer Research | Nucleic acid molecules encoding the MAGE-1 tumor rejection antigen precursor |
US6060257A (en) * | 1994-06-03 | 2000-05-09 | Ludwig Institute For Cancer Research | Tumor rejection antigens presented by HLA-B44 molecules, and uses thereof |
US5587289A (en) * | 1995-03-14 | 1996-12-24 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules which are members of the MAGE-Xp family and uses thereof |
WO1997013858A2 (en) * | 1995-10-12 | 1997-04-17 | Chiron Corporation | Baboon mage-3 homologs, dna encoding the homologs, and a process for their use |
UY24367A1 (es) * | 1995-11-23 | 2000-10-31 | Boehringer Ingelheim Int | Vacunas contra tumores y procedimiento para su produccion |
CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
FR2746110B1 (fr) * | 1996-03-14 | 1998-04-17 | Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants | |
US6027924A (en) * | 1997-04-25 | 2000-02-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecule coding for tumor rejection antigen precursor MAGE-C1 and uses thereof |
US5965535A (en) | 1997-09-12 | 1999-10-12 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
US6716809B1 (en) | 1997-09-12 | 2004-04-06 | Ludwig Institute For Cancer Research | Mage-A3 peptides presented by HLA class molecules |
PT1584685E (pt) | 1998-02-05 | 2011-06-17 | Glaxosmithkline Biolog Sa | Derivados de antigénios associados a tumores da família mage, utilizados para a preparação de proteínas de fusão com epítopos auxiliares t e de composições para vacinação |
US6446109B2 (en) * | 1998-06-29 | 2002-09-03 | Sun Microsystems, Inc. | Application computing environment |
US7960540B2 (en) * | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
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EP1181304B1 (en) * | 1999-04-08 | 2007-10-10 | Antisoma Research Limited | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
US20080318889A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US20080318890A1 (en) * | 1999-04-08 | 2008-12-25 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
IT1312568B1 (it) * | 1999-05-21 | 2002-04-22 | Genera Spa | Peptidi immunogenici e loro uso. |
JP4540033B2 (ja) | 1999-10-22 | 2010-09-08 | サノフィ パストゥール リミテッド | 腫瘍抗原に対する免疫応答を誘発および/または増強する方法 |
JP3603138B2 (ja) * | 2000-02-18 | 2004-12-22 | 独立行政法人理化学研究所 | 細胞死抑制タンパク質 |
ATE513913T1 (de) | 2000-05-10 | 2011-07-15 | Sanofi Pasteur Ltd | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
AU2001272491A1 (en) * | 2000-06-26 | 2002-01-08 | Smithkline Beecham Biologicals (S.A.) | Triple fusion proteins comprising ubiquitin fused between thioredoxin and a polypeptide of interest |
ATE527375T1 (de) | 2001-04-12 | 2011-10-15 | Imp Innovations Ltd | Diagnose und behandlung von brustkrebs mit scn5a |
US7049413B2 (en) | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
US20030148973A1 (en) * | 2001-05-23 | 2003-08-07 | Peter Emtage | MAGE-A1 peptides for treating or preventing cancer |
US20030113919A1 (en) * | 2001-08-17 | 2003-06-19 | Aventis Pasteur, Ltd. | Immunogenic targets for melanoma |
AU2003223527B2 (en) | 2002-04-09 | 2009-01-15 | Sanofi Pasteur Limited | Modified CEA nucleic acid and expression vectors |
US20040223949A1 (en) * | 2002-10-22 | 2004-11-11 | Sunnybrook And Women's College Health Sciences Center Aventis Pasteur, Ltd. | Vaccines using high-dose cytokines |
CN101124327A (zh) * | 2003-10-08 | 2008-02-13 | 圣诺菲·帕斯图尔公司 | 经修饰的cea/b7载体 |
DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
US20070154889A1 (en) * | 2004-06-25 | 2007-07-05 | Veridex, Llc | Methods and reagents for the detection of melanoma |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
GB0700284D0 (en) * | 2007-01-08 | 2007-02-14 | Glaxosmithkline Biolog Sa | Combination therapy |
DK2224954T3 (en) | 2007-11-07 | 2014-03-03 | Celldex Therapeutics Inc | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
JP5779352B2 (ja) | 2008-03-14 | 2015-09-16 | サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー | 複製欠損フラビウイルスワクチンおよびワクチンベクター |
WO2011130434A2 (en) | 2010-04-13 | 2011-10-20 | Celldex Therapeutics Inc. | Antibodies that bind human cd27 and uses thereof |
NZ730355A (en) | 2011-05-24 | 2022-10-28 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Individualized vaccines for cancer |
GB201120860D0 (en) | 2011-12-05 | 2012-01-18 | Cambridge Entpr Ltd | Cancer immunotherapy |
WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
WO2014082729A1 (en) | 2012-11-28 | 2014-06-05 | Biontech Ag | Individualized vaccines for cancer |
WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
CN106459203B (zh) | 2014-06-06 | 2021-08-03 | 百时美施贵宝公司 | 抗糖皮质激素诱导肿瘤坏死因子受体(gitr)的抗体及其用途 |
WO2016040682A1 (en) | 2014-09-10 | 2016-03-17 | Genentech, Inc. | Immunogenic mutant peptide screening platform |
WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
WO2016094309A1 (en) | 2014-12-10 | 2016-06-16 | Myosotis | Inhibition of tnf signaling in cancer immunotherapy |
WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
US20180044429A1 (en) | 2015-03-09 | 2018-02-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
SI3303396T1 (sl) | 2015-05-29 | 2023-01-31 | Bristol-Myers Squibb Company | Protitelesa proti OX40 in njihova uporaba |
US10786547B2 (en) | 2015-07-16 | 2020-09-29 | Biokine Therapeutics Ltd. | Compositions, articles of manufacture and methods for treating cancer |
WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
GB201519340D0 (en) | 2015-11-02 | 2015-12-16 | Cambridge Entpr Ltd | Methods of T-lymphocyte expansion |
GB201519481D0 (en) | 2015-11-04 | 2015-12-16 | Cancer Rec Tech Ltd | Immunomodulatory antibodies |
JP6983776B2 (ja) | 2015-11-19 | 2021-12-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | グルココルチコイド誘発腫瘍壊死因子受容体(gitr)に対する抗体およびその使用 |
WO2017184619A2 (en) | 2016-04-18 | 2017-10-26 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
GB201616238D0 (en) | 2016-09-23 | 2016-11-09 | Adaptimmune Ltd | Modified T cells |
AU2018205890B2 (en) | 2017-01-05 | 2021-09-02 | Kahr Medical Ltd. | A sirpalpha-41BBL fusion protein and methods of use thereof |
WO2018127917A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-41bbl fusion protein and methods of use thereof |
GB201700345D0 (en) | 2017-01-09 | 2017-02-22 | F-Star Beta Ltd | Conditional agonists of immune responses |
IL250916A0 (en) | 2017-03-02 | 2017-06-29 | Geiger Benjamin | Methods for growing t cells in culture and their use |
US20210187023A1 (en) | 2017-06-27 | 2021-06-24 | The Trustees Of Princeton University | Compositions And Methods For Enhancing Immunotherapy |
GB201713078D0 (en) | 2017-08-15 | 2017-09-27 | Adaptimmune Ltd | T Cell Modification |
CN111836635A (zh) | 2018-01-26 | 2020-10-27 | 剑桥企业有限公司 | 肽交换蛋白 |
WO2020012486A1 (en) | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF |
GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
WO2020041662A1 (en) | 2018-08-24 | 2020-02-27 | The Trustees Of Princeton University | Immunotherapy with metabolic enzyme expression |
GB201820444D0 (en) | 2018-12-14 | 2019-01-30 | Adaptimmune Ltd | Marker for T cell expansion |
AU2020311636A1 (en) | 2019-07-11 | 2022-03-03 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
GB201911954D0 (en) | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | Lentiviral transduction methods |
US20230048361A1 (en) | 2019-12-31 | 2023-02-16 | Kahr Medical Ltd. | Methods of culturing t cells and uses of same |
WO2021137231A1 (en) | 2019-12-31 | 2021-07-08 | Kahr Medical Ltd. | Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same |
CN111647066B (zh) * | 2020-07-01 | 2020-12-18 | 维肽瀛(上海)生物技术有限公司 | Wt1多肽肿瘤抑制剂 |
IL276599A (en) | 2020-08-09 | 2022-03-01 | Yeda Res & Dev | T cell receptor unique to mage-a1 and its uses |
GB202303250D0 (en) | 2023-03-06 | 2023-04-19 | King S College London | Method and compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61104788A (ja) * | 1984-10-26 | 1986-05-23 | Teijin Ltd | 核酸塩基配列 |
US5342774A (en) * | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
JPH05246889A (ja) * | 1992-03-05 | 1993-09-24 | Seitai Chiyousetsu Kenkyusho:Kk | 制癌方法および制癌剤 |
US5405940A (en) * | 1992-08-31 | 1995-04-11 | Ludwig Institute For Cancer Research | Isolated nonapeptides derived from MAGE genes and uses thereof |
-
1993
- 1993-03-26 US US08/037,230 patent/US6235525B1/en not_active Expired - Lifetime
-
1994
- 1994-03-09 ZA ZA941644A patent/ZA941644B/xx unknown
- 1994-03-17 CA CA002159098A patent/CA2159098C/en not_active Expired - Lifetime
- 1994-03-17 WO PCT/US1994/002877 patent/WO1994023031A1/en active IP Right Grant
- 1994-03-17 JP JP52211494A patent/JP3594307B2/ja not_active Expired - Lifetime
- 1994-03-17 AT AT94912246T patent/ATE229072T1/de active
- 1994-03-17 AU AU64475/94A patent/AU685790B2/en not_active Expired
- 1994-03-17 KR KR1019950704143A patent/KR100288749B1/ko not_active IP Right Cessation
- 1994-03-17 NZ NZ263693A patent/NZ263693A/en not_active IP Right Cessation
- 1994-03-17 EP EP94912246A patent/EP0690915B1/en not_active Expired - Lifetime
- 1994-03-17 DE DE69431834T patent/DE69431834T2/de not_active Expired - Lifetime
- 1994-03-26 CN CN94103919A patent/CN1110556C/zh not_active Expired - Lifetime
- 1994-07-18 TW TW083106555A patent/TW432111B/zh not_active IP Right Cessation
-
1995
- 1995-09-20 NO NO953699A patent/NO953699L/no not_active Application Discontinuation
- 1995-09-25 FI FI954536A patent/FI954536A0/fi unknown
-
1997
- 1997-11-12 US US08/967,727 patent/US6025474A/en not_active Expired - Lifetime
-
1999
- 1999-05-17 US US09/312,464 patent/US6599699B1/en not_active Expired - Lifetime
- 1999-09-23 US US09/404,026 patent/US6565857B1/en not_active Expired - Fee Related
-
2000
- 2000-05-26 US US09/579,197 patent/US6552180B1/en not_active Expired - Fee Related
- 2000-05-31 US US09/583,848 patent/US6946289B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO953699L (no) | 1995-11-20 |
US6946289B1 (en) | 2005-09-20 |
EP0690915B1 (en) | 2002-12-04 |
EP0690915A1 (en) | 1996-01-10 |
NZ263693A (en) | 1996-07-26 |
TW432111B (en) | 2001-05-01 |
EP0690915A4 (en) | 1997-11-12 |
WO1994023031A1 (en) | 1994-10-13 |
AU685790B2 (en) | 1998-01-29 |
CA2159098C (en) | 2003-04-29 |
DE69431834D1 (de) | 2003-01-16 |
US6565857B1 (en) | 2003-05-20 |
JP3594307B2 (ja) | 2004-11-24 |
US6599699B1 (en) | 2003-07-29 |
CA2159098A1 (en) | 1994-10-13 |
JPH08508402A (ja) | 1996-09-10 |
US6235525B1 (en) | 2001-05-22 |
DE69431834T2 (de) | 2003-09-18 |
US6552180B1 (en) | 2003-04-22 |
AU6447594A (en) | 1994-10-24 |
FI954536A (fi) | 1995-09-25 |
US6025474A (en) | 2000-02-15 |
NO953699D0 (no) | 1995-09-20 |
FI954536A0 (fi) | 1995-09-25 |
ATE229072T1 (de) | 2002-12-15 |
CN1093751A (zh) | 1994-10-19 |
CN1110556C (zh) | 2003-06-04 |
KR100288749B1 (ko) | 2001-05-02 |
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