ZA939367B - Antidepressant and antiperkinsonian compounds - Google Patents
Antidepressant and antiperkinsonian compoundsInfo
- Publication number
- ZA939367B ZA939367B ZA939367A ZA939367A ZA939367B ZA 939367 B ZA939367 B ZA 939367B ZA 939367 A ZA939367 A ZA 939367A ZA 939367 A ZA939367 A ZA 939367A ZA 939367 B ZA939367 B ZA 939367B
- Authority
- ZA
- South Africa
- Prior art keywords
- antiperkinsonian
- antidepressant
- compounds
- antiperkinsonian compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK921541A DK154192D0 (da) | 1992-12-23 | 1992-12-23 | Heterocycliske forbindelser |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA939367B true ZA939367B (en) | 1994-08-08 |
Family
ID=8105889
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939365A ZA939365B (en) | 1992-12-23 | 1993-12-14 | Alkyl substituted heterocyclic compounds |
ZA939367A ZA939367B (en) | 1992-12-23 | 1993-12-14 | Antidepressant and antiperkinsonian compounds |
ZA939366A ZA939366B (en) | 1992-12-23 | 1993-12-14 | Aryl substituted heterocyclic compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939365A ZA939365B (en) | 1992-12-23 | 1993-12-14 | Alkyl substituted heterocyclic compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA939366A ZA939366B (en) | 1992-12-23 | 1993-12-14 | Aryl substituted heterocyclic compounds |
Country Status (4)
Country | Link |
---|---|
US (3) | US5374636A (ko) |
KR (3) | KR100344328B1 (ko) |
DK (1) | DK154192D0 (ko) |
ZA (3) | ZA939365B (ko) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6706880B2 (en) * | 1990-08-09 | 2004-03-16 | Research Triangle Institute | Cocaine receptor binding ligands |
US7189737B2 (en) | 1991-08-09 | 2007-03-13 | Research Triangle Institute | Cocaine receptor binding ligands |
US6531483B1 (en) * | 1990-08-09 | 2003-03-11 | Research Triangle Institute | Cocaine receptor binding ligands |
US5736123A (en) * | 1990-08-09 | 1998-04-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5935953A (en) * | 1990-08-09 | 1999-08-10 | Research Triangle Institute | Methods for controlling invertebrate pests using cocaine receptor binding ligands |
US6329520B1 (en) * | 1990-08-09 | 2001-12-11 | Research Triangle Institute | Cocaine receptor binding ligands |
US7011813B2 (en) * | 1990-08-09 | 2006-03-14 | Research Triangle Institute | Cocaine receptor binding ligands |
US5698179A (en) * | 1992-02-25 | 1997-12-16 | Neuro Imaging Technologies, Llc | Iodinated neuroprobe for mapping monoamine reuptake sites |
US5750089A (en) * | 1996-01-11 | 1998-05-12 | Neuro Imaging Technologies, Llc | Halogenated neuroprobe for mapping monoamine reuptake sites |
US5760055A (en) * | 1992-03-13 | 1998-06-02 | Wake Forest University | Biologically active tropane derivatives |
US6632456B1 (en) * | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
JP3731005B2 (ja) * | 1995-06-06 | 2006-01-05 | ジーイー ヘルスケア リミテッド | モノアミン再取込み部位をマッピングするためのヨウ素標識ニューロプローブ |
TR199800628T2 (xx) * | 1995-10-13 | 1998-07-21 | Neurosearch A/S | 8-Azabisiklo$3.2.1]okt-2-en t�revleri, bunlar�n haz�rlanmas� ve kullan�m�. |
US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
AU778629B2 (en) * | 1996-08-22 | 2004-12-16 | Research Triangle Institute | Cocaine receptor binding ligands |
EP0944626A4 (en) * | 1996-12-02 | 2002-09-04 | Univ Georgetown | TROPANE DERIVATIVES AND SYNTHESIS METHOD |
US5834484A (en) * | 1997-03-12 | 1998-11-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Cocaine analogs |
US6013242A (en) * | 1998-01-13 | 2000-01-11 | Wake Forest University | Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
RU2309953C2 (ru) | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе |
EP1257541B1 (en) * | 2000-01-11 | 2008-09-03 | Molecular Insight Pharmaceuticals, Inc. | Polypharmacophoric agents |
US6479509B1 (en) | 2000-05-22 | 2002-11-12 | Research Triangle Institute | Method of promoting smoking cessation |
US7084152B2 (en) | 2000-07-11 | 2006-08-01 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
US20040030131A1 (en) * | 2000-10-04 | 2004-02-12 | Martine Keenan | Pharmaceutical compounds |
JP2004520396A (ja) * | 2001-02-15 | 2004-07-08 | ニューロサーチ、アクティーゼルスカブ | 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療 |
US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
US7381733B2 (en) * | 2001-11-30 | 2008-06-03 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
JP2005529156A (ja) * | 2002-03-28 | 2005-09-29 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | トロパン化合物 |
EP1675591B1 (en) * | 2003-10-16 | 2011-08-10 | NeuroSearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
WO2005070429A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
WO2005070427A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
US20050278472A1 (en) * | 2004-06-14 | 2005-12-15 | Gierke Justin T | USB extender |
GEP20094640B (en) | 2004-07-15 | 2009-03-10 | Bristol Myers Squibb Co | Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
EP1904069B1 (en) | 2005-07-15 | 2018-06-13 | Albany Molecular Research, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
MX2011011907A (es) | 2009-05-12 | 2012-01-20 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma. |
EP2429295B1 (en) * | 2009-05-12 | 2013-12-25 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
WO2010132487A1 (en) | 2009-05-12 | 2010-11-18 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
EP2606049A4 (en) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-METHANO- AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USES THEREOF FOR BLOCKING NOREPINEPHRINE, DOPAMINE, AND SEROTONIN REUPTAKE |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US813404A (en) * | 1905-07-19 | 1906-02-27 | Joseph W Mccord | Process for removing rough and irregular foreign seeds from clover and other smooth seeds. |
US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
CA2123570C (en) * | 1991-11-15 | 2003-11-04 | Michael J. Kuhar | Cocaine receptor binding ligands |
-
1992
- 1992-12-23 DK DK921541A patent/DK154192D0/da not_active Application Discontinuation
-
1993
- 1993-07-16 US US08/093,182 patent/US5374636A/en not_active Expired - Lifetime
- 1993-07-16 US US08/093,181 patent/US5444070A/en not_active Expired - Lifetime
- 1993-07-16 US US08/093,183 patent/US5369113A/en not_active Expired - Lifetime
- 1993-12-14 ZA ZA939365A patent/ZA939365B/xx unknown
- 1993-12-14 ZA ZA939367A patent/ZA939367B/xx unknown
- 1993-12-14 ZA ZA939366A patent/ZA939366B/xx unknown
- 1993-12-23 KR KR1019930029244A patent/KR100344328B1/ko not_active IP Right Cessation
- 1993-12-23 KR KR1019930029243A patent/KR100300799B1/ko not_active IP Right Cessation
- 1993-12-23 KR KR1019930029245A patent/KR100310663B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5374636A (en) | 1994-12-20 |
ZA939365B (en) | 1994-08-08 |
US5369113A (en) | 1994-11-29 |
KR940013508A (ko) | 1994-07-15 |
KR100344328B1 (ko) | 2002-11-29 |
KR940013555A (ko) | 1994-07-15 |
US5444070A (en) | 1995-08-22 |
ZA939366B (en) | 1994-08-08 |
KR940013507A (ko) | 1994-07-15 |
KR100310663B1 (ko) | 2002-06-20 |
KR100300799B1 (ko) | 2001-11-22 |
DK154192D0 (da) | 1992-12-23 |
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