ZA938016B - Agents for lowering cholesterol - Google Patents
Agents for lowering cholesterolInfo
- Publication number
- ZA938016B ZA938016B ZA938016A ZA938016A ZA938016B ZA 938016 B ZA938016 B ZA 938016B ZA 938016 A ZA938016 A ZA 938016A ZA 938016 A ZA938016 A ZA 938016A ZA 938016 B ZA938016 B ZA 938016B
- Authority
- ZA
- South Africa
- Prior art keywords
- lowering cholesterol
- agents
- dihydroequilenin
- hyperlipidemia
- atherosclerosis
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- RYWZPRVUQHMJFF-KSZLIROESA-N 17alpha-Dihydroequilenin Chemical compound OC1=CC=C2C(CC[C@]3([C@H]4CC[C@H]3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-KSZLIROESA-N 0.000 abstract 1
- RYWZPRVUQHMJFF-UHFFFAOYSA-N 17alpha-Dihydroequilenin Natural products OC1=CC=C2C(CCC3(C4CCC3O)C)=C4C=CC2=C1 RYWZPRVUQHMJFF-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97034892A | 1992-11-02 | 1992-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA938016B true ZA938016B (en) | 1995-04-28 |
Family
ID=25516811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA938016A ZA938016B (en) | 1992-11-02 | 1993-10-27 | Agents for lowering cholesterol |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5510342A (ja) |
| EP (1) | EP0666747B1 (ja) |
| JP (1) | JP3621095B2 (ja) |
| CN (1) | CN1089238C (ja) |
| AT (1) | ATE204755T1 (ja) |
| AU (1) | AU5544994A (ja) |
| CA (1) | CA2148357A1 (ja) |
| DE (1) | DE69330680T2 (ja) |
| DK (1) | DK0666747T3 (ja) |
| ES (1) | ES2161750T3 (ja) |
| IL (1) | IL107343A (ja) |
| PT (1) | PT666747E (ja) |
| SG (1) | SG49785A1 (ja) |
| TW (1) | TW237385B (ja) |
| WO (1) | WO1994009789A1 (ja) |
| ZA (1) | ZA938016B (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19524937A1 (de) * | 1995-07-08 | 1997-01-09 | Jenapharm Gmbh | Pharmazeutische Präparate zur Prophylaxe und Therapie radikalvermittelter Zellschädigungen und zur medikamentösen Substitution beim Mann |
| US5719137A (en) * | 1996-12-03 | 1998-02-17 | Wake Forest University | Method of preventing neurodegeneration and cognitive dysfunction using 17α-dihydroequilenin |
| US7022688B1 (en) | 1996-12-10 | 2006-04-04 | Wyeth | Use of 17β-dihydroequilenin as an antioxidant |
| TW422693B (en) * | 1996-12-10 | 2001-02-21 | American Home Prod | 17<beta>-dihydroequilenin as an antioxidant |
| US7459445B2 (en) * | 2000-03-10 | 2008-12-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and topical pharmaceutical formulations of the same |
| US6660726B2 (en) * | 2000-03-10 | 2003-12-09 | Endeavor Pharmaceuticals | Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same |
| US6855703B1 (en) | 2000-03-10 | 2005-02-15 | Endeavor Pharmaceuticals | Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds |
| US7989436B2 (en) | 2003-07-23 | 2011-08-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and pharmaceutical formulations comprising the same |
| CA2441252A1 (en) * | 2001-03-16 | 2002-10-10 | Wyeth | Estrogen replacement therapy |
| US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
| WO2004091535A2 (en) * | 2003-04-11 | 2004-10-28 | Barr Laboratories, Inc. | Methods of administering estrogens and progestins |
| EP1853272A1 (en) * | 2005-02-03 | 2007-11-14 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
| KR20090034798A (ko) * | 2006-03-23 | 2009-04-08 | 에밀리타 데 구스만 브라이어 | 아포지단백질 핑거프린팅 기술 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4154820A (en) * | 1976-02-23 | 1979-05-15 | Akzona Incorporated | Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers |
| US4826831A (en) * | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
-
1993
- 1993-10-21 IL IL10734393A patent/IL107343A/xx not_active IP Right Cessation
- 1993-10-27 ZA ZA938016A patent/ZA938016B/xx unknown
- 1993-11-01 AU AU55449/94A patent/AU5544994A/en not_active Abandoned
- 1993-11-01 PT PT94900472T patent/PT666747E/pt unknown
- 1993-11-01 WO PCT/US1993/010471 patent/WO1994009789A1/en active IP Right Grant
- 1993-11-01 AT AT94900472T patent/ATE204755T1/de not_active IP Right Cessation
- 1993-11-01 JP JP51137294A patent/JP3621095B2/ja not_active Expired - Fee Related
- 1993-11-01 DE DE69330680T patent/DE69330680T2/de not_active Expired - Fee Related
- 1993-11-01 DK DK94900472T patent/DK0666747T3/da active
- 1993-11-01 SG SG1996005818A patent/SG49785A1/en unknown
- 1993-11-01 EP EP94900472A patent/EP0666747B1/en not_active Expired - Lifetime
- 1993-11-01 CN CN93114127A patent/CN1089238C/zh not_active Expired - Fee Related
- 1993-11-01 CA CA002148357A patent/CA2148357A1/en not_active Abandoned
- 1993-11-01 ES ES94900472T patent/ES2161750T3/es not_active Expired - Lifetime
- 1993-11-02 TW TW082109201A patent/TW237385B/zh active
-
1995
- 1995-03-15 US US08/404,943 patent/US5510342A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0666747B1 (en) | 2001-08-29 |
| SG49785A1 (en) | 1998-06-15 |
| JP3621095B2 (ja) | 2005-02-16 |
| CN1089238C (zh) | 2002-08-21 |
| ES2161750T3 (es) | 2001-12-16 |
| TW237385B (ja) | 1995-01-01 |
| EP0666747A1 (en) | 1995-08-16 |
| US5510342A (en) | 1996-04-23 |
| CN1094283A (zh) | 1994-11-02 |
| PT666747E (pt) | 2002-02-28 |
| ATE204755T1 (de) | 2001-09-15 |
| IL107343A0 (en) | 1994-01-25 |
| CA2148357A1 (en) | 1994-05-11 |
| WO1994009789A1 (en) | 1994-05-11 |
| IL107343A (en) | 2003-10-31 |
| AU5544994A (en) | 1994-05-24 |
| JPH08503702A (ja) | 1996-04-23 |
| DE69330680T2 (de) | 2002-06-13 |
| DK0666747T3 (da) | 2001-12-27 |
| DE69330680D1 (de) | 2001-10-04 |
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