ZA937112B - 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same - Google Patents

17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Info

Publication number
ZA937112B
ZA937112B ZA937112A ZA937112A ZA937112B ZA 937112 B ZA937112 B ZA 937112B ZA 937112 A ZA937112 A ZA 937112A ZA 937112 A ZA937112 A ZA 937112A ZA 937112 B ZA937112 B ZA 937112B
Authority
ZA
South Africa
Prior art keywords
androstene
androstane
heterocyclyl
aryl
preparation
Prior art date
Application number
ZA937112A
Other languages
English (en)
Inventor
Peiro Melloni
Mara Ferrandi
Marina Mauro
Luigi Bernardi
Marco Frigerio
Luisa Quadri
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ZA937112B publication Critical patent/ZA937112B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA937112A 1992-09-29 1993-09-24 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same ZA937112B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4232681A DE4232681C2 (de) 1992-09-29 1992-09-29 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number Publication Date
ZA937112B true ZA937112B (en) 1995-07-25

Family

ID=6469164

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA937112A ZA937112B (en) 1992-09-29 1993-09-24 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same

Country Status (12)

Country Link
US (2) US5556846A (ja)
EP (1) EP0590271B1 (ja)
JP (1) JPH06192287A (ja)
KR (1) KR940007054A (ja)
AT (1) ATE145649T1 (ja)
CA (1) CA2106916A1 (ja)
DE (2) DE4232681C2 (ja)
DK (1) DK0590271T3 (ja)
ES (1) ES2094974T3 (ja)
GR (1) GR3021789T3 (ja)
HK (1) HK1005880A1 (ja)
ZA (1) ZA937112B (ja)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1279386B1 (it) * 1994-11-07 1997-12-10 Sigma Tau Ind Farmaceuti 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994334A (en) * 1997-02-05 1999-11-30 University Of Maryland Androgen synthesis inhibitors
US5994335A (en) 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2009137335A1 (en) * 2008-05-05 2009-11-12 The Scripps Research Institute Synthesis of (+) corstistatin a and related compounds
JP2012516900A (ja) 2009-02-05 2012-07-26 トーカイ ファーマシューティカルズ，インク． ステロイド性ｃｙｐ１７阻害剤／抗アンドロゲン剤の新しいプロドラッグ
SG2014010912A (en) 2009-03-23 2014-06-27 Sigma Tau Ind Farmaceuti 5-ß, 14-ß-ANDROSTANE DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEINURIA, GLOMERULOSCLEROSIS AND RENAL FAILURE
WO2011059969A2 (en) * 2009-11-13 2011-05-19 Tokai Pharmaceuticals, Inc. Mammalian metabolites of steroids
CA3152410A1 (en) 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
SG11201507093WA (en) 2013-03-14 2015-10-29 Univ Maryland Baltimore Office Of Technology Transfer Androgen receptor down-regulating agents and uses thereof
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
RS60420B1 (sr) 2013-04-17 2020-07-31 Sage Therapeutics Inc 19-nor neuroaktivni steroidi za metode lečenja
IL286794B2 (en) 2013-04-17 2024-06-01 Sage Therapeutics Inc 19- NOR C3, 3- dimomer C21- N- pyrazole Steroids and methods of using them
RU2754534C2 (ru) 2013-07-19 2021-09-03 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, композиции и их использование
RU2016104643A (ru) 2013-08-12 2017-09-19 Токай Фармасьютикалз, Инк. Биомаркёры для лечения неопластических заболеваний с применением нацеленных на андроген методов лечения
DK3488852T3 (da) 2013-08-23 2021-02-01 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser deraf
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2016061537A1 (en) 2014-10-16 2016-04-21 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
CN107404877A (zh) 2014-10-16 2017-11-28 萨奇治疗股份有限公司 靶向cns 障碍的组合物和方法
SI3224269T1 (sl) 2014-11-27 2020-10-30 Sage Therapeutics, Inc. Sestavki in metode za zdravljenje CNS motenj
PL3250210T3 (pl) * 2015-01-26 2021-07-26 Sage Therapeutics, Inc. Kompozycje i sposoby leczenia zaburzeń OUN
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
EP3481844B1 (en) 2016-07-11 2024-04-17 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
AU2017297375B2 (en) 2016-07-11 2022-09-15 Sage Therapeutics, Inc. C17, C20, and C21 substituted neuroactive steroids and their methods of use
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405127A (en) * 1965-07-13 1968-10-08 Sterling Drug Inc 12, 17-dioxygenated steroids
DE1768800C3 (de) * 1968-07-02 1978-07-06 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von 14 ß- Hydroxy-3oxo-5 a-card-20(22)- enoliden
DE2614046C2 (de) * 1976-04-01 1984-08-02 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
IT1250410B (it) * 1991-02-14 1995-04-07 Simes Composti steroidei attivi sul sistema cardiovascolare
DE4232638C2 (de) * 1992-09-29 1994-11-17 Sigma Tau Ind Farmaceuti 17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Also Published As

Publication number Publication date
US5556846A (en) 1996-09-17
GR3021789T3 (en) 1997-02-28
DK0590271T3 (da) 1996-12-16
DE69306212T2 (de) 1997-04-24
CA2106916A1 (en) 1994-03-30
KR940007054A (ko) 1994-04-26
DE69306212D1 (de) 1997-01-09
JPH06192287A (ja) 1994-07-12
ATE145649T1 (de) 1996-12-15
US5721227A (en) 1998-02-24
EP0590271A3 (en) 1994-07-06
HK1005880A1 (en) 1999-01-29
DE4232681C2 (de) 1994-11-24
ES2094974T3 (es) 1997-02-01
EP0590271A2 (en) 1994-04-06
EP0590271B1 (en) 1996-11-27
DE4232681A1 (de) 1994-03-31

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