ZA936945B - Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates. - Google Patents

Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.

Info

Publication number
ZA936945B
ZA936945B ZA936945A ZA936945A ZA936945B ZA 936945 B ZA936945 B ZA 936945B ZA 936945 A ZA936945 A ZA 936945A ZA 936945 A ZA936945 A ZA 936945A ZA 936945 B ZA936945 B ZA 936945B
Authority
ZA
South Africa
Prior art keywords
preparing
substituted pyrrolo
pyrimidine intermediates
pyrimidine
intermediates
Prior art date
Application number
ZA936945A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA936945B publication Critical patent/ZA936945B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA936945A 1992-09-25 1993-09-20 Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates. ZA936945B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95151592A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
ZA936945B true ZA936945B (en) 1995-03-20

Family

ID=25491768

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA936945A ZA936945B (en) 1992-09-25 1993-09-20 Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.

Country Status (6)

Country Link
US (1) US5416211A (en:Method)
KR (1) KR100297957B1 (en:Method)
TW (1) TW228522B (en:Method)
UA (1) UA34423C2 (en:Method)
YU (1) YU61793A (en:Method)
ZA (1) ZA936945B (en:Method)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
NZ503600A (en) * 1997-09-26 2001-08-31 Lilly Co Eli A process for preparing 5-substituted pyrrolo[2,3-d]pyrimidines which provide an aldehyde analogue amendable to isolation
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
US7138521B2 (en) * 2000-02-25 2006-11-21 Eli Lilly And Company Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor
WO2008021410A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
EP2305681A1 (en) * 2006-08-14 2011-04-06 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
ES2356792T3 (es) * 2006-08-14 2011-04-13 Sicor, Inc. Procedimientos para la preparación de sales farmacéuticamente aceptables liofilizadas de pemetrexed diácido.
EP1957497B1 (en) * 2006-08-14 2015-09-30 Sicor, Inc. Processes for preparing intermediates of pemetrexed
CA2681829A1 (en) * 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
EP2008995B1 (en) 2007-06-29 2013-09-11 Ricoh Company, Ltd. Azo compound and method of preparing the azo compound
US20090069349A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
TW201118098A (en) * 2009-08-13 2011-06-01 Reddy S Lab Liimited Dr Processes for preparing pemetrexed
WO2012012404A1 (en) 2010-07-19 2012-01-26 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
IT1401677B1 (it) 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
WO2012056285A1 (en) 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
KR101308767B1 (ko) 2011-01-20 2013-12-31 에스티팜 주식회사 고 순도 페메트렉세드 디에틸 에스테르의 제조방법 및 이 방법을 포함하는 페메트렉세드 이나트륨염의 제조방법
ITRM20120398A1 (it) * 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102887902B (zh) * 2012-10-10 2015-05-20 北京莱瑞森医药科技有限公司 一种合成高纯度培美酸的制备工艺
CN103086912A (zh) * 2012-11-14 2013-05-08 湖北一半天制药有限公司 用于制备培美曲塞及其中间体的方法
WO2014167585A1 (en) 2013-04-12 2014-10-16 Actavis Group Ptc Ehf. Pemetrexed formulation
ES2657944T3 (es) 2013-06-14 2018-03-07 Synthon B.V. Sal estable de arginina de pemetrexed y composiciones que la comprenden
CN107628947B (zh) * 2017-09-14 2020-07-28 浙江工业大学 一种培美曲塞二钠关键中间体的制备方法
CA3090494A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
WO2020222151A1 (en) 2019-05-01 2020-11-05 Intas Pharmaceuticals Ltd. A stable, ready to use aqueous pharmaceutical composition of pemetrexed

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US5416211A (en) 1995-05-16
UA34423C2 (uk) 2001-03-15
TW228522B (en:Method) 1994-08-21
YU61793A (sh) 1997-05-28
KR940007034A (ko) 1994-04-26
KR100297957B1 (ko) 2001-10-24

Similar Documents

Publication Publication Date Title
ZA936945B (en) Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.
ZA994003B (en) Pyrrolo[2,3-d]pyrimidine compounds.
AU4757593A (en) Process for preparing 5-substituted pyrrolo{2,3-d}pyrimidines
HUP0102574A3 (en) Pyrrolo[2,3-d]pyrimidine compounds
EP0630763A3 (de) Verfahren zum Herstellen von lackierten Teilen.
RU93055352A (ru) Способ получения 5-замещенных пирроло /2,3-d/ пиримидинов
GR3036917T3 (en) Process for the preparation of pyrimidine compounds
AU5491699A (en) Process for the preparation of pyrrolo(2,3-d)pyrimidines
EP0643155A3 (en) Process for the preparation of fluorinated chemical compounds.
AU7513794A (en) Improved process for preparing 2-amino-4,6-dichloropyrimidine
AU1526197A (en) Improved process for preparing 4,6-disubstituted pyrido{3,4-d}pyrimidines
PH31154A (en) Process for preparing 1-alkylryl-2-alkyl-5-formyl-imidazole.
ZA982912B (en) 6,7-disubstituted-4-aminopyrido [2,3-d] pyrimidine compounds
ZA975198B (en) Improved process for preparing potassium clavulanate.
PL336265A1 (en) 5,6,7-trisubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
EP0663207A3 (en) Bamboo salt manufacturing process.
ZA9610053B (en) Process for preparing dioxoazabicyclohexanes.
IL118816A0 (en) Process for preparing 5-substituted pyrrolo-[2,3-d] pyrimidines
IL104477A0 (en) Process for preparing 4,6-dialkoxy-pyrimidines
HU9701313D0 (en) Process for producing 4-hydroxy-5-halogeno-pyrrolo[2,3-d]pyrimidine as intermediate
ZA972928B (en) Improved process for pyrimidinone compounds.
EP0747364A3 (de) Verfahren zur Herstellung von 2,4,6-Trichlorpyrimidin
HUT64035A (en) Process for producing 1-propargyl-imidazolidine-2,4-dione
ZA200005581B (en) Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof.
EP0644193A3 (en) Process for preparing 2-acetylamino-6-chloropurine.