ZA936945B - Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates. - Google Patents

Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.

Info

Publication number
ZA936945B
ZA936945B ZA936945A ZA936945A ZA936945B ZA 936945 B ZA936945 B ZA 936945B ZA 936945 A ZA936945 A ZA 936945A ZA 936945 A ZA936945 A ZA 936945A ZA 936945 B ZA936945 B ZA 936945B
Authority
ZA
South Africa
Prior art keywords
preparing
substituted pyrrolo
pyrimidine intermediates
pyrimidine
intermediates
Prior art date
Application number
ZA936945A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA936945B publication Critical patent/ZA936945B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA936945A 1992-09-25 1993-09-20 Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates. ZA936945B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95151592A 1992-09-25 1992-09-25

Publications (1)

Publication Number Publication Date
ZA936945B true ZA936945B (en) 1995-03-20

Family

ID=25491768

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA936945A ZA936945B (en) 1992-09-25 1993-09-20 Process for preparing 5-substituted pyrrolo[2,3-d] pyrimidine intermediates.

Country Status (6)

Country Link
US (1) US5416211A (cg-RX-API-DMAC7.html)
KR (1) KR100297957B1 (cg-RX-API-DMAC7.html)
TW (1) TW228522B (cg-RX-API-DMAC7.html)
UA (1) UA34423C2 (cg-RX-API-DMAC7.html)
YU (1) YU61793A (cg-RX-API-DMAC7.html)
ZA (1) ZA936945B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
ZA987550B (en) * 1997-09-26 2000-02-21 Lilly Co Eli Processes and intermediates useful to make antifolates.
CN1213998C (zh) * 1997-09-26 2005-08-10 伊莱利利公司 用于制造抗叶酸剂的方法和中间体
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
US7138521B2 (en) * 2000-02-25 2006-11-21 Eli Lilly And Company Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor
WO2008021410A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
TWI377955B (en) * 2006-08-14 2012-12-01 Sicor Inc Processes for preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
KR101359838B1 (ko) * 2006-08-14 2014-02-07 시코르, 인크. 페메트렉세드 이산의 결정형 및 이의 제조 방법
TWI374886B (en) 2006-08-14 2012-10-21 Sicor Inc Processes for preparing intermediates of pemetrexed
CA2681829A1 (en) * 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
US8232376B2 (en) 2007-06-29 2012-07-31 Ricoh Company, Ltd. Azo compound and method of preparing the azo compound
US20090069349A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
TW201118098A (en) * 2009-08-13 2011-06-01 Reddy S Lab Liimited Dr Processes for preparing pemetrexed
JP2013531067A (ja) 2010-07-19 2013-08-01 バイエル ヘルスケア リミティド ライアビリティ カンパニー 疾病及び状態の処置及び予防のためのフルオロ置換オメガ−カルボキシアリールジフェニル尿素を用いた組み合わせ薬
IT1401677B1 (it) 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
WO2012056285A1 (en) 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
KR101308767B1 (ko) 2011-01-20 2013-12-31 에스티팜 주식회사 고 순도 페메트렉세드 디에틸 에스테르의 제조방법 및 이 방법을 포함하는 페메트렉세드 이나트륨염의 제조방법
ITRM20120398A1 (it) * 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN102887902B (zh) * 2012-10-10 2015-05-20 北京莱瑞森医药科技有限公司 一种合成高纯度培美酸的制备工艺
CN103086912A (zh) * 2012-11-14 2013-05-08 湖北一半天制药有限公司 用于制备培美曲塞及其中间体的方法
WO2014167585A1 (en) 2013-04-12 2014-10-16 Actavis Group Ptc Ehf. Pemetrexed formulation
EP3008064B1 (en) 2013-06-14 2017-11-22 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
CN107628947B (zh) * 2017-09-14 2020-07-28 浙江工业大学 一种培美曲塞二钠关键中间体的制备方法
CN111954530A (zh) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 γ聚谷氨酸化培美曲塞及其用途
CN111954531A (zh) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 α聚谷氨酸化培美曲塞及其用途
EP3962453A4 (en) 2019-05-01 2023-01-25 Intas Pharmaceuticals Ltd. STABLE, READY-TO-USE AQUEOUS PHARMACEUTICAL COMPOSITION OF PEMETREXED

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
AU654140B2 (en) * 1990-07-31 1994-10-27 Lilly Industries Limited N-benzyl indoles, processes for their preparation or pharmaceutical compositions containing them

Also Published As

Publication number Publication date
TW228522B (cg-RX-API-DMAC7.html) 1994-08-21
KR100297957B1 (ko) 2001-10-24
US5416211A (en) 1995-05-16
UA34423C2 (uk) 2001-03-15
KR940007034A (ko) 1994-04-26
YU61793A (sh) 1997-05-28

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