ZA933336B - Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type. - Google Patents

Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type.

Info

Publication number
ZA933336B
ZA933336B ZA933336A ZA933336A ZA933336B ZA 933336 B ZA933336 B ZA 933336B ZA 933336 A ZA933336 A ZA 933336A ZA 933336 A ZA933336 A ZA 933336A ZA 933336 B ZA933336 B ZA 933336B
Authority
ZA
South Africa
Prior art keywords
dithiolanylglycine
type
protease inhibitors
hiv protease
containing hiv
Prior art date
Application number
ZA933336A
Other languages
English (en)
Inventor
Dieter Haebich
Wolfgang Bender
Jutta Hansen
Arnold Paessens
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA933336B publication Critical patent/ZA933336B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA933336A 1992-05-14 1993-05-13 Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type. ZA933336B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4215874A DE4215874A1 (de) 1992-05-14 1992-05-14 Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp

Publications (1)

Publication Number Publication Date
ZA933336B true ZA933336B (en) 1993-12-07

Family

ID=6458834

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA933336A ZA933336B (en) 1992-05-14 1993-05-13 Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type.

Country Status (16)

Country Link
US (1) US5424426A (ko)
EP (1) EP0569811B1 (ko)
JP (1) JPH069628A (ko)
KR (1) KR930023363A (ko)
AT (1) ATE158304T1 (ko)
AU (1) AU666532B2 (ko)
CA (1) CA2095968A1 (ko)
DE (2) DE4215874A1 (ko)
DK (1) DK0569811T3 (ko)
ES (1) ES2107578T3 (ko)
GR (1) GR3025478T3 (ko)
HU (1) HUT65911A (ko)
IL (1) IL105669A (ko)
NZ (1) NZ247608A (ko)
TW (1) TW265347B (ko)
ZA (1) ZA933336B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
NZ249789A (en) 1992-03-11 1997-07-27 Narhex Ltd Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
WO2001082919A2 (en) * 2000-05-04 2001-11-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods of and compounds for inhibiting calpains
JP3756133B2 (ja) 2002-07-29 2006-03-15 旭化成ケミカルズ株式会社 グラフト共重合体およびその樹脂組成物
WO2006034277A1 (en) * 2004-09-17 2006-03-30 Comentis, Inc. Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof
EP1871739A1 (en) 2005-04-08 2008-01-02 Comentis, Inc. Compounds which inhibit beta-secretase activity and methods of use thereof
WO2009015369A2 (en) * 2007-07-26 2009-01-29 Comentis, Inc. Compounds which inhibit beta-secretase activity and methods of use thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
DK414389A (da) * 1988-08-24 1990-02-26 Merck & Co Inc Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning
JPH04503214A (ja) * 1989-02-10 1992-06-11 シュラム，ヴォルフガング 対称性蛋白質、特に酵素を阻害する薬剤
WO1990012804A2 (en) * 1989-04-18 1990-11-01 The Upjohn Company Peptides having novel polar n-terminal groups
DE3912829A1 (de) * 1989-04-19 1990-10-25 Bayer Ag Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3939747A1 (de) * 1989-06-09 1990-12-13 Bayer Ag Renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPH05501879A (ja) * 1989-10-27 1993-04-08 ジ・アップジョン・カンパニー Ｈｉｖおよび他のレトロウイルスを処理する方法およびそれに有用な化合物
GB8927872D0 (en) * 1989-12-08 1990-02-14 Beecham Group Plc Pharmaceuticals
DE3941235A1 (de) * 1989-12-14 1991-06-20 Bayer Ag Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
JPH05503703A (ja) * 1990-01-09 1993-06-17 スミスクライン・ビーチャム・コーポレイション Ｈｉｖプロテアーゼ抑制剤
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
EP0438311A3 (en) * 1990-01-19 1992-07-01 Merck & Co. Inc. Di- and tripeptide renin inhibitors
DE4004898A1 (de) * 1990-02-16 1991-08-22 Merck Patent Gmbh Peptid-analoga
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4038921A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Renininhibitorische peptide vom cyclohexylstatin-typ, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4038947A1 (de) * 1990-12-06 1992-06-11 Bayer Ag Dithiolano- und dithianoglycin-haltige renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
DE59307366D1 (de) 1997-10-23
EP0569811A1 (de) 1993-11-18
AU666532B2 (en) 1996-02-15
JPH069628A (ja) 1994-01-18
IL105669A0 (en) 1993-09-22
HU9301388D0 (en) 1993-09-28
US5424426A (en) 1995-06-13
IL105669A (en) 1998-02-22
KR930023363A (ko) 1993-12-18
HUT65911A (en) 1994-07-28
DE4215874A1 (de) 1993-11-18
EP0569811B1 (de) 1997-09-17
DK0569811T3 (da) 1998-05-04
NZ247608A (en) 1995-01-27
CA2095968A1 (en) 1993-11-15
ATE158304T1 (de) 1997-10-15
AU3716093A (en) 1993-11-18
TW265347B (ko) 1995-12-11
ES2107578T3 (es) 1997-12-01
GR3025478T3 (en) 1998-02-27

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