ZA933336B - Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type. - Google Patents
Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type.Info
- Publication number
- ZA933336B ZA933336B ZA933336A ZA933336A ZA933336B ZA 933336 B ZA933336 B ZA 933336B ZA 933336 A ZA933336 A ZA 933336A ZA 933336 A ZA933336 A ZA 933336A ZA 933336 B ZA933336 B ZA 933336B
- Authority
- ZA
- South Africa
- Prior art keywords
- dithiolanylglycine
- type
- protease inhibitors
- hiv protease
- containing hiv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4215874A DE4215874A1 (de) | 1992-05-14 | 1992-05-14 | Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA933336B true ZA933336B (en) | 1993-12-07 |
Family
ID=6458834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA933336A ZA933336B (en) | 1992-05-14 | 1993-05-13 | Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostere type. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5424426A (ko) |
EP (1) | EP0569811B1 (ko) |
JP (1) | JPH069628A (ko) |
KR (1) | KR930023363A (ko) |
AT (1) | ATE158304T1 (ko) |
AU (1) | AU666532B2 (ko) |
CA (1) | CA2095968A1 (ko) |
DE (2) | DE4215874A1 (ko) |
DK (1) | DK0569811T3 (ko) |
ES (1) | ES2107578T3 (ko) |
GR (1) | GR3025478T3 (ko) |
HU (1) | HUT65911A (ko) |
IL (1) | IL105669A (ko) |
NZ (1) | NZ247608A (ko) |
TW (1) | TW265347B (ko) |
ZA (1) | ZA933336B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
NZ249789A (en) | 1992-03-11 | 1997-07-27 | Narhex Ltd | Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions |
US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
WO2001082919A2 (en) * | 2000-05-04 | 2001-11-08 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods of and compounds for inhibiting calpains |
JP3756133B2 (ja) | 2002-07-29 | 2006-03-15 | 旭化成ケミカルズ株式会社 | グラフト共重合体およびその樹脂組成物 |
WO2006034277A1 (en) * | 2004-09-17 | 2006-03-30 | Comentis, Inc. | Bicyclic compounds which inhibit beta-secretase activity and methods of use thereof |
EP1871739A1 (en) | 2005-04-08 | 2008-01-02 | Comentis, Inc. | Compounds which inhibit beta-secretase activity and methods of use thereof |
WO2009015369A2 (en) * | 2007-07-26 | 2009-01-29 | Comentis, Inc. | Compounds which inhibit beta-secretase activity and methods of use thereof |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
DK414389A (da) * | 1988-08-24 | 1990-02-26 | Merck & Co Inc | Farmaceutisk praeparat indeholdende et aminosyrederivat med renin-inhibitorisk virkning |
JPH04503214A (ja) * | 1989-02-10 | 1992-06-11 | シュラム,ヴォルフガング | 対称性蛋白質、特に酵素を阻害する薬剤 |
WO1990012804A2 (en) * | 1989-04-18 | 1990-11-01 | The Upjohn Company | Peptides having novel polar n-terminal groups |
DE3912829A1 (de) * | 1989-04-19 | 1990-10-25 | Bayer Ag | Verwendung von renininhibitorischen peptiden als mittel gegen retroviren |
DE4004820A1 (de) * | 1989-08-05 | 1991-04-25 | Bayer Ag | Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3939747A1 (de) * | 1989-06-09 | 1990-12-13 | Bayer Ag | Renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
JPH05501879A (ja) * | 1989-10-27 | 1993-04-08 | ジ・アップジョン・カンパニー | Hivおよび他のレトロウイルスを処理する方法およびそれに有用な化合物 |
GB8927872D0 (en) * | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Pharmaceuticals |
DE3941235A1 (de) * | 1989-12-14 | 1991-06-20 | Bayer Ag | Neue peptide, ihre herstellung und ihre verwendung in arzneimitteln |
CA2032259A1 (en) * | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
JPH05503703A (ja) * | 1990-01-09 | 1993-06-17 | スミスクライン・ビーチャム・コーポレイション | Hivプロテアーゼ抑制剤 |
DE4001236A1 (de) * | 1990-01-18 | 1991-07-25 | Bayer Ag | Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren |
EP0438311A3 (en) * | 1990-01-19 | 1992-07-01 | Merck & Co. Inc. | Di- and tripeptide renin inhibitors |
DE4004898A1 (de) * | 1990-02-16 | 1991-08-22 | Merck Patent Gmbh | Peptid-analoga |
CA2036398C (en) * | 1990-02-23 | 2000-06-13 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Hiv protease inhibiting agents |
CA2036397C (en) * | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors containing derived amino acid units |
CA2036413C (en) * | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors |
IE68045B1 (en) * | 1990-05-11 | 1996-05-15 | Abbott Lab | Renin inhibitors |
AU7732691A (en) * | 1990-06-01 | 1991-12-05 | Ciba-Geigy Ag | Hiv protease inhibitors and processes for their preparation |
DE4038921A1 (de) * | 1990-12-06 | 1992-06-11 | Bayer Ag | Renininhibitorische peptide vom cyclohexylstatin-typ, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4038947A1 (de) * | 1990-12-06 | 1992-06-11 | Bayer Ag | Dithiolano- und dithianoglycin-haltige renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1992
- 1992-05-14 DE DE4215874A patent/DE4215874A1/de not_active Withdrawn
-
1993
- 1993-04-23 AU AU37160/93A patent/AU666532B2/en not_active Ceased
- 1993-05-03 DK DK93107140.1T patent/DK0569811T3/da active
- 1993-05-03 DE DE59307366T patent/DE59307366D1/de not_active Expired - Fee Related
- 1993-05-03 ES ES93107140T patent/ES2107578T3/es not_active Expired - Lifetime
- 1993-05-03 EP EP93107140A patent/EP0569811B1/de not_active Expired - Lifetime
- 1993-05-03 AT AT93107140T patent/ATE158304T1/de not_active IP Right Cessation
- 1993-05-07 TW TW082103565A patent/TW265347B/zh active
- 1993-05-10 US US08/059,488 patent/US5424426A/en not_active Expired - Fee Related
- 1993-05-10 JP JP5131052A patent/JPH069628A/ja active Pending
- 1993-05-11 CA CA002095968A patent/CA2095968A1/en not_active Abandoned
- 1993-05-11 IL IL105669A patent/IL105669A/en not_active IP Right Cessation
- 1993-05-12 NZ NZ247608A patent/NZ247608A/xx unknown
- 1993-05-13 ZA ZA933336A patent/ZA933336B/xx unknown
- 1993-05-13 HU HU9301388A patent/HUT65911A/hu unknown
- 1993-05-13 KR KR1019930008201A patent/KR930023363A/ko not_active Application Discontinuation
-
1997
- 1997-11-26 GR GR970403127T patent/GR3025478T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE59307366D1 (de) | 1997-10-23 |
EP0569811A1 (de) | 1993-11-18 |
AU666532B2 (en) | 1996-02-15 |
JPH069628A (ja) | 1994-01-18 |
IL105669A0 (en) | 1993-09-22 |
HU9301388D0 (en) | 1993-09-28 |
US5424426A (en) | 1995-06-13 |
IL105669A (en) | 1998-02-22 |
KR930023363A (ko) | 1993-12-18 |
HUT65911A (en) | 1994-07-28 |
DE4215874A1 (de) | 1993-11-18 |
EP0569811B1 (de) | 1997-09-17 |
DK0569811T3 (da) | 1998-05-04 |
NZ247608A (en) | 1995-01-27 |
CA2095968A1 (en) | 1993-11-15 |
ATE158304T1 (de) | 1997-10-15 |
AU3716093A (en) | 1993-11-18 |
TW265347B (ko) | 1995-12-11 |
ES2107578T3 (es) | 1997-12-01 |
GR3025478T3 (en) | 1998-02-27 |
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