ZA927751B - Anti-endotoxin compound and related molecules and methods. - Google Patents

Anti-endotoxin compound and related molecules and methods.

Info

Publication number
ZA927751B
ZA927751B ZA927751A ZA927751A ZA927751B ZA 927751 B ZA927751 B ZA 927751B ZA 927751 A ZA927751 A ZA 927751A ZA 927751 A ZA927751 A ZA 927751A ZA 927751 B ZA927751 B ZA 927751B
Authority
ZA
South Africa
Prior art keywords
methods
related molecules
endotoxin compound
endotoxin
compound
Prior art date
Application number
ZA927751A
Other languages
English (en)
Inventor
William J Christ
Lynn D Hawkins
Osamu Asano
Tsutomu Kawata
Seiichi Kobay Ashi
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ZA927751B publication Critical patent/ZA927751B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA927751A 1991-10-11 1992-10-08 Anti-endotoxin compound and related molecules and methods. ZA927751B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77610091A 1991-10-11 1991-10-11

Publications (1)

Publication Number Publication Date
ZA927751B true ZA927751B (en) 1993-06-10

Family

ID=25106455

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927751A ZA927751B (en) 1991-10-11 1992-10-08 Anti-endotoxin compound and related molecules and methods.

Country Status (4)

Country Link
US (1) US5530113A (xx)
KR (1) KR930007942A (xx)
TW (1) TW250482B (xx)
ZA (1) ZA927751B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
US6417172B1 (en) 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5750664A (en) 1995-06-05 1998-05-12 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
WO1997011708A1 (en) * 1995-09-29 1997-04-03 Eisai Research Institute Method for treating alcoholic liver disease
US6235724B1 (en) * 1996-07-03 2001-05-22 Eisai Co., Ltd. Injections containing lipid a analogues and process for the preparation thereof
US6444654B1 (en) 1997-01-21 2002-09-03 Board Of Regents Of University Of Nebraska Isolated asgal lipopolysaccharides and use of same to inhibit innate immune response
US6172220B1 (en) 1997-01-21 2001-01-09 Board Of Regents Of University Of Nebraska Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis
PT1007509E (pt) * 1997-08-29 2004-07-30 Univ Johns Hopkins Compostos antimicrobioticos
AU2003200765B2 (en) * 1997-08-29 2007-01-25 The Johns Hopkins University Antimicrobial compounds
US6713654B1 (en) * 1997-08-29 2004-03-30 The Johns Hopkins University School Of Medicine Antimicrobial compounds
US6011066A (en) * 1998-02-02 2000-01-04 Veterans General Hospital-Taipei Method for treating septic shock
DE60036790T2 (de) 1999-01-14 2008-07-24 Eisai R&D Management Co., Ltd. Verwendung von e5564 zur behandlung von sepsis durch intravenöse infusion
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
AU2008202882B2 (en) * 1999-02-01 2011-06-16 Eisai R & D Management Co., Ltd. Immunological adjuvant compound
WO2001060382A1 (en) 2000-02-18 2001-08-23 Eisai Co., Ltd. Micelles
WO2002085117A1 (en) * 2001-04-24 2002-10-31 Eisai Co., Ltd. Methods and compositions for preventing and treating septic shock and endotoxemia
EP2338497A1 (en) 2001-08-10 2011-06-29 Eisai R&D Management Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
WO2003106473A1 (ja) * 2002-06-18 2003-12-24 三共株式会社 グルコシルリピッドa1位カルボキシメチル類縁体
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
ES2639812T3 (es) 2003-01-06 2017-10-30 Corixa Corporation Ciertos compuestos de fosfato de aminoalquil glucosaminida y sus usos
US7951232B2 (en) * 2006-02-09 2011-05-31 Elevance Renewable Sciences, Inc. Surface coating compositions and methods
MX2008010359A (es) * 2006-02-09 2009-01-30 Elevance Renewable Sciences Composiciones, metodos y sistemas antimicrobianos.
CN101516396B (zh) 2006-09-26 2013-10-09 传染性疾病研究院 包含合成佐剂的疫苗组合物
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
CA2698668A1 (en) * 2007-09-07 2009-03-19 University Of Georgia Research Foundation, Inc. Synthetic lipid a derivative
US8722064B2 (en) 2009-06-05 2014-05-13 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
CN102917715B (zh) 2010-02-16 2015-07-01 Tfk株式会社 疾病的预防改善剂、持久力提高剂、抗疲劳剂、以及使用它们的药品和饮食品
EP3632463A1 (en) 2011-04-08 2020-04-08 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
NZ701881A (en) 2012-05-16 2016-10-28 Immune Design Corp Vaccines for hsv-2
EP3711768A1 (en) 2013-04-18 2020-09-23 Immune Design Corp. Gla monotherapy for use in cancer treatment
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
IL276608B2 (en) 2018-02-12 2024-04-01 Inimmune Corp TOLL-like receptor ligands
US10765633B2 (en) 2018-12-17 2020-09-08 Eisai R&D Management Co., Ltd Formulation comprising liposomes

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Publication number Priority date Publication date Assignee Title
US4495346A (en) * 1981-03-30 1985-01-22 Wisconsin Alumni Research Foundation Method of preparing a disaccharide
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
JPS6153295A (ja) * 1984-08-24 1986-03-17 Dai Ichi Seiyaku Co Ltd ジサツカライド誘導体
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
JP2535048B2 (ja) * 1988-02-29 1996-09-18 第一製薬株式会社 新規ジサッカライド誘導体及びその塩
ZA881430B (xx) * 1988-03-02 1988-10-28
US5134230A (en) * 1988-03-02 1992-07-28 Daiichi Pharmaceutical Co., Ltd. 2-Deoxy-2-aminoglucopyranoside derivatives
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5041427A (en) * 1989-07-21 1991-08-20 Wisconsin Alumni Research Foundation Lipid A derivatives
US5158939A (en) * 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
JPH0655749B2 (ja) * 1989-09-20 1994-07-27 日本たばこ産業株式会社 リピッドａ単糖類縁体
JP2839916B2 (ja) * 1989-10-20 1998-12-24 三共株式会社 リピドａ３位エーテル類縁体
US5158941A (en) * 1990-06-08 1992-10-27 E. I. Du Pont De Nemours And Company Lipid A analog as stimulant for production of interleukin-1 in human monocytes and tumor cell growth inhibitor
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods

Also Published As

Publication number Publication date
KR930007942A (ko) 1993-05-20
TW250482B (xx) 1995-07-01
US5530113A (en) 1996-06-25

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