ZA927751B - Anti-endotoxin compound and related molecules and methods. - Google Patents

Anti-endotoxin compound and related molecules and methods.

Info

Publication number
ZA927751B
ZA927751B ZA927751A ZA927751A ZA927751B ZA 927751 B ZA927751 B ZA 927751B ZA 927751 A ZA927751 A ZA 927751A ZA 927751 A ZA927751 A ZA 927751A ZA 927751 B ZA927751 B ZA 927751B
Authority
ZA
South Africa
Prior art keywords
methods
related molecules
endotoxin compound
endotoxin
compound
Prior art date
Application number
ZA927751A
Other languages
English (en)
Inventor
William J Christ
Lynn D Hawkins
Osamu Asano
Tsutomu Kawata
Seiichi Kobay Ashi
Daniel P Rossignol
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ZA927751B publication Critical patent/ZA927751B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA927751A 1991-10-11 1992-10-08 Anti-endotoxin compound and related molecules and methods. ZA927751B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77610091A 1991-10-11 1991-10-11

Publications (1)

Publication Number Publication Date
ZA927751B true ZA927751B (en) 1993-06-10

Family

ID=25106455

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927751A ZA927751B (en) 1991-10-11 1992-10-08 Anti-endotoxin compound and related molecules and methods.

Country Status (4)

Country Link
US (1) US5530113A (Direct)
KR (1) KR930007942A (Direct)
TW (1) TW250482B (Direct)
ZA (1) ZA927751B (Direct)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
US6417172B1 (en) * 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5750664A (en) * 1995-06-05 1998-05-12 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
AU7254396A (en) * 1995-09-29 1997-04-17 Eisai Research Institute Method for treating alcoholic liver disease
EP0909562B1 (en) * 1996-07-03 2005-06-29 Eisai Co., Ltd. Injections containing lipid a analogues and process for the preparation thereof
US6172220B1 (en) 1997-01-21 2001-01-09 Board Of Regents Of University Of Nebraska Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis
US6444654B1 (en) 1997-01-21 2002-09-03 Board Of Regents Of University Of Nebraska Isolated asgal lipopolysaccharides and use of same to inhibit innate immune response
CA2301943C (en) * 1997-08-29 2008-11-04 The Johns Hopkins University Antimicrobial compounds
AU2003200765B2 (en) * 1997-08-29 2007-01-25 The Johns Hopkins University Antimicrobial compounds
US6713654B1 (en) * 1997-08-29 2004-03-30 The Johns Hopkins University School Of Medicine Antimicrobial compounds
US6011066A (en) * 1998-02-02 2000-01-04 Veterans General Hospital-Taipei Method for treating septic shock
DE60036790T2 (de) 1999-01-14 2008-07-24 Eisai R&D Management Co., Ltd. Verwendung von e5564 zur behandlung von sepsis durch intravenöse infusion
US20040006242A1 (en) 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
AU2008202882B2 (en) * 1999-02-01 2011-06-16 Eisai R & D Management Co., Ltd. Immunological adjuvant compound
EP2452684B1 (en) 2000-02-18 2018-01-24 Eisai R&D Management Co., Ltd. Micelles
WO2002085117A1 (en) * 2001-04-24 2002-10-31 Eisai Co., Ltd. Methods and compositions for preventing and treating septic shock and endotoxemia
WO2003013440A2 (en) 2001-08-10 2003-02-20 Eisai Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
AU2003242470A1 (en) * 2002-06-18 2003-12-31 Sankyo Company, Limited 1-carboxymethyl analogues of glucosyl lipid a
MXPA05007295A (es) 2003-01-06 2005-09-30 Corixa Corp Ciertos compuestos de fosfato de aminoalquil glucosaminida y su uso.
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US7951232B2 (en) * 2006-02-09 2011-05-31 Elevance Renewable Sciences, Inc. Surface coating compositions and methods
CN101969771A (zh) * 2006-02-09 2011-02-09 埃莱文斯可更新科学公司 抗微生物组合物、方法和体系
PT2486938T (pt) 2006-09-26 2018-06-12 Infectious Disease Res Inst Composição para vacina contendo adjuvante sintético
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8563523B2 (en) * 2007-09-07 2013-10-22 University Of Georgia Research Foundation, Inc. Synthetic lipid A derivative
LT2437753T (lt) * 2009-06-05 2016-12-12 Infectious Disease Research Institute Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos
EP2537523B1 (en) 2010-02-16 2016-03-30 TFK Co., Ltd Prophylactic/ameliorating agent for diseases, endurance improving agent and anti-fatigue agent, and pharmaceutical agent, food and beverage each comprising any one of those agents
CN103596586A (zh) 2011-04-08 2014-02-19 免疫设计公司 免疫原性组合物及使用所述组合物诱导体液和细胞免疫反应的方法
HRP20181102T1 (hr) 2012-05-16 2018-09-07 Immune Design Corp Cjepiva za hsv-2
HK1214510A1 (zh) 2013-04-18 2016-07-29 Immune Design Corp. 用於癌症治疗的gla单一疗法
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
FI3752182T3 (fi) 2018-02-12 2024-07-30 Inimmune Corp Tollin kaltaisen reseptorin ligandeja
EP3897665A4 (en) 2018-12-17 2022-09-28 Eisai R&D Management Co., Ltd. FORMULATION INCLUDING LIPOSOMES

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Publication number Priority date Publication date Assignee Title
US4495346A (en) * 1981-03-30 1985-01-22 Wisconsin Alumni Research Foundation Method of preparing a disaccharide
US5057598A (en) * 1983-05-06 1991-10-15 Centocor, Inc. Monoclonal antibodies reactive with endotoxin core
US4844894A (en) * 1984-07-12 1989-07-04 Ribi Immunochem Research Inc. Method of inhibiting the onset of septicemia and endotoxemia
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
JPS6153295A (ja) * 1984-08-24 1986-03-17 Dai Ichi Seiyaku Co Ltd ジサツカライド誘導体
US5066794A (en) * 1984-08-24 1991-11-19 Daiichi Pharmaceutical Co., Ltd. Process for preparing a disaccharide derivative
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4877611A (en) * 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4929604A (en) * 1986-05-28 1990-05-29 Board Of Regents, The University Of Texas System Lipopolysaccharides of reduced toxicity and the production thereof
JP2535048B2 (ja) * 1988-02-29 1996-09-18 第一製薬株式会社 新規ジサッカライド誘導体及びその塩
US5134230A (en) * 1988-03-02 1992-07-28 Daiichi Pharmaceutical Co., Ltd. 2-Deoxy-2-aminoglucopyranoside derivatives
ZA881430B (Direct) * 1988-03-02 1988-10-28
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5041427A (en) * 1989-07-21 1991-08-20 Wisconsin Alumni Research Foundation Lipid A derivatives
US5158939A (en) * 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
JPH0655749B2 (ja) * 1989-09-20 1994-07-27 日本たばこ産業株式会社 リピッドａ単糖類縁体
JP2839916B2 (ja) * 1989-10-20 1998-12-24 三共株式会社 リピドａ３位エーテル類縁体
US5158941A (en) * 1990-06-08 1992-10-27 E. I. Du Pont De Nemours And Company Lipid A analog as stimulant for production of interleukin-1 in human monocytes and tumor cell growth inhibitor
AU660325B2 (en) * 1991-10-11 1995-06-22 Eisai Co. Ltd. Anti-endotoxin compounds and related molecules and methods

Also Published As

Publication number Publication date
US5530113A (en) 1996-06-25
KR930007942A (ko) 1993-05-20
TW250482B (Direct) 1995-07-01

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