ZA922873B - N - hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]-ureas as lipoxygenase inhibitors - Google Patents

N - hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]-ureas as lipoxygenase inhibitors

Info

Publication number
ZA922873B
ZA922873B ZA922873A ZA922873A ZA922873B ZA 922873 B ZA922873 B ZA 922873B ZA 922873 A ZA922873 A ZA 922873A ZA 922873 A ZA922873 A ZA 922873A ZA 922873 B ZA922873 B ZA 922873B
Authority
ZA
South Africa
Prior art keywords
halophenylthio
enyl
ureas
prop
hydroxy
Prior art date
Application number
ZA922873A
Other languages
English (en)
Inventor
Gary Alan Hite
Edward David Mihelich
David Wells Snyder
Tulio Suarez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA922873B publication Critical patent/ZA922873B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA922873A 1991-04-23 1992-04-21 N - hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]-ureas as lipoxygenase inhibitors ZA922873B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69020491A 1991-04-23 1991-04-23

Publications (1)

Publication Number Publication Date
ZA922873B true ZA922873B (en) 1993-10-21

Family

ID=24771539

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA922873A ZA922873B (en) 1991-04-23 1992-04-21 N - hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]-ureas as lipoxygenase inhibitors

Country Status (17)

Country Link
US (1) US5283361A (cs)
EP (1) EP0510948A1 (cs)
JP (1) JPH05117227A (cs)
KR (1) KR920019740A (cs)
CN (1) CN1066062A (cs)
AU (1) AU638641B2 (cs)
BR (1) BR9201452A (cs)
CA (1) CA2066508A1 (cs)
CS (1) CS119492A3 (cs)
FI (1) FI921786A7 (cs)
HU (1) HUT62557A (cs)
IE (1) IE921279A1 (cs)
IL (1) IL101625A0 (cs)
MX (1) MX9201808A (cs)
NO (1) NO921530L (cs)
TW (1) TW199141B (cs)
ZA (1) ZA922873B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物
EP0736006A1 (en) * 1993-12-22 1996-10-09 Pfizer Inc. Phenylthiophenyl cycloalkenyl hydroxyureas as lipoxygenase inhibitors
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
JP3929140B2 (ja) * 1997-10-27 2007-06-13 日本碍子株式会社 耐蝕性部材およびその製造方法
CN104042617A (zh) 2009-04-29 2014-09-17 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
CN102659637B (zh) * 2012-05-21 2014-05-14 上海大学 一种制备双羟基脲的新方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT82200B (pt) * 1985-03-16 1990-02-08 Wellcome Found Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
US5185363A (en) * 1986-04-25 1993-02-09 Abbott Laboratories Urea based lipoxygenase inhibiting compounds
GB8619593D0 (en) * 1986-08-12 1986-09-24 Roussel Lab Ltd Chemical compounds
EP0279263B1 (en) * 1987-02-10 1993-08-04 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
NO171906C (no) * 1989-02-03 1993-05-19 Wellcome Found Analogifremgangsmaate for fremstilling av anti-inflammatorisk aktive arylforbindelser
JPH04504261A (ja) * 1989-03-30 1992-07-30 アボツト・ラボラトリーズ 尿素系リポキシゲナーゼ阻害化合物
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents

Also Published As

Publication number Publication date
JPH05117227A (ja) 1993-05-14
AU638641B2 (en) 1993-07-01
CN1066062A (zh) 1992-11-11
HUT62557A (en) 1993-05-28
HU9201343D0 (en) 1992-07-28
NO921530D0 (no) 1992-04-21
US5283361A (en) 1994-02-01
MX9201808A (es) 1994-05-31
BR9201452A (pt) 1992-12-01
FI921786A7 (fi) 1992-10-24
CS119492A3 (en) 1992-12-16
KR920019740A (ko) 1992-11-19
IL101625A0 (en) 1992-12-30
FI921786A0 (fi) 1992-04-22
AU1500992A (en) 1992-10-29
CA2066508A1 (en) 1992-10-24
EP0510948A1 (en) 1992-10-28
NO921530L (no) 1992-10-26
IE921279A1 (en) 1992-11-04
TW199141B (cs) 1993-02-01

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