ZA918293B - 1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application - Google Patents

1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application

Info

Publication number
ZA918293B
ZA918293B ZA918293A ZA918293A ZA918293B ZA 918293 B ZA918293 B ZA 918293B ZA 918293 A ZA918293 A ZA 918293A ZA 918293 A ZA918293 A ZA 918293A ZA 918293 B ZA918293 B ZA 918293B
Authority
ZA
South Africa
Prior art keywords
ethanone
quinolin
piperidin
phenylethyl
dihydro
Prior art date
Application number
ZA918293A
Other languages
English (en)
Inventor
Jonathan Frost
Frost Jonathan
Patrick Lardenois
Lardenois Patrick
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA918293B publication Critical patent/ZA918293B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA918293A 1990-10-18 1991-10-17 1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application ZA918293B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9012872A FR2668149B1 (fr) 1990-10-18 1990-10-18 Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.

Publications (1)

Publication Number Publication Date
ZA918293B true ZA918293B (en) 1992-07-29

Family

ID=9401336

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918293A ZA918293B (en) 1990-10-18 1991-10-17 1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application

Country Status (18)

Country Link
US (1) US5212181A (ja)
EP (1) EP0481853A1 (ja)
JP (1) JPH04257579A (ja)
KR (1) KR920008029A (ja)
AU (1) AU638173B2 (ja)
CA (1) CA2052760A1 (ja)
CS (1) CS315291A3 (ja)
FI (1) FI914906A (ja)
FR (1) FR2668149B1 (ja)
HU (1) HUT59391A (ja)
IE (1) IE913653A1 (ja)
IL (1) IL99779A0 (ja)
MX (1) MX9101604A (ja)
NO (1) NO914071L (ja)
NZ (1) NZ240261A (ja)
PL (1) PL292089A1 (ja)
PT (1) PT99247A (ja)
ZA (1) ZA918293B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524846A1 (fr) * 1991-06-27 1993-01-27 Synthelabo Dérivés de 2-(pipéridin-1-y1) éthanol, leur préparation et leur application en thérapeutique
US6255322B1 (en) * 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
FR2699534B1 (fr) * 1992-12-21 1995-02-03 Synthelabo Dérivés de alpha-thiényl-pipéridine-1-éthanol, leur préparation et leur application en thérapeutique.
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
AU7474998A (en) * 1997-05-07 1998-11-27 Emory University Haloisoquinoline carboxamide
WO2004011430A1 (ja) * 2002-07-25 2004-02-05 Yamanouchi Pharmaceutical Co., Ltd. ナトリウムチャネル阻害剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2668149A1 (fr) 1992-04-24
NO914071D0 (no) 1991-10-17
AU638173B2 (en) 1993-06-17
IE913653A1 (en) 1992-04-22
US5212181A (en) 1993-05-18
AU8589291A (en) 1992-04-30
HUT59391A (en) 1992-05-28
JPH04257579A (ja) 1992-09-11
NZ240261A (en) 1993-01-27
NO914071L (no) 1992-04-21
EP0481853A1 (fr) 1992-04-22
IL99779A0 (en) 1992-08-18
FR2668149B1 (fr) 1994-09-23
FI914906A0 (fi) 1991-10-17
FI914906A (fi) 1992-04-19
PT99247A (pt) 1992-08-31
HU913267D0 (en) 1992-01-28
CS315291A3 (en) 1992-05-13
CA2052760A1 (en) 1992-04-19
KR920008029A (ko) 1992-05-27
MX9101604A (es) 1992-06-05
PL292089A1 (en) 1992-06-26

Similar Documents

Publication Publication Date Title
PL327406A1 (en) 1-(1,2-disubstituted-piperidinyl)-4-substituted derivatives of piperazine
NZ325845A (en) 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives, preparation and pharmaceutical use thereof
HUP9602601A3 (en) Piperidine and piperazine derivatives, medicines containing them as active ingredient and their use
NO972679L (no) Fremgangsmåte for fremstilling av 1-(2'-deoksy-2',2'-difluor-D-ribofuranosyl-4-aminopyrimidin-2-on)hydroklorid
HU9402827D0 (en) 4-[4'-piperidinyl or 3'pirrolidinyl] substituted imidazoles as h3-receptor antagonists and therapeutic uses thereof
HU913747D0 (en) 1,2,3,6-tetrahydropiridine and piperidine derivatives substituted by n-(hydroxy-alkyl)-group
CS332591A3 (en) 1-(2-arylethyl)pyrrolidines, process of their preparation and pharmaceuticals prepared on the base thereof
FR2681325B1 (fr) Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
ZA918293B (en) 1-(3,4-dihydro-2-oxo-1h-quinolin-6-yl)-2(4-(2-phenylethyl)piperidin-1-yl)ethanol and-ethanone,their preparation and their therapeutic application
IL97447A0 (en) Derivatives of 4-(aminomethyl)piperidine,their preparation and their therapeutic application
IL87339A0 (en) 2-((4-piperidyl)methyl)-1,2,3-4-tetrahydroisoquinoline derivatives,their preparation and their application in therapy
FR2681319B1 (fr) Derives de 1-(phenoxyalkyl)piperidine, leur preparation et leur application en therapeutique.
EP0714890A3 (de) Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin
IL102334A0 (en) 2-(1-piperidyl)ethanol derivatives,their preparation and their therapeutic application
ZA895271B (en) ((4-piperidyl)methyl)-2,3-dihydro-1h-isoindole and-2,3,4,5-tetrahydro-1h-benzazepine derivatives,their preparation and their application in therapy
FR2672286B1 (fr) Derives de 1-(4-chlorophenyl)-2-[4-(phenylmethyl)piperidin-1-yl]ethanol, leur preparation et leur application en therapeutique.
FR2678269B1 (fr) Derives de 1-(4-chlorophenyl)-2-[4-(2-phenylethyl)piperidin-1-yl]ethanol, leur application et leur preparation en therapeutique.
IL90909A0 (en) ((4-piperidyl)methyl)-2.3-dihydro-1h-isoindole and-2.3.4.5.-tetrahydro-1h-benzazepine derivatives their preparation and their application in therapy
MY108199A (en) Tricyclic pyridone derivative
NZ316981A (en) 4-(cycloalkyl)piperidine and 4-(cycloalkylalkyl)piperidine derivatives, preparation thereof and therapeutical applications thereof
IL97859A0 (en) 1,5-benzothiazepinone derivatives,their preparation and pharmaceutical use
NZ315363A (en) 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4-(naphthalen-1-yl)piperazine derivatives, preparation thereof and therapeutical use thereof
AU653800B2 (en) 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use
GB2325229B (en) 2,3-Disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof
IL100729A (en) 1-(2( 3(-dideoxy- 2-fluoro- -darabinofuranosyl)- cytosine and uracil derivatives