ZA911740B - Tris-maleimido compounds as intermediates in trifunctional antibody synthesis - Google Patents
Tris-maleimido compounds as intermediates in trifunctional antibody synthesisInfo
- Publication number
- ZA911740B ZA911740B ZA911740A ZA911740A ZA911740B ZA 911740 B ZA911740 B ZA 911740B ZA 911740 A ZA911740 A ZA 911740A ZA 911740 A ZA911740 A ZA 911740A ZA 911740 B ZA911740 B ZA 911740B
- Authority
- ZA
- South Africa
- Prior art keywords
- intermediates
- tris
- antibody synthesis
- trifunctional antibody
- maleimido compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/491,386 US5091542A (en) | 1990-03-09 | 1990-03-09 | Tris-maleimido compounds as intermediates in trifunctional antibody synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA911740B true ZA911740B (en) | 1992-11-25 |
Family
ID=23951991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA911740A ZA911740B (en) | 1990-03-09 | 1991-03-08 | Tris-maleimido compounds as intermediates in trifunctional antibody synthesis |
Country Status (8)
Country | Link |
---|---|
US (1) | US5091542A (de) |
EP (1) | EP0446071A3 (de) |
JP (1) | JPH06228091A (de) |
AU (1) | AU638313B2 (de) |
CA (1) | CA2037811A1 (de) |
IL (1) | IL97460A0 (de) |
NO (1) | NO176438C (de) |
ZA (1) | ZA911740B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262524A (en) * | 1990-03-09 | 1993-11-16 | Hybritech Incorporated | Method for the synthesis of trifunctional maleimide-antibody complex |
US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
US6685930B1 (en) * | 1991-03-27 | 2004-02-03 | Tanox, Inc. | Methods and substances for recruiting therapeutic agents to solid tumors |
US6511663B1 (en) * | 1991-06-11 | 2003-01-28 | Celltech R&D Limited | Tri- and tetra-valent monospecific antigen-binding proteins |
GB9112536D0 (en) * | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
EP0569141A3 (de) * | 1992-04-14 | 1994-10-26 | Hybritech Inc | Methode zur Hemmung des Wachstums von multidrugresistenten Tumoren durch Antikörper. |
ATE222264T1 (de) * | 1992-10-02 | 2002-08-15 | Diatide Inc | Multimerische mehrzweckwirkstoffe gegen thrombose |
GB2278357B (en) * | 1992-12-10 | 1997-03-05 | Celltech Ltd | Humanised antibodies directed against A33 antigen |
US6307026B1 (en) * | 1992-12-10 | 2001-10-23 | Celltech Limited | Humanized antibodies directed against A33 antigen |
DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
DE4310141A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Homobidentale trifunktionelle Linker |
DE4334873A1 (de) * | 1993-10-13 | 1995-04-20 | Nycomed Arzneimittel Gmbh | Asymmetrisch substituierte Diaminodicarbonsäurederivate und Verfahren zu deren Herstellung |
US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
DK0912612T3 (da) * | 1996-07-25 | 2004-02-02 | Gsf Forschungszentrum Umwelt | Forenklet fremstilling af bispecifikke antistoffragmenter |
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US20020094316A1 (en) * | 2001-01-09 | 2002-07-18 | Shuang Liu | Polypodal chelants for metallopharmaceuticals |
US6803406B2 (en) | 2002-03-29 | 2004-10-12 | National Starch And Chemical Investmnet Holding Corporation | Electron donors, electron acceptors and adhesion promoters containing disulfide |
EP1660519B1 (de) * | 2003-07-29 | 2014-05-14 | Immunomedics, Inc. | Konjugate von 2-[18F]Fluor-2-desoxy-D-glucose und einem Peptid-Molekül |
AU2006223002A1 (en) | 2005-03-14 | 2006-09-21 | Medimmune, Llc | Macromolecules comprising a thioether cross-link |
JP4793714B2 (ja) * | 2005-05-19 | 2011-10-12 | 独立行政法人産業技術総合研究所 | 新規クロスリンカー化合物 |
WO2008123478A1 (en) * | 2007-03-29 | 2008-10-16 | Canon Kabushiki Kaisha | Active energy ray curable liquid composition and liquid cartridge |
US8124791B2 (en) * | 2007-03-29 | 2012-02-28 | Canon Kabushiki Kaisha | Active energy ray curable liquid composition and liquid cartridge |
US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
WO2013173337A2 (en) * | 2012-05-15 | 2013-11-21 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
US9901647B2 (en) | 2013-02-28 | 2018-02-27 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
AU2017310436B2 (en) | 2016-08-09 | 2022-08-25 | Seagen Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
AR128330A1 (es) * | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpo y métodos de estos |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH634558A5 (de) * | 1978-04-06 | 1983-02-15 | Ciba Geigy Ag | Verfahren zur herstellung von aliphatischen n-substituierten maleinimiden. |
US4433059A (en) * | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4722892A (en) * | 1984-08-31 | 1988-02-02 | Meares Claude F | Monoclonal antibodies against metal chelates |
US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4814438A (en) * | 1986-12-24 | 1989-03-21 | Eli Lilly And Company | Immunoglobulin conjugates of 2',2'-difluronucleosides |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
AU626809B2 (en) * | 1987-10-30 | 1992-08-13 | Abbott Laboratories | Heterobifunctional coupling agents |
US5066490A (en) * | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
-
1990
- 1990-03-09 US US07/491,386 patent/US5091542A/en not_active Expired - Fee Related
-
1991
- 1991-03-06 IL IL97460A patent/IL97460A0/xx unknown
- 1991-03-07 AU AU72724/91A patent/AU638313B2/en not_active Ceased
- 1991-03-08 JP JP3068824A patent/JPH06228091A/ja active Pending
- 1991-03-08 EP EP19910301962 patent/EP0446071A3/en not_active Withdrawn
- 1991-03-08 NO NO910922A patent/NO176438C/no unknown
- 1991-03-08 ZA ZA911740A patent/ZA911740B/xx unknown
- 1991-03-08 CA CA002037811A patent/CA2037811A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0446071A2 (de) | 1991-09-11 |
AU7272491A (en) | 1991-09-12 |
NO910922L (no) | 1991-09-10 |
US5091542A (en) | 1992-02-25 |
NO176438C (no) | 1995-04-05 |
CA2037811A1 (en) | 1991-09-10 |
AU638313B2 (en) | 1993-06-24 |
IL97460A0 (en) | 1992-06-21 |
NO176438B (no) | 1994-12-27 |
JPH06228091A (ja) | 1994-08-16 |
NO910922D0 (no) | 1991-03-08 |
EP0446071A3 (en) | 1992-05-13 |
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