DK0912612T3 - Forenklet fremstilling af bispecifikke antistoffragmenter - Google Patents

Forenklet fremstilling af bispecifikke antistoffragmenter

Info

Publication number
DK0912612T3
DK0912612T3 DK96927598T DK96927598T DK0912612T3 DK 0912612 T3 DK0912612 T3 DK 0912612T3 DK 96927598 T DK96927598 T DK 96927598T DK 96927598 T DK96927598 T DK 96927598T DK 0912612 T3 DK0912612 T3 DK 0912612T3
Authority
DK
Denmark
Prior art keywords
antibody fragments
bispecific antibody
simplified preparation
simplified
preparation
Prior art date
Application number
DK96927598T
Other languages
English (en)
Inventor
Gundram Jung
Original Assignee
Gsf Forschungszentrum Umwelt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Application granted granted Critical
Publication of DK0912612T3 publication Critical patent/DK0912612T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
DK96927598T 1996-07-25 1996-07-25 Forenklet fremstilling af bispecifikke antistoffragmenter DK0912612T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1996/003275 WO1998004592A1 (de) 1996-07-25 1996-07-25 Vereinfachte herstellung bispezifischer antikörperfragmente

Publications (1)

Publication Number Publication Date
DK0912612T3 true DK0912612T3 (da) 2004-02-02

Family

ID=8166274

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96927598T DK0912612T3 (da) 1996-07-25 1996-07-25 Forenklet fremstilling af bispecifikke antistoffragmenter

Country Status (5)

Country Link
EP (1) EP0912612B1 (da)
JP (1) JP3266276B2 (da)
DE (1) DE59610754D1 (da)
DK (1) DK0912612T3 (da)
WO (1) WO1998004592A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10034607A1 (de) 2000-07-20 2002-02-07 Gundram Jung Multispezifisches Reagenz zur selektiven Stimulierung von Zelloberflächenrezeptoren
CA2550996A1 (en) * 2003-12-22 2005-07-14 Centocor, Inc. Methods for generating multimeric molecules
WO2008119353A1 (en) * 2007-03-29 2008-10-09 Genmab A/S Bispecific antibodies and methods for production thereof
DE102007023183A1 (de) * 2007-05-18 2008-11-20 Universitätsklinikum Hamburg-Eppendorf (UKE) Verwendung von Autoantikörpern gegen CD28 als prognostischer Marker beim malignen Melanom
SG184427A1 (en) 2010-04-20 2012-11-29 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
LT2771364T (lt) 2011-10-27 2019-09-10 Genmab A/S Heterodimerinių baltymų gamyba
WO2016097300A1 (en) 2014-12-19 2016-06-23 Genmab A/S Rodent bispecific heterodimeric proteins
CN111246885A (zh) 2017-10-20 2020-06-05 豪夫迈·罗氏有限公司 从单特异性抗体生成多特异性抗体的方法
TWI832824B (zh) 2017-10-30 2024-02-21 瑞士商赫孚孟拉羅股份公司 自單特異性抗體於活體內產生多特異性抗體之方法
KR102627248B1 (ko) 2018-02-26 2024-01-19 싸이노슈어, 엘엘씨 Q-스위치드 캐비티 덤핑 서브 나노초 레이저
KR102607909B1 (ko) 2020-08-19 2023-12-01 젠코어 인코포레이티드 항-cd28 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091542A (en) * 1990-03-09 1992-02-25 Hybritech Incorporated Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
GB9200417D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates

Also Published As

Publication number Publication date
WO1998004592A1 (de) 1998-02-05
EP0912612A1 (de) 1999-05-06
JP3266276B2 (ja) 2002-03-18
EP0912612B1 (de) 2003-10-01
DE59610754D1 (de) 2003-11-06

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