ZA908725B - Imidazo(4,5-b)quinolinyloxyalkanoic acid amides with enhanced water solubility - Google Patents

Imidazo(4,5-b)quinolinyloxyalkanoic acid amides with enhanced water solubility

Info

Publication number
ZA908725B
ZA908725B ZA908725A ZA908725A ZA908725B ZA 908725 B ZA908725 B ZA 908725B ZA 908725 A ZA908725 A ZA 908725A ZA 908725 A ZA908725 A ZA 908725A ZA 908725 B ZA908725 B ZA 908725B
Authority
ZA
South Africa
Prior art keywords
imidazo
acid amides
water solubility
enhanced water
quinolinyloxyalkanoic acid
Prior art date
Application number
ZA908725A
Other languages
English (en)
Inventor
Nicholas Meanwell
Meanwell Nicholas
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA908725B publication Critical patent/ZA908725B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA908725A 1989-11-01 1990-10-31 Imidazo(4,5-b)quinolinyloxyalkanoic acid amides with enhanced water solubility ZA908725B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/430,228 US4943573A (en) 1989-11-01 1989-11-01 Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility

Publications (1)

Publication Number Publication Date
ZA908725B true ZA908725B (en) 1991-07-31

Family

ID=23706624

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908725A ZA908725B (en) 1989-11-01 1990-10-31 Imidazo(4,5-b)quinolinyloxyalkanoic acid amides with enhanced water solubility

Country Status (20)

Country Link
US (1) US4943573A (fi)
EP (1) EP0426180A3 (fi)
JP (1) JPH03169880A (fi)
KR (1) KR910009705A (fi)
CN (1) CN1025999C (fi)
AU (1) AU639033B2 (fi)
CA (1) CA2027935A1 (fi)
EG (1) EG19372A (fi)
FI (1) FI92697C (fi)
HU (1) HU209305B (fi)
IE (1) IE61579B1 (fi)
IL (1) IL96167A (fi)
MY (1) MY105308A (fi)
NO (1) NO175531C (fi)
NZ (1) NZ235868A (fi)
OA (1) OA09323A (fi)
PT (1) PT95765A (fi)
RU (1) RU2041210C1 (fi)
YU (1) YU205590A (fi)
ZA (1) ZA908725B (fi)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis
US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
WO1996005202A1 (fr) * 1994-08-17 1996-02-22 Nippon Hypox Laboratories Inc. Derive de l'imidazoquinoleine
US5798767A (en) * 1996-03-15 1998-08-25 Rendition, Inc. Method and apparatus for performing color space conversion using blend logic
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
US20030186963A1 (en) * 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
WO2003031432A1 (en) * 2001-10-12 2003-04-17 Novo Nordisk A/S Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US8227603B2 (en) * 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) * 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
RS54542B1 (en) * 2006-08-02 2016-06-30 Cytokinetics, Inc. CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS INCLUDING IMIDAZOPYRIMIDINE
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US7851484B2 (en) * 2007-03-30 2010-12-14 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
CA2849213A1 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination of riluzole and ck-2017357 for treating als
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PT3004138T (pt) 2013-06-05 2024-06-18 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
IL74349A (en) * 1984-02-15 1988-07-31 Syntex Inc (2-oxo-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolinyl)-oxyalkylamides,their preparation and pharmaceutical compositions containing them
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility

Also Published As

Publication number Publication date
FI92697B (fi) 1994-09-15
EP0426180A2 (en) 1991-05-08
HU209305B (en) 1994-04-28
PT95765A (pt) 1991-09-13
HUT56102A (en) 1991-07-29
YU205590A (sh) 1992-09-07
US4943573A (en) 1990-07-24
AU6567990A (en) 1991-05-23
NO175531B (no) 1994-07-18
EP0426180A3 (en) 1992-01-08
IL96167A (en) 1994-11-11
NO904689L (no) 1991-05-02
HU906977D0 (en) 1991-05-28
IE61579B1 (en) 1994-11-16
NO175531C (no) 1994-10-26
EG19372A (en) 1994-12-30
KR910009705A (ko) 1991-06-28
IL96167A0 (en) 1991-07-18
NZ235868A (en) 1993-12-23
AU639033B2 (en) 1993-07-15
FI905326A0 (fi) 1990-10-29
CA2027935A1 (en) 1991-05-02
CN1025999C (zh) 1994-09-28
MY105308A (en) 1994-09-30
OA09323A (en) 1992-09-15
CN1051359A (zh) 1991-05-15
IE903923A1 (en) 1991-05-08
FI92697C (fi) 1994-12-27
NO904689D0 (no) 1990-10-30
RU2041210C1 (ru) 1995-08-09
JPH03169880A (ja) 1991-07-23

Similar Documents

Publication Publication Date Title
ZA908725B (en) Imidazo(4,5-b)quinolinyloxyalkanoic acid amides with enhanced water solubility
CY2076B1 (en) N-[pyrrolo(2,3-d)pyrimidin-3-ylacyl]-glutamic acid derivatives
ZA87143B (en) Pyrido(2,3-b)indoles
ZA911398B (en) Carboxylic acid derivatives
EP0457960A3 (en) High acid concentration dialysates
GB8630759D0 (en) Carboxylic acid derivatives
ZA913132B (en) Carboxylic acid derivatives
GB2229781B (en) Water supply point
GB2234061B (en) Water monitor
GB8909380D0 (en) Water soluble pesticide solution
GB8921635D0 (en) 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
PH23637A (en) 2,1-benzonthiazepine-2,2-dioxide-5-carboxylic acid derivatives
GB2227018B (en) Piperazinylalkylcarboxylic acid adamantylamides
GB8809871D0 (en) -amino-alkanoic acid derivative & processes
GB8909277D0 (en) 3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CS775988A1 (en) 7-chloro-1-(2,4 dinitrophynel)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxyl acid
EP0415556A3 (en) Water soluble 1,2-dithio-3-thiones
IE870741L (en) PYRIDO /4,3-b/ /1,6/-NAPHTHYRIDINES
IE860734L (en) PYRIDO (3,4:4,5) PYRROLO (3,2-c) PYRIDINES
ZA9010295B (en) Imidazo(4,5-c)pyridines as antiosteoporotic agents
GB8621544D0 (en) Pyrido(3 4-blindole derivatives
ZA902133B (en) Acrylamido-penicillanic acid derivatives
ZA90510B (en) Carboxylic-and sulfonic acid amides
IE861718L (en) Substituted Tetrahydropyrido (1,2-a) Indoles
GB8612942D0 (en) Towing bar