ZA905148B - 2-(aminoaryl)indoles and indolines,a process for their preparation and their use as medicaments - Google Patents
2-(aminoaryl)indoles and indolines,a process for their preparation and their use as medicamentsInfo
- Publication number
- ZA905148B ZA905148B ZA905148A ZA905148A ZA905148B ZA 905148 B ZA905148 B ZA 905148B ZA 905148 A ZA905148 A ZA 905148A ZA 905148 A ZA905148 A ZA 905148A ZA 905148 B ZA905148 B ZA 905148B
- Authority
- ZA
- South Africa
- Prior art keywords
- indolines
- aminoaryl
- indoles
- medicaments
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/375,550 US5166170A (en) | 1989-07-03 | 1989-07-03 | 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA905148B true ZA905148B (en) | 1991-04-24 |
Family
ID=23481318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA905148A ZA905148B (en) | 1989-07-03 | 1990-07-02 | 2-(aminoaryl)indoles and indolines,a process for their preparation and their use as medicaments |
Country Status (13)
Country | Link |
---|---|
US (1) | US5166170A (hu) |
EP (1) | EP0406734A3 (hu) |
JP (1) | JPH0344370A (hu) |
KR (1) | KR910002795A (hu) |
AU (1) | AU5801990A (hu) |
CA (1) | CA2020298A1 (hu) |
FI (1) | FI903298A0 (hu) |
HU (1) | HUT54643A (hu) |
IE (1) | IE902402A1 (hu) |
IL (1) | IL94951A0 (hu) |
NO (1) | NO902933L (hu) |
PT (1) | PT94573A (hu) |
ZA (1) | ZA905148B (hu) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
FR2779723B1 (fr) * | 1998-06-12 | 2000-07-13 | Cird Galderma | Composes biaryles heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
US7713964B2 (en) * | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US7605156B2 (en) * | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US6797708B2 (en) * | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
US7101875B2 (en) * | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
US6984735B2 (en) * | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
RU2004126671A (ru) * | 2002-02-06 | 2005-04-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероарилсоединения, полезные в качестве ингибиторов gsk-3 |
JP4500689B2 (ja) | 2002-12-26 | 2010-07-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的エストロゲン受容体モジュレーター |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
SG151267A1 (en) | 2004-03-15 | 2009-04-30 | Ptc Therapeutics Inc | Carboline derivatives useful in the inhibition of angiogenesis |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US8013006B2 (en) | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
JP2008507518A (ja) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎を治療するためのチエノピリジン |
TW200718687A (en) * | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
DK3122426T3 (da) | 2014-03-28 | 2023-04-03 | Univ Duke | Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer |
US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
US3642778A (en) * | 1969-10-22 | 1972-02-15 | Robins Co Inc A H | Benzimidazo(1 2-d)(1 4)benzodiazepin-6(5h)-ones |
US3642779A (en) * | 1969-10-22 | 1972-02-15 | Robins Co Inc A H | Indolo(1 2-d)(1 4)benzodiazepin-6-ones |
US3941806A (en) * | 1970-04-14 | 1976-03-02 | A. H. Robins Company | 7-(α-Acetylbenzyl)indoline |
US3732236A (en) * | 1971-04-12 | 1973-05-08 | Mead Johnson & Co | 2-phenyl-indoline amidines |
FR2275461A1 (fr) * | 1974-06-18 | 1976-01-16 | Labaz | Nouveaux stabilisants des polymeres et copolymeres du chlorure de vinyle |
US4448784A (en) * | 1982-04-12 | 1984-05-15 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof |
LU85544A1 (fr) * | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
JPS6253962A (ja) * | 1985-08-31 | 1987-03-09 | Teikoku Hormone Mfg Co Ltd | 2−フエニルインド−ル誘導体 |
EP0226508A1 (fr) * | 1985-12-02 | 1987-06-24 | Sanofi | Dérivés de l'indolo(3,2-c)quinoléine, leur procédé de préparation et leur activité antitumorale |
FR2590899A1 (fr) * | 1985-12-02 | 1987-06-05 | Sanofi Sa | Chloro-6 11-h indolo 3,2-c quinoleines un procede de preparation et leur application en tant qu'intermediaires de synthese |
FR2614618B1 (fr) * | 1987-04-30 | 1989-07-07 | Cird | Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire |
-
1989
- 1989-07-03 US US07/375,550 patent/US5166170A/en not_active Expired - Fee Related
-
1990
- 1990-06-29 FI FI903298A patent/FI903298A0/fi not_active Application Discontinuation
- 1990-06-30 EP EP19900112522 patent/EP0406734A3/en not_active Withdrawn
- 1990-07-02 IE IE240290A patent/IE902402A1/en unknown
- 1990-07-02 ZA ZA905148A patent/ZA905148B/xx unknown
- 1990-07-02 NO NO90902933A patent/NO902933L/no unknown
- 1990-07-02 HU HU904059A patent/HUT54643A/hu unknown
- 1990-07-02 JP JP2172849A patent/JPH0344370A/ja active Pending
- 1990-07-02 IL IL94951A patent/IL94951A0/xx unknown
- 1990-07-02 AU AU58019/90A patent/AU5801990A/en not_active Abandoned
- 1990-07-03 PT PT94573A patent/PT94573A/pt not_active Application Discontinuation
- 1990-07-03 CA CA002020298A patent/CA2020298A1/en not_active Abandoned
- 1990-07-03 KR KR1019900009988A patent/KR910002795A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US5166170A (en) | 1992-11-24 |
CA2020298A1 (en) | 1991-01-04 |
IL94951A0 (en) | 1991-06-10 |
EP0406734A2 (en) | 1991-01-09 |
NO902933D0 (no) | 1990-07-02 |
PT94573A (pt) | 1991-03-20 |
HUT54643A (en) | 1991-03-28 |
IE902402A1 (en) | 1991-06-19 |
AU5801990A (en) | 1991-01-03 |
JPH0344370A (ja) | 1991-02-26 |
FI903298A0 (fi) | 1990-06-29 |
NO902933L (no) | 1991-01-04 |
HU904059D0 (en) | 1990-12-28 |
KR910002795A (ko) | 1991-02-26 |
EP0406734A3 (en) | 1991-12-27 |
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