ZA902965B - Hepatospecific insulin analogues - Google Patents

Hepatospecific insulin analogues

Info

Publication number
ZA902965B
ZA902965B ZA902965A ZA902965A ZA902965B ZA 902965 B ZA902965 B ZA 902965B ZA 902965 A ZA902965 A ZA 902965A ZA 902965 A ZA902965 A ZA 902965A ZA 902965 B ZA902965 B ZA 902965B
Authority
ZA
South Africa
Prior art keywords
insulin analogues
hepatospecific
hepatospecific insulin
insulin
analogues
Prior art date
Application number
ZA902965A
Other languages
English (en)
Inventor
Panayotis G Katsoyannis
G Katsoyannis Panayotis
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Publication of ZA902965B publication Critical patent/ZA902965B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
ZA902965A 1989-04-20 1990-04-19 Hepatospecific insulin analogues ZA902965B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34092989A 1989-04-20 1989-04-20

Publications (1)

Publication Number Publication Date
ZA902965B true ZA902965B (en) 1991-02-27

Family

ID=23335524

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902965A ZA902965B (en) 1989-04-20 1990-04-19 Hepatospecific insulin analogues

Country Status (15)

Country Link
EP (1) EP0469084B1 (fi)
JP (1) JPH04504858A (fi)
AT (1) ATE120762T1 (fi)
AU (1) AU631868B2 (fi)
CA (1) CA2014896A1 (fi)
DE (1) DE69018461T2 (fi)
FI (1) FI914898A0 (fi)
GR (1) GR1000908B (fi)
HU (1) HU210142B (fi)
IE (1) IE67353B1 (fi)
IL (1) IL94163A (fi)
NO (1) NO301544B1 (fi)
PT (1) PT93832B (fi)
WO (1) WO1990012814A1 (fi)
ZA (1) ZA902965B (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK33591D0 (fi) * 1991-02-27 1991-02-27 Novo Nordisk As
US5268453A (en) * 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
GB9316895D0 (en) * 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
US6342225B1 (en) 1993-08-13 2002-01-29 Deutshces Wollforschungsinstitut Pharmaceutical active conjugates
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
EP1174437A4 (en) 1999-04-26 2006-03-15 Ajinomoto Kk HORMONAL INHIBITOR STIMULATING MELANOCYTES
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
WO2006019015A1 (ja) * 2004-08-18 2006-02-23 Kaneka Corporation インスリン結合たんぱく質と結合能力のあるペプチドおよび吸着材
WO2007020256A1 (en) 2005-08-16 2007-02-22 Novo Nordisk A/S Method for making mature insulin polypeptides
HUE029512T2 (en) 2006-09-22 2017-03-28 Novo Nordisk As Protease Resistant Insulin Analogs
JP5503968B2 (ja) 2006-09-27 2014-05-28 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
US20110065633A1 (en) 2008-01-30 2011-03-17 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
CN102245633A (zh) * 2008-12-09 2011-11-16 诺沃—诺迪斯克有限公司 新的胰岛素类似物
CA2744558A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
JP5789515B2 (ja) 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン類似体
AU2011268327B2 (en) 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
EP2585102B1 (en) 2010-06-24 2015-05-06 Indiana University Research and Technology Corporation Amide-based insulin prodrugs
WO2013096386A1 (en) 2011-12-20 2013-06-27 Indiana University Research And Technology Corporation Ctp-based insulin analogs for treatment of diabetes
JP6387008B2 (ja) 2012-09-26 2018-09-05 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリンアナローグダイマー
US9670162B2 (en) 2013-03-14 2017-06-06 The Board Of Trustees Of The Leland Stanford Junio Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof
RU2678134C2 (ru) 2013-03-14 2019-01-23 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Конъюгаты инсулин-инкретин
WO2015052088A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
EP3206710B1 (en) 2014-09-24 2020-05-06 Indiana University Research & Technology Corporation Incretin-insulin conjugates
ES2947409T3 (es) 2014-09-24 2023-08-08 Univ Indiana Res & Tech Corp Profármacos de insulina a base de amida lipídica
HRP20221324T1 (hr) 2016-12-16 2022-12-23 Novo Nordisk A/S Farmaceutski pripravci koji sadrže inzulin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
JPH04504858A (ja) 1992-08-27
EP0469084B1 (en) 1995-04-05
IE67353B1 (en) 1996-03-20
EP0469084A1 (en) 1992-02-05
NO914085L (no) 1991-11-28
GR1000908B (el) 1993-03-16
HU210142B (en) 1995-02-28
DE69018461T2 (de) 1995-08-03
IL94163A (en) 1995-08-31
DE69018461D1 (de) 1995-05-11
PT93832A (pt) 1990-11-20
HUT59941A (en) 1992-07-28
IE901404L (en) 1990-10-20
NO301544B1 (no) 1997-11-10
FI914898A0 (fi) 1991-10-17
HU903398D0 (en) 1991-12-30
IL94163A0 (en) 1991-01-31
WO1990012814A1 (en) 1990-11-01
PT93832B (pt) 1996-09-30
NO914085D0 (no) 1991-10-17
CA2014896A1 (en) 1990-10-20
AU5541590A (en) 1990-11-16
AU631868B2 (en) 1992-12-10
GR900100290A (en) 1991-09-27
ATE120762T1 (de) 1995-04-15

Similar Documents

Publication Publication Date Title
IE901404L (en) Hepatospecific insulin analogues
NZ506447A (en) Peptide analogues of insulin with alanine substitutions and pharmaceutical use
ES552093A0 (es) Un procedimiento para sintetizar una secuencia de aminoacidos que contienen la totalidad o parte de la secuencia de aminoacidos de la preprorrelaxina -h2 humana.
PL297610A1 (fi)
DE68929217D1 (en) Insulinotropes hormon
AU7565091A (en) Use of copper(ii) containing compounds to accelerate wound healing
IS2812A7 (is) Aðferð og tæki til notkunar og framleiðslu á efnum samsvarandi Dynorphin Amidum
IS4510A (is) Peptíð p277 hliðstæður og lyfjasamsetningar sem innihalda þær, til meðhöndlunar eða sjúkdómsgreiningar á sykursýki
AU1971988A (en) Pharmaceutical compositions for the treatment of uraemia
HU9300100D0 (en) Antagonists of excitatoric amino acids
CA2020663A1 (en) Substitution analogues of magainin peptides
SE7501342L (fi)
DE3561201D1 (en) Medicaments containing tripeptides
GB9125024D0 (en) Rheumatoid arthritus treatment
DE3268716D1 (en) Peptides and process for their preparation
EP0486964A3 (en) S(+)-phenyl-alkanoic acids and alpha-hydroxy-alkanoic acids containing complexes
EP0248231A3 (en) Pharmacologically active peptides
IL89877A0 (en) Process for the preparation of proteins which start with n-terminal proline
ATE112290T1 (de) Peptiden von retinblastoma gen produkten und antikoerper dagegen.
GB9604518D0 (en) Novel compounds
ES521569A0 (es) Un procedimiento para obtener una composicion farmaceutica liofilizada a base de interferon y un aminoacido estabilizante.
IT1241459B (it) Composizioni farmaceutiche per la somministrazione rettale di calcitonina