ZA9010082B - 2,19-methyleneoxy and 2,19-methylenethio bridged steriods as aromatase and 19-hydroxylase inhibitors - Google Patents

2,19-methyleneoxy and 2,19-methylenethio bridged steriods as aromatase and 19-hydroxylase inhibitors

Info

Publication number
ZA9010082B
ZA9010082B ZA9010082A ZA9010082A ZA9010082B ZA 9010082 B ZA9010082 B ZA 9010082B ZA 9010082 A ZA9010082 A ZA 9010082A ZA 9010082 A ZA9010082 A ZA 9010082A ZA 9010082 B ZA9010082 B ZA 9010082B
Authority
ZA
South Africa
Prior art keywords
methylenethio
steriods
methyleneoxy
aromatase
bridged
Prior art date
Application number
ZA9010082A
Other languages
English (en)
Inventor
Norton Paul Peet
Paul Peet Norton
John O'neal Johnston
O'neal Johnston John
Joseph Paul Burkhart
Paul Burkhart Joseph
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA9010082B publication Critical patent/ZA9010082B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA9010082A 1989-12-20 1990-12-14 2,19-methyleneoxy and 2,19-methylenethio bridged steriods as aromatase and 19-hydroxylase inhibitors ZA9010082B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344189A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
ZA9010082B true ZA9010082B (en) 1991-10-30

Family

ID=23800602

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9010082A ZA9010082B (en) 1989-12-20 1990-12-14 2,19-methyleneoxy and 2,19-methylenethio bridged steriods as aromatase and 19-hydroxylase inhibitors

Country Status (20)

Country Link
EP (1) EP0434020B1 (zh)
JP (1) JP2922653B2 (zh)
KR (1) KR100187781B1 (zh)
CN (1) CN1035768C (zh)
AR (1) AR248410A1 (zh)
AT (1) ATE124417T1 (zh)
AU (1) AU630008B2 (zh)
CA (1) CA2032311C (zh)
DE (1) DE69020520T2 (zh)
DK (1) DK0434020T3 (zh)
ES (1) ES2076286T3 (zh)
FI (1) FI107925B (zh)
GR (1) GR3017136T3 (zh)
HU (1) HU208024B (zh)
IE (1) IE67557B1 (zh)
IL (1) IL96695A (zh)
NO (1) NO177676C (zh)
NZ (1) NZ236473A (zh)
PT (1) PT96258B (zh)
ZA (1) ZA9010082B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491136A (en) * 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) * 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) * 1971-10-19 1976-05-04 Derek Harold Richard Barton Chemical compounds
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Also Published As

Publication number Publication date
NZ236473A (en) 1993-04-28
HU908299D0 (en) 1991-06-28
ES2076286T3 (es) 1995-11-01
AU6808390A (en) 1991-10-17
NO177676C (no) 1995-11-01
EP0434020B1 (en) 1995-06-28
DE69020520T2 (de) 1995-11-30
DE69020520D1 (de) 1995-08-03
CN1052678A (zh) 1991-07-03
IE904597A1 (en) 1991-07-03
NO177676B (no) 1995-07-24
DK0434020T3 (da) 1995-08-28
CN1035768C (zh) 1997-09-03
IL96695A (en) 1996-08-04
KR910011888A (ko) 1991-08-07
AR248410A1 (es) 1995-08-18
AU630008B2 (en) 1992-10-15
HUT56380A (en) 1991-08-28
FI906269A0 (fi) 1990-12-19
EP0434020A1 (en) 1991-06-26
PT96258B (pt) 1998-09-30
KR100187781B1 (ko) 1999-06-01
IE67557B1 (en) 1996-04-17
NO905494L (no) 1991-06-21
HU208024B (en) 1993-07-28
JP2922653B2 (ja) 1999-07-26
FI107925B (fi) 2001-10-31
PT96258A (pt) 1991-09-30
NO905494D0 (no) 1990-12-19
JPH04128297A (ja) 1992-04-28
FI906269A (fi) 1991-06-21
ATE124417T1 (de) 1995-07-15
CA2032311C (en) 2002-08-27
GR3017136T3 (en) 1995-11-30
IL96695A0 (en) 1991-09-16
CA2032311A1 (en) 1991-06-21

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