ZA898784B - Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof - Google Patents

Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof

Info

Publication number
ZA898784B
ZA898784B ZA898784A ZA898784A ZA898784B ZA 898784 B ZA898784 B ZA 898784B ZA 898784 A ZA898784 A ZA 898784A ZA 898784 A ZA898784 A ZA 898784A ZA 898784 B ZA898784 B ZA 898784B
Authority
ZA
South Africa
Prior art keywords
dipeptides
renin
preparation
urea derivatives
agents containing
Prior art date
Application number
ZA898784A
Other languages
English (en)
Inventor
Wolfgang Rueger
Rueger Wolfgang
Hansjoerg Urbach
Urbach Hansjoerg
Dieter Ruppert
Ruppert Dieter
Bernward Schoelkens
Schoelkens Bernward
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA898784B publication Critical patent/ZA898784B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA898784A 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof ZA898784B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839126A DE3839126A1 (de) 1988-11-19 1988-11-19 Renin-hemmende harnstoffderivate von dipeptiden, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA898784B true ZA898784B (en) 1990-08-29

Family

ID=6367476

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898784A ZA898784B (en) 1988-11-19 1989-11-17 Renin-inhibiting urea derivatives of dipeptides,a process for the preparation thereof,agents containing these,and the use thereof

Country Status (12)

Country Link
EP (1) EP0370382A3 (da)
JP (1) JPH02180898A (da)
KR (1) KR900007868A (da)
AU (1) AU616071B2 (da)
DE (1) DE3839126A1 (da)
DK (1) DK579089A (da)
FI (1) FI895462A0 (da)
HU (1) HU203771B (da)
IL (1) IL92348A0 (da)
NO (1) NO894569L (da)
PT (1) PT92330A (da)
ZA (1) ZA898784B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE4014421A1 (de) * 1990-05-05 1991-11-07 Merck Patent Gmbh Aminosaeurederivate
DK2935222T3 (da) 2012-12-21 2019-01-07 Epizyme Inc Prmt5-inhibitorer og anvendelser deraf
CA2899363A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
WO2014100734A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
EP3177288A4 (en) 2014-08-04 2018-04-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
GB8707412D0 (en) * 1987-03-27 1987-04-29 Fujisawa Pharmaceutical Co Peptide compounds
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Also Published As

Publication number Publication date
FI895462A0 (fi) 1989-11-16
HU203771B (en) 1991-09-30
DK579089D0 (da) 1989-11-17
EP0370382A2 (de) 1990-05-30
KR900007868A (ko) 1990-06-02
PT92330A (pt) 1990-05-31
EP0370382A3 (de) 1991-04-10
NO894569D0 (no) 1989-11-16
AU616071B2 (en) 1991-10-17
AU4479889A (en) 1990-08-09
DE3839126A1 (de) 1990-05-23
IL92348A0 (en) 1990-07-26
HU895948D0 (en) 1990-02-28
DK579089A (da) 1990-05-20
JPH02180898A (ja) 1990-07-13
NO894569L (no) 1990-05-21
HUT53122A (en) 1990-09-28

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