ZA896778B - Fluoro-substituted epipodophyllotoxin glucoside - Google Patents
Fluoro-substituted epipodophyllotoxin glucosideInfo
- Publication number
- ZA896778B ZA896778B ZA896778A ZA896778A ZA896778B ZA 896778 B ZA896778 B ZA 896778B ZA 896778 A ZA896778 A ZA 896778A ZA 896778 A ZA896778 A ZA 896778A ZA 896778 B ZA896778 B ZA 896778B
- Authority
- ZA
- South Africa
- Prior art keywords
- fluoro
- substituted
- epipodophyllotoxin glucoside
- epipodophyllotoxin
- glucoside
- Prior art date
Links
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title 1
- -1 epipodophyllotoxin glucoside Chemical class 0.000 title 1
- 229930182478 glucoside Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/240,971 US4912204A (en) | 1988-09-06 | 1988-09-06 | Fluoro-substituted epipodophyllotoxin glucosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA896778B true ZA896778B (en) | 1990-06-27 |
Family
ID=22908678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA896778A ZA896778B (en) | 1988-09-06 | 1989-09-05 | Fluoro-substituted epipodophyllotoxin glucoside |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4912204A (he) |
| EP (1) | EP0358197A3 (he) |
| JP (1) | JPH02115194A (he) |
| KR (1) | KR920000646B1 (he) |
| AU (1) | AU606536B2 (he) |
| CA (1) | CA1323628C (he) |
| DK (1) | DK169240B1 (he) |
| FI (1) | FI894124A (he) |
| HU (1) | HU205132B (he) |
| IL (1) | IL91521A (he) |
| NO (1) | NO170687C (he) |
| NZ (1) | NZ230496A (he) |
| YU (1) | YU161989A (he) |
| ZA (1) | ZA896778B (he) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061791A (en) * | 1988-12-21 | 1991-10-29 | Warner-Lambert Company | 4-bromo-4'-demethylepipodophyllotoxin derivatives |
| US4965348A (en) * | 1989-05-19 | 1990-10-23 | Bristol-Myers Company | Dimeric epipodophyllotoxin glucoside derivatives |
| US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
| US5034380A (en) * | 1989-11-20 | 1991-07-23 | Bristol-Myers Squibb Company | Alkoxymethylidene epipodophyllotoxin glucosides |
| US5081234A (en) * | 1990-04-30 | 1992-01-14 | Bristol-Myers Squibb Co. | 4'-demethylepipodophyllotoxin glycosides |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP1881000A1 (en) * | 2006-07-17 | 2008-01-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents |
| CN102115483B (zh) * | 2009-12-30 | 2014-12-17 | 苏州天人合生物技术有限公司 | 卤代双去氧糖衍生物及其制备方法与应用 |
| CN103739635B (zh) * | 2014-01-22 | 2016-05-25 | 江苏省原子医学研究所 | 一种三氟甘露糖中间体的纯化方法 |
| CN115141208B (zh) * | 2022-08-05 | 2024-03-08 | 贵州大学 | 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1171314A (fr) * | 1955-05-13 | 1959-01-23 | Sandoz Ag | Produits de condensation de glucosides avec des composés carbonyliques et leur préparation |
| NL6613143A (he) * | 1965-09-21 | 1967-03-22 | ||
| DE3374317D1 (en) * | 1982-11-26 | 1987-12-10 | Nippon Kayaku Kk | Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof |
| JPS6032799A (ja) * | 1983-07-29 | 1985-02-19 | Microbial Chem Res Found | 新規４′−デメチル−４−エピポドフィロトキシン誘導体 |
| JPS60246393A (ja) * | 1984-05-22 | 1985-12-06 | Nippon Kayaku Co Ltd | エトポシドの新規製造法 |
| JPS61227590A (ja) * | 1985-04-02 | 1986-10-09 | Microbial Chem Res Found | 新規４′−デメチル−４−エピポドフイロトキシン誘導体 |
| IL77334A (en) * | 1985-12-16 | 1991-04-15 | Univ Bar Ilan | Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor |
| CN1042362A (zh) * | 1988-10-31 | 1990-05-23 | 布里斯托尔-米尔斯公司 | 表鬼臼脂素糖苷的磷酸和磺酸酯的制备方法 |
-
1988
- 1988-09-06 US US07/240,971 patent/US4912204A/en not_active Expired - Fee Related
-
1989
- 1989-08-18 YU YU01619/89A patent/YU161989A/xx unknown
- 1989-08-30 NZ NZ230496A patent/NZ230496A/xx unknown
- 1989-09-01 FI FI894124A patent/FI894124A/fi not_active Application Discontinuation
- 1989-09-04 IL IL9152189A patent/IL91521A/he not_active IP Right Cessation
- 1989-09-05 ZA ZA896778A patent/ZA896778B/xx unknown
- 1989-09-05 DK DK439589A patent/DK169240B1/da not_active IP Right Cessation
- 1989-09-05 NO NO893548A patent/NO170687C/no unknown
- 1989-09-05 CA CA000610251A patent/CA1323628C/en not_active Expired - Fee Related
- 1989-09-05 KR KR1019890012830A patent/KR920000646B1/ko not_active IP Right Cessation
- 1989-09-06 JP JP1229485A patent/JPH02115194A/ja active Granted
- 1989-09-06 AU AU41150/89A patent/AU606536B2/en not_active Ceased
- 1989-09-06 EP EP19890116448 patent/EP0358197A3/en not_active Ceased
- 1989-09-06 HU HU894651A patent/HU205132B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO170687C (no) | 1992-11-18 |
| IL91521A (he) | 1994-01-25 |
| HUT51284A (en) | 1990-04-28 |
| JPH02115194A (ja) | 1990-04-27 |
| US4912204A (en) | 1990-03-27 |
| DK439589A (da) | 1990-03-07 |
| EP0358197A2 (en) | 1990-03-14 |
| NO893548D0 (no) | 1989-09-05 |
| KR900004759A (ko) | 1990-04-13 |
| NO893548L (no) | 1990-03-07 |
| DK439589D0 (da) | 1989-09-05 |
| FI894124A (fi) | 1990-03-07 |
| HU205132B (en) | 1992-03-30 |
| KR920000646B1 (ko) | 1992-01-20 |
| CA1323628C (en) | 1993-10-26 |
| FI894124A0 (fi) | 1989-09-01 |
| YU161989A (en) | 1991-02-28 |
| IL91521A0 (en) | 1990-04-29 |
| NZ230496A (en) | 1991-11-26 |
| JPH0567640B2 (he) | 1993-09-27 |
| EP0358197A3 (en) | 1991-04-03 |
| DK169240B1 (da) | 1994-09-19 |
| NO170687B (no) | 1992-08-10 |
| AU606536B2 (en) | 1991-02-07 |
| AU4115089A (en) | 1990-04-26 |
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