NO893548L - Fremgangsmaate til fremstilling av fluorsubstituerte 4'-demetylepipodofyllotoksinglukosider. - Google Patents

Fremgangsmaate til fremstilling av fluorsubstituerte 4'-demetylepipodofyllotoksinglukosider.

Info

Publication number
NO893548L
NO893548L NO89893548A NO893548A NO893548L NO 893548 L NO893548 L NO 893548L NO 89893548 A NO89893548 A NO 89893548A NO 893548 A NO893548 A NO 893548A NO 893548 L NO893548 L NO 893548L
Authority
NO
Norway
Prior art keywords
locosides
demethylepipodophyllotoxing
fluoro
substituted
procedure
Prior art date
Application number
NO89893548A
Other languages
English (en)
Other versions
NO170687C (no
NO893548D0 (no
NO170687B (no
Inventor
Takeshi Ohnuma
Tetsuro Yamasaki
Hideo Kamei
Takayuki Naito
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO893548D0 publication Critical patent/NO893548D0/no
Publication of NO893548L publication Critical patent/NO893548L/no
Publication of NO170687B publication Critical patent/NO170687B/no
Publication of NO170687C publication Critical patent/NO170687C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO893548A 1988-09-06 1989-09-05 Analogifremgangsmaate til fremstilling av fluorsubstituerte 4'-demetylepipodofyllotoksin-glukosider NO170687C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/240,971 US4912204A (en) 1988-09-06 1988-09-06 Fluoro-substituted epipodophyllotoxin glucosides

Publications (4)

Publication Number Publication Date
NO893548D0 NO893548D0 (no) 1989-09-05
NO893548L true NO893548L (no) 1990-03-07
NO170687B NO170687B (no) 1992-08-10
NO170687C NO170687C (no) 1992-11-18

Family

ID=22908678

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893548A NO170687C (no) 1988-09-06 1989-09-05 Analogifremgangsmaate til fremstilling av fluorsubstituerte 4'-demetylepipodofyllotoksin-glukosider

Country Status (14)

Country Link
US (1) US4912204A (no)
EP (1) EP0358197A3 (no)
JP (1) JPH02115194A (no)
KR (1) KR920000646B1 (no)
AU (1) AU606536B2 (no)
CA (1) CA1323628C (no)
DK (1) DK169240B1 (no)
FI (1) FI894124A (no)
HU (1) HU205132B (no)
IL (1) IL91521A (no)
NO (1) NO170687C (no)
NZ (1) NZ230496A (no)
YU (1) YU161989A (no)
ZA (1) ZA896778B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061791A (en) * 1988-12-21 1991-10-29 Warner-Lambert Company 4-bromo-4'-demethylepipodophyllotoxin derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1881000A1 (en) * 2006-07-17 2008-01-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Conjugates of 2-fluoro-2-deoxy-glucose and their uses as anti cancer agents
CN102115483B (zh) * 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
CN103739635B (zh) * 2014-01-22 2016-05-25 江苏省原子医学研究所 一种三氟甘露糖中间体的纯化方法
CN115141208B (zh) * 2022-08-05 2024-03-08 贵州大学 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (no) * 1965-09-21 1967-03-22
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
CN1042362A (zh) * 1988-10-31 1990-05-23 布里斯托尔-米尔斯公司 表鬼臼脂素糖苷的磷酸和磺酸酯的制备方法

Also Published As

Publication number Publication date
NO170687C (no) 1992-11-18
IL91521A (en) 1994-01-25
HUT51284A (en) 1990-04-28
JPH02115194A (ja) 1990-04-27
US4912204A (en) 1990-03-27
DK439589A (da) 1990-03-07
EP0358197A2 (en) 1990-03-14
NO893548D0 (no) 1989-09-05
KR900004759A (ko) 1990-04-13
DK439589D0 (da) 1989-09-05
FI894124A (fi) 1990-03-07
HU205132B (en) 1992-03-30
KR920000646B1 (ko) 1992-01-20
CA1323628C (en) 1993-10-26
FI894124A0 (fi) 1989-09-01
YU161989A (en) 1991-02-28
IL91521A0 (en) 1990-04-29
NZ230496A (en) 1991-11-26
JPH0567640B2 (no) 1993-09-27
EP0358197A3 (en) 1991-04-03
ZA896778B (en) 1990-06-27
DK169240B1 (da) 1994-09-19
NO170687B (no) 1992-08-10
AU606536B2 (en) 1991-02-07
AU4115089A (en) 1990-04-26

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