ZA895086B - New 1,4-diazepine derivatives having anti-ulcer activity - Google Patents

New 1,4-diazepine derivatives having anti-ulcer activity

Info

Publication number
ZA895086B
ZA895086B ZA895086A ZA895086A ZA895086B ZA 895086 B ZA895086 B ZA 895086B ZA 895086 A ZA895086 A ZA 895086A ZA 895086 A ZA895086 A ZA 895086A ZA 895086 B ZA895086 B ZA 895086B
Authority
ZA
South Africa
Prior art keywords
new
ulcer activity
diazepine derivatives
diazepine
derivatives
Prior art date
Application number
ZA895086A
Other languages
English (en)
Inventor
Jacobus Antonius Joseph Hartog
Antonius Joseph Den Ha Jacobus
Herman Heinrich Va Stuivenberg
Heinrich Van Stuivenber Herman
Ineke Van Wijngaarden
Van Wijngaarden Ineke
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of ZA895086B publication Critical patent/ZA895086B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA895086A 1988-07-07 1989-07-04 New 1,4-diazepine derivatives having anti-ulcer activity ZA895086B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8801716 1988-07-07

Publications (1)

Publication Number Publication Date
ZA895086B true ZA895086B (en) 1990-05-30

Family

ID=19852585

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895086A ZA895086B (en) 1988-07-07 1989-07-04 New 1,4-diazepine derivatives having anti-ulcer activity

Country Status (16)

Country Link
US (2) US4985423A (sv)
EP (1) EP0350131A3 (sv)
JP (1) JPH0259582A (sv)
KR (1) KR900001696A (sv)
CN (1) CN1028408C (sv)
AU (1) AU626892B2 (sv)
CA (1) CA1315781C (sv)
DK (1) DK330689A (sv)
FI (1) FI93118C (sv)
HU (1) HU204528B (sv)
IL (1) IL90865A (sv)
NO (1) NO170282C (sv)
NZ (1) NZ229815A (sv)
PT (1) PT91052B (sv)
TW (1) TW219896B (sv)
ZA (1) ZA895086B (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015904D0 (en) 2000-06-28 2000-08-23 Hoffmann La Roche Inhibitors of HPV E1 helicase enzyme
DE10312969A1 (de) * 2003-03-24 2004-10-07 Bayer Healthcare Ag Benzofuro-1,4-diazepin-2-on-Derivate
WO2009049362A1 (en) * 2007-10-15 2009-04-23 Monash University A1 adenosine receptor allosteric enhancers
WO2015088565A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910887A (en) * 1972-12-07 1975-10-07 Degussa Azabenzo-1,5-diazepines
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds
GB8409960D0 (en) * 1984-04-17 1984-05-31 Searle & Co Therapeutic method
US5087625A (en) * 1990-10-19 1992-02-11 Boehringer Ingelheim Pharmaceuticals, Inc. Pyridodiazepines and their use in the prevention or treatment of HIV infection

Also Published As

Publication number Publication date
TW219896B (sv) 1994-02-01
IL90865A (en) 1994-02-27
DK330689A (da) 1990-01-08
FI93118B (sv) 1994-11-15
NZ229815A (en) 1992-03-26
NO892772L (no) 1990-01-08
EP0350131A2 (en) 1990-01-10
EP0350131A3 (en) 1991-07-10
FI893250A (sv) 1990-01-08
HU204528B (en) 1992-01-28
AU626892B2 (en) 1992-08-13
DK330689D0 (da) 1989-07-04
US4985423A (en) 1991-01-15
AU3795489A (en) 1990-01-11
CA1315781C (en) 1993-04-06
PT91052A (pt) 1990-02-08
IL90865A0 (en) 1990-02-09
PT91052B (pt) 1995-01-31
FI893250A0 (sv) 1989-07-04
NO892772D0 (no) 1989-07-04
NO170282B (no) 1992-06-22
NO170282C (no) 1992-09-30
KR900001696A (ko) 1990-02-27
CN1040027A (zh) 1990-02-28
JPH0259582A (ja) 1990-02-28
CN1028408C (zh) 1995-05-17
US5140024A (en) 1992-08-18
FI93118C (sv) 1995-02-27

Similar Documents

Publication Publication Date Title
GB2153821B (en) 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives
ZA895085B (en) New substituted 1,7-annelated 1h-indizoles
EP0202580A3 (en) 3,4-dihydrobenzopyran derivatives
AR244666A1 (es) Procedimiento para preparar compuestos piperidinilicos 1,4-disustituidos, utiles como analgesicos y relajantes musculares.
PH25045A (en) 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives
ZA869591B (en) Substituted 5,6-dialkoxyquinazoline derivatives
PH25616A (en) 1,2,3,4-tetrahydro-5-nitro-pyrimidine derivatives
ZA884858B (en) Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having opiate-antagonistic activity
ZA8784B (en) 1,6-anhydro-beta-hexopyranose derivatives
ZA893569B (en) 1,1-dioxo-cephem-4-carbothiolic acid derivatives
EP0183975A3 (en) 5,6,7,8-tetrafluoroanthraquinone derivatives
EP0316843A3 (en) 1,2,3,4-tetrahydro-5-nitropyrimidine derivatives
ZA895086B (en) New 1,4-diazepine derivatives having anti-ulcer activity
IL83679A0 (en) 2,4,6-trihydroxy-s-triazine derivatives
HK185395A (en) 9,11-Epoxy-21-hydroxypregnane derivatives
IL74595A0 (en) 1,2,4-triazacycloalkadiene derivatives
ZA90301B (en) 8,9-annelated-1,2,3,4-tetrahydro-beta-carboline derivatives
ZA895454B (en) 2,2-dihalogenocy-clopropyl-hydroxy-ethyltriazoles
GB8523735D0 (en) 1,2-benzoxathiine derivatives
ZA891059B (en) 1-aminomethyl-3-(2,4-difluoro-3-chlorophenyl)-4-cyano-pyrroles
ZA899367B (en) 4,5,6,7-tetrahydrobenzimidazole derivatives
IE890176L (en) 1,4-disubstituted-piperidinyl compounds
ZA89387B (en) 1,4-disubstituted-piperidinyl compounds
IE882053L (en) Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives
CS267188A1 (en) 1,2,2,6,6-pentamethyl-4-allyloxypiperidine