ZA894671B - Mercapto-phenylalcanoylamino acid amides,their preparation and their use as collagenase inhibitors - Google Patents
Mercapto-phenylalcanoylamino acid amides,their preparation and their use as collagenase inhibitorsInfo
- Publication number
- ZA894671B ZA894671B ZA894671A ZA894671A ZA894671B ZA 894671 B ZA894671 B ZA 894671B ZA 894671 A ZA894671 A ZA 894671A ZA 894671 A ZA894671 A ZA 894671A ZA 894671 B ZA894671 B ZA 894671B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- group
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Photoreceptors In Electrophotography (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888814813A GB8814813D0 (en) | 1988-06-22 | 1988-06-22 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA894671B true ZA894671B (en) | 1990-07-25 |
Family
ID=10639132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA894671A ZA894671B (en) | 1988-06-22 | 1989-06-20 | Mercapto-phenylalcanoylamino acid amides,their preparation and their use as collagenase inhibitors |
Country Status (15)
Country | Link |
---|---|
US (1) | US5124322A (fr) |
EP (1) | EP0358305B1 (fr) |
JP (1) | JPH0253765A (fr) |
KR (1) | KR910000614A (fr) |
AT (1) | ATE93517T1 (fr) |
AU (1) | AU615554B2 (fr) |
DE (1) | DE68908643T2 (fr) |
DK (1) | DK304289A (fr) |
ES (1) | ES2058531T3 (fr) |
GB (1) | GB8814813D0 (fr) |
IE (1) | IE891998L (fr) |
NZ (1) | NZ229630A (fr) |
PT (1) | PT90912B (fr) |
TW (1) | TW197421B (fr) |
ZA (1) | ZA894671B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9000846D0 (en) * | 1990-01-15 | 1990-03-14 | Beecham Group Plc | Novel compounds |
US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5831004A (en) | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
IL115995A0 (en) * | 1994-11-15 | 1996-01-31 | Bayer Ag | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
JP2000502351A (ja) * | 1995-12-22 | 2000-02-29 | イーライ・リリー・アンド・カンパニー | 医薬化合物 |
BR9712792A (pt) * | 1996-08-28 | 1999-12-14 | Procter & Gamble | Inibidores de metaloprotease bidentada. |
US7195759B2 (en) * | 2001-06-06 | 2007-03-27 | The University Of Manitoba | Therapeutic uses of glandular kallikrein |
US20090162342A1 (en) * | 2001-06-07 | 2009-06-25 | Sanomune Inc. | Therapeutic uses of glandular kallikrein |
WO2013173923A1 (fr) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations de kallikréine 1 de tissu humain pour l'administration parentérale et procédés associés |
SI2854841T1 (sl) | 2012-06-04 | 2017-06-30 | Diamedica Inc. | Glikozilacijske izooblike humanega tkivnega kalikreina-1 |
CA3054962A1 (fr) | 2017-03-09 | 2018-09-13 | Rick PAULS | Formes posologiques de kallicreine tissulaire 1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4623729A (en) * | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
DK681287A (da) * | 1986-12-24 | 1988-06-25 | Beecham Group Plc | Hidtil ukendte forbindelser |
DE3889726T2 (de) * | 1987-03-17 | 1994-10-13 | Res Corp Technologies Inc | Synthetische inhibitoren von säugetier-collagenase. |
-
1988
- 1988-06-22 GB GB888814813A patent/GB8814813D0/en active Pending
-
1989
- 1989-06-19 US US07/367,961 patent/US5124322A/en not_active Expired - Fee Related
- 1989-06-20 EP EP89306228A patent/EP0358305B1/fr not_active Expired - Lifetime
- 1989-06-20 IE IE891998A patent/IE891998L/xx unknown
- 1989-06-20 DK DK304289A patent/DK304289A/da unknown
- 1989-06-20 AU AU36675/89A patent/AU615554B2/en not_active Ceased
- 1989-06-20 PT PT90912A patent/PT90912B/pt not_active IP Right Cessation
- 1989-06-20 NZ NZ229630A patent/NZ229630A/en unknown
- 1989-06-20 DE DE89306228T patent/DE68908643T2/de not_active Expired - Fee Related
- 1989-06-20 ZA ZA894671A patent/ZA894671B/xx unknown
- 1989-06-20 AT AT89306228T patent/ATE93517T1/de not_active IP Right Cessation
- 1989-06-20 ES ES89306228T patent/ES2058531T3/es not_active Expired - Lifetime
- 1989-06-21 KR KR1019890008639A patent/KR910000614A/ko not_active Application Discontinuation
- 1989-06-21 JP JP1159378A patent/JPH0253765A/ja active Pending
- 1989-06-22 TW TW078104797A patent/TW197421B/zh active
Also Published As
Publication number | Publication date |
---|---|
KR910000614A (ko) | 1991-01-29 |
ATE93517T1 (de) | 1993-09-15 |
PT90912B (pt) | 1994-12-30 |
DE68908643T2 (de) | 1994-03-17 |
TW197421B (fr) | 1993-01-01 |
DK304289A (da) | 1989-12-23 |
AU3667589A (en) | 1990-01-04 |
EP0358305B1 (fr) | 1993-08-25 |
US5124322A (en) | 1992-06-23 |
ES2058531T3 (es) | 1994-11-01 |
GB8814813D0 (en) | 1988-07-27 |
PT90912A (pt) | 1989-12-29 |
DE68908643D1 (de) | 1993-09-30 |
IE891998L (en) | 1989-12-22 |
JPH0253765A (ja) | 1990-02-22 |
EP0358305A1 (fr) | 1990-03-14 |
AU615554B2 (en) | 1991-10-03 |
NZ229630A (en) | 1991-12-23 |
DK304289D0 (da) | 1989-06-20 |
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