DE68908643D1 - Mercapto-phenylalkanoylaminosäure-Amide, deren Herstellung und deren Verwendung als Collagenase-Inhibitoren. - Google Patents

Mercapto-phenylalkanoylaminosäure-Amide, deren Herstellung und deren Verwendung als Collagenase-Inhibitoren.

Info

Publication number
DE68908643D1
DE68908643D1 DE89306228T DE68908643T DE68908643D1 DE 68908643 D1 DE68908643 D1 DE 68908643D1 DE 89306228 T DE89306228 T DE 89306228T DE 68908643 T DE68908643 T DE 68908643T DE 68908643 D1 DE68908643 D1 DE 68908643D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
optionally substituted
group
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89306228T
Other languages
English (en)
Other versions
DE68908643T2 (de
Inventor
Ian C O Beecham Pharmac Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of DE68908643D1 publication Critical patent/DE68908643D1/de
Application granted granted Critical
Publication of DE68908643T2 publication Critical patent/DE68908643T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE89306228T 1988-06-22 1989-06-20 Mercapto-phenylalkanoylaminosäure-Amide, deren Herstellung und deren Verwendung als Collagenase-Inhibitoren. Expired - Fee Related DE68908643T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888814813A GB8814813D0 (en) 1988-06-22 1988-06-22 Novel compounds

Publications (2)

Publication Number Publication Date
DE68908643D1 true DE68908643D1 (de) 1993-09-30
DE68908643T2 DE68908643T2 (de) 1994-03-17

Family

ID=10639132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89306228T Expired - Fee Related DE68908643T2 (de) 1988-06-22 1989-06-20 Mercapto-phenylalkanoylaminosäure-Amide, deren Herstellung und deren Verwendung als Collagenase-Inhibitoren.

Country Status (15)

Country Link
US (1) US5124322A (de)
EP (1) EP0358305B1 (de)
JP (1) JPH0253765A (de)
KR (1) KR910000614A (de)
AT (1) ATE93517T1 (de)
AU (1) AU615554B2 (de)
DE (1) DE68908643T2 (de)
DK (1) DK304289A (de)
ES (1) ES2058531T3 (de)
GB (1) GB8814813D0 (de)
IE (1) IE891998L (de)
NZ (1) NZ229630A (de)
PT (1) PT90912B (de)
TW (1) TW197421B (de)
ZA (1) ZA894671B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds
US5352705A (en) * 1992-06-26 1994-10-04 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
HRP950558A2 (en) * 1994-11-15 1997-12-31 Scott M. Wilhelm Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
JP2000502351A (ja) * 1995-12-22 2000-02-29 イーライ・リリー・アンド・カンパニー 医薬化合物
BR9712792A (pt) * 1996-08-28 1999-12-14 Procter & Gamble Inibidores de metaloprotease bidentada.
US7195759B2 (en) * 2001-06-06 2007-03-27 The University Of Manitoba Therapeutic uses of glandular kallikrein
US20090162342A1 (en) * 2001-06-07 2009-06-25 Sanomune Inc. Therapeutic uses of glandular kallikrein
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en) 2012-06-04 2013-12-05 Matthew Charles Human tissue kallikrein 1 glycosylation isoforms
AU2018230478A1 (en) 2017-03-09 2019-09-12 Diamedica Inc. Dosage forms of tissue kallikrein 1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
WO1988006890A1 (en) * 1987-03-17 1988-09-22 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase

Also Published As

Publication number Publication date
NZ229630A (en) 1991-12-23
TW197421B (de) 1993-01-01
ATE93517T1 (de) 1993-09-15
ES2058531T3 (es) 1994-11-01
DK304289D0 (da) 1989-06-20
DK304289A (da) 1989-12-23
EP0358305B1 (de) 1993-08-25
PT90912A (pt) 1989-12-29
PT90912B (pt) 1994-12-30
KR910000614A (ko) 1991-01-29
EP0358305A1 (de) 1990-03-14
GB8814813D0 (en) 1988-07-27
AU615554B2 (en) 1991-10-03
US5124322A (en) 1992-06-23
AU3667589A (en) 1990-01-04
IE891998L (en) 1989-12-22
JPH0253765A (ja) 1990-02-22
DE68908643T2 (de) 1994-03-17
ZA894671B (en) 1990-07-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee