ZA892171B - 4-aryl-4-piperidine(or pyrrolidine or hexahydroazepine)carbinols and heterocyclic analogs thereof - Google Patents
4-aryl-4-piperidine(or pyrrolidine or hexahydroazepine)carbinols and heterocyclic analogs thereofInfo
- Publication number
- ZA892171B ZA892171B ZA892171A ZA892171A ZA892171B ZA 892171 B ZA892171 B ZA 892171B ZA 892171 A ZA892171 A ZA 892171A ZA 892171 A ZA892171 A ZA 892171A ZA 892171 B ZA892171 B ZA 892171B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbinols
- aryl
- hexahydroazepine
- pyrrolidine
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17435688A | 1988-03-28 | 1988-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA892171B true ZA892171B (en) | 1990-11-28 |
Family
ID=22635870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA892171A ZA892171B (en) | 1988-03-28 | 1989-03-22 | 4-aryl-4-piperidine(or pyrrolidine or hexahydroazepine)carbinols and heterocyclic analogs thereof |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0337167B1 (no) |
JP (1) | JP2907860B2 (no) |
KR (1) | KR0140891B1 (no) |
AT (1) | ATE109465T1 (no) |
AU (1) | AU623637B2 (no) |
CA (1) | CA1337418C (no) |
DE (1) | DE68917185T2 (no) |
DK (1) | DK145689A (no) |
ES (1) | ES2056990T3 (no) |
FI (1) | FI94240C (no) |
HU (1) | HU213671B (no) |
IE (1) | IE65811B1 (no) |
IL (1) | IL89746A0 (no) |
MY (1) | MY103990A (no) |
NO (1) | NO891260L (no) |
NZ (1) | NZ228479A (no) |
PT (1) | PT90127B (no) |
RU (1) | RU1836346C (no) |
ZA (1) | ZA892171B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA915660B (en) * | 1990-07-24 | 1992-05-27 | Merrell Dow Pharma | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis |
DE4112353A1 (de) * | 1991-04-16 | 1992-10-22 | Basf Ag | 1,3,4-trisubstituierte piperidin-derivate, ihre herstellung und verwendung |
ATE188472T1 (de) * | 1992-10-28 | 2000-01-15 | Merck Sharp & Dohme | 4-arylmethyloxymethyl piperidine als tachykinin antagonisten |
AU2002230665A1 (en) | 2000-12-06 | 2002-06-18 | Sepracor, Inc. | 4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands |
AU2002337863B2 (en) * | 2001-10-16 | 2007-10-11 | Endo Pharmaceuticals Inc. | Carbinols for the treatment of neuropathic dysfunction |
US20070249607A1 (en) | 2006-04-17 | 2007-10-25 | Bristol-Myers Squibb Company | Nk-1 and serotonin transporter inhibitors |
US8071778B2 (en) | 2006-07-27 | 2011-12-06 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
US8026257B2 (en) | 2007-07-11 | 2011-09-27 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
CN110520129A (zh) | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
JP7185633B2 (ja) | 2017-02-17 | 2022-12-07 | トレベナ・インコーポレイテッド | 7員アザ複素環を含有するデルタ-オピオイド受容体調節化合物、その使用方法及び製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB888657A (en) * | 1958-07-14 | 1962-01-31 | J F Macfarlan & Co Ltd | Piperidine carbinols |
US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
BE775611A (fr) * | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
US4284635A (en) * | 1978-11-29 | 1981-08-18 | Eli Lilly And Company | Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines |
JPS58213756A (ja) * | 1982-05-07 | 1983-12-12 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | 4−アリ−ル−4−ピペリジンカルビノ−ル類 |
US4485109A (en) * | 1982-05-07 | 1984-11-27 | E. I. Du Pont De Nemours And Company | 4-Aryl-4-piperidinecarbinols |
-
1989
- 1989-02-22 CA CA000591753A patent/CA1337418C/en not_active Expired - Lifetime
- 1989-03-22 ZA ZA892171A patent/ZA892171B/xx unknown
- 1989-03-22 DE DE68917185T patent/DE68917185T2/de not_active Expired - Lifetime
- 1989-03-22 DK DK145689A patent/DK145689A/da not_active Application Discontinuation
- 1989-03-22 AT AT89105083T patent/ATE109465T1/de not_active IP Right Cessation
- 1989-03-22 ES ES89105083T patent/ES2056990T3/es not_active Expired - Lifetime
- 1989-03-22 NO NO89891260A patent/NO891260L/no unknown
- 1989-03-22 EP EP89105083A patent/EP0337167B1/en not_active Expired - Lifetime
- 1989-03-23 NZ NZ228479A patent/NZ228479A/en unknown
- 1989-03-23 IE IE91389A patent/IE65811B1/en not_active IP Right Cessation
- 1989-03-27 RU SU894613736A patent/RU1836346C/ru active
- 1989-03-27 IL IL89746A patent/IL89746A0/xx not_active IP Right Cessation
- 1989-03-27 MY MYPI89000381A patent/MY103990A/en unknown
- 1989-03-28 HU HU891532A patent/HU213671B/hu not_active IP Right Cessation
- 1989-03-28 FI FI891473A patent/FI94240C/fi not_active IP Right Cessation
- 1989-03-28 JP JP1074129A patent/JP2907860B2/ja not_active Expired - Lifetime
- 1989-03-28 AU AU31717/89A patent/AU623637B2/en not_active Ceased
- 1989-03-28 KR KR1019890003866A patent/KR0140891B1/ko not_active IP Right Cessation
- 1989-03-28 PT PT90127A patent/PT90127B/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU623637B2 (en) | 1992-05-21 |
HU213671B (en) | 1997-09-29 |
JPH0249766A (ja) | 1990-02-20 |
PT90127B (pt) | 1994-06-30 |
KR890014475A (ko) | 1989-10-23 |
EP0337167A1 (en) | 1989-10-18 |
NO891260D0 (no) | 1989-03-22 |
FI94240B (fi) | 1995-04-28 |
FI94240C (fi) | 1995-08-10 |
ATE109465T1 (de) | 1994-08-15 |
DK145689A (da) | 1989-09-29 |
IE890913L (en) | 1989-09-28 |
MY103990A (en) | 1993-10-30 |
ES2056990T3 (es) | 1994-10-16 |
IE65811B1 (en) | 1995-11-15 |
DK145689D0 (da) | 1989-03-22 |
IL89746A0 (en) | 1989-09-28 |
RU1836346C (ru) | 1993-08-23 |
HUT50787A (en) | 1990-03-28 |
CA1337418C (en) | 1995-10-24 |
KR0140891B1 (ko) | 1998-06-01 |
FI891473A (fi) | 1989-09-29 |
DE68917185T2 (de) | 1995-01-05 |
EP0337167B1 (en) | 1994-08-03 |
FI891473A0 (fi) | 1989-03-28 |
NO891260L (no) | 1989-09-29 |
DE68917185D1 (de) | 1994-09-08 |
NZ228479A (en) | 1991-12-23 |
JP2907860B2 (ja) | 1999-06-21 |
PT90127A (pt) | 1989-11-10 |
AU3171789A (en) | 1989-09-28 |
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