ZA889235B - Method of inhibiting the activity of leukocyte derived cytokines - Google Patents

Method of inhibiting the activity of leukocyte derived cytokines

Info

Publication number
ZA889235B
ZA889235B ZA889235A ZA889235A ZA889235B ZA 889235 B ZA889235 B ZA 889235B ZA 889235 A ZA889235 A ZA 889235A ZA 889235 A ZA889235 A ZA 889235A ZA 889235 B ZA889235 B ZA 889235B
Authority
ZA
South Africa
Prior art keywords
activity
inhibiting
cytokines
derived cytokines
tnf
Prior art date
Application number
ZA889235A
Other languages
English (en)
Inventor
Gerald L Mandell
L Mandell Gerald
Gail W Sullivan
W Sullivan Gail
William J Novick Jr
J Novick William Jr
Original Assignee
Hoechst Roussel Pharma
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma, Univ Virginia filed Critical Hoechst Roussel Pharma
Publication of ZA889235B publication Critical patent/ZA889235B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
ZA889235A 1987-12-11 1988-12-09 Method of inhibiting the activity of leukocyte derived cytokines ZA889235B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/131,785 US4965271A (en) 1986-12-31 1987-12-11 Method of inhibiting the activity of leukocyte derived cytokines

Publications (1)

Publication Number Publication Date
ZA889235B true ZA889235B (en) 1990-09-26

Family

ID=22451018

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA889235A ZA889235B (en) 1987-12-11 1988-12-09 Method of inhibiting the activity of leukocyte derived cytokines

Country Status (11)

Country Link
US (1) US4965271A (xx)
EP (1) EP0344288B1 (xx)
JP (1) JP2507105B2 (xx)
AT (1) ATE118347T1 (xx)
AU (2) AU632466B2 (xx)
CA (1) CA1334508C (xx)
DE (1) DE3853067T2 (xx)
IE (1) IE69868B1 (xx)
IL (1) IL88656A (xx)
WO (1) WO1989005145A1 (xx)
ZA (1) ZA889235B (xx)

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US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
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US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
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SG176313A1 (en) 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
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WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
CA2576826C (en) * 2004-08-02 2014-09-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
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Also Published As

Publication number Publication date
CA1334508C (en) 1995-02-21
EP0344288B1 (en) 1995-02-15
ATE118347T1 (de) 1995-03-15
EP0344288A4 (en) 1992-01-15
DE3853067T2 (de) 1995-06-14
AU652094B2 (en) 1994-08-11
EP0344288A1 (en) 1989-12-06
US4965271A (en) 1990-10-23
IL88656A (en) 1993-07-08
WO1989005145A1 (en) 1989-06-15
DE3853067D1 (de) 1995-03-23
JPH02502542A (ja) 1990-08-16
IE883687L (en) 1989-06-11
AU3564193A (en) 1993-06-03
JP2507105B2 (ja) 1996-06-12
AU632466B2 (en) 1993-01-07
IE69868B1 (en) 1996-10-16
AU2828589A (en) 1989-07-05

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