IL88656A - Pharmaceutical formulations containing 1,3-disubstituted-7- (oxohydrocarbyl) xanthine derivatives for inhibiting the activity of leukocyte- derived cytokines - Google Patents

Pharmaceutical formulations containing 1,3-disubstituted-7- (oxohydrocarbyl) xanthine derivatives for inhibiting the activity of leukocyte- derived cytokines

Info

Publication number
IL88656A
IL88656A IL88656A IL8865688A IL88656A IL 88656 A IL88656 A IL 88656A IL 88656 A IL88656 A IL 88656A IL 8865688 A IL8865688 A IL 8865688A IL 88656 A IL88656 A IL 88656A
Authority
IL
Israel
Prior art keywords
activity
leukocyte
inhibiting
oxohydrocarbyl
disubstituted
Prior art date
Application number
IL88656A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Univ Virginia Alummi Patents F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma, Univ Virginia Alummi Patents F filed Critical Hoechst Roussel Pharma
Priority to IL10292088A priority Critical patent/IL102920A/en
Priority to IL10292288A priority patent/IL102922A/en
Priority to IL10292188A priority patent/IL102921A/en
Priority to IL10291988A priority patent/IL102919A/en
Priority to IL102919A priority patent/IL102919A0/xx
Priority to IL102922A priority patent/IL102922A0/xx
Priority to IL102921A priority patent/IL102921A0/xx
Priority to IL102920A priority patent/IL102920A0/xx
Publication of IL88656A publication Critical patent/IL88656A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
IL88656A 1987-12-11 1988-12-11 Pharmaceutical formulations containing 1,3-disubstituted-7- (oxohydrocarbyl) xanthine derivatives for inhibiting the activity of leukocyte- derived cytokines IL88656A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL10292088A IL102920A (en) 1987-12-11 1988-12-11 Pharmaceutical preparations containing a history of 1,3-similar-7-) oxohydrocarbyl (xanthine to reduce various undesirable conditions in patients
IL10292288A IL102922A (en) 1987-12-11 1988-12-11 Pharmaceutical preparations containing a history of 1,3-similar-7-) oxohydrocarbyl (xanthine to inhibit tissue damage caused by cytokines derived from oocytes
IL10292188A IL102921A (en) 1987-12-11 1988-12-11 Pharmaceutical preparations containing a history similar to 1,3-bitter-7-) oxohydrocarbyl (xanthine to prevent and treat an immune reaction
IL10291988A IL102919A (en) 1987-12-11 1988-12-11 Spirit preparations containing 1,3-similar histories - 7-) Oxohydrocarbyl (xanthan for VIH treatment and disease states
IL102919A IL102919A0 (en) 1987-12-11 1992-08-23 Pharmaceutical compositions containing xanthine derivatives
IL102922A IL102922A0 (en) 1987-12-11 1992-08-23 Pharmaceutical compositions containing xanthine derivatives
IL102921A IL102921A0 (en) 1987-12-11 1992-08-23 Pharmaceutical compositions containing xanthine derivatives
IL102920A IL102920A0 (en) 1987-12-11 1992-08-23 Pharmaceutical compositions containing xanthine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/131,785 US4965271A (en) 1986-12-31 1987-12-11 Method of inhibiting the activity of leukocyte derived cytokines

Publications (1)

Publication Number Publication Date
IL88656A true IL88656A (en) 1993-07-08

Family

ID=22451018

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88656A IL88656A (en) 1987-12-11 1988-12-11 Pharmaceutical formulations containing 1,3-disubstituted-7- (oxohydrocarbyl) xanthine derivatives for inhibiting the activity of leukocyte- derived cytokines

Country Status (11)

Country Link
US (1) US4965271A (xx)
EP (1) EP0344288B1 (xx)
JP (1) JP2507105B2 (xx)
AT (1) ATE118347T1 (xx)
AU (2) AU632466B2 (xx)
CA (1) CA1334508C (xx)
DE (1) DE3853067T2 (xx)
IE (1) IE69868B1 (xx)
IL (1) IL88656A (xx)
WO (1) WO1989005145A1 (xx)
ZA (1) ZA889235B (xx)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096906A (en) * 1986-12-31 1992-03-17 University Of Virginia Alumni Patents Foundation Method of inhibiting the activity of leukocyte derived cytokines
US5272153A (en) * 1986-12-31 1993-12-21 Hoechst-Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5196429A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5196430A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
NZ240644A (en) * 1990-11-21 1994-08-26 Smithkline Beecham Corp Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
IL100195A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament having immuno suppressing activity
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
IL100194A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
GB9109645D0 (en) * 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US5169840A (en) * 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
CA2109796C (en) * 1991-05-24 2004-04-27 James A. Bianco Modulation of cellular response to external stimuli
US5856115A (en) * 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
WO1993003728A1 (en) * 1991-08-27 1993-03-04 Temple University Of The Commonwealth System Of Xanthine suppression of antigen activation of t- or b-cells
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
ES2173871T3 (es) * 1991-10-31 2002-11-01 Univ Manchester Tratamiento de condiciones neurologicas por un compuesto inhibidor de la interleukina-1.
EP0628057B1 (en) 1992-02-28 1999-10-20 Board Of Regents The University Of Texas System Use of a therapeutical COMPOSITION FOR THE TREATMENT OF THERMAL INJURY
US5580873A (en) * 1992-03-04 1996-12-03 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds to treat proliferative vascular diseases
US5648357A (en) * 1992-03-04 1997-07-15 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
DK0584347T3 (da) * 1992-03-04 2003-02-24 Cell Therapeutics Inc Enantiomere hydroxylerede xanthinforbindelser
JP3076672B2 (ja) * 1992-06-18 2000-08-14 三井化学株式会社 キノリン誘導体のフマル酸塩
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US5780476A (en) * 1992-11-16 1998-07-14 Cell Therapeutics, Inc. Hydroxyl-containing xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5795897A (en) * 1992-11-18 1998-08-18 Cell Therapeutics, Inc. Oxohexyl methylxanthine compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
AU6087894A (en) * 1993-01-14 1994-08-15 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
WO1994016704A1 (en) * 1993-01-19 1994-08-04 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
WO1995022546A1 (en) * 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5698518A (en) * 1994-03-30 1997-12-16 Oklahoma Medical Research Foundation Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US6075029A (en) * 1998-01-02 2000-06-13 Cell Therapeutics, Inc. Xanthine modulators of metabolism of cellular P-450
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
SG176313A1 (en) 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
SE0200667D0 (sv) 2002-03-05 2002-03-05 A & Science Invest Ab Novel use of cytokine inhibitors
WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
CA2576826C (en) * 2004-08-02 2014-09-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
RU2008122978A (ru) 2005-11-09 2009-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы, композиции и наборы для лечения медицинских состояний
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576947A (en) * 1967-12-16 1986-03-18 Hoechst Aktiengesellschaft Pharmaceutical compositions
US4515795A (en) * 1968-11-25 1985-05-07 Hoechst Aktiengesellschaft Pharmaceutical compositions
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH608236A5 (xx) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4002756A (en) * 1974-04-22 1977-01-11 Interx Research Corporation Useful pro-drug forms of theophylline
EP0005015B1 (en) * 1978-04-22 1986-10-29 BEECHAM - WUELFING GmbH & Co. KG Use of a xanthine derivate in the manufacture of a medicament
IL59665A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
US4225607A (en) * 1979-05-14 1980-09-30 Johann A. Wulfing Pharmaceutical composition containing a xanthine derivative
DE3173289D1 (en) * 1980-06-21 1986-02-06 Beecham Wuelfing Gmbh & Co Kg Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation
US4511557A (en) * 1981-08-24 1985-04-16 Gauri Kailash Kumar Pharmaceutical composition
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment
GB8501488D0 (en) * 1985-01-21 1985-02-20 Beecham Group Plc Treatment
JPH062675B2 (ja) * 1985-04-05 1994-01-12 ヘキストジヤパン株式会社 記憶障害治療剤
GB8621869D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Treatment
IL100533A (en) * 1986-12-31 1994-05-30 Hoechst Roussel Pharma Pharmaceutical preparations containing a history of xanthine for VIH treatment and disease states
DE3817955A1 (de) * 1988-05-27 1989-11-30 Hoechst Ag Tnf-inhibitor enthaltendes arzneimittel

Also Published As

Publication number Publication date
CA1334508C (en) 1995-02-21
EP0344288B1 (en) 1995-02-15
ATE118347T1 (de) 1995-03-15
EP0344288A4 (en) 1992-01-15
DE3853067T2 (de) 1995-06-14
AU652094B2 (en) 1994-08-11
ZA889235B (en) 1990-09-26
EP0344288A1 (en) 1989-12-06
US4965271A (en) 1990-10-23
WO1989005145A1 (en) 1989-06-15
DE3853067D1 (de) 1995-03-23
JPH02502542A (ja) 1990-08-16
IE883687L (en) 1989-06-11
AU3564193A (en) 1993-06-03
JP2507105B2 (ja) 1996-06-12
AU632466B2 (en) 1993-01-07
IE69868B1 (en) 1996-10-16
AU2828589A (en) 1989-07-05

Similar Documents

Publication Publication Date Title
IL88656A (en) Pharmaceutical formulations containing 1,3-disubstituted-7- (oxohydrocarbyl) xanthine derivatives for inhibiting the activity of leukocyte- derived cytokines
IL106861A (en) Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines
KR950002755A (ko) 워트마닌 및 그의 유사체에 의한 포스파티딜이노시톨 3-키나제의 억제
KR920009399A (ko) 면역 억제 활성을 갖는 약제를 제조하기 위한 크산틴의 용도
FI901549A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten fenyylialkyleeniaminosubstituoitujen puriini- ja pyratsolo/3,4-d/pyrimidiinijohdannaisten valmistamiseksi
EP0195496A3 (en) Use of xanthines in the treatment of proliferative skin disease
GB1435916A (en) Pharmaceutical weight-reducing compositions
AU3624089A (en) Analgesic phenothiazine derivatives
KR890009890A (ko) 하이드록시 피리미딘의 아실 유도체
EP0347880A3 (en) Imidazo[2,1-b]benzothiazole compounds and antiulcer compositions containing the same
EP0719777A3 (en) N-oxotetrahydro-beta-carbolines
EP0373591A3 (en) Polyhydroxybenzyloxypropanolamines
ES8707968A1 (es) Procedimiento para la obtencion de derivados de hexosa acilados
GB1486869A (en) Pyridoquinolines
KR900700105A (ko) 백혈구 유도 사이토킨의 활성을 억제시키는 방법
EP0246529A3 (en) Long acting pyrrolo (2,3-g) isoquinolin-4-one derivatives
AU8060487A (en) 4-hydroxy-4-(substituted thioalkenyl)-cyclohexane- carboxylic acids and derivatives thereof
IL106854A0 (en) Pharmaceutical compositions containing xanthine derivatives for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
RH1 Patent not in force