ES8703858A1 - Procedimiento para la obtencion de (tio)morfolinas - Google Patents

Procedimiento para la obtencion de (tio)morfolinas

Info

Publication number
ES8703858A1
ES8703858A1 ES547616A ES547616A ES8703858A1 ES 8703858 A1 ES8703858 A1 ES 8703858A1 ES 547616 A ES547616 A ES 547616A ES 547616 A ES547616 A ES 547616A ES 8703858 A1 ES8703858 A1 ES 8703858A1
Authority
ES
Spain
Prior art keywords
atoms
alkyl
thiomorpholines
morpholines
alkoxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547616A
Other languages
English (en)
Other versions
ES547616A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES547616A0 publication Critical patent/ES547616A0/es
Publication of ES8703858A1 publication Critical patent/ES8703858A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER TIOMORFOLINAS. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (E-H) CON UN DERIVADO DE ACIDO CARBOXILICO DE FORMULA (COOH-CHR3-NH-NHR4-COOR5), EN UN DISOLVENTE INERTE DICLOROMETANO Y ENTRE C10 Y 40JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES. SIENDO AR FENILO INSUSTITUIDO O SUSTITUIDO POR ALQUILO DE C 1 A 4, ALCOXI DE C 1 A 4 Y OTROS; E EL RESTO DE FORMULA (II); R1 Y R5 IGUALES O DIFERENTES H, ALQUILO DE C 1 A 4, CICLOALQUILO DE C 3 A 7 Y OTROS; R2 H O ALQUILO DE C 1 A 6; R3 CH3- O -(CH2)4-NH2; R4 CH3- O (CH2)2-AR Y Z O, S, SO Y OTROS. SE UTILIZAN COMO REDUCTORES DE LA PRESION SANGUINEA POR SU EFECTO VASODILATADOR.
ES547616A 1984-10-04 1985-10-04 Procedimiento para la obtencion de (tio)morfolinas Expired ES8703858A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843436386 DE3436386A1 (de) 1984-10-04 1984-10-04 (thio)morpholine

Publications (2)

Publication Number Publication Date
ES547616A0 ES547616A0 (es) 1987-03-01
ES8703858A1 true ES8703858A1 (es) 1987-03-01

Family

ID=6247068

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547616A Expired ES8703858A1 (es) 1984-10-04 1985-10-04 Procedimiento para la obtencion de (tio)morfolinas

Country Status (7)

Country Link
EP (1) EP0176903A1 (es)
JP (1) JPS6191180A (es)
AU (1) AU4827885A (es)
DE (1) DE3436386A1 (es)
ES (1) ES8703858A1 (es)
HU (1) HU195838B (es)
ZA (1) ZA857683B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014142108A1 (ja) * 2013-03-12 2014-09-18 独立行政法人産業技術総合研究所 線量分布測定装置
JP2022525036A (ja) * 2019-03-07 2022-05-11 アーバーメンティス・エルエルシー 非サイケデリック／精神異常発現性の投与量及び製剤で投与される神経可塑性作用を有する物質を含む組成物並びに使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75019B (es) * 1980-09-17 1984-07-12 Univ Miami
LU83327A1 (fr) * 1981-04-29 1983-03-24 Midit Procede de preparation de derives de 1,4-thiazine,leur utilisation ainsi que compositions contenant ces derives

Also Published As

Publication number Publication date
JPS6191180A (ja) 1986-05-09
HU195838B (en) 1988-07-28
EP0176903A1 (de) 1986-04-09
AU4827885A (en) 1986-04-10
DE3436386A1 (de) 1986-04-10
HUT42764A (en) 1987-08-28
ES547616A0 (es) 1987-03-01
ZA857683B (en) 1986-05-28

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