ZA889235B - Method of inhibiting the activity of leukocyte derived cytokines - Google Patents

Method of inhibiting the activity of leukocyte derived cytokines

Info

Publication number
ZA889235B
ZA889235B ZA889235A ZA889235A ZA889235B ZA 889235 B ZA889235 B ZA 889235B ZA 889235 A ZA889235 A ZA 889235A ZA 889235 A ZA889235 A ZA 889235A ZA 889235 B ZA889235 B ZA 889235B
Authority
ZA
South Africa
Prior art keywords
activity
inhibiting
cytokines
derived cytokines
tnf
Prior art date
Application number
ZA889235A
Other languages
English (en)
Inventor
Gerald L Mandell
L Mandell Gerald
Gail W Sullivan
W Sullivan Gail
William J Novick Jr
J Novick William Jr
Original Assignee
Hoechst Roussel Pharma
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma, Univ Virginia filed Critical Hoechst Roussel Pharma
Publication of ZA889235B publication Critical patent/ZA889235B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
ZA889235A 1987-12-11 1988-12-09 Method of inhibiting the activity of leukocyte derived cytokines ZA889235B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/131,785 US4965271A (en) 1986-12-31 1987-12-11 Method of inhibiting the activity of leukocyte derived cytokines

Publications (1)

Publication Number Publication Date
ZA889235B true ZA889235B (en) 1990-09-26

Family

ID=22451018

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA889235A ZA889235B (en) 1987-12-11 1988-12-09 Method of inhibiting the activity of leukocyte derived cytokines

Country Status (11)

Country Link
US (1) US4965271A (de)
EP (1) EP0344288B1 (de)
JP (1) JP2507105B2 (de)
AT (1) ATE118347T1 (de)
AU (2) AU632466B2 (de)
CA (1) CA1334508C (de)
DE (1) DE3853067T2 (de)
IE (1) IE69868B1 (de)
IL (1) IL88656A (de)
WO (1) WO1989005145A1 (de)
ZA (1) ZA889235B (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096906A (en) * 1986-12-31 1992-03-17 University Of Virginia Alumni Patents Foundation Method of inhibiting the activity of leukocyte derived cytokines
US5196429A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5196430A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5272153A (en) * 1986-12-31 1993-12-21 Hoechst-Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
EP1132471A3 (de) 1989-09-12 2001-11-28 F. Hoffmann-La Roche Ag TNF-bindende Proteine
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5958413A (en) * 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
NZ240644A (en) * 1990-11-21 1994-08-26 Smithkline Beecham Corp Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
IL100194A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
IL100195A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament having immuno suppressing activity
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
GB9109645D0 (en) * 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US5169840A (en) * 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
AU664189B2 (en) * 1991-05-24 1995-11-09 Fred Hutchinson Cancer Research Center Modulation of cellular response to external stimuli
US5856115A (en) * 1991-05-24 1999-01-05 Fred Hutchinson Cancer Research Center Assay for identification therapeutic agents
WO1993003728A1 (en) * 1991-08-27 1993-03-04 Temple University Of The Commonwealth System Of Xanthine suppression of antigen activation of t- or b-cells
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
JP3623501B2 (ja) * 1991-10-31 2005-02-23 ザ ビクトリア ユニバーシティ オブ マンチェスター インターロイキン−１阻害化合物による神経病学的状態の治療
CA2131190C (en) 1992-02-28 2008-08-12 Peter E. Lipsky Compositions and methods for the treatment of thermal injury
US5580874A (en) * 1992-03-04 1996-12-03 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
DK0584347T3 (da) * 1992-03-04 2003-02-24 Cell Therapeutics Inc Enantiomere hydroxylerede xanthinforbindelser
US5648357A (en) * 1992-03-04 1997-07-15 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
JP3076672B2 (ja) * 1992-06-18 2000-08-14 三井化学株式会社 キノリン誘導体のフマル酸塩
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5804584A (en) * 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5795897A (en) * 1992-11-18 1998-08-18 Cell Therapeutics, Inc. Oxohexyl methylxanthine compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
WO1994015605A1 (en) * 1993-01-14 1994-07-21 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
AU6092794A (en) * 1993-01-19 1994-08-15 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
WO1995022546A1 (en) * 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
US5698518A (en) * 1994-03-30 1997-12-16 Oklahoma Medical Research Foundation Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US6075029A (en) * 1998-01-02 2000-06-13 Cell Therapeutics, Inc. Xanthine modulators of metabolism of cellular P-450
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
AU2002362443B2 (en) * 2001-10-01 2008-05-15 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
SE0200667D0 (sv) 2002-03-05 2002-03-05 A & Science Invest Ab Novel use of cytokine inhibitors
US7442687B2 (en) * 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
EP2266994B1 (de) * 2004-08-02 2013-04-03 University Of Virginia Patent Foundation 2-propynyl-adenosin-Analoga mit modifizierten 5'-Ribosegruppen mit A2A-Agonistenaktivität
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
EP2218442A1 (de) 2005-11-09 2010-08-18 CombinatoRx, Inc. Verfahren, Zusammensetzungen und Kits zur Behandlung von ophthalmologischen Erkrankungen
US8178509B2 (en) * 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576947A (en) * 1967-12-16 1986-03-18 Hoechst Aktiengesellschaft Pharmaceutical compositions
US4515795A (en) * 1968-11-25 1985-05-07 Hoechst Aktiengesellschaft Pharmaceutical compositions
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH608236A5 (de) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4002756A (en) * 1974-04-22 1977-01-11 Interx Research Corporation Useful pro-drug forms of theophylline
DE2967632D1 (en) * 1978-04-22 1986-12-04 Beecham Wuelfing Gmbh & Co Kg Use of a xanthine derivate in the manufacture of a medicament
IL59665A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
US4225607A (en) * 1979-05-14 1980-09-30 Johann A. Wulfing Pharmaceutical composition containing a xanthine derivative
DE3173289D1 (en) * 1980-06-21 1986-02-06 Beecham Wuelfing Gmbh & Co Kg Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation
US4511557A (en) * 1981-08-24 1985-04-16 Gauri Kailash Kumar Pharmaceutical composition
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment
GB8501488D0 (en) * 1985-01-21 1985-02-20 Beecham Group Plc Treatment
JPH062675B2 (ja) * 1985-04-05 1994-01-12 ヘキストジヤパン株式会社 記憶障害治療剤
GB8621869D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Treatment
IL106861A (en) * 1986-12-31 1997-02-18 Hoechst Roussel Pharma Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines
DE3817955A1 (de) * 1988-05-27 1989-11-30 Hoechst Ag Tnf-inhibitor enthaltendes arzneimittel

Also Published As

Publication number Publication date
ATE118347T1 (de) 1995-03-15
IL88656A (en) 1993-07-08
AU652094B2 (en) 1994-08-11
AU2828589A (en) 1989-07-05
AU3564193A (en) 1993-06-03
DE3853067T2 (de) 1995-06-14
JPH02502542A (ja) 1990-08-16
EP0344288A4 (en) 1992-01-15
CA1334508C (en) 1995-02-21
IE69868B1 (en) 1996-10-16
EP0344288B1 (de) 1995-02-15
DE3853067D1 (de) 1995-03-23
WO1989005145A1 (en) 1989-06-15
AU632466B2 (en) 1993-01-07
US4965271A (en) 1990-10-23
IE883687L (en) 1989-06-11
JP2507105B2 (ja) 1996-06-12
EP0344288A1 (de) 1989-12-06

Similar Documents

Publication Publication Date Title
AU652094B2 (en) Method of inhibiting the activity of leukocyte derived cytokines
GR3024054T3 (en) Purine derivatives as interleukin-1 inhibitors
KR950002755A (ko) 워트마닌 및 그의 유사체에 의한 포스파티딜이노시톨 3-키나제의 억제
EP0401958A3 (de) Fotochromische Verbindung, deren Zusammensetzung und Verwendung
TNSN86111A1 (fr) Procede de preparation d'hydroxyalkylxanthines tertiaires
EP0265640A3 (de) Azaindol- und Indolizinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
KR920009399A (ko) 면역 억제 활성을 갖는 약제를 제조하기 위한 크산틴의 용도
EP0319947A3 (de) Bis-S-alkylbenzolabkömmlinge
CA2026130A1 (en) Aniline-based oil-soluble azo dyes
EP0357403A3 (de) Substituierte beta-Diketone
EP0195496A3 (de) Verwendung von Xanthinen zur Behandlung von proliferativer Hauterkrankung
GB8410396D0 (en) Carbocyclic compounds
JPS57200373A (en) Thiazolidine derivative
KR890009890A (ko) 하이드록시 피리미딘의 아실 유도체
EP0719777A3 (de) N-oxotetrahydro-beta-carboline
KR900700105A (ko) 백혈구 유도 사이토킨의 활성을 억제시키는 방법
EP0283551A3 (de) Verbesserungsmittel zur Gehirndurchblutung und für den Metabolismus
ES8703858A1 (es) Procedimiento para la obtencion de (tio)morfolinas
EP0210653A3 (de) Pyrazolo[4,3-d]pyrimidinderivat, Verfahren zu seiner Herstellung und dieses enthaltendes antihyperlipidemisches oder antiatherosklerotisches Mittel
GB2071093B (en) Benzothiopyrano(2,3-c)pyridines
SE505301E (sv) Golvbrunn med vattenlås vars ena kant befinner sig närmare golvbrunnsstommens botten än den andra kanten
EP0280841A3 (de) Organosilikon-Verbindungen und deren Verwendung
ATE61352T1 (de) 4-hydroxy-4-(substituierte alkenyl)cyclohexancarbons|ure.
JPS5283559A (en) 2-substituted-1,3-diazacycloalkanes
TH13784EX (th) อนุพันธ์ของพิริมีดีนนิ้วคลิโอไซด์ซึ่งมีฤทธิ์ต่อ ต้านเนื้องอก, การเตรียมสารเหล่านั้นและการใช้สาร เหล่านั้น