ZA888241B - Process for the synthesis of 3-thio-4-quinolene derivatives and intermediate compounds for use therein,and their use as medicaments - Google Patents
Process for the synthesis of 3-thio-4-quinolene derivatives and intermediate compounds for use therein,and their use as medicamentsInfo
- Publication number
- ZA888241B ZA888241B ZA888241A ZA888241A ZA888241B ZA 888241 B ZA888241 B ZA 888241B ZA 888241 A ZA888241 A ZA 888241A ZA 888241 A ZA888241 A ZA 888241A ZA 888241 B ZA888241 B ZA 888241B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinolene
- medicaments
- thio
- synthesis
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878726950A GB8726950D0 (en) | 1987-11-18 | 1987-11-18 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA888241B true ZA888241B (en) | 1989-10-25 |
Family
ID=10627131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA888241A ZA888241B (en) | 1987-11-18 | 1988-11-03 | Process for the synthesis of 3-thio-4-quinolene derivatives and intermediate compounds for use therein,and their use as medicaments |
Country Status (28)
Country | Link |
---|---|
US (2) | US5011931A (es) |
EP (2) | EP0343206A1 (es) |
JP (1) | JPH02502013A (es) |
KR (1) | KR890701563A (es) |
AT (1) | ATE69221T1 (es) |
AU (1) | AU628305B2 (es) |
BG (1) | BG50157A3 (es) |
CS (1) | CS274487B2 (es) |
DD (1) | DD290188A5 (es) |
DE (1) | DE3866086D1 (es) |
ES (1) | ES2038310T3 (es) |
FI (1) | FI91063C (es) |
GB (1) | GB8726950D0 (es) |
GR (1) | GR3003378T3 (es) |
HU (1) | HU204511B (es) |
IE (1) | IE883366L (es) |
IL (1) | IL88358A (es) |
MX (1) | MX168918B (es) |
NZ (1) | NZ227008A (es) |
PH (1) | PH27439A (es) |
PL (1) | PL157191B1 (es) |
PT (1) | PT89024B (es) |
RO (1) | RO104615B1 (es) |
SU (1) | SU1766255A3 (es) |
TW (1) | TW204344B (es) |
WO (1) | WO1989004827A1 (es) |
YU (1) | YU46989B (es) |
ZA (1) | ZA888241B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
US6194433B1 (en) | 1998-10-05 | 2001-02-27 | Neal R. Cutler | Sexual dysfunction in females |
US6110489A (en) * | 1998-05-01 | 2000-08-29 | Cutler; Neal R. | Use of quinolines and quinolones to treat male erectile dysfunction |
US6132753A (en) * | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6426084B1 (en) | 2000-06-19 | 2002-07-30 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6132757A (en) | 1998-05-01 | 2000-10-17 | Neal R. Cutler | Treatment of sexual dysfunction in certain patient groups |
US6303135B1 (en) | 1999-07-08 | 2001-10-16 | Neal R. Cutler | Use of quinolines and quinolones to treat male erectile dysfunction |
US6307050B1 (en) * | 2000-08-29 | 2001-10-23 | R. T. Alamo Venture I Llc | Method of synthesizing flosequinan from 4-fluoroanthranilic acid |
US6451813B1 (en) | 2001-01-26 | 2002-09-17 | R. T. Alamo Ventures I, Llc | Treatment of gastroparesis in certain patient groups |
US6562838B2 (en) * | 2001-01-26 | 2003-05-13 | R. T. Alamo Ventures I, L.L.C. | Treatment of cardiovascular disease with quinolinone enantiomers |
US6458804B1 (en) | 2001-01-26 | 2002-10-01 | R.T. Alamo Venturesi, Llc | Methods for the treatment of central nervous system disorders in certain patient groups |
US6531603B1 (en) | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6660864B2 (en) | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6657061B2 (en) | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6573382B2 (en) | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
US6649764B2 (en) * | 2001-10-25 | 2003-11-18 | R. T. Alamo Ventures I, Llc | Stereospecific enrichment of heterocyclic enantiomers |
US6730790B2 (en) * | 2002-03-01 | 2004-05-04 | R.T. Alamo Ventures I. Llc | Chlorinated heterocyclic compounds and methods of synthesis |
US7041677B2 (en) * | 2002-03-01 | 2006-05-09 | R.T. Alamo Ventures I, Llc | Use of monochloroflosequinan in the treatment of sexual dysfunction |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
KR20190116576A (ko) | 2009-05-06 | 2019-10-14 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920699A (en) * | 1974-04-26 | 1975-11-18 | Warner Lambert Co | Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby |
US4192873A (en) * | 1976-11-25 | 1980-03-11 | Ciba-Geigy Corporation | Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
NZ193167A (en) * | 1979-03-27 | 1984-08-24 | Boots Co Plc | Quinoline derivatives and pharmaceutical compositions |
IE51542B1 (en) * | 1980-09-26 | 1987-01-07 | Boots Co Ltd | Therapeutic agents |
FR2532939A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
DE3578374D1 (de) * | 1984-01-13 | 1990-08-02 | Boots Co Ltd | Verwendung von chinolonen fuer die herstellung eines arzneimittels zur behandlung von herzerkrankungen. |
FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
GB8515209D0 (en) * | 1985-06-15 | 1985-07-17 | Boots Co Plc | Therapeutic agents |
GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
GB8726950D0 (en) * | 1987-11-18 | 1987-12-23 | Boots Co Plc | Chemical process |
-
1987
- 1987-11-18 GB GB878726950A patent/GB8726950D0/en active Pending
-
1988
- 1988-11-03 ZA ZA888241A patent/ZA888241B/xx unknown
- 1988-11-07 DE DE8888310463T patent/DE3866086D1/de not_active Expired - Fee Related
- 1988-11-07 WO PCT/GB1988/000952 patent/WO1989004827A1/en active IP Right Grant
- 1988-11-07 JP JP63508842A patent/JPH02502013A/ja active Pending
- 1988-11-07 RO RO140740A patent/RO104615B1/ro unknown
- 1988-11-07 KR KR1019890701326A patent/KR890701563A/ko not_active Application Discontinuation
- 1988-11-07 EP EP88909581A patent/EP0343206A1/en active Pending
- 1988-11-07 EP EP88310463A patent/EP0317149B1/en not_active Expired - Lifetime
- 1988-11-07 ES ES198888310463T patent/ES2038310T3/es not_active Expired - Lifetime
- 1988-11-07 AT AT88310463T patent/ATE69221T1/de not_active IP Right Cessation
- 1988-11-07 AU AU26163/88A patent/AU628305B2/en not_active Ceased
- 1988-11-07 HU HU886294A patent/HU204511B/hu not_active IP Right Cessation
- 1988-11-07 US US07/378,216 patent/US5011931A/en not_active Expired - Fee Related
- 1988-11-09 IE IE883366A patent/IE883366L/xx unknown
- 1988-11-09 PH PH37784A patent/PH27439A/en unknown
- 1988-11-10 MX MX013748A patent/MX168918B/es unknown
- 1988-11-10 IL IL88358A patent/IL88358A/xx unknown
- 1988-11-11 TW TW077107879A patent/TW204344B/zh active
- 1988-11-11 YU YU209788A patent/YU46989B/sh unknown
- 1988-11-15 CS CS748988A patent/CS274487B2/cs unknown
- 1988-11-16 DD DD88321853A patent/DD290188A5/de not_active IP Right Cessation
- 1988-11-17 PT PT89024A patent/PT89024B/pt not_active IP Right Cessation
- 1988-11-18 NZ NZ227008A patent/NZ227008A/en unknown
- 1988-11-18 PL PL1988275880A patent/PL157191B1/pl unknown
-
1989
- 1989-05-17 SU SU894614311A patent/SU1766255A3/ru active
- 1989-07-13 FI FI893405A patent/FI91063C/fi not_active IP Right Cessation
- 1989-07-17 BG BG89219A patent/BG50157A3/xx unknown
-
1991
- 1991-03-01 US US07/663,085 patent/US5079264A/en not_active Expired - Fee Related
- 1991-12-18 GR GR91402063T patent/GR3003378T3/el unknown
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