ZA887264B - Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use - Google Patents

Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use

Info

Publication number
ZA887264B
ZA887264B ZA887264A ZA887264A ZA887264B ZA 887264 B ZA887264 B ZA 887264B ZA 887264 A ZA887264 A ZA 887264A ZA 887264 A ZA887264 A ZA 887264A ZA 887264 B ZA887264 B ZA 887264B
Authority
ZA
South Africa
Prior art keywords
renin
preparation
agents containing
dipeptides
inhibiting
Prior art date
Application number
ZA887264A
Other languages
English (en)
Inventor
Adalbert Wagner
Wagner Adalbert
Bernward Schoelkens
Schoelkens Bernward
Heinz-Werner Kleemann
Kleemann Heinz-Werner
Hansjoerg Urbach
Urbach Hansjoerg
Dieter Ruppert
Ruppert Dieter
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA887264B publication Critical patent/ZA887264B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA887264A 1987-09-30 1988-09-28 Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use ZA887264B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873732971 DE3732971A1 (de) 1987-09-30 1987-09-30 Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA887264B true ZA887264B (en) 1989-06-28

Family

ID=6337246

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA887264A ZA887264B (en) 1987-09-30 1988-09-28 Renin-inhibiting dipeptides,a process for the preparation thereof,agents containing them,and their use

Country Status (13)

Country Link
EP (1) EP0310015A3 (fr)
JP (1) JPH01121258A (fr)
KR (1) KR890005146A (fr)
AU (1) AU624579B2 (fr)
DE (1) DE3732971A1 (fr)
DK (1) DK543788A (fr)
FI (1) FI884455A (fr)
HU (1) HU203118B (fr)
IL (1) IL87912A0 (fr)
NO (1) NO884324L (fr)
NZ (1) NZ226361A (fr)
PT (1) PT88622B (fr)
ZA (1) ZA887264B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87614A0 (en) * 1987-09-16 1989-01-31 Abbott Lab Peptidylheterocycles
DE3804793A1 (de) * 1988-02-16 1989-08-24 Hoechst Ag Renin-hemmende aminosaeurederivate
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3913290A1 (de) * 1989-04-22 1990-10-25 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
TW225540B (fr) * 1990-06-28 1994-06-21 Shionogi & Co
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists
JP4696352B2 (ja) * 2000-11-30 2011-06-08 トヨタ自動車株式会社 車両用電源装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
GB2200115B (en) * 1987-01-21 1990-11-14 Sandoz Ltd Novel peptide derivatives, their production and use

Also Published As

Publication number Publication date
EP0310015A3 (fr) 1992-05-20
AU2295988A (en) 1989-06-29
HU203118B (en) 1991-05-28
DE3732971A1 (de) 1989-04-20
DK543788D0 (da) 1988-09-29
KR890005146A (ko) 1989-05-13
IL87912A0 (en) 1989-03-31
NO884324L (no) 1989-03-31
PT88622B (pt) 1993-07-30
JPH01121258A (ja) 1989-05-12
EP0310015A2 (fr) 1989-04-05
FI884455A0 (fi) 1988-09-28
PT88622A (pt) 1989-07-31
FI884455A (fi) 1989-03-31
AU624579B2 (en) 1992-06-18
HUT48278A (en) 1989-05-29
DK543788A (da) 1989-03-31
NZ226361A (en) 1991-12-23
NO884324D0 (no) 1988-09-29

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